Regulation of cyclin-Cdk activity in mammalian cells

Cellular and Molecular Life Sciences

Volumn 59, Issue 1, 2002, Pages 126-142

  Obaya, A J ^a   Sedivy, J M ^b  

^a DEPARTAMENTO DE BIOQUÍMICA Y BIOLOGÍA MOLECULAR   (Spain)

^b BROWN UNIVERSITY   (United States)

Author keywords

Cdk; Cdk inhibitor; Cdk phosphorylation; Cell cycle; Cellular localization; Cyclin; E2F Rb restriction point; Rb phosphorylation; Ubiquitin proteasome pathway

Indexed keywords

CYCLIN DEPENDENT KINASE; CYCLIN DEPENDENT KINASE 2; CYCLINE; PROTEASOME; RETINOBLASTOMA PROTEIN; UBIQUITIN;

ANIMAL CELL; CELL CYCLE; CELL CYCLE G1 PHASE; CELL CYCLE S PHASE; CONTROLLED STUDY; DEPHOSPHORYLATION; ENZYME REGULATION; GENE EXPRESSION SYSTEM; MAMMAL CELL; NONHUMAN; PROTEIN DEGRADATION; PROTEIN LOCALIZATION; PROTEIN PHOSPHORYLATION; REVIEW; SIGNAL TRANSDUCTION;

ANIMALS; CELL CYCLE; CYCLIN-DEPENDENT KINASES; CYCLINS; ENZYME INHIBITORS; HUMANS; MAMMALS; PHOSPHORYLATION; PROTEIN BINDING; PROTEIN PROCESSING, POST-TRANSLATIONAL; PROTEIN TRANSPORT;

ANIMALIA; MAMMALIA;

EID: 0036163745     PISSN: 1420682X     EISSN: None     Source Type: Journal    
DOI: 10.1007/s00018-002-8410-1     Document Type: Review

