Control of the eukaryotic cell cycle by MAP kinase signaling pathways

FASEB Journal

Volumn 14, Issue 14, 2000, Pages 2147-2157

  Wilkinson, Marc G ^a   Millar, Jonathan B A ^b  

^a GLAXOSMITHKLINE   (United Kingdom)

^b NATIONAL INSTITUTE FOR MEDICAL RESEARCH   (United Kingdom)

Author keywords

CDK; MAPK; Proliferation; Signal transduction

Indexed keywords

CYCLINE; CYTOKINE; DNA; MITOGEN ACTIVATED PROTEIN KINASE; PHOSPHATASE; PROTEIN; PROTEIN KINASE; PROTEIN P21; PROTEIN P53; RAS PROTEIN; RECEPTOR;

CELL CYCLE; CELL GROWTH; CELL PROLIFERATION; HUMAN; NONHUMAN; PHOSPHORYLATION; PRIORITY JOURNAL; REVIEW; SIGNAL TRANSDUCTION;

EUKARYOTA; INVERTEBRATA;

EID: 0033729838     PISSN: 08926638     EISSN: None     Source Type: Journal    
DOI: 10.1096/fj.00-0102rev     Document Type: Review

References (105)

1. Regulation of transcription by MAP kinase cascades
2. SAPKs and transcription factors do the nucleocytoplasmic tango
3. Mitogen-activated protein kinase pathways
4. MAP kinase pathways in yeast: For mating and more
5. JNKI: A protein kinase stimulated by UV light and Ha-Ras that binds and phosphorylates the c-jun activation domain
6. Interleukin-1 activates a novel protein kinase cascade that results in the phosphorylation of hsp27
7. An osmosensing signal transduction pathway in mammalian cells
8. A MAP kinase targeted by endotoxin and hyperosmolarity in mammalian cells
9. The stress-activated protein kinase family of c-jun kinases
10. A protein kinase involved in the regulation of inflammatory cytokine biosynthesis
11. A novel kinase cascade triggered by stress and heat shock that stimulates MAPKAP kinase-2 and phosphorylation of the small heat shock proteins
12. Pyp1 and Pyp2 PTPases dephosphorylate an osmosensing MAP kinase controlling cell size at division in fission yeast
13. Cell cycle control linked to extracellular environment by MAP kinase pathway in fission yeast
14. Conjugation, meiosis, and the osmotic stress response are regulated by Spc1 kinase through Atf1 transcription factor in fission yeast
15. The Atf1 transcription factor is a target for the Sty1 stress-activated MAP kinase pathway in fission yeast
16. Sin1: An evolutionarily conserved component of the eukaryotic SAPK pathway
17. CDK inhibitors: Positive and negative regulators of G1-phase progression
18. Control of the yeast cell cycle by the Cdc28 protein kinase
19. Ste5 tethers multiple protein kinases in the MAP kinase cascade required for mating in S. cerevisiae
20. Nuclear shuttling of yeast scaffold Ste5 is required for its recruitment to the plasma membrane and activation of the mating MAPK cascade
21. FAR1 links the signal transduction pathway to the cell cycle machinery in yeast
22. Direct inhibition of the yeast cyclin-dependent kinase Cdc28-Cln by Far1
23. Far1 and Fus3 link the mating pheromone signal transduction pathway to three G1-phase Cdc28 kinase complexes
24. FAR1 and the G1 phase specificity of cell cycle arrest by mating factor in Saccharomyces cerevisiae
25. Phosphorylation- and ubiquitin-dependent degradation of the cyclin-dependent kinase inhibitor Far1p in budding yeast
26. Identification of a gene necessary for cell cycle arrest by a negative growth factor of yeast: FAR1 is an inhibitor of a G1 cyclin, CLN2
27. Ste12 and Mcm1 regulate cell cycle-dependent transcription of FAR1
28. Fus3p and Kss1p control G1 arrest in Saccharomyces cerevisiae through a balance of distinct arrest and proliferative functions that operate in parallel with Far1p
29. Pheromone-dependent G1 cell cycle arrest requires Far1 phosphorylation, but may not involve inhibition of Cdc28-Cln2 kinase, in vivo
30. Mitosis in transition
31. Universal control mechanism regulating onset of M-phase
32. Tyrosine phosphorylation of the fission yeast cdc2+ protein kinase regulates entry into mitosis
