p27(K1P1) blocks cyclin E-dependent transactivation of cyclin A gene expression

Molecular and Cellular Biology

Volumn 17, Issue 1, 1997, Pages 407-415

  Zerfass Thome, Karin ^a   Schulze, Almut ^a   Zwerschke, Werner ^a   Vogt, Beate ^a   Helin, Kristian ^b   Bartek, Jiri ^c   Henglein, Berthold ^d   Jansen Dürr, Pidder ^a  

^a GERMAN CANCER RESEARCH CENTER DKFZ   (Germany)

^b EUROPEAN INSTITUTE OF ONCOLOGY   (Italy)

^c DANISH CANCER SOCIETY RESEARCH CENTER   (Denmark)

^d INSTITUT CURIE   (France)

Author keywords

[No Author keywords available]

Indexed keywords

CYCLIN A; CYCLIN E; CARRIER PROTEIN; CDK2 PROTEIN, HUMAN; CDK2 PROTEIN, MOUSE; CDKN1B PROTEIN, MOUSE; CELL CYCLE PROTEIN; CYCLIN DEPENDENT KINASE; CYCLIN DEPENDENT KINASE 2; CYCLIN DEPENDENT KINASE INHIBITOR 1B; CYCLINE; DNA BINDING PROTEIN; ENZYME INHIBITOR; HYBRID PROTEIN; MICROTUBULE ASSOCIATED PROTEIN; NUCLEAR PROTEIN; PROTEIN P107; PROTEIN SERINE THREONINE KINASE; RBL1 PROTEIN, HUMAN; RBL1 PROTEIN, MOUSE; RETINOBLASTOMA BINDING PROTEIN 1; TRANSCRIPTION FACTOR; TRANSCRIPTION FACTOR DP1; TRANSCRIPTION FACTOR E2F; TUMOR SUPPRESSOR PROTEIN;

ARTICLE; BINDING SITE; CELL CYCLE G1 PHASE; CELL CYCLE S PHASE; COMPLEX FORMATION; GENE EXPRESSION REGULATION; HUMAN; HUMAN CELL; PRIORITY JOURNAL; PROMOTER REGION; PROTEIN METABOLISM; PROTEIN PROCESSING; REPORTER GENE; TRANSACTIVATION; TRANSCRIPTION REGULATION; VIRUS TRANSFORMATION; ANIMAL; BIOLOGICAL MODEL; CELL STRAIN 3T3; DRUG ANTAGONISM; GENETIC TRANSFECTION; GENETICS; METABOLISM; MOUSE; PHYSIOLOGY; PROTEIN BINDING;

MAMMALIA;

3T3 CELLS; ANIMALS; BINDING SITES; CARRIER PROTEINS; CDC2-CDC28 KINASES; CELL CYCLE PROTEINS; CYCLIN-DEPENDENT KINASE 2; CYCLIN-DEPENDENT KINASE INHIBITOR P27; CYCLIN-DEPENDENT KINASES; CYCLINS; DNA-BINDING PROTEINS; E2F TRANSCRIPTION FACTORS; ENZYME INHIBITORS; G1 PHASE; HUMANS; MICE; MICROTUBULE-ASSOCIATED PROTEINS; MODELS, GENETIC; NUCLEAR PROTEINS; PROMOTER REGIONS (GENETICS); PROTEIN BINDING; PROTEIN-SERINE-THREONINE KINASES; RECOMBINANT FUSION PROTEINS; RETINOBLASTOMA-LIKE PROTEIN P107; TRANS-ACTIVATION (GENETICS); TRANSCRIPTION FACTOR DP1; TRANSCRIPTION FACTORS; TRANSFECTION; TUMOR SUPPRESSOR PROTEINS;

EID: 0030614579     PISSN: 02707306     EISSN: None     Source Type: Journal    
DOI: 10.1128/MCB.17.1.407     Document Type: Article

References (63)

