The consensus motif for phosphorylation by cyclin D1-Cdk4 is different from that for phosphorylation by cyclin A/E-Cdk2

EMBO Journal

Volumn 15, Issue 24, 1996, Pages 7060-7069

  Kitagawa, Masatoshi ^a   Higashi, Hideaki ^a   Jung, Hai Kwan ^b   Suzuki Takahashi, Ikuko ^a   Ikeda, Masako ^c   Tamai, Katsuyuki ^c   Kato, Jun Ya ^d   Segawa, Kaoru ^e   Yoshida, Eisaku ^a   Nishimura, Susumu ^a   Taya, Yoichi ^b  

^a TAIHO PHARMACEUTICAL CO LTD   (Japan)

^b NATIONAL CANCER CENTER RESEARCH INSTITUTE   (Japan)

^c Medical & Biological Laboratories Co Ltd   (Japan)

^d NARA INSTITUTE OF SCIENCE AND TECHNOLOGY   (Japan)

^e KEIO UNIVERSITY   (Japan)

Author keywords

Cdk2; Cdk4; Cell cycle; Cyclin D1; p107; RB protein

Indexed keywords

ANTIBODY; CYCLIN A; CYCLIN D1; CYCLIN DEPENDENT KINASE; PHOSPHOSERINE; RECOMBINANT PROTEIN; RETINOBLASTOMA PROTEIN; SYNTHETIC PEPTIDE; TRANSCRIPTION FACTOR E2F;

AMINO ACID SEQUENCE; ANIMAL CELL; ARTICLE; CELL CYCLE G1 PHASE; CONSENSUS SEQUENCE; CONTROLLED STUDY; HUMAN; HUMAN CELL; MOUSE; NONHUMAN; PRIORITY JOURNAL; PROTEIN BINDING; PROTEIN PHOSPHORYLATION; PROTEIN PROTEIN INTERACTION; STRUCTURE ACTIVITY RELATION;

EID: 12644284504     PISSN: 02614189     EISSN: None     Source Type: Journal    
DOI: 10.1002/j.1460-2075.1996.tb01097.x     Document Type: Article

References (57)