33. Phosphorylation at Thr167 is required for Schizosaccharomyces pombe p34cdc2 function
34. The cdc25 M-phase inducer: An unconventional protein phosphatase
35. Discrete roles of the Spc1 kinase and the Atf1 transcription factor in the UV response of Schizosaccharomyces pombe
36. Premature senescence involving p53 and p16 is activated in response to constitutive MEK/MAPK mitogenic signaling
37. Oncogenic ras provokes premature cell senescence associated with accumulation of p53 and p16INK4a
38. High-intensity Raf signal causes cell cycle arrest mediated by p21Cip1
39. Raf-induced proliferation or cell cycle arrest is determined by the level of Raf activity with arrest mediated by p21Cip1
40. Histone acetylases and deacetylases in cell proliferation
41. Transforming p21ras mutants and c-Ets-2 activate the cyclin D1 promoter through distinguishable regions
42. Cyclin D1 expression is regulated positively by the p42/p44MAPK and negatively by the p38/HOG-MAPK pathway
43. Ras transformation results in an elevated level of cyclin D1 and acceleration of G1 progression in NIH 3T3 cells
44. Myc and Ras collaborate in inducing accumulation of active cyclin E/Cdk2 and E2F
45. Cyclin D1 is dispensable for G1 control in retinoblastoma gene-deficient cells independently of cdk4 activity
46. Ras signalling is required for inactivation of the tumour suppressor pRb cell-cycle control protein
47. Ras signalling linked to the cell-cycle machinery by the retinoblastoma protein
48. Inhibition of ras-induced proliferation and cellular transformation by p16INK4
49. D-type cyclin-dependent kinase activity in mammalian cells
50. Regulation of p21 (cip1) expression by growth factors and the extracellular matrix reveals a role for transient ERK activity in G1 phase
51. Assembly of cyclin D-dependent kinase and titration of p27Kip1 regulated by mitogen-activated protein kinase kinase (MEK1)
52. The p21(Cip1) and p27(Kip1) CDK 'inhibitors' are essential activators of cyclin D-dependent kinases in murine fibroblasts
53. Cyclin E-CDK2 is a regulator of p27Kip1
54. Ras links growth factor signaling to the cell cycle machinery via regulation of cyclin D1 and the Cdk inhibitor p27KIP1
55. Induction of p27Kip1 degradation and anchorage independence by Ras through the MAP kinase signaling pathway
56. Ras activity late in G1 phase required for p27kip1 downregulation, passage through the restriction point, and entry, into S phase in growth factor-stimulated NIH 3T3 fibroblasts
57. Role of the ubiquitin-proteasome pathway in regulating abundance of the cyclin-dependent kinase inhibitor p27
58. Integrin-mediated cell adhesion activates mitogen-activated protein kinases
59. Integrin-mediated signal transduction linked to Ras pathway by GRB2 binding to focal adhesion kinase
60. Integrin-dependent activation of MAP kinase: A link to shape-dependent cell proliferation
61. Cell anchorage permits efficient signal transduction between ras and its downstream kinases
62. Integrins can collaborate with growth factors for phosphorylation of receptor tyrosine kinases and MAP kinase activation: Roles of integrin aggregation and occupancy of receptors
63. Growth factor activation of MAP kinase requires cell adhesion
64. Cytoskeletal integrity is required throughout the mitogen stimulation phase of the cell cycle and mediates the anchorage-dependent expression of cyclin D1
65. Ras induces anchorage-independent growth by subverting multiple adhesion-regulated cell cycle events
66. Anchorage-dependent transcription of the cyclin A gene
67. Adhesion-dependent cell cycle progression linked to the expression of cyclin D1, activation of cyclin E-cdk2, and phosphorylation of the retinoblastoma protein
68. Alpha5Betal integrin controls cyclinD1 expression by sustaining mitogen-activated protein kinase activity in growth factor-treated cells
