Complete inhibition of Cdk/cyclin by one molecule of p21(Cip1)

Genes and Development

Volumn 12, Issue 24, 1998, Pages 3882-3888

  Hengst, Ludger ^a,b   Göpfert, Ulrich ^a   Lashuel, Hilal A ^b   Reed, Steven I ^b  

^a MAX PLANCK INSTITUTE OF BIOCHEMISTRY   (Germany)

^b SCRIPPS RESEARCH INSTITUTE   (United States)

Author keywords

Cell cycle; Cyclin dependent kinase; Cyclin dependent kinase inhibitor; P21(Cip1)

Indexed keywords

CYCLIN A; CYCLIN DEPENDENT KINASE; ENZYME INHIBITOR; PROTEIN P21;

ANIMAL CELL; ARTICLE; CELL CYCLE; COMPLEX FORMATION; CONTROLLED STUDY; ENZYME ACTIVITY; ENZYME INHIBITION; NONHUMAN; PRIORITY JOURNAL; PROTEIN PHOSPHORYLATION; ULTRACENTRIFUGATION;

ANIMALIA;

EID: 0032535375     PISSN: 08909369     EISSN: None     Source Type: Journal    
DOI: 10.1101/gad.12.24.3882     Document Type: Article

References (22)

1. Andrews, P. 1970. Estimation of molecular size and molecular weights of biological compounds by gel filtration. Meth. Biochem. Anal. 18: 1-53.
2. Carnero, A. and G. Hannon. 1998. The INK4 family of CDK inhibitors. Curr. Top. Microbiol. Immunol. 227: 43-55.
3. Chen, J., P.K. Jackson, M.W. Kirschner, and A. Dutta. 1995. Separate domains of p21 involved in the inhibition of Cdk kinase and PCNA. Nature 374: 386-388.
4. Dulic, V., G. Stein, D. Far, and S. Reed. 1998. Nuclear accumulation of p21Cip1 at the onset of mitosis: a role at the G2/ M-phase transition. Mol. Cell. Biol. 18: 546-557.
5. Harper, J. 1997. Cyclin dependent kinase inhibitors. Cancer Surv. 29: 91-107.
6. Harper, J.W., S.J. Elledge, K. Keyomarsi, B. Dynlacht, L.H. Tsai, P. Zhang, S. Dobrowolski, C. Bai, C.L. Connell, E. Swindell, M.P. Fox, and N. Wei. 1995. Inhibition of cyclin-dependent kinases by p21. Mol Biol. Cell. 6: 387-400.
7. Hengst, L. and S. Reed. 1998. Inhibitors of the Cip/Kip family. Curr. Top. Microbiol. Immunol. 227: 25-41.
8. Hengst, L., V. Dulic, J.M. Slingerland, E. Lees, and S.I. Reed. 1994. A cell cycle-regulated inhibitor of cyclin-dependent kinases. Proc. Natl. Acad. Sci. 91: 5291-5295.
9. Kriwacki, R., L. Hengst, L. Tennant, S. Reed, and P. Wright. 1996. Structural studies of p21Waf1/Cip1/Sdi1 in the free and Cdk2-bound state: Conformational disorder mediates binding diversity. Proc. Natl. Acad. Sci. 93: 11504-11509.
10. Li, Y., C.W. Jenkins, M.A. Nichols, and Y. Xiong. 1994. Cell cycle expression and p53 regulation of the cyclin-dependent kinase inhibitor p21. Oncogene 9: 2261-2268.
11. Luo, Y., J. Hurwitz, and J. Massagué. 1995. Cell-cycle inhibition by independent CDK and PCNA binding domains in p21Cip1. Nature 375: 159-161.
12. Morgan, D.O. 1995. Principles of CDK regulation. Nature 374: 131-134.
13. Nigg, E.A. 1995. Cyclin-dependent protein kinases: Key regulators of the eukaryotic cell cycle. BioEssays 17: 471-480.
14. Noda, A., Y. Ning, S.F. Venable, S.O. Pereira, and J.R. Smith. 1994. Cloning of senescent cell-derived inhibitors of DNA synthesis using an expression screen. Exp. Cell. Res. 211: 90-98.
15. Pines, J. 1995. Cyclins and cyclin-dependent kinases: A biochemical view. Biochem. J. 308: 697-711.
16. Russo, A.A., P.D. Jeffrey, A.K. Patten, J. Massague, and N.P. Pavletich. 1996. Crystal structure of the p27Kip1 cyclin-dependent -kinase inhibitor bound to the cyclin A-Cdk2 complex. Nature 382: 325-331.
17. Sheaff, R.J., M. Groudine, M. Gordon, J.M. Roberts, and B.E. Clurman. 1997. Cyclin E-Cdk2 is a regulator of p27Kip1. Genes & Dev. 11: 1464-1478.
18. Sherr, C.J. and J.M. Roberts. 1995. Inhibitors of mammalian G1 cyclin-dependent kinases. Genes & Dev. 9: 1149-1163.
19. Toyoshima, H. and T. Hunter. 1994. p27, a novel inhibitor of G1 cyclin-Cdk protein kinase activity, is related to p21. Cell 78: 67-74.
20. Vlach, J., S. Hennecke, and B. Amati. 1997. Phosphorylation-dependent degradation of the cyclin-dependent kinase inhibitor p27Kip1. EMBO J. 16: 5334-5344.
21. Zhang, H., G.J. Hannon, and D. Beach. 1994a. p21-containing cyclin kinases exist in both active and inactive states. Genes &. Dev. 8: 1750-1758.
22. Zhang, H., G.J. Hannon, D. Casso, and D. Beach. 1994b. p21 is a component of active cell cycle kinases. Cold Spring Harbor Symp. Quant. Biol. 59: 21-29.