HIRA, a mammalian homologue of saccharomyces cerevisiae transcriptional co-repressors, interacts with Pax3

Nature Genetics

Volumn 20, Issue 1, 1998, Pages 74-77

  Magnaghi, Paola ^a   Roberts, Catherine ^a   Lorain, Stéphanie ^b   Lipinski, Marc ^b   Scambler, Peter J ^a  

^a UNIVERSITY COLLEGE LONDON   (United Kingdom)

^b INSTITUT GUSTAVE ROUSSY   (France)

Author keywords

[No Author keywords available]

Indexed keywords

TRANSCRIPTION FACTOR; TRANSCRIPTION FACTOR PAX3; UNCLASSIFIED DRUG;

ANIMAL EXPERIMENT; ANIMAL MODEL; ANIMAL TISSUE; ARTICLE; CELL CYCLE; CHROMATIN STRUCTURE; CHROMOSOME 22Q; CONTROLLED STUDY; DIGEORGE SYNDROME; EMBRYO; GENE MUTATION; MOUSE; NEURAL TUBE DEFECT; NONHUMAN; PHENOTYPE; PRIORITY JOURNAL; PROTEIN DOMAIN; PROTEIN PROTEIN INTERACTION; SACCHAROMYCES CEREVISIAE; VELOCARDIOFACIAL SYNDROME; WAARDENBURG SYNDROME;

ANIMALS; CELL CYCLE PROTEINS; CELLS, CULTURED; DNA-BINDING PROTEINS; GENE EXPRESSION REGULATION, DEVELOPMENTAL; HISTONES; HOMEODOMAIN PROTEINS; HYBRID CELLS; MICE; MUSCLE PROTEINS; NERVE TISSUE PROTEINS; NEURAL CREST; NUCLEAR PROTEINS; PAIRED BOX TRANSCRIPTION FACTORS; PAX7 TRANSCRIPTION FACTOR; PRECIPITIN TESTS; RECOMBINANT FUSION PROTEINS; REPRESSOR PROTEINS; TRANSCRIPTION FACTORS;

EID: 0031713666     PISSN: 10614036     EISSN: None     Source Type: Journal    
DOI: 10.1038/1739     Document Type: Article

References (30)

