Analysis of cyclin D3-cdk4 complexes in fibroblasts expressing and lacking p27kip1 and p21cip1

Molecular and Cellular Biology

Volumn 20, Issue 23, 2000, Pages 8748-8757

  Bagui, T K ^a   Jackson, R J ^a   Agrawal, D ^a   Pledger, W J ^a  

^a Cancer Center and Research Institute   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

CELL EXTRACT; CYCLIN D3; CYCLIN DEPENDENT KINASE; MONOCLONAL ANTIBODY; PROTEIN P21; PROTEIN P27;

ANIMAL CELL; ARTICLE; CELL TYPE; CHEMICAL COMPOSITION; COMPLEX FORMATION; CONTROLLED STUDY; ENZYME ACTIVITY; FIBROBLAST; MOUSE; NONHUMAN; PRIORITY JOURNAL; PROTEIN ANALYSIS; PROTEIN ASSEMBLY; PROTEIN EXPRESSION; PROTEIN PROTEIN INTERACTION;

3T3 CELLS; ANIMALS; CELL CYCLE PROTEINS; CYCLIN D1; CYCLIN-DEPENDENT KINASE 4; CYCLIN-DEPENDENT KINASE INHIBITOR P21; CYCLIN-DEPENDENT KINASE INHIBITOR P27; CYCLIN-DEPENDENT KINASES; CYCLINS; EMBRYO; MICE; MICE, INBRED BALB C; MICROTUBULE-ASSOCIATED PROTEINS; MUTATION; PROTEIN BINDING; PROTO-ONCOGENE PROTEINS; RETINOBLASTOMA PROTEIN; TUMOR SUPPRESSOR PROTEINS;

ANIMALIA;

EID: 0034459450     PISSN: 02707306     EISSN: None     Source Type: Journal    
DOI: 10.1128/MCB.20.23.8748-8757.2000     Document Type: Article

References (52)

1. kip1 synthesis by platelet-derived growth factor in BALB/c 3T3 cells
2. 1 phase by specific inhibition of CDK2 kinase activity
3. Kip1 with cyclin A-Cdk2 and cyclin D2-Cdk4
4. Radiation-induced cell cycle arrest compromised by p21 deficiency
5. 1 arrest with inhibition of cyclin-dependent kinase (CDK) 2 and CDK4 in human breast carcinoma cells
6. The E2F transcription factor is a cellular target for the RB protein
7. Kip1 CDK "inhibitors" are essential activators of cyclin D-dependent kinases in murine fibroblasts
8. Kip1 regulated by mitogen-activated protein kinase kinase (MEK1)
9. Kip1 for restriction point control of the fibroblast cell cycle
10. Kip1-deficient cells
11. STATs and gene regulation
12. Structural basis for specificity and potency of a flavonoid inhibitor of human CDK2, a cell cycle kinase
13. 1/S-regulatory genes
14. kip1 in BALB/c-3T3 cells
15. 1 arrest
16. Functional interactions of the retinoblastoma protein with mammalian D-type cyclins
17. TGFβ inhibition of Cdk4 synthesis is linked to cell cycle arrest
18. Kip1-deficient mice
19. Inactivation of a Cdk2 inhibitor during interleukin 2-induced proliferation of human T lymphocytes
20. Collaboration of G1 cyclins in the functional inactivation of the retinoblastoma protein
21. Inhibitors of the Cip/Kip family
22. Direct binding of cyclin D to the retinoblastoma gene product (pRb) and pRb phosphorylation by the cyclin D-dependent kinase CDK4
23. Kip1) of cyclin-dependent kinase 4 activation
24. Kip1
25. New functional activities for the p21 family of CDK inhibitors
26. Regulation of exit from quiescence by p27 and cyclin D1-CDK4
27. KIP2, a cyclin-dependent kinase inhibitor with unique domain structure and tissue distribution
28. Cell cycle expression and p53 regulation of the cyclin-dependent kinase inhibitor p21
29. Functional inactivation of the retinoblastoma protein requires sequential modification by at least two distinct cyclin-cdk complexes
30. 1 phase of the cell cycle
31. Biochemical and cellular effects of roscovitine, a potent and selective inhibitor of the cyclin-dependent kinases cdc2, cdk2 and cdk5
32. Kip1 mRNA is a mechanism contributing to accumulation during growth arrest
33. Kip1 display increased body size, multiple organ hyperplasia, retinal dysplasia, and pituitary tumors
34. Kip1 cyclin-dependent kinase inhibitor prevented by rapamycin
35. Cyclin D-cdk subunit arrangement is dependent on the availability of competing INK and p21 class inhibitors
36. The restriction point and control of cell proliferation
37. An ordered sequence of events is required before BALB/c-3T3 cells become committed to DNA synthesis
38. kip1, a cyclin-Cdk inhibitor, links transforming growth factor-β and contact inhibition to cell cycle arrest
39. Redistribution of the CDK inhibitor p27 between different cyclin-CDK complexes in the mouse fibroblast cell cycle and in cells arrested with lovastatin or ultraviolet irradiation
40. 0state) in fibroblasts
41. The p161NK4a/CDKN2A tumor suppressor and its relatives
42. Kip1 cyclin-dependent-kinase inhibitor bound to the cyclin A-Cdk2 complex
43. Cancer cell cycles
44. 1-phase progression
45. 1 cyclin-dependent kinases
46. CAK, the p34cdc2 activating kinase, contains a protein identical or closely related to p40MO15
47. 1 cyclin-Cdk protein kinase activity, is related to p21
48. The retinoblastoma protein and cell cycle control
49. kip1 by platelet-derived growth factor and plasma factors in density-arrested fibroblasts
50. Growth factor regulation of cyclin D1 mRNA expression through protein synthesis-dependent and -independent mechanisms
51. p21-containing cyclin kinases exist in both active and inactive states
52. kip1