69. Divergent signaling pathways link focal adhesion kinase to mitogen-activated protein kinase cascades
70. Focal adhesion kinase overexpression enhances ras-dependent integrin signaling to ERK2/mitogen-activated protein kinase through interactions with and activation of c-Src
71. The adaptor protein Shc couples a class of integrins to the control of cell cycle progression
72. Dependence of cyclin E-CDK2 kinase activity on cell anchorage
73. Activation of Raf by ionizing radiation
74. The ras oncogenes increase the intrinsic resistance of NIH 3T3 cells to ionizing radiation
75. Mitogen-activated protein kinase kinase 2 activation is essential for progression through the G2/M checkpoint arrest in cells exposed to ionizing radiation
76. Mitogen-activated protein kinase kinase activity is required for the G2/M transition of the cell cycle in mammalian fibroblasts
77. Components of a new human protein kinase signal transduction pathway
78. Big mitogen-activated protein kinase 1 (BMK1) is a redox-sensitive kinase
79. BMK1/ERK5 regulates serum-induced early gene expression through transcription factor MEF2C
80. Contribution of the ERK5/MEK5 pathway to Ras/Raf signalling and growth control
81. Activation of the protein kinase ERK5/BMK1 by receptor tyrosine kinases. Identification and characterization of a signaling pathway to the nucleus
82. Bmk1/Erk5 is required for cell proliferation induced by epidermal growth factor
83. Regulation of Rb and E2F by signal transduction cascades: Divergent effects of JNK1 and p38 kinases
84. c-Jun regulates cell cycle progression and apoptosis by distinct mechanisms
85. Control of cell cycle progression by c-Jun is p53 dependent
86. Cell cycle arrest and reversion of Ras-induced transformation by a conditionally activated form of mitogen-activated protein kinase kinase kinase 3
87. Cdc42Hs, but not Rac1, inhibits serum-stimulated cell cycle progression at G1/S through a mechanism requiring p38/RK
88. Activation of the protein kinase p38 in the spindle assembly checkpoint and mitotic arrest
89. Biphasic activation of p21Ras by endothelin-1 sequentially activates the ERK cascade and phosphatidylinositol 3-kinase
90. Multiple ras effector pathways contribute to G(1) cell cycle progression
91. Glycogen synthase kinase-3beta regulates cyclin D1 proteolysis and subcellular localization
92. Absence of excitotoxicity-induced apoptosis in the hippocampus of mice lacking the Jnk3 gene
93. The Jnk1 and Jnk2 protein kinases are required for regional specific apoptosis during early brain development
94. Complexes of p21RAS with JUN N-terminal kinase and JUN proteins
95. Direct interaction between Ras and the kinase domain of mitogen-activated protein kinase kinase kinase (MEKK1)
96. Tyrosine 763 of the murine granulocyte colony-stimulating factor receptor mediates Ras-dependent activation of the JNK/SAPK mitogen-activated protein kinase pathway
97. Rapid induction of heparin-binding epidermal growth factor/diptheria toxin receptor expression by Raf and Ras oncogenes
98. Cellular survival: A play in three Akts
99. Signals from Ras and Rho GTPases interact to regulate expression of p21Waf1/Cip1
100. Mitogen-activated protein kinases activate the serine/threonine kinases Mnk1 and Mnk2
101. Phosphorylation of the cap-binding protein eukaryotic translation initiation factor 4E by protein kinase Mnk1 in vivo
102. The phosphorylation of eukaryotic initiation factor eIF4E in response to phorbol esters, cell stresses, and cytokines is mediated by distinct MAP kinase pathways
103. Regulation of carbamoyl phosphate synthetase by MAP kinase
104. MEKK3 directly regulates MEK5 activity as part of the big mitogen-activated protein kinase 1 (BMK1) signaling pathway
105. MEKKs, GCKs, MLKs, PAKs, TAKs, and tpls: Upstream regulators of the c-.Jun amino-terminal kinases?