1. Baldin,V., Lukas,J., Marcote,M.J., Pugano,M. and Draetta,G. (1993) Cyclin D1 is a nuclear protein required for cell cycle progression in G1. Genes Dev., 7, 812-821.
2. Bates,S., Bonetta,L., MacAllan,D., Holder,A., Dickson,C. and Peters,G. (1994) CDK6 (PLSTIRE) and CDK4 (PSK-J3) are a distinct subset of the cyclin-dependent kinases that associate with cyclin D1. Oncogene, 9, 71-79.
3. Beijershergen,R.L., Carlee,L., Kerkhoven,R.M. and Bernards,R. (1995) Regulation of the retinoblastoma protein-related p107 by G1 cyclin complexes. Genes Dev., 9, 1340-1353.
4. Durfee,T., Becherer,K. Chen,P.-L., Yeh,S.-H., Yang,Y., Kilbum,A.E., Lee,W.H. and Elledge,S.J. (1993) The retinoblastoma protein associates with the protein phosphatase type I catalytic subunit. Genes Dev., 7, 555-569.
5. Dynlacht,B.D., Flores,O, Lees,J.A. and Harlow,E. (1994) Differential regulation of E2F trans-activation by cyclin/cdk2 complex. Genes Dev., 8, 1772-1786.
6. Ewen,M.E., Xing,Y., Lawrence,J.B. and Livingston,D.M. (1991) Molecular cloning, chromosomal mapping, and expression of the cDNA for p 107, a retinoblastoma gene product-related protein. Cell, 66, 1155-1164.
7. Ewen,M.E., Sluss,H.K., Sherr,C.J., Matsushime,H., Kato,J. and Livingston,D.M. (1993) Functional interaction of the retinoblastoma protein with mammalian D-type cyclins. Cell, 73, 487-497.
8. Gonzalez,F.A., Raden,D.L. and Davis,R.J. (1991) Identification of substrate recognition determinants for human ERK1 and ERK2 protein kinases. J. Biol. Chem., 256, 22159-22163.
9. INK4/MTS2-related CDK6 inhibitor, correlates with wild-type pRb function. Genes Dev., 8, 2939-2951.
10. Hamel,P.A., Gill,R.M., Phillipes,R.A. and Gallie,B.L. (1992) Regions controlling hyperphosphorylation and conformation of the retinoblastoma gene product are independent of domains required for transcriptional repression. Oncogene, 7, 693-701.
11. Helin,K. and Harlow,E. (1993) The retinoblastoma protein as a transcriptional repressor. Trends Cell Biol., 3, 43-46.
12. Higashi,H., Suzuki-Takahashi,I., Taya,Y. Segawa,K., Nishimura,S. and Kitagawa,M. (1995) Differences in substrate specificity between Cdk2-cyclinA and Cdk2-cyclin E in vitro. Biochem. Biophys. Res. Commun., 216, 520-525.
13. Higashi,H., Suzuki-Takahashi,I., Saitoh,S., Segawa,K., Taya,Y., Okuyama,A., Nishimura,S. and Kitagawa,M. (1996) Cyclin-dependent kinase 2 (Cdk2) forms an inactive complex with cyclin D1 since Cdk2 associated with cyclin D1 is not phosphorylated by Cdk7-cyclin-H. Eur. J. Biochem., 237, 460-467.
14. Hinds,P.W., Mittanacht,S., Dulic,V., Arnold,A. and Weinberg,R.A. (1992) Regulation of retinoblastoma protein function by ectopic expression of human cyclins. Cell, 70, 993-1006.
15. Hu,Q., Dyson,N. and Harlow,E. (1990) The regions of the retinoblastoma protein needed for binding to adenovirus E1A or SV40 large T antigen are common sites for mutations. EMBO J., 9, 1147-1115.
16. Kamb,A. (1995) Cell-cycle regulators and cancer. Trends Genet., 11, 136-140.
17. Kato,J., Matsushime,H., Hiebert,S.W., Ewen,M.E. and Sherr,C.J. (1993) Direct binding of cyclin D to the retinoblastoma gene product (pRB) and pRB phosphorylation by the cyclin D-dependent kinase CDK4. Genes Dev., 7, 331-342.
18. Kitagawa,M. et al. (1992) cdc2-like kinase is associated with the retinoblastoma protein. Oncogene, 7, 1067-1074.
19. Kitagawa,M. et al. (1993) Butyrolactone I, a selective inhibitor of cdk2 and cdc2 kinase. Oncogene, 8, 2425-2432.
20. Kitaguwa,M., Higashi,H., Takahashi,I.-S., Okabe,T., Ogino,H., Taya,Y., Nishimura,S. and Okuyama,A. (1994) A cyclin-dependent kinase inhibitor, butyrolactone I, inhibits phosphorylation of RB protein and cell cycle progression. Oncogene, 9, 2549-2557.
21. Kitagawa,M., Higashi,H., Takahashi,I.-S., Hanks,S.K., Segawa,K., Taya,Y., Nishimura,S. and Okuyama,A. (1995) Phosphorylation of E2F-1 by cyclin A-cdk2. Oncogene, 10, 229-236.
22. Krek,W., Ewen,M.E., Shirodkar,S., Arany,Z., Kaelin,W.G.Jr and Livingston,D.M. (1994) Negative regulation of the growth-promoting transcription factor E2F-1 by a stably bound cyclin A-dependent protein kinase. Cell, 78, 161-172.
23. Lees,J.A., Buchkovich,K.J., Marshak,D.R., Anderson,C.W. and Harlow,E. (1991) The retinoblastoma protein is phosphorylated on multiple sites by human cdc2. EMBO J., 10, 4279-4290.
24. Lukas,J., Bartkova,J., Ronde,M., Strauss,M. and Bartek,J. (1995a) Cyclin D1 is dispensable for G1 control in retinoblastoma gene deficient cells, independent of CDK4 kinase activity. Mol. Cell. Biol., 15, 2600-2611.
25. Lukas,J., Parry,D., Aagaard,L., Mann,D.J., Bartkova,J., Strauss,M., Peters,G. and Bartek,J. (1995b) Retinoblastoma-protein-dependent cell-cycle inhibition by the tumor suppressor p16. Nature, 375, 503-506.
26. PSK-13/cdk4) for mammalian D-type G1 cyclins. Cell, 71, 323-334.
27. Matsushime,H., Quelle,D.E., Shurtleff,S.A., Shibuya,M., Sherr,C.J. and Kato,J. (1994) D-type cyclin-dependent kinase activity in mammalian cells. Mol. Cell. Biol., 14, 2066-2076.