1. Bartek, J., Z. Staskova, G. Draetta, and J. Lukas. 1993. Molecular pathology of the cell cycle in human cancer cells. Stem Cells 11:51-58.
2. Beijersbergen, R. L., L. Carlee, R. M. Kerkhoven, and R. Bernards. 1995. Regulation of the retinoblastoma protein-related p107 by G(1) cyclin complexes. Genes Dev. 9:1340-1353.
3. Beijersbergen, R. L., R. M. Kerkhoven, L. A. Zhu, L. Carlee, P. M. Voorhoeve, and R. Bernards. 1994. E2F-4, a new member of the E2F gene family, has oncogenic activity and associates with p107 in vivo. Genes Dev. 8:2680-2690.
4. Chen, C., and H. Okayama. 1987. High-efficiency transformation of mammalian cells by plasmid DNA. Mol. Cell. Biol. 7:2745-2752.
5. Cobrinik, D., M. H. Lee, G. Hannon, G. Mulligan, R. T. Bronson, N. Dyson, E. Harlow, D. Beach, R. A. Weinberg, and T. Jacks. 1996. Shared role of the pRB-related p130 and p107 proteins in limb development. Genes Dev. 10:1633-1644.
6. Cobrinik, D., P. Whyte, D. S. Peeper, T. Jacks, and R. A. Weinberg. 1993. Cell cycle-specific association of E2F with the p130 E1A-binding protein. Genes Dev. 7:2392-2404.
7. Dulic, V., E. Lees, and S. Reed. 1992. Association of human cyclin E with a periodic G1-S phase protein kinase. Science 257:1958-1961.
8. Dynlacht, B., O. Flores, J. A. Lees, and E. Harlow. 1994. Differential regulation of E2F trans-activation by cyclin/cdk2 complexes. Genes Dev. 8:1772-1786.
9. Dyson, N., M. Dembski, A. Fattaey, C. Ngwu, M. Ewen, and K. Helin. 1993. Analysis of p107-associated proteins: p107 associates with a form of E2F that differs from pRB-associated E2F-1. J. Virol. 67:7641-7647.
10. Fagan, R., K. J. Flint, and N. Jones. 1994. Phosphorylation of E2F-1 modulates its interaction with the retinoblastoma gene product and the adenoviral E4 19 kDa protein. Cell 78:799-811.
11. Ginsberg, D., G. Vairo, T. Chittenden, Z. X. Xiao, G. F. Xu, K. L. Wydner, J. A. Decaprio, J. B. Lawrence, and D. M. Livingston. 1994. E2F-4, a new member of the E2F transcription factor family, interacts with p 107. Genes Dev. 8:2665-2679.
12. Girard, F., U. Strausfeld, A. Fernandez, and N. Lamb. 1991. Cyclin A is required for the onset of DNA replication in mammalian fibroblasts. Cell 67:1169-1179.
13. Girling, R., J. F. Partridge, L. R. Bandara, N. Burden, N. F. Totty, J. J. Hsuan, and N. B. Lathangue. 1993. A new component of the transcription factor DRTF1/E2F. Nature 365:468.
14. Guadagno, T., M. Ohtsubo, J. M. Roberts, and R. Assoian. 1993. A link between cyclin A expression and adhesion-dependent cell cycle progression. Science 262:1572-1575.
15. INK4B/MTS2-related CDK6 inhibitor, correlates with wild-type pRB function. Genes Dev. 8:2939-2952.
16. Helin, K., C.-L. Wu, A. R. Fattaey, J. A. Lees, B. D. Dynlacht, C. Ngwu, and E. Harlow. 1993. Heterodimerization of the transcription factors E2F-1 and DP-1 leads to cooperative trans-activation. Genes Dev. 7:1850-1861.
17. Henglein, B., X. Chenivesse, J. Wang, D. Eick, and C. Brechot. 1994. Structure and cell cycle regulated transcription of the human cyclin A gene. Proc. Natl. Acad. Sci. USA 91:5490-5494.
18. Hengst, L. and S. I. Reed. 1996. Translational control of p27(Kip1) accumulation during the cell cycle. Science 271:1861-1864.
19. Hofmann, F., and D. M. Livingston. 1996. Differential effects of cdk2 and cdk3 on the control of pRb and E2F function during G(1) exit. Genes Dev. 10:851-861.
20. Hunter, T., and J. Pines. 1994. Cyclins and cancer. 2. Cyclin D and CDK inhibitors come of age. Cell 79:573-582.
21. Jansen-Dürr, P., A. Meichle, P. Steiner, M. Pagano, K. Finke, J. Botz, J. Weßbecher, G. Draetta, and M. Eilers. 1993. Differential modulation of cyclin gene expression by MYC. Proc. Natl. Acad. Sci. USA 90:2547-2552.
22. Johnson, D. G., K. Ohtani, and J. R. Nevins. 1994. Autoregulatory control of E2F1 expression in response to positive and negative regulators of cell cycle progression. Genes Dev. 8:1514-1525.
