The CD40/CD154 receptor/ligand dyad

Cellular and Molecular Life Sciences

Volumn 58, Issue 1, 2001, Pages 4-43

  Schonbeck U ^a   Libby, P ^a  

^a HARVARD MEDICAL SCHOOL   (United States)

Author keywords

Arteriosclerosis; CD154; CD40; Immunity; Inflammation

Indexed keywords

CELL ADHESION MOLECULE; CELL SURFACE RECEPTOR; CYTOKINE; PROTEIN CD154; PROTEIN CD40; UNCLASSIFIED DRUG;

APOPTOSIS; ARTICLE; ATHEROSCLEROSIS; AUTOIMMUNE DISEASE; B LYMPHOCYTE; BASOPHIL; CANCER; DEGENERATIVE DISEASE; DENDRITIC CELL; ENDOTHELIUM CELL; EOSINOPHIL; FIBROBLAST; GRAFT VERSUS HOST REACTION; HEMATOPOIETIC CELL; HUMORAL IMMUNITY; IMMUNE RESPONSE; IMMUNOREGULATION; INFLAMMATION; LYMPHOCYTE; MONOCYTE; PROTEIN SYNTHESIS; SMOOTH MUSCLE; T LYMPHOCYTE;

EID: 0035129767     PISSN: 1420682X     EISSN: None     Source Type: Journal    
DOI: 10.1007/pl00000776     Document Type: Article