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69. Human cyclins B1 and B2 are localized to strikingly different structures: B1 to microtubules, B2 primarily to the Golgi apparatus
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71. Cyclin B2-null mice develop normally and are fertile whereas cyclin B1-null mice die in utero
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80. cdc2 activation: Identification of an activating kinase
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88. Effects of phosphorylation by CAK on cyclin binding by cdc2 and cdk2
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90. Dephosphorylation of cdk2 Thr160 by the cyclin-dependent kinase-interacting phosphatase KAP in the absence of cyclin
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93. Phosphoprotein-protein interactions revealed by the crystal strucure of kinase-associated phosphatase in complex with phospho-cdk2
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101. Human Wee1 kinase inhibits cell division by phosphorylating p34cdc2 exclusively on Tyr15
102. Myt1: A membrane-associated inhibitory kinase that phosphorylates Cdc2 on both threonine-14 and tyrosine-15
103. Membrane localization of the kinase which phosphorylates p34cdc2 on threonine 14
104. The human Myt1 kinase preferentially phosphorylates Cdc2 on threonine 14 and localizes to the endoplasmic reticulum and Golgi complex
105. Human Myt1 is a cell cycle-regulated kinase that inhibits Cdc2 but not Cdk2 activity
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115. Binding of 14-3-3beta to the carboxyl terminus of Weel increases Weel stability, kinase activity, and G2-M cell population
116. Negative regulation of Wee1 expression and Cdc2 phosphorylation during p53-mediated growth arrest and apoptosis
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118. cdc2 kinase of both Thr-14 and Tyr-15 by human Cdc25B phosphatase
119. Cdc25M2 activation of cyclin-dependent kinases by dephosphorylation of threonine-14 and tyrosine-15
120. Cell cycle regulation by the Cdc25 phosphatase family
121. Phosphorylation and activation of human cdc25C by cdc2-cyclin B and its involvement in the self-amplification of MPF at mitosis
122. 1/S transition
123. Regulatory phosphorylation of the p34cdc2 protein kinase in vertebrates
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126. The Polo-like kinase Plx1 is a component of the MPF amplification loop at the G2/M-phase transition of the cell cycle in Xenopus eggs
127. Activated Polo-like kinase Plx1 is required at multiple points during mitosis in Xenopus laevis
128. 2 arrest in human cells
129. The role of cdc2 feedback loop control in the DNA damage checkpoint in mammalian cells
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135. Checkpoints on the road to mitosis
136. 1 cyclin dependent kinases
137. 1-phase progression
138. A new regulatory motif in cell cycle control causing specific inhibition of cyclinD/cdk4
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141. Ink4a
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143. Identification of cdk4 sequences involved in cyclin D1 and p16 binding
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145. Kip1 coordinate their inhibitory interactions with cdk4 and cdk2
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148. Regulation of Cdk7-carboxyl-terminal domain kinase activity by the tumor suppressor p16(INK4A) contributes to cell cycle regulation
149. The p21 cdk-interacting protein Cip1 is a potent inhibitor of G1 cyclin-dependent kinases
150. Kip1, a cyclin-dependent kinase inhibitor and a potential mediator of extracellular antimitogenic signals
151. p27, a novel inhibitor of G1 cyclin-cdk protein kinase activity, is related to p21
152. KIP2, a cyclin-dependent kinase inhibitor with unique domain structure and tissue distribution
153. p21 is a universal inhibitor of cyclin kinases
154. WAF1/cip1 is induced in p53-mediated G1 arrest and apoptosis
155. p53-dependent inhibition of cyclin-dependent kinase activities in human fibroblasts during radiation-induced G1 arrest
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158. Proliferating cell nuclear antigen and p21 are components of multiple cell cycle kinase complexes
159. The p21 inhibitor of cyclin-dependent kinases controls DNA replication by interaction with PCNA
160. Differential effects by the p21 cdk inhibitor on PCNA dependent DNA replication and repair
161. Negative regulation of G1 in mammalian cells: Inhibition of cyclin E-dependent kinase by TGF-β
162. Kip1, a cyclin-cdk inhibitor, links transforming growth factor-β and contact inhibition to cell cycle arrest
163. CIPI cdk inhibitor family, is a candidate tumor suppressor gene
164. Identification of Myc-dependent step during the formation of active G1 cyclin-cdk complexes
165. Role of the ubiquitin-proteasome pathway in regulating abundance of the cyclin-dependent inhibitor p27
166. Direct induction of cyclin D2 by Myc contributes to cell cycle progression and sequestration of p27
167. Cip1
168. Regulation of exit from quiescence by p27 and cyclin D1-cdk4
169. c-Myc regulates cyclin D-cdk4 and -cdk6 activity but affects cell cycle progression at multiple independent points
170. INK4a-mediated growth suppression
171. Induced expression of p16(INK4a) inhibits both cdk4- and cdk2-associated kinase activity by reassortment of cyclin-cdk-inhibitor complexes
