SCF and APC: The yin and yang of cell cycle regulated proteolysis

Current Opinion in Cell Biology

Volumn 10, Issue 6, 1998, Pages 759-768

  Peters, Jan Michael ^a  

^a RESEARCH INSTITUTE OF MOLECULAR PATHOLOGY   (Austria)

Author keywords

[No Author keywords available]

Indexed keywords

CELL CYCLE PROTEIN; CYCLIN DEPENDENT KINASE; UBIQUITIN; UBIQUITIN CONJUGATING ENZYME;

ANIMAL CELL; CELL CYCLE; CELL CYCLE G1 PHASE; CELL CYCLE S PHASE; HUMAN; HUMAN CELL; MITOSIS; NONHUMAN; PRIORITY JOURNAL; PROTEIN DEGRADATION; REVIEW;

ANIMALIA;

EID: 0031772952     PISSN: 09550674     EISSN: None     Source Type: Journal    
DOI: 10.1016/S0955-0674(98)80119-1     Document Type: Article

References (97)

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83. of outstanding interest Lorca T, Castro A, Martinez AM, Vigneron S, Morin N, Sigrist S, Lehner C, Doree M, Labbe JC. Fizzy is required for activation of the APCyclosome in Xenopus egg extracts. of special interest EMBO J. 17:1988;3565-3575 A Xenopus ortholog of Fizzy/Cdc20 is identified and shown to be required for mitotic APC activation in Xenopus extracts. Fizzy is reported to be part of a high molecular weight complex distinct from the APC, in contrast to what has been reported for budding yeast Cdc20 and human Cdh1 [68,69,88].
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91. CDH1 in vitro.
92. Heichmann KA, Roberts JM. CDC16 controls initiation at chromosome replication origins. of special interest Mol Cell. 1:1998;457-463 The second of two papers by the same authors in which evidence is presented that subunits of the budding yeast APC are required to prevent rereplication of chromosomal DNA. This conclusion has been challenged in [93].
93. 2 and M phases? of special interest EMBO J. 16:1997;5988-5997 This paper challenges the view presented in [92] and an earlier paper by Heichman and Roberts by presenting evidence that budding yeast APC mutants overreplicate mitochondrial DNA but not chromosomal DNA.
94. Li Y, Gorbea C, Mahaffey D, Rechsteiner M, Benezra R. MAD2 associates with the cyclosome/anaphase-promoting complex and inhibits its activity. of special interest Proc Natl Acad Sci USA. 94:1997;12431-12436 It is shown that human MAD2 and APC are physically associated in checkpoint-arrested mitotic cells, and that addition of recombinant MAD2 to Xenopus extracts can block cyclin B proteolysis.
95. Hwang LH, Lau LF, Smith DL, Mistrot CA, Hardwick KG, Hwang ES, Amon A, Murray AW. Budding yeast Cdc20: a target of the spindle checkpoint. of outstanding interest Science. 279:1998;1041-1044 Budding yeast Mad2 and Mad3 are shown to coprecipitate with Cdc20 during all stages of the cell cycle, and two-hybrid data indicate that Mad1 may also be part of this complex. Experiments similar to those described for Slp1 in [77] provide evidence that the binding of Mad proteins to Cdc20 is required for activation of the spindle checkpoint.
96. Cohen-Fix O, Koshland D. The anaphase inhibitor of Saccharomyces cerevisiae Pds1p is a target of the DNA damage checkpoint pathway. of special interest Proc Natl Acad Sci USA. 94:1997;14361-14366 Budding yeast Pds1 is shown to be phosphorylated in response to DNA damage but not following incomplete DNA replication. Pds1 phosphorylation depends on Mec1 and Rad9 but not on Rad53. The possibility is discussed that Pds1 phosphorylation may prevent its degradation and could thus block anaphase, but this hypothesis remains unproven.
97. Vorlaufer E, Peters J-M. Regulation of the cyclin B degradation system by an inhibitor of mitotic proteolysis. of special interest Mol Biol Cell. 9:1998;1817-1831 Provides evidence that a stoichiometric inhibitor prevents cyclin B degrdation during the cytostatic factor arrest of Xenopus eggs during meiosis II.