Inhibition of cyclin D1 phosphorylation on threonine-286 prevents its rapid degradation via the ubiquitin-proteasome pathway

Genes and Development

Volumn 11, Issue 8, 1997, Pages 957-972

  Diehl, J Alan ^a   Zindy, Frederique ^a   Sherr, Charles J ^a  

^a ST JUDE CHILDREN S RESEARCH HOSPITAL   (United States)

Author keywords

cyclin D destruction; Cyclin D1 phosphorylation; Rb protein; ubiquitin proteasome pathway

Indexed keywords

CYCLINE; PROTEASOME; THREONINE; UBIQUITIN;

AMINO ACID SEQUENCE; ANIMAL CELL; ARTICLE; ENZYME ACTIVATION; ENZYME BINDING; NONHUMAN; PRIORITY JOURNAL; PROTEIN DEGRADATION; PROTEIN EXPRESSION; PROTEIN METABOLISM; PROTEIN PHOSPHORYLATION; PROTEIN STABILITY;

ANIMALIA; INSECTA;

EID: 0030916209     PISSN: 08909369     EISSN: None     Source Type: Journal    
DOI: 10.1101/gad.11.8.957     Document Type: Article

References (61)

1. Amon, A., S. Irniger, and K. Nasmyth. 1994. Closing the cell cycle circle in yeast: G2 cyclin proteoylsis initiated at mitosis persists until the activation of G1 cyclins in the next cell cycle. Cell 77: 1037-1050.
2. Bai, C., P. Sen, K. Hofmann, L. Ma, M. Goebl, J.W. Harper, and S.J. Elledge. 1996. SKP1 connects cell cycle regulators to the ubiquitin proteolysis machinery through a novel motif, the F-box. Cell 86: 263-274.
3. 1. Genes & Dev. 7: 812-821.
4. Bates, S., D. Parry, L. Bonetta, K. Vousden, C. Dickson, and G. Peters. 1994. Absence of cyclin D/cdk4 complexes in cells lacking functional retinoblastoma protein. Oncogene 9: 1633-1640.
5. Boyle, W.J., P. Van der Geer, and T. Hunter. 1991. Protein phosphorylation, part B. Methods Enzymol. 201: 21-27.
6. Bram, R.J. and G.R. Crabtree. 1994. Calcium signaling in T cells stimulated by a cyclophilin B-binding protein. Nature 371: 355-358.
7. Chen, C. and H. Okayama. 1987. High-efficiency transformation of mammalian cells by plasmid DNA. Mol. Cell. Biol. 7: 2745-2752.
8. Chen, Z., J. Hagler, V.J. Palombella, F. Melandri, D. Scherer, D. Ballard, and T. Maniatis. 1995. Signal-induced site-specific phosphorylation targets IKBα to the ubiquitin-proteasome pathway. Genes & Dev. 9: 1586-1597.
9. Ciechanover, A. 1994. The ubiquitin-proteasome proteolytic pathway. Cell 79: 13-21.
10. Clurman, B.E., R.J. Sheaff, K. Thress, M. Groudine, and J.M. Roberts. 1996. Turnover of cyclin E by the ubiquitin-proteasome pathway is regulated by CDK2 binding and cyclin phosphorylation. Genes & Dev. 10: 1979-1990.
11. Deshaies, R.J. 1995. Make it or break it: The role of ubiquitin-dependent proteolysis in cellular regulation. Trends Cell Biol. 5: 428-434.
12. Deshaies, R.J., V. Chau, and M. Kirschner. 1995. Ubiquitination of the G1 cyclin Cln2p by a Cdc34p-dependent pathway. EMBO J. 14: 303-312.
13. Downing, J.R., C.W. Rettenmier, and C.J. Sherr. 1988. Ligand-induced tyrosine kinase activity of the colony stimulating factor-1 receptor in a murine macrophage cell line. Mol. Cell. Biol. 8: 1795-1799.
14. Dulic, V., E. Lees, and S.I. Reed. 1992. Association of human cyclin E with a periodic G1-S phase protein kinase. Science 257: 1958-1961.
15. Ewen, M.E., H.K. Sluss, C.J. Sherr, H. Matsushime, J. Kato, and D.M. Livingston. 1993. Functional interactions of the retinoblastoma protein with mammalian D-type cyclins. Cell 73: 487-497.
16. Glotzer, M., A.W. Murray, and M.W. Kirschner. 1991. Cyclin is degraded by the ubiquitin pathway. Nature 349: 132-138.
17. Hilt, W. and D.H. Wolf. 1996. Proteasomes: Destruction as a programme. Trends Biochem. Sci. 21: 96-102.