23. Kato, J. Y., M. Matsuoka, K. Polyak, J. Massague, and C. J. Sherr. 1994. Cyclic AMP-induced G1 phase arrest mediated by an inhibitor (p27(Kip1)) of cyclin-dependent kinase 4 activation. Cell 79:487-496.
24. Knoblich, J. A., K. Sauer, L. Jones, H. Richardson, R. Saint, and C. F. Lehner. 1994. Cyclin E controls S phase progression and its down-regulation during Drosophila embryogenesis is required for the arrest of cell proliferation. Cell 77:107-120.
25. Koff, A., F. Cross, A. Fisher, J. Schumacher, K. Leguellec, M. Philippe, and J. M. Roberts. 1991. Human cyclin E, a new cyclin that interacts with two members of the cdc2 gene family. Cell 66:1217-1228.
26. Koff, A., A. Giordano, D. Desai, K. Yamashita, J. W. Harper, S. Elledge, T. Nishimoto, D. O. Morgan, B. R. Franza, and J. M. Roberts. 1992. Formation and activation of a cyclin E-cdk2 complex during the G1 phase of the human cell cycle. Science 257:1689-1694.
27. Krek, W., M. E. Ewen, S. Shirodkar, Z. Arany, W. G. Kaelin, and D. M. Livingston. 1994. Negative regulation of the growth-promoting transcription factor E2F-1 by a stably bound cyclin A-dependent protein kinase. Cell 78:161-172.
28. Lees, E., B. Faha, V. Dulic, S. I. Reed, and E. Harlow. 1992. Cyclin E/cdk2 and cyclin A/cdk2 kinases associate with p107 and E2F in a temporally distinct manner. Genes Dev. 6:1874-1885.
29. Mailer, J. L. 1991. Mitotic control. Curr. Opin. Cell Biol. 3:269-275.
30. Motokura, T., T. Bloom, H. G. Kim, H. Jüppner, J. V. Ruderman, H. M. Kronenberg, and A. Arnold. 1991. A novel cyclin encoded by a bcl1-linked candidate oncogene. Nature 350:512-515.
31. Nakayama, K., N. Ishida, M. Shirane, A. Inomata, T. Inoue, N. Shishido, I. Hori, D. Y. Loh, and K. Nakayama. 1996. Mice lacking p27(Kip1) display increased body size, multiple organ hyperplasia, retinal dysplasia, and pituitary tumors. Cell 85:707-720.
32. Nourse, J., E. Firpo, W. M. Flanagan, S. Coats, K. Polyak, M. H. Lee, J. Massague, G. R. Crabtree, and J. M. Roberts. 1994. lnterleukin-2-mediated elimination of the p27(Kip1) cyclin-dependent kinase inhibitor prevented by rapamycin. Nature 372:570-573.
33. 1-to-S phase transition. Mol. Cell. Biol. 15:2612-2624.
34. Pagano, M., G. Draetta, and P. Jansen-Dürr. 1992. Association of cdk2 kinase with the transcription factor E2F during S phase. Science 255:1144-1147.
35. Pagano, M., R. Pepperkok, F. Verde, W. Ansorge, and G. Draetta. 1992. Cyclin A is required at two points in the human cell cycle. EMBO J. 11:961-971.
36. Pagano, M., S. W. Tam, A. M. Theodoras, P. Beerromero, G. Delsal, V. Chau, P. R. Yew, G. F. Draetta, and M. Rolfe. 1995. Role of the ubiquitinproteasome pathway in regulating abundance of the cyclin-dependent kinase inhibitor p27. Science 269:682-685.
37. Pines, J. 1993. Cyclins and cyclin-dependent kinases-take your partners. Trends Biochem. Sci. 18:195-197.
38. Polyak, K., J. Y. Kato, M. J. Solomon, C. J. Sherr, J. Massague, J. M. Roberts, and A. Koff. 1994. p27(kip1), a cyclin-Cdk inhibitor, links transforming growth factor-beta and contact inhibition to cell cycle arrest. Genes Dev. 8:9-22.
39. Polyak, K., M. H. Lee, H. Erdjumentbromage, A. Koff, J. M. Roberts, P. Tempst, and J. Massague. 1994. Cloning of p27(Kip1), a cyclin-dependent kinase inhibitor and a potential mediator of extracellular antimitogenic signals. Cell 78:59-66.
40. Poon, R. Y. C., H. Toyoshima, and T. Hunter. 1995. Redistribution of the CDK inhibitor p27 between different cyclin center dot CDK complexes in the mouse fibrohlast cell cycle and in cells arrested with lovastatin or ultraviolet irradiation. Mol. Biol. Cell 6:1197-1213.
41. 1/S phase transition by expression of cyclins D1 and E with an inducible system. Mol. Cell. Biol. 14:1669-1679.