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171. CD40 expressed on thymic epithelial cells provides costimulatin for proliferation but not for apoptosis of human thymocytes
172. Expression of the CD40 antigen on normal endothelial cells and in benign and malignant tumours of vascular origin
173. Endothelial expression of CD40 in renal cell carcinoma
174. CD40 antigen is expressed by endothelial cells and tumor cells in Kaposi's sarcoma
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176. Immunohistologic analysis of renal CD40 and CD40L expression in lupus nephritis and other glomerulonephritides
177. Alzheimer's beta-amyloid peptides induce inflammatory cascade in human vascular cells: The roles of cytokines and CD40
178. CD40-mediated signal transduction in human airway smooth muscle
179. Regulation of matrix metalloproteinase expression in human vascular smooth muscle cells by T lymphocytes: A role for CD40 signaling in plaque rupture?
180. Expression of stromelysin-3 in atherosclerotic lesions: Regulation via CD40-CD40 ligand signaling in vitro and in vivo
181. Discordant expression of Bcl-x and Bcl-2 by keratinocytes in vitro and psoriatic keratinocytes in vivo
182. Human epidermal keratinocytes are induced to secrete interleukin-6 and co-stimulate T lymphocyte proliferation by a CD40-dependent mechanism
183. CD40 is functionally expressed on human keratinocytes
184. CD40 ligation of human keratinocytes inhibits their proliferation and induces their differentiation
185. CD40 expression in epidermal tumors
186. CD40 expression by human fibroblasts
187. Functional CD40 antigen on B cells, dendritic cells tend fibroblasts
188. The finctional CD40 antigen of fibroblasts may contribute to the proliferation of rheumatoid synovium
189. Human thyroid fibroblasts exhibit a distinctive phenotype in culture: Characteristic ganglioside profile and functional CD40 expression
190. Human orbital fibroblasts are activated through CD40 to induce proinflammatory cytokine production
191. CD40 mediated activation of gingival and periodontal ligament fibroblasts
192. CD40 engagement up-regulates cyclooxygenase-2 expression and prostaglandin E2 production in human lung fibroblasts
193. Activation of human orbital fibroblasts through CD40 engagement results in a dramatic induction of hyaluronan synthesis and prostaglandin endoperoxide H synthase-2 expression: Insights into potential pathogenic mechanisms of thyroid-associated ophthalmopathy
194. CD40 engagement modulates the production of matrix metalloproteinases by gingival fibroblasts
195. CD40 is functional activation antigen and B7-independent T cell costimulatory molecule onpnormal human lung fibroblasts
196. Nodular sclerosing, mixed cellularity and lymphocyte-depleted variants of Hodgkin's disease are probable dendritic cell malignancies
197. CD40 expression in Hodgkin's disease
198. Expression of functional CD40 antigen on Reed-Sternberg cells and Hodgkin's disease cell lines
199. Expression and function of CD40 on Hodgkin and Reed-Sternberg cells and the possible relevance for Hodgkin's disease
200. Recombinant CD30 ligand and CD40 ligand share common biological activities on Hodgkin and Reed-Sternberg cells
201. Expression of immune regulatory molecules in Epstein-Barr virus-associated nasopharyngeal carcinomas with prominent lymphoid stroma: Evidence for a functional interaction between epithelial tumor cells and infiltrating lymphoid cells
202. CE40 is a prognostic marker in primary cutaneous malignant melanoma
203. Expression of fimctional CD40 on human osteosarcoma and Ewing's sarcoma cells
204. CD40 is functionally expressed on human breast carcinomas: Variable inducibility by cytokines and enhancement of Fas-mediated apoptosis
205. CD40 ligand-CD40 interaction induces chemokines in cervical carcinoma cells in synergism with IFN-gamma
206. CD40-mediated signaling in B cells. Balancing cell survival, growth, and death
207. Structural characteristic of CD40 ligand that determine biological function
208. Association between IL-6 and CD40 signaling IL-6 induces phosphorylation of CD40 receptors
209. Identification of the intractoplasmic region essential for signal transduction through a B cell activation molecule, CD40
210. A novel RING finger protein interacts with the cytoplasmic domain of CD40
211. Stimulation of protein tyrosine phosphorylation, phosphoinositide turnover, and multiple previously unidentified scrine/ threonine-specific protein kinases by the pan-B-cell receptor CD40/Bp50 at discrete developmental stages of human B-cell ontogeny
212. Signal transduction via CD40 involves activation of lyn kinase and phosphatidylinositol-3-kinase, and phosphorylation of phospholipase C gamma 2
213. Phosphatidylinositol 3-kinase activation in normal human B lymphocytes
214. Activation of the Ras signaling pathway by the CD40 receptor
215. Differential coupling of membrane Ig and CD40 to the extracelhdarly regulated kinase signaling pathway
216. Cyclic-AMP modulates downstream events in CD40-mediated signal transduction, but inhibition of protein kinase A has no direct effect on CD40 signaling
217. Mechanisms of T cell contact-dependent B cell activation
218. Induction of the transcription factors NF-kappa B, AP-I and NF-AT during B cell stimulation through the CD40 receptor
219. Possible role of nuclear factor-kappa B activity in germline C epsilon transcription in a human Burkitt lymphoma B cell line
220. Protein tyrosine kinase activation and protein kinase C translocation are functional components of CD40 signal transduction in resting human B cells
221. Isolation and characterization of murine fra-l: Induction mediated by CD40 and surface Ig is protein kinase C dependent
222. Antigen and helper T lymphocytes activate B lymphocytes by distinct signaling pathways
223. Signaling events during helper T cell-dependent B cell activation. I. Analysis of the signal transduction pathways triggered by activated helper T cell in resting B cells
224. Cross-linking CD40 on B cells preferentially induces stress-actiwted protein kinases rather than mitogen-activated protein kinases
225. Differential activation of the ERK, JNK, and p38 mitogen-activated protein kinases by CD40 and the B cell antigen receptor
226. Activation of mitogen-activated protein kinases via CD40 is distinct from that stimulated by surface IgM on B cells
227. Tumor necrosis factor receptor-associated factor 6 (TRAF6) stimulates extracellular signal-regulated kinase (ERK) activity in CD40 signaling along a ras-independent pathway
228. CD40 ligation results in protein kinase C-independent activation of ERK and JNK in resting murine splenic B cells
229. CD40 signaling of monocyte inflammatory cytokine synthesis through an ERK1/2-dependent pathway: A target of interleukin IL-4 and IL-10 antiinflammatory action
230. Transmembrane signals generated through MHC class 11, CD19, CD20, CD40 antigens induce LFA-1 dependent and independent adhesion in human B cells through a tyrosine kinase-dependent pathway
231. Protein tyrosine phosphorylation is mandatory for CD40-mediated