28. Mayol,X., Garriga,J. and Grana,X. (1995) Cell cycle-dependent phosphorylation of the retinoblastoma-related protein p 130. Oncogene, 11, 801-808.
29. ink4 requires functional retinoblastoma protein. Proc. Natl Acad. Sci. USA, 92, 6289-6293.
30. Meyerson,M. and Harlow,E. (1994) Identification of G1 kinase activity for cdk6, a novel cyclin D partner. Mol. Cell. Biol., 14, 2077-2086.
31. Mittnacht,S., Lees,J.A., Desai,D., Harlow,E., Morgan,D.O. and Weinberg,R.A. (1994) Distinct sub-populations of the retinoblastoma protein show a distinct pattern of phosphorylation. EMKO J., 13, 118-127.
32. Muller,R., Mumberg,D. and Lucibello,F. (1993) Signals and genes in the control of cell-cycle progression. Biochim. Biophys. Acta, 1155, 151-179.
33. Nigg,E.A. (1993) Targets of cyclin-dependent protein kinases. Curr. Opin. Cell Biol., 5, 187-193.
34. Ohtsubo,M. and Roberts,J.M. (1993) Cyclin-dependent regulation of G1 in mammalian fibroblasts. Science, 259, 1908-1911.
35. Ohtsubo,M., Theodoras,A.M., Schumacher,J., Roberts,J.M. and Pagano, M. (1995) Human cyclin E, a nuclear protein essential for the G1 to S phase transition. Mol. Cell. Biol., 15, 2612-2624.
36. Pagano,M., Pepperkok,R., Lukas,J., Baldin,V., Ansorge,W., Bartek,J. and Draetta,G. (1993) Regulation of the cell cycle by the cdk2 protein kinase in cultured human fibroblasts. J. Cell Biol., 121, 101-111.
37. Pines,J. (1993) Cyclins and cyclin-dependent kinases: take your partners. Trends Biochem. Sci., 18, 195-197.
38. Quelle,D.E., Ashmum,R.A., Shurtleff,S.A., Kato,J., Barsagi,D., Roussel,M.F. and Sheer,C.J. (1993) Overexpression of mouse D-type cyclins accerelates G1 phase in rodent fibroblasts. Genes Der., 7, 1559-1571.
39. Resnitzky,D. and Reed,S.I. (1995) Different roles for cyclins D1 and E in regulation of the G1-to-S transition. Mol. Cell. Biol., 15, 3463-3469.
40. Resnitzky,D., Gossen,M., Bujard,H. and Reed,S.I. (1994) Acceleration of the G1/S phase transition by expression of cyclins D1 and E with an inducible system. Mol. Cell Biol., 14, 1669-1679.
41. 2 phase of the cell cycle and associates with cyclin A. Proc. Natl Acatl. Sci. USA, 89, 2824-2828.
42. Roussel,M.F., Theodoras,A.M., Pagano,M. and Sherr,C.J. (1995) Rescue of defective mitogenic signaling by D-type cyclins. Proc. Natl. Acad Sci. USA, 92, 6837-6841.
43. 706-to-Tyr substitution in the retinoblastoma protein. FEBS Lett., 340, 181-184.
44. Sherr,C.J. (1995) D-type cyclins. Trends Biochem. Sci., 20, 187-190.
45. Sherr,C.J. and Roberts,J.M. (1995) Inhibitors of mammalian G1 cyclindependent kinases. Genes Dev., 9, 1149-1163.
46. Skapek,S.X., Rhee,J., Spicer,D.B. and Lassar,A.B. (1995) Inhibition of myogenic differentiation in proliferating myoblasts by cyclin D-dependent kinase. Science, 267, 1022-1025.
47. Takahashi,I.-S., Kitagawa,M., Saijo,M., Higashi,H., Ogino,H., Matsumoto,H., Taya,Y., Nishimura,S. and Okuyama,A. (1995) The interaction of E2F with pRB and with p107 are regulated via the phosphorylation of pRB and p107 by a cyclin-dependent kinase. Oncogene, 10, 1691-1698.
48. Taya,Y. (1995) Cell cycle-dependent phosphorylation of the tumor suppressor RB protein. Molecular Cells, 5, 191-195.
49. Taya,Y., Yasuda,H., Kamijyo,M., Nakaya,K., Nakamura,Y., Ohba,Y. and Nishimura,S. (1989) In vitro phosphorylation of the tumor suppressor gene RB protein by mitosis-specific histone H1 kinase. Biochem. Biophys. Res. Commun., 164, 580-586.
50. Taya,Y., Yasuda,H., Kamijyo,M., Nakaya,K., Nakamura,Y., Ohba,Y. and Nishimura,S. (1990) in Kunudson,A.G.Jr, Stanbridge,E.J., Sugimura,T., Terada,M, and Watanabe,S. (eds). Genetic Basis for Carcinogenesis. Japan Sci. Soc. Press, Tokyo/Taylor & Francis Ltd, London, pp.171-176.
51. Tsai,L.-H., Lees,E., Faha,B., Harlow,E. and Riabowol,K. (1993) The cdk2 kinase is required for the G1-to-S transition in mammalian cells. Oncogene, 8, 1593-1602.
52. Ueno,Y., Makino,S., Kitagawa,M., Nishimura,S., Taya,Y. and Hata,T. (1995) Chemical synthesis of phosphopeptides using the arylthio group for protection of phosphate: application to identification of cdc2 kinase phosphorylation sites. Int. J Peptide Protein Res., 46, 106-112.
53. van den Heuvel,S. and Harlow,E. (1993) Distinct roles for cyclin-dependent kinases in cell cycle control. Science, 262, 2050-2054.
54. Wang,Y. and Prives,C. (1995) Increased and altered DNA binding of human p53 by S and G2/M but not G1 cyclin-dependent kinases. Nature, 376, 88-91.
55. Weinberg,R.A. (1995) The retinoblastoma protein and a cell cycle control. Cell, 81, 323-330.
56. Wimmel,A., Lucibello,F., Sewing,A., Adolph,S. and Muller,R. (1994) Inducible acceleration of G1 progression through tetracyclin-regulated expression of human cyclin E. Oncogene, 9, 995-997.
57. Zhu,L., van den Heuvel,S., Helin,K., Fattaey,A., Ewen,M., Livingston, D.M., Dyson,N. and Harlow,E. (1993) Inhibition of cell proliferation by p107 a relative of the retinoblastoma protein. Genes Dev., 7, 1111-1125.