1. Halford, S. et al. Isolation of a putative transcriptional regulator from the region of 22q11 deleted in DiGeorge Syndrome, Shprintzen syndrome and familial congenital heart disease. Hum. Mol. Genet. 2, 2099-2107 (1993).
2. Lamour, V. et al. A human homolog of the S. cerevisiae HIR1 and HIR2 transcriptional repressors cloned from the DiGeorge syndrome critical region. Hum. Mol. Genet. 4, 791-799 (1995).
3. Spector, M.S., Raff, A., DeSilva, H., Lee, K. & Osley, M.A. Hirlp and Hir2p function as transcriptional corepressors to regulate histone gene transcription in the Saccharomyces cerevisiae cell cycle. Mol. Cell. Biol. 17, 545-552 (1997).
4. Dallapiccola, B., Pizzuti, A. & Novelli, G. How many breaks do we need to CATCH on 22q11? Am. J. Hum. Genet. 59, 7-11 (1996).
5. Kurahashi, H. et al. Deletion mapping of 22q11 in CATCH22 syndrome: identification of a second critical region. Am. J. Hum. Genet. 58, 1377-1881 (1996).
6. Rizzu, P. et al. Cloning and comparative mapping of a gene deleted in DiGeorge and velocardiofacial syndromes conserved in the Celegans genome. Mamm. Genome 7, 639-643 (1996).
7. Carlson, C. et al. Molecular definition of 22q11 deletions in 151 VCFS patients: integration within a 10kb physical map. Am. J. Hum. Genet. 61, 620-629 (1997).
8. Budarf, M.L. & Emanuel, B.S. Progress in the autosomal segmental aneusomy syndromes (SASs): single or multi-locus disorders? Hum. Mol. Genet. 6, 1657-1665 (1997).
9. Kirby, M.L. & Waldo, K.L. Role of the neural crest in congenital heart disease. Circulation 82, 332-340 (1990).
10. Manley, N. & Capecchi, M.R. The role of Hoxa-3 in mouse thymus and thyroid development. Development 121, 1989-2003 (1995).
11. Roberts, C., Daw, S., Halford, S. & Scambler, P.J. Cloning and Developmental Expression Analysis of Chick Hira, a candidate gene for DiGeorge syndrome. Hum. Mol. Genet. 6, 237-246 (1997).
12. Wilming, L.G., Snoeren, C.A.S., van Rijswijk, A., Grosveld, F. & Meijers, C. The murine homologue of HIRA, a DiGeorge syndrome candidate gene, is expressed in embryonic structures affected in CATCH22 patients. Hum. Mol. Genet. 6, 247-258 (1997).
13. Lorain, S. et al. Core histones and HIRIP3, a novel histone-binding protein, directly interact with the WD repeat protein HIRA. Mol. Cell. Biol. in press (1998).
14. Goulding, M.D., Chalepakis, G., Deutsch, E., Erselius, J.R. & Gruss, P. Pax-3, a novel murine DNA binding protein expressed during early embryogenesis. EMBO J. 10, 1135-1147 (1991).
15. Zappavigna, V., Falciola, L., Citterich, M.H., Mavilio, F. & Blanchi, M.E. HMG1 interacts with Hox proteins and enhances their DNA binding and transcriptional activation. EMBO J. 15, 5981-4991 (1996).
16. Jostes, B., Walther, C. & Gruss, P. The murine paired box gene, Pax7, is expressed specifically during the development of the nervous and muscular system. Mech. Dev. 33, 27-38 (1991).
17. + mutant mice. Development 122, 831-838 (1996).
18. Conway, S.J., Henderson, D.J. & Copp, A.J. Pax3 is required for cardiac neural crest migration in the mouse: evidence from the splotch (Sp2H) mutant. Development 124, 505-514 (1997).
19. Read, A.P. & Newton, V.E. Waardenburg syndrome. J. Med. Genet. 34, 656-665 (1997).
20. Franz, T. Persistent truncus arteriosus in the Splotch mutant mouse. Anat. Embryol. 180, 457-464 (1989).
21. Zlotogora, J., Lerer, I., Bar-David, S., Ergaz, Z. & Abeliovich, D. Homozygosity for Waardenburg syndrome. Am. J. Hum. Genet. 56, 1173-1178 (1995).
22. Steel, K.P. & Smith, R.J. Normal hearing in Splotch (Sp/+), the mouse homologue of Waardenburg syndrome type I. Nature Genet. 2, 75-79 (1992).
23. Daw, S.C.M. et al. A common region of 10p deleted in DiGeorge and velo-cardiofacial syndrome. Nature Genet. 13, 458-460 (1996).
24. Edmundson, D.G., Smith, M.M. & Roth, S.Y. Repression domain of the yeast global represser Tup1 interacts directly with histones H3 and H4. Genes Dev. 10, 1247-1259 (1996).
25. Gould, A. Functions of mammalian Polycomb group and trithorax group related genes. Curr. Opin. Genet. Dev. 7, 488-494 (1997).
26. Hollenberg, S.M., Sternglanz, R., Cheng, P.F. & Weintraub, H. Identification of a new family of tissue-specific basic helix-loop-helix proteins with a two-hybrid system. Mol. Cell. Biol. 15, 3813-3822 (1995).
27. Bours, V. et al. The oncoprotein BCL-3 directly transactivates through kappaB motifs via association with DNA-binding p50b homodimers. Cell 72, 729-739 (1993).
28. Harlow, E. & Lane, D. Antibodies: A Laboratory Manual. (Cold Spring Harbor Laboratory, New York, 1988).
29. d mouse neural tube explants. Teratology 42, 171-182 (1990).
30. Chalepakis, G., Jones, F.S., Edelman, G.M. & Gruss, P. Pax3 contains domains for transcription activation and transcription inhibition. Proc. Natl Acad. Sci. USA 91, 12745-12749 (1994).