Cyclin A is destroyed in prometaphase and can delay chromosome alignment and anaphase

Journal of Cell Biology

Volumn 153, Issue 1, 2001, Pages 121-135

  Elzen, Nicole Den ^a   Pines, Jonathon ^a  

^a IMPERIAL CANCER RESEARCH FUND   (United Kingdom)

Author keywords

Cell cycle; Chromosome; Cyclin; Mitosis; Proteolysis

Indexed keywords

CYCLIN A;

ANAPHASE; ARTICLE; CELL CYCLE; CHROMOSOME REARRANGEMENT; CHROMOSOME REPLICATION; HUMAN; HUMAN CELL; METAPHASE; MITOSIS; MITOSIS SPINDLE; PRIORITY JOURNAL; PROTEIN DEGRADATION;

ANAPHASE; BIOLOGICAL MARKERS; CHROMOSOMES, HUMAN; CYCLIN A; CYCLIN-DEPENDENT KINASES; GREEN FLUORESCENT PROTEINS; HELA CELLS; HUMANS; LUMINESCENT PROTEINS; METAPHASE; MITOSIS; RECOMBINANT FUSION PROTEINS;

ANIMALIA;

EID: 0035795414     PISSN: 00219525     EISSN: None     Source Type: Journal    
DOI: 10.1083/jcb.153.1.121     Document Type: Article

References (61)

1. Sister chromatid separation and chromosome re-duplication are regulated by different mechanisms in response to spindle damage
2. Cytoplasmic accumulation of cyclin B1 in human cells: Association with a detergent-resistant compartment and with the centrosome
3. Cell cycle-regulated proteolysis of mitotic target proteins
4. Association of spindle assembly checkpoint component XMAD2 with unattached kinetochores
5. Temporal and spatial control of cyclin B1 destruction in metaphase
6. The Drosophila cell cycle gene fizzy is required for normal degradation of cyclins A and B during mitosis and has homology to the CDC20 gene of Saccharomyces cerevisiae
7. Chromosome missegregation and apoptosis in mice lacking the mitotic checkpoint protein Mad2
8. The checkpoint protein MAD2 and the mitotic regulator CDC20 form a ternary complex with the anaphase-31promoting complex to control anaphase initiation
9. Triggering of cyclin degradation in interphase extracts of amphibian eggs by cdc2 kinase
10. Human cyclin A is required for mitosis until mid prophase
11. Anaphase-promoting complex/cyclosome-dependent proteolysis of human cyclin A starts at the beginning of mitosis and is not subject to the spindle assembly checkpoint
12. Delayed cyclin A and B1 degradation in non-transformed mammalian cells
13. Cyclin is degraded by the ubiquitin pathway
14. Microinjection of antibody to Mad2 protein into mammalian cells in mitosis induces premature anaphase
15. Translocation of cyclin B1 to the nucleus at prophase requires a phosphorylation-dependent nuclear import signal
16. The spindle checkpoint
17. The ubiquitin system
18. Components of a system that ligates cyclin to ubiquitin and their regulation by the protein kinase cdc2
19. Anaphase is initiated by proteolysis rather than by the inactivation of maturation-promoting factor
20. Visualization of Mad2 dynamics at kinetochores, along spindle fibers, and at spindle poles in living cells
21. The requirements for protein synthesis and degradation, and the control of destruction of cyclins A and B in the meiotic and mitotic cell cycles of the clam embryo
22. A 20S complex containing CDC27 and CDC16 catalyzes the mitosis-specific conjugation of ubiquitin to cyclin B
23. How proteolysis drives the cell cycle
24. Mutagenic analysis of the destruction signal of mitotic cyclins and structural characterization of ubiquitinated intermediates
25. The "destruction box" of cyclin A allows B-type cyclins to be ubiquitinated, but not efficiently destroyed
26. Identification of the domains in cyclin A required for binding to, and activation of, p34cdc2 and p32cdk2 protein kinase subunits
27. Cyclin/Cdkdependent initiation of DNA replication in a human cell-free system
28. The roles of Drosophila cyclins A and B in mitotic control
29. Mitotic forces control a cell-cycle checkpoint
30. Identification of a human mitotic checkpoint gene: hsMAD2
31. MAD2 associates with the cyclosome/anaphase-promoting complex and inhibits its activity
32. Fizzy is required for activation of the APC/cyclosome in Xenopus egg extracts
33. Cyclin A-Cys41 does not undergo cell cycle-dependent degradation in Xenopus extracts
34. Cyclin A-cdc2 kinase does not trigger but delays cyclin degradation in interphase extracts of amphibian eggs
35. Control of programmed cyclin destruction in a cell-free system
36. Both cyclin A delta 60 and B delta 97 are stable and arrest cells in M-phase, but only cyclin B delta 97 turns on cyclin destruction
37. The A- and B-type cyclin associated cdc2 kinases in Xenopus turn on and off at different times in the cell cycle
38. Regulation of the APC and the exit from mitosis
39. Animal cell cycles and their control
40. Human p55(CDC)/Cdc20 associates with cyclin A and is phosphorylated by the cyclin A-Cdk2 complex
41. Relocation and distinct subcellular localization of p34cdc2-cyclin B complex at meiosis reinitiation in starfish oocytes
42. Cyclin A is required at two points in the human cell cycle
43. Localization of cell cycle regulators by immunofluorescence
44. Human cyclin A is adenovirus E1A-associated protein p60, and behaves differently from cyclin B
45. Human cyclins A and B are differentially located in the cell and undergo cell cycle-dependent nuclear transport
46. Anaphase onset in vertebrate somatic cells is controlled by a checkpoint that monitors sister kinetochore attachment to the spindle
47. The checkpoint delaying anaphase in response to chromosome monoorientation is mediated by an inhibitory signal produced by unattached kinetochores
48. APC(Cdc20) promotes exit from mitosis by destroying the anaphase inhibitor Pds1 and cyclin Clb5
49. Exit from mitosis is regulated by Drosophila fizzy and the sequential destruction of cyclins A, B and B3
50. Destruction of Xenopus cyclins A and B2, but not B1, requires binding to p34cdc2
51. DNA damage leads to a cyclin A-dependent delay in metaphase-anaphase transition in the Drosophila gastrula
52. The cyclosome, a large complex containing cyclin-selective ubiquitin ligase activity, targets cyclins for destruction at the end of mitosis
53. Chromosome segregation: Dual control ensures fidelity
54. Kinetochore localization of murine Bub1 is required for normal mitotic timing and checkpoint response to spindle damage
55. Cell cycle synchronization: Reversible induction of G2 synchrony in cultured rodent and human diploid fibroblasts
56. Dominant-negative cyclin-selective ubiquitin carrier protein E2-C/ UbcH10 blocks cells in metaphase
57. Localization of Mad2 to kinetochores depends on microtubule attachment, not tension
58. CDK1 inactivation regulates anaphase spindle dynamics and cytokinesis in vivo
59. The A- and B-type cyclins of Drosophila are accumulated and destroyed in temporally distinct events that define separable phases of the G2-M transition
60. Pds1p, an inhibitor of anaphase in budding yeast, plays a critical role in the APC and checkpoint pathway(s)
61. The role of the destruction box and its neighbouring lysine residues in cyclin B for anaphase ubiquitin-dependent proteolysis in fission yeast: Defining the D-box receptor