The human Myt1 kinase preferentially phosphorylates Cdc2 on threonine 14 and localizes to the endoplasmic reticulum and Golgi complex

Molecular and Cellular Biology

Volumn 17, Issue 2, 1997, Pages 571-583

  Liu, Feng ^a   Stanton, Jeffrey J ^a   Wu, Zhiqi ^a   Piwnica Worms, Helen ^a,b  

^a WASHINGTON UNIVERSITY   (United States)

^b WASHINGTON UNIVERSITY SCHOOL OF MEDICINE   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

CYCLINE; PROTEIN KINASE; THREONINE;

AMINO ACID SEQUENCE; ANIMAL CELL; ARTICLE; CATALYSIS; CELL CYCLE; CELLULAR DISTRIBUTION; ENDOPLASMIC RETICULUM; ENZYME ACTIVITY; GOLGI COMPLEX; HELA CELL; MITOSIS; NONHUMAN; PRIORITY JOURNAL; PROMOTER REGION; PROTEIN PHOSPHORYLATION; XENOPUS LAEVIS;

EID: 0031053117     PISSN: 02707306     EISSN: None     Source Type: Journal    
DOI: 10.1128/MCB.17.2.571     Document Type: Article

References (60)

1. Atherton-Fessler, S., G. Hannig, and H. Piwnica-Worms. 1993. Reversible tyrosine phosphorylation and cell cycle control. Semin. Cell Biol. 4:433-442.
2. cdc2 inhibitory kinases. Mol. Biol. Cell 5:989-1001.
3. cdc2 regulation. Mol. Cell Biol. 13:1675-1685.
4. Bailly, E., J. Pines, T. Hunter, and M. Bornens. 1992. Cytoplasmic accumulation of cyclin B1 in human cells: association with a detergent-resistant compartment and with the centrosome. J. Cell Sci. 101:529-545.
5. Balch, W. E., W. G. Dunphy, A. W. Braell, and J. E. Rothman. 1984. Reconstitution of the transport of protein between successive compartments of the golgi measured by the coupled incorporation of N-acetylglucosamine. Cell 39:405-416.
6. Baldin, V., and B. Ducommun. 1995. Subcellular localisation of human wee1 kinase is regulated during the cell cycle. J. Cell Sci. 108:2425-2432.
7. CDC28 in response to G1 and G2 cyclins. EMBO J. 12:3417-3426.
8. Campbell, S. D., F. Sprenger, B. A. Edgar, and P. H. O'Farrell. 1995. Drosophila Wee1 kinase rescues fission yeast from mitotic catastrophe and phosphorylates Drosophila Cdc2 in vitro. Mol. Biol. Cell 6:1333-1347.
9. Den Haese, G. J., N. Walworth, A. M. Carr, and K. L. Gould. 1995. The Wee1 protein kinase regulates T14 phosphorylation of fission yeast Cdc2. Mol. Biol. Cell 6:371-385.
10. Draetta, G., and D. Beach. 1988. Activation of cdc2 protein kinase during mitosis in human cells: cell cycle-dependent phosphorylation and subunit rearrangement. Cell 54:17-26.
11. Draetta, G., H. Piwnica-Worms, D. Morrison, B. Druker, T. Roberts, and D. Beach. 1988. Human cdc2 protein kinase is a major cell-cycle regulated tyrosine kinase substrate. Nature 336:738-744.
12. Dunphy, W. G., and A. Kumagai. 1991. The cdc25 protein contains an intrinsic phosphatase activity. Cell 67:189-196.
13. wee1 mitotic inhibitor is a tyrosine/serine kinase. Nature 349:808-811.
14. Frangioni, J. V., P. H. Beahm, V. Shifrib, C. Jost, and B. G. Neel. 1992. The nontransmembrane tyrosine phosphatase FTP-1B localizes to the endoplasmic reticulum via its 35 amino acid C-terminal sequence. Cell 68:545-560.
15. Frangioni, J. V., A. Oda, M. Smith, E. W. Salsman, and B. G. Neel. 1993. Calpain-catalyzed cleavage and subcellular relocation of protein phosphotyrosine 1B (PTP-1B) in human platelets. EMBO J. 12:4843-4856.