172. Ink4a, but not constitutively active pRb, can impose a sustained G1 arrest: Molecular mechanisms and implications for oncogenesis
173. New functional activities for the p21 family of CDK inhibitors
174. p21-containing cyclin kinases exist in both active and inactive states
175. Inhibition of cyclin-dependent kinases by p21
176. Cip1
177. Stoichiometry of cyclin A-cyclin-dependent kinase 2 inhibition by p21 (Cip1/Waf1)
178. Kip1) of cyclin-dependent kinase 4 activation
179. Inactivation of the cyclin D-dependent kinase in the rat fibroblast cell line, 3Y1, induced by contact inhibition
180. Waf1 inhibits the activity of cyclin dependent kinase 2 by preventing its activating phosphorylation
181. The N-terminal domains of cyclin-dependent inhibitory proteins block the phosphorylation of cdk2/cyclin E by the cdk-activating kinase
182. Kip1 with cyclin A-cdk2 and cyclin D2-cdk4
183. Formation of p27-CDK complexes during the human mitotic cell cycle
184. cip1
185. A unique role for the Rb protein in controlling E2F accumulation during cell growth and differentiation
186. E2F-4 switches from p130 to p107 and pRB in response to cell cycle reentry
187. Implication of transcription factor E2F in regulation of DNA replication
188. Heterodimerization of the transcription factor E2F-1 and DP-1 leads to cooperative trans-activation
189. Binding to DNA and the retinoblastoma gene product promoted by complex formation of different E2F family members
190. In vivo association of E2F and DP family proteins
191. A potent transrepression domain in the retinoblastoma protein induces a cell cycle arrest when bound to E2F sites
192. Mechanism of active transcriptional repression by the retinoblastoma protein
193. Functional interactions between the hBRM/hBRG1 transcriptional activators and the pRB family of proteins
194. The retinoblastoma protein and BRG1 form a complex and cooperate to induce cell cycle arrest
195. Retinoblastoma protein recruits histone deacetylase to repress transcription
196. Retinoblastoma protein represses transcription by recruiting a histone deacetylase
197. Cancer cell cycles
198. Kip1 blocks cyclin E-dependent transactivation of cyclin A gene expression
199. Cell cycle regulation of the cyclin A gene promoter is mediated by a variant E2F site
200. Human cyclin E, a nuclear protein essential for the G1-to-S phase transition
201. Cyclin A is required at two points in the human cell cycle
202. Cyclin A is required for the onset of DNA replication in mammalian fibroblats
203. Exit from G1 and S phase of the cell cycle is regulated by repressor complexes containing HDAC-Rb-hSWI/SNF and Rb-hSWI/SNF
204. BRG-1 is required for RB-mediated cell cycle arrest
205. Deregulated transcription factor E2F-1 expression leads to S-phase entry and p53-mediated apoptosis
206. Deregulated expression of E2F-1 induces S-phase entry and leads to apoptosis
207. Ink4A-mediated growth suppression
208. Cyclin E-induced S phase without activation of the pRb/E2F pathway
209. 1/S-promoting mechanism parallel to the pRb/E2F pathway
210. Collaborative role of E2F transcriptional activity and G1 cyclin-dependent kinase activity in the induction of S phase
211. Transcription factor E2F and cyclin E-cdk2 complex cooperate to induce chromosomal DNA replication in Xenopus oocytes
212. SCF and APC: The yin and yang of cell cycle regulated proteolysis
213. The anaphase-promoting complex: New subunits and regulators
214. Identification of a cullin homology region in a subunit of the anapahase-promoting complex
215. Cdc53 is a scaffold protein for multiple Cdc34/Skp1/F-box protein complexes that regulate cell division and methionine biosyntheis in yeast
216. Association of human CUL-1 and ubiquitin-conjugating enzyme cdc34 with the F-box protein p45Skp2: Evidence for evolutionary conservation in the subunit composition of the CDC34-SCF pathway
217. Human CUL-1 forms an evolutionary conserved ubiquitin ligase complex (SCF) with SKP1 and an F-box protein
218. F-box proteins are components of E3 complexes and act as receptors to recruit phosphorylated substrates for ubiquitination
219. A family of mammalian F-box proteins
220. Skp2 is required for the ubiquitin-mediated degradation of the CDK inhibitor p27
221. β-RTCP-ubiquitin ligase com-plex associates specifically with phosphorylated destruction motifs in IκBα and B-catenin and stimulates IκBα ubiquitination in vitro
222. Activation of the human anaphase promoting complex by proteins of the CDC20/Fizzy family
223. The checkpoint protein MAD2 and the mitotic regulator CDC20 form a ternary complex with the anaphase-promoting complex to control anaphase initiation
224. The role of controlled proteolysis in cell-cycle regulation
225. 1 checkpoint
226. Kip1 downregulation, passage through the restriction point, and entry into S phase in growth factor-stimulated NIH 3T3 fibroblasts
227. Kip1 regulated by mitogen-activated protein kinase kinase (MEK1)
228. Kip1, and cell cycle progression in human capillary endothelial cells by cell shape and cytoskeletal tension
229. MAP kinase cascade is required for p27 downregulation and S phase entry in fibroblasts and epithelial cells
230. Control of the eukaryotic cell cycle by MAP kinase signaling pathway
231. Kip1 through the phosphatidylinositol 3-kinase/AKT pathway
232. Oncogenic signals of HER-2/neu in regulating the stability of the cyclin-dependent kinase inhibitor p27
233. Wnt1 and MEK1 cooperate to promote cyclin D1 accumulation and cellular transformation