42. Rosenberg, A. R., F. Zindy, F. Ledeist, H. Mouly, P. Metezeau, C. Brechot, and E. Lamas. 1995. Overexpression of human cyclin A advances entry into S phase. Oncogene 10:1501-1509.
43. Russo, A. A., P. D. Jeffrey, A. K. Patten, J. Massague, and N. P. Pavletich. 1996. Crystal structure of the p27(Kip1) cyclin-dependent-kinase inhibitor bound to the cyclin A Cdk2 complex. Nature 382:325-331.
44. Schulze, A. Unpublished data.
45. Schulze, A., K. Zerfaß, D. Spitkovsky, J. Berges, S. Middendorp, P. Jansen-Dürr, and B. Henglein. 1995. Cell cycle regulation of cyclin A gene transcription is mediated by a variant E2F binding site. Proc. Natl. Acad. Sci. USA 92:11264-11268.
46. Schulze, A., K. Zerfaß, D. Spitkovsky, B. Henglein, and P. Jansen-Dürr. 1994. Activation of the E2F transcription factor by cyclin D1 is blocked by p16INK4, the product of the putative tumor suppressor gene MTS1. Oncogene 9:3475-3482.
47. Serrano, M., G. J. Hannon, and D. Beach. 1993. A new regulatory motif in cell-cycle control causing specific inhibition of cyclin-D/CDK4. Nature 366: 704-707.
48. Sherr, C. J. 1994. G1 phase progression: cycling on cue. Cell 79:551-555.
49. Shiyanov, P., S. Bagchi, G. Adami, J. Kokontis, N. Hay, M. Arroyo, A. Morozov, and P. Raychaudhuri. 1996. p21 disrupts the interaction between cdk2 and the E2F-p130 complex. Mol. Cell. Biol. 16:737-744.
50. Stein, G. H., and V. Dulic. 1995. Origins of G(1) arrest in senescent human fibroblasts. Bioessays 17:537-543.
51. Toyoshima, H., and T. Hunter. 1994. p27, a novel inhibitor of G1 cyclin-Cdk protein kinase activity, is related to p21. Cell 78:67-74.
52. Tsai, L. H., E. Harlow, and M. Meyerson. 1991. Isolation of the human cdk2 gene that encodes the cyclin A-and adenovirus E1A-associated p33 kinase. Nature 353:174-177.
53. van den Heuvel, S., and E. Harlow. 1993. Distinct roles for cyclin-dependent kinases in cell cycle control. Science 262:2050-2054.
54. Wang, J., X. Chenivesse, B. Henglein, and C. Brechot. 1990. Hepatitis B virus integration in a cyclin A gene in a hepatocellular carcinoma. Nature 343: 555-557.
55. Wang, J., X. Chenivesse, B. Henglein, and C. Brechot. 1990. Hepatitis B virus integration in a cyclin A gene in a hepatocellular carcinoma. Nature 343: 555-557.
56. Wimmel, A., F. Lucibello, A. Sewing, S. Adolph, and R. Müller. 1994. Inducible acceleration of G(1) progression through tetracycline-regulated expression of human cyclin E. Oncogene 9:995-997.
57. Zerfass, K., A. Schulze, D. Spitkovsky, V. Friedman, B. Henglein, and P. Jansen-Dürr. 1995. Sequential activation of cyclin E and cyclin A gene expression by human papillomavirus type 16 E7 through sequences necessary for transformation. J. Virol. 69:6389-6399.
58. Zerfass, K., D. Spitkovsky, A. Schulze, S. Joswig, B. Henglein, and P. Jansen-Dürr. 1996. Adenovirus E1A activates cyclin A gene transcription in the absence of growth factors through interaction with p107. J. Virol. 70: 2637-2642.
59. Zerfass-Thome, K. Unpublished results.
60. Zhu, L., G. Enders, J. A. Lees, R. L. Beijersbergen, R. Bernards, and E. Harlow. 1995. The pRB-related protein p107 contains two growth suppression domains: independent interactions with E2F and cyclin/cdk complexes. EMBO J. 14:1904-1913.
61. Zhu, L., E. Harlow, and B. D. Dynlacht. 1995. p107 uses a p21(CIP1)-related domain to bind cyclin/cdk2 and regulate interactions with E2F. Genes Dev. 9:1740-1752.
62. Zindy, F., E. Lamas, X. Chenivesse, J. Sobczak, D. Fesquet, J. Wang, B. Henglein, and C. Brechot. 1991. Cyclin A is required in S phase in normal epithelial cells. Biophys. Biochem. Res. Commun. 182:1144-1154.
63. Zwicker, J., F. C. Lucibello, L. A. Wolfraim, C. Gross, M. Truss, K. Engeland, and R. Muller. 1995. Cell cycle regulation of the cyclin A, cdc25C and cdc2 genes is based on a common mechanism of transcriptional repression. EMBO J. 14:4514-4522.