16. Gallant, P., and E. Nigg. 1994. Identification of a novel vertebrate cyclin: cyclin B3 shares properties with both A- and B-type cyclins. EMBO J. 13:595-605.
17. cdc2 Cell 67:197-211.
18. Glotzer, M., A. W. Murray, and M. W. Kirschner. 1991. Cyclin is degraded by the ubiquitin pathway. Nature 349:132-138.
19. Gu, Y., J. Rosenblatt, and D. O. Morgan. 1992. Cell cycle regulation of CDK2 activity by phosphorylation of Thr 160 and Tyr 15. EMBO J. 11:3995-4005.
20. Heald, R., M. McLoughlin, and F. McKeon. 1993. Human Wee1 maintains mitotic timing by protecting the nucleus from cytoplasmically activated Cdc2 kinase. Cell 74:463-474.
21. Honda, R., Y. Ohba, and H. Yasuda. 1992. The cell cycle regulator, human p50wee1, is a tyrosine kinase and not a serine/tyrosine kinase. Biochem. Biophys. Res. Commun. 186:1333-1338.
22. +-like gene in human cells. Nature 353:80-83.
23. Jackman, M., M. Firth, and J. Pines. 1995. Human cyclins B1 and B2 are localized to strikingly different structures: B1 to microtubules, B2 to primarily to the golgi apparatus. EMBO J. 14:1646-1654.
24. Kornbluth, S., B. Sebastian, T. Hunter, and J. Newport. 1994. Membrane localization of the kinase which phosphorylates p34cdc2 on threonine 14. Mol. Biol. Cell 5:273-282.
25. Krek, W., and E. A. Nigg. 1991. Differential phosphorylation of vertebrate p34cdc2 kinase at the G1/S and G2/M transitions of the cell cycle: identification of major phosphorylation sites. EMBO J. 10:305-316.
26. cdc2 on tyrosine 15. J. Biol. Chem. 269:30530-30537.
27. Lee, M. S., S. Ogg, M. Xu, L. L. Parker, D. J. Donoghue, J. L. Maller, and H. Piwnica-Worms. 1992. cdc25 + encodes a protein phosphatase that dephosphorylates p34cdc2. Mol. Biol. Cell 3:73-84.
28. Liu, F., and H. Piwnica-Worms. Unpublished observation.
29. Matsuura, I., and J. H. Wang. 1996. Demonstration of cyclin-dependent kinase inhibitory serine/threonine kinase in bovine thymus. J. Biol. Chem. 271:5443-5450.
30. McGowan, C. H., and P. Russell. 1993. Human Wee1 kinase inhibits cell division by phosphorylating p34cdc2 exclusively on Tyr 15. EMBO J. 12:75-85.
31. McGowan, C. H., and P. Russell. 1995. Cell cycle regulation of human WEE1. EMBO J. 14:2166-2175.
32. Meijer, L., L. Azzi, and J. Y. J. Wang. 1991. Cyclin B targets p34cdc2 for tyrosine phosphorylation. EMBO J. 10:1545-1554.
33. Morgan, D. O. 1995. Principles of CDK regulation. Nature 374:131-134.
34. Morla, A., G. Draetta, D. Beach, and J. Wang. 1989. Reversible tyrosine phosphorylation of cdc2: dephosphorylation accompanies activation during entry into mitosis. Cell 58:193-203.
35. Mueller, P. R., T. R. Coleman, and W. G. Dunphy. 1995. Cell cycle regulation of a Xenopus Wee1-like kinase. Mol. Biol. Cell 6:119-134.
36. Mueller, P. R., T. R. Coleman, A. Kumagai, and W. G. Dunphy. 1995. Myt1: a membrane-associated inhibitory kinase that phosphorylates Cdc2 on both threonine-14 and tyrosine-15. Science 270:86-90.
37. Murray, A. W., M. J. Solomon, and M. W. Kirschner. 1989. The role of cyclin synthesis and degradation in the control of maturation promoting factor activity. Nature 339:280-286.