234. Kip1-cdk2 complex formation: Receptor overexpression does not determine growth dependency
235. Glycogen synthase kinase-3β regulates cyclin D1 proteolysis and subcellular localization
236. Inhibition of cyclin D1 phosphorylation on threonine-286 prevents its rapid degradation via the ubiquitin-proteasome pathway
237. Cullin-3 targets cyclin E for ubiquitination and controls S phase in mammalian cells
238. Ubiquitination of free cyclin D1 is independent of phosphorylation on threonine 286
239. Culprits in the degradation of cyclin E apprehended
240. Kip1 accumulation during the cell cycle
241. Kip1 is abrogated by c-Myc
242. Cell cycle-dependent phosphorylation of p27 cyclin-dependent kinase (cdk) inhibitor by cyclin E/cdk2
243. Cell-free degradation of p27(Kip1), a G1 cyclin-dependent kinase inhibitor, is dependent of cdk2 activity and the proteasome
244. Mechanism of cdk2/cyclin E inhibition by p27 and p27 phosphorylation
245. A new group of conserved coactivators that increase the specificity of AP-1 transcription factors
246. Kip1 is instigated by Jabl
247. Skp2 complex through phosphorylated Thr187 in p27
248. Waf1 and cyclin D proteins
249. Skp2 are essential elements of the cyclin A-cdk2 S phase kinase
250. Kip1 degradation and induces S phase in quiescent cells
251. Targeted disruption of Skp2 results in accumulation of cyclin E and p27(kip1), polyploidy and centrosome overduplication
252. Kip1 meets SKP2: New links in cell-cycle control
253. Kip1 by ubiquitination
254. Myc-enhanced expression of Cull promotes ubiquitin-dependent proteolysis and cell cycle progression
255. Role of E2F in cell cycle control and cancer
256. The retinoblastoma gene product protects E2F-1 from degradation by the ubiquitin-proteasome pathway
257. Degradation of E2F by the ubiquitin-proteasome pathway: Regulation by retinoblastoma family proteins and adenovirus transforming proteins
258. Regulation of E2F through ubiquitin-proteasome-dependent degradation: Stabilization by the pRB tumor suppressor protein
259. Skipping into the E2F1-destruction pathway
260. Interaction between ubiquitin-protein ligase SCFSKP2 and E2F-1 underlies the regulation of E2F-1 degradation
261. Destruction of Xenopus cyclins A and B2 but not B1, requires binding to p34cdc2
262. Cell-cycle regulated degradation of Xenopus cyclin B2 requires binding to p34cdc2
263. The cyclosome, a large complex containing cyclin-selective ubiquitin ligase activity, targets cyclins for destruction at the end of mitosis
264. The 'destruction box' of cyclin A allows B-type cyclins to be ubiquitinated, but not efficiently destroyed
265. Regulation of the APC and the exit from mitosis
266. Human cyclin A is required for mitosis until mid prophase
267. Cyclin A is destroyed in prometaphase and can delay chromosome alignment and anaphase
268. Temporal and spatial control of cyclin B1 destruction in metaphase
269. Anaphase-promoting complex/cyclosome-dependent proteolysis of human cyclin A starts at the beginning of mitosis and is not subject to the spindle assembly checkpoint
270. Proteasome-dependent degradation of human Cdc25B phosphatase
271. Cdc25A stability is controlled by the ubiquitin-proteasome pathway during cell cycle progression and terminal differentiation
272. Rapid destruction of human Cdc25A in response to DNA damage
273. SE1-1
274. Cyclin D1 is a nuclear protein required for cell cycle progression in G1
275. A dominant-negative cyclin D1 mutant prevents nuclear import of cyclin-dependent kinase 4 (cdk4) and its phosphorylation by cdk-activating kinase
276. 1 cyclin-dependent kinases in the liver: Role of nuclear localization and p27 sequestration
277. Cdc25 is a nuclear protein expressed constitutively throughout the cell cycle in nontransformed mammalian cells
278. Ubiquitination of p27 is regulated by Cdk-dependent phosphorylation and trimeric complex formation
279. Cyclin E-mediated elimination of p27 requires its interaction with the nuclear pore-associated protein mNPAP60
280. Cell cycle-dependent localization of the cdk2-cyclin E complex in Cajal (coiled) bodies
281. E2F activity is regulated by cell cycle-dependent changes in subcellular localization
282. Induction of S-phase entry by E2F transcription factors depends on their nuclear localization
283. Nuclear localization of DP and E2F transcription factors by heterodimeric partners and retinoblastoma protein family members
284. The subcellular localization of E2F-4 is cell-cycle dependent
285. Cell cycle regulation of the E2F transcription factor involves an interaction with cyclin A
286. Cyclin E/cdk2 and cyclin A/cdk2 kinases associate with p107 and E2F in a temporally distinct manner
287. A cyclin A-protein kinase complex possess sequence-specific DNA binding activity: p33cdk2 is a component of the E2F-cyclin A complex
288. MPF localization is controlled by nuclear export
289. Control of cyclin B1 localization through regulated binding of the nuclear export factor CRM1
290. Cyclin F regulates the nuclear localization of cyclin B1 through a cyclin-cyclin interaction
291. The differential localization of human cyclin A and B is due to a cytoplasmic retention signal in cyclin B
292. Human cyclins A and B are differentially located in the cell and undergo cell cycle dependent nuclear transport
293. Nuclear localization of cyclin B1 mediates its biological activity and it is regulated by phosphorylation
294. Combinatorial control of cyclin B1 nuclear trafficking through phosphorylation at multiple sites