18. Hirai, H. and C.J. Sherr. 1996. Interaction of D-type cyclins with a novel myb-like transcription factor, DMP1. Mol. Cell. Biol. 16: 6457-6467.
19. Inaba, T., T. Inukai, T. Yoshihara, H. Seyschab, R.A. Ashmun, C.E. Canman, S.J. Laken, M.B. Kastan, and A.T. Look. 1996. Reversal of apoptosis by the leukaemia-associated E2A-HLF chimaeric transcription factor. Nature 382: 541-544.
20. Irniger, S., S. Piatti, C. Michaelis, and K. Nasmyth. 1995. Genes involved in sister chromatid separation are needed for B-type cyclin proteoylsis in budding yeast. Cell 81: 269-277.
21. Jentsch, S. and S. Schlenker. 1995. Selective protein degradation: A journey's end within the proteasome. Cell 82: 881-884.
22. Kato, J., H. Matsushime, S.W. Hiebert, M.E. Ewen, and C.J. Sherr. 1993. Direct binding of cyclin D to the retinoblastoma gene product (pRb) and pRb phosphorylation by the cyclin D-dependent kinase, CDK4. Genes & Dev. 7: 331-342.
23. Kato, J., M. Matsuoka, D.K. Strom, and C.J. Sherr. 1994. Regulation of cyclin D-dependent kinase 4 (cdk4) by cdk4-activating kinase. Mol. Cell. Biol. 14: 2713-2721.
24. King, R.W., J.-M. Peters, S. Tugendreich, M. Rolfe, P. Hieter, and M.W. Kirschner. 1995. A 20S complex containing CDC27 and CDC16 catalyzes the mitosis-specific conjugation of ubiquitin to cyclin B. Cell 81: 279-288.
25. King, R.W., R.J. Deshaies, J.-M. Peters, and M.W. Kirschner. 1996. How proteolysis drives the cell cycle. Science 274: 1652-1659.
26. Kitagawa, M., H. Higashi, H.-K. Jung, I. Suzuki-Takahashi, M. Ikeda, K. Tamai, J. Kato, K. Segawa, E. Yoshida, S. Nishimura, and Y. Taya. 1996. The consensus motif for phosphorylation by cyclin D1-cdk4 is different from that for phosphorylation by cyclin A/E-cdk2. EMBO J. 15: 7060-7069.
27. Koff, A., A. Giordano, D. Desai, K. Yamashita, J.W. Harper, S. Elledge, T. Nishimoto, D.O. Morgan, B.R. Franza, and J.M. Roberts. 1992. Formation and activation of a cyclin E-cdk2 complex during the G1 phase of the human cell cycle. Science 257: 1689-1694.
28. Krude, T., M. Jackman, J. Pines, and R.A. Laskey. 1997. Cyclin/cdk-dependent initiation of DNA replication in a human cell-free system. Cell 88: 109-119.
29. Lanker, S., M.H. Valdivieso, and C. Wittenberg. 1996. Rapid degradation of the G1 cyclin Cln2 induced by CDK-dependent phosphorylation. Science 271: 1597-1601.
30. Lukas, J., M. Pagano, Z. Staskova, G. Draetta, and J. Bartek. 1994. Cyclin D1 protein oscillates and is essential for cell cycle progression in human tumor lines. Oncogene 9: 707-718.
31. Lukas, J., J. Bartkova, M. Rohde, M. Strauss, and J. Bartek. 1995. Cyclin D1 is dispensable for G1 control in retinoblastoma gene-deficient cells, independent of CDK4 activity. Mol. Cell. Biol. 15: 2600-2611.
32. Matsuoka, M., J. Kato, R.P. Fisher, D.O. Morgan, and C.J. Sherr. 1994. Activation of cyclin-dependent kinase-4 (CDK4) by mouse MO15-associated kinase. Mol. Cell. Biol. 14: 7265-7275.
33. Matsushime, H., M.F. Roussel, R.A. Ashmun, and C.J. Sherr. 1991. Colony-stimulating factor 1 regulates novel cyclins during the G1 phase of the cell cycle. Cell 65: 701-713.
34. PSK-J3/CDK4) for mammalian D-type G1 cyclins. Cell 71: 323-334.
35. Matsushime, H., D.E. Quelle, S.A. Shurtleff, M. Shibuya, C.J. Sherr, and J. Kato. 1994. D-type cyclin-dependent kinase activity in mammalian cells. Mol. Cell. Biol. 14: 2066-2076.
36. Morgan, D.O. 1995. Principles of cdk regulation. Nature 374: 131-134.
37. Norbury, C. and P. Nurse. 1992. Animal cell cycles and their control. Annu. Rev. Biochem. 61: 441-470.
38. Ohtsubo, M. and J.M. Roberts. 1993. Cyclin-dependent regulation of G1 in mammalian fibroblasts. Science 259: 1908-1912.
39. Ohtsubo, M., A.M. Theodoras, J. Schumacher, J.M. Roberts, and M. Pagano. 1995. Human cyclin E, a nuclear protein essential for the G1 to S phase transition. Mol. Cell. Biol. 15: 2612-2624.
40. Pagano, M., S.W. Tam, A.M. Theodoras, P. Beer-Romano, G. Dal Sal, V. Chau, P.R. Yew, G.F. Draetta, and M. Rolfe. 1995. Role of the ubiquitin-proteasome pathway in regulating abundance of the cyclin-dependent kinase inhibitor p27. Science 269: 682-685.
41. Peters, J.-M., R.W. King, C. Hoog, and M.W. Kirschner. 1996. Identification of BIME as a subunit of the anaphase-promoting complex. Science 274: 1199-1201.
42. 1 phase in rodent fibroblasts. Genes & Dev. 7: 1559-1571.
43. Reed, S.I. 1992. The role of p34 kinases in the G1 to S-phase transition. Annu. Rev. Cell Biol. 8: 529-561.
44. Resnitzky, D., M. Gossen, H. Bujard, and S.I. Reed. 1994. Acceleration of the G1/S phase transition by expression of cyclins D1 and E with an inducible system. Mol. Cell. Biol. 14: 1669-1679.
45. Rettenmier, C.W., J.H. Chen, M.F. Roussel, and C.J. Sherr. 1985. The product of the c-fms proto-oncogene: A glycoprotein with associated tyrosine kinase activity. Science 228: 320-322.
46. Rock, K.L., C. Gramm, L. Rothstein, K. Clark, R. Stein, L. Dick, D. Hwang, and A.L. Goldberg. 1994. Inhibitors of the proteasome block the degradation of most cell proteins and the generation of peptides presented on MHC class I molecules. Cell 78: 761-771.
47. Rogers, S., R. Wells, and M. Rechsteiner. 1986. Amino acid sequences common to rapidly degraded proteins: The PEST hypothesis. Science 234: 364-368.
48. Salama, S.R., K.B. Hendricks, and J. Thorner. 1994. G1 cyclin degradation: The PEST motif of yeast Cln2 is necessary, but not sufficient, for rapid protein turnover. Mol. Cell. Biol. 14: 7953-7966.
49. Seufert, W., B. Futcher, and S. Jentsch. 1995. Role of a ubiquitin-conjugating enzyme in degradation of S- and M-phase cyclins. Nature 373: 78-81.
50. 1 cyclins. Cell 73: 1059-1065.
51. _. 1996. Cancer cell cycles. Science 274: 1672-1677.
52. 1 cyclin-dependent kinases. Genes & Dev. 9: 1149-1163.
53. Sudakin, V., D. Ganoth, A. Dahan, H. Heller, J. Hershko, F.C. Luca, J.V. Ruderman, and A. Hershko. 1995. The cyclosome, a large complex containing cyclin-selective ubiquitin ligase activity, targets cyclins for destruction at the end of mitosis. Mol. Biol. Cell 6: 185-198.
54. Summers, M.D. and G.E. Smith. 1987. A manual of methods for baculovirus vectors and insect culture procedures. Tex. Agric. Exp. Stn. Bull. no. 1555.
55. Treier, M., L.M. Staszewski, and D. Bohman. 1994. Ubiquitin-dependent c-jun degradation in vivo is mediated by the δ domain. Cell 78: 787-798.
56. Vallance, S.J., H. Lee, M.F. Roussel, S.A. Shurtleff, J. Kato, D.K. Strom, and C.J. Sherr. 1993. Monoclonal antibodies to mammalian D-type G1 cyclins. Hybridoma 13: 37-44.
57. Weinberg, R.A. 1995. The retinoblastoma protein and cell cycle control. Cell 81: 323-330.
58. Won, K.-A. and S.I. Reed. 1996. Activation of cyclin E/CDK2 is coupled to site-specific autophosphorylation and ubiquitin-dependent degradation of cyclin E. EMBO J. 15: 4182-4193.
59. Xiong, Y., H. Zhang, and D. Beach. 1992. D-type cyclins associate with multiple protein kinases and the DNA replication and repair factor PCNA. Cell 71: 505-514.
60. Cdc-28-mediated control of Cln3 cyclin degradation. Mol. Cell. Biol. 15: 731-741.
61. Zhang, H., Y. Xiong, and D. Beach. 1993. Proliferating cell nuclear antigen and p21 are components of multiple cell cycle kinase complexes. Mol. Biol. Cell 4: 897-906.