38. Norbury, C., J. Blow, and P. Nurse. 1991. Regulatory phosphorylation of the p34cdc2 protein kinase in vertebrates. EMBO J. 10:3321-3329.
39. Norbury, C., and P. Nurse. 1992. Animal cell cycles and their control. Annu. Rev. Biochem. 61:441-470.
40. Nurse, P. 1990. Universal control mechanism regulating onset of M-phase. Nature 344:503-507.
41. Pardee, A. B. 1989. G1 events and regulation of cell proliferation. Science 246:603-608.
42. Parker, L. L., S. Atherton-Fessler, M. S. Lee, S. Ogg, F. L. Falk, K. I. Swenson, and H. Piwnica-Worms. 1991. Cyclin promotes the tyrosine phosphorylation of p34cdc2 in a wee1+ dependent manner. EMBO J. 10:1255-1263.
43. Parker, L. L., S. Atherton-Fessler, and H. Piwnica-Worms. 1992. p107wee1 is a dual-specificity kinase that phosphorylates p34cdc2 on tyrosine 15. Proc. Natl. Acad. Sci. USA 89:2917-2921.
44. Parker, L. L., and H. Piwnica-Worms. 1992. Inactivation of the p34cdc2/ cyclin B complex by the human WEE1 tyrosine kinase. Science 257:1955-1957.
45. Parker, L. L., P. J. Sylvestre, M. J. Byrnes, F. Liu, and H. Piwnica-Worms. 1995. Identification of a 95-kDa WEE1-like tyrosine kinase in HeLa cells. Proc. Natl. Acad. Sci. USA 92:9638-9642.
46. Parker, L. L., S. A. Walter, and H. Piwnica-Worms. 1993. Phosphorylation and inactivation of p107wee1 hy the nim1/cdr1 kinase. Nature 363:736-738.
47. Pines, J. 1993. Cyclins and cyclin-dependent kinases: take your partners. Trends Biochem. Sci. 18:195-197.
48. Pines, J., and T. Hunter. 1994. The differential localization of human cyclins A and B is due to a cytoplasmic retention signal in cyclin B. EMBO J. 13:3772-3781.
49. Piwnica-Worms, H. 1990. Expression of proteins in insect cells using baculovirus vectors. Greene Publishing Associates, Brooklyn, N.Y.
50. +, a gene encoding a protein kinase homolog. Cell 49:559-567.
51. Sambrook, J., E. F. Fritsch, and T. Maniatis. 1989. Molecular cloning: a laboratory manual. Cold Spring Harbor Laboratory, Cold Spring Harbor, N.Y.
52. Sebastian, B., A. Kakizuka, and T. Hunter. 1993. Cdc25M2 activation of cyclin-dependent kinases by dephosphorylation of threonine 14 and tyrosine 15. Proc. Natl. Acad. Sci. USA 90:3521-3524.
53. Sherr, C. J., and J. M. Roberts. 1995. Inhibitors of mammalian G1 cyclin-dependent kinases. Genes Dev. 9:1149-1163.
54. Solomon, M. J. 1993. Activation of the various cyclin/cdc2 protein kinases. Curr. Biol. 5:180-186.
55. cdc2 activation: identification of an activating kinase. Mol. Biol. Cell 3:13-27.
56. cdc2/cyclin B complex in vitro by human CDC25 protein. Nature 351:242-245.
57. Terada, Y., M. Tatsuka, S. Jinno, and H. Okavama. 1995. Requirement for tyrosinc phosphorylation of Cdk4 in G1 arrest induced hy ultraviolet irradiation. Nature 376:358-362.
58. Terasaki, M., L. B. Chen, and K. Fujiwara. 1986. Microtubules and the endoplasmic reticulum are highly interdependent structures. J. Cell Biol. 103:1557-1568.
59. van der Geer, P., and T. Hunter. 1994. Phosphopeptidc mapping and phosphoamino acid analysis by electrophoresis and chromatography on thin-layer cellulose plates. Electrophorcsis 15:544-554.
60. Watanabe, N., M. Broome, and T. Hunter. 1995. Regulation of the human WEE1Hu CDK tyrosine 15-kinase during the cell cycle. EMBO J. 14:1878-1891.