MAD2 haplo-insufficiency causes premature anaphase and chromosome instability in mammalian cells

Nature

Volumn 409, Issue 6818, 2001, Pages 355-359

  Michel, Loren S ^a,b,c   Liberal, Vasco ^b,c   Chatterjee, Anupam ^d   Kirchwegger, Regina ^b,c   Pasche, Boris ^e   Gerald, William ^b   Dobles, Max ^f   Sorger, Peter K ^f   Murty, V V V S ^d   Benezra, Robert ^b,c  

^a Department of Medicine ^*

^b MEMORIAL SLOAN KETTERING CANCER CENTER   (United States)

^c Weill Cornell Graduate School of Biomedical Sciences   (United States)

^d Surgeons of Columbia University ^*  (United States)

^e NORTHWESTERN UNIVERSITY   (United States)

^f MASSACHUSETTS INSTITUTE OF TECHNOLOGY   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

PROTEIN MAD2;

ALLELE; ANAPHASE; ANIMAL CELL; ARTICLE; CARCINOGENESIS; CHROMOSOME ANALYSIS; CHROMOSOME SEGREGATION; LUNG TUMOR; MAMMAL; METAPHASE; MITOSIS INHIBITION; NONHUMAN; PRIORITY JOURNAL; PROTEIN ANALYSIS; SISTER CHROMATID;

ANAPHASE; ANIMALS; ANTINEOPLASTIC AGENTS; CALCIUM-BINDING PROTEINS; CARRIER PROTEINS; CELL CYCLE PROTEINS; CELLS, CULTURED; CHROMOSOME ABERRATIONS; CHROMOSOME SEGREGATION; FUNGAL PROTEINS; GENE DELETION; GENES, CDC; HUMANS; KARYOTYPING; LUNG NEOPLASMS; MICE; MITOSIS; NOCODAZOLE; NUCLEAR PROTEINS; TUMOR CELLS, CULTURED;

ANIMALIA; MAMMALIA; MURINAE;

EID: 0035905811     PISSN: 00280836     EISSN: None     Source Type: Journal    
DOI: 10.1038/35053094     Document Type: Article

References (29)

1. Identification of a human mitotic checkpoint gene: hsMAD2
2. The checkpoint delaying anaphase in response to chromosome monoorientation is mediated by an inhibitory signal produced by unattached kinetochores
3. Mutations in the essential spindle checkpoint gene bub1 cause chromosome missegregation and fail to block apoptosis in Drosophila
4. Components of the spindle-assembly checkpoint are essential in Caenorhabditis elegans
5. Chromosome missegregation and apoptosis in mice lacking the mitotic checkpoint protein Mad2
6. Bub3 gene disruption in mice reveals essential mitotic spindle checkpoint function during early embryogenesis
7. Genetic instabilities in human cancers
8. Mutations of mitotic checkpoint genes in human cancers
9. Genetic instability in colorectal cancers
10. Uncoupling of S phase and mitosis induced by anticancer agents in cells lacking p21
11. MAD2 associates with the cyclosome/anaphase-promoting complex and inhibits its activity
12. The checkpoint protein MAD2 and the mitotic regulator CDC20 form a ternary complex with the anaphase-promoting complex to control anaphase initiation
13. Mad2 transiently associates with an APC/p55Cdc complex during mitosis
14. Identification of a vertebrate sister-chromatid separation inhibitor involved in transformation and tumorigenesis
15. Sister chromatid separation and chromosome re-duplication are regulated by different mechanisms in response to spindle damage
16. The spindle assembly checkpoint
17. Cdc28 activates exit from mitosis in budding yeast
18. Protein phosphatase 2A regulates MPF activity and sister chromatid cohesion in budding yeast
19. Modeling human lung cancer in mice: Similarities and shortcomings
20. Tumour amplified kinase STK15/BTAK induces centrosome amplification, aneuploidy and transformation
21. Deregulated cyclin E induces chromosome instability
22. Identification of frequent impairment of the mitotic checkpoint and molecular analysis of the mitotic checkpoint genes, hsMAD2 and p55CDC, in human lung cancers
23. Characterization of MAD2B and other mitotic spindle checkpoint genes
24. Map location and gene structure of the Homo sapiens mitotic arrest deficient 2 (MAD2L1) gene at 4q27
25. Genetic alterations in hepatocellular carcinomas: Association between loss of chromosome 4q and p53 gene mutations
26. Recurring chromosome abnormalities in Hodgkin's disease
27. Multiple regions of chromosome 4 demonstrating allelic losses in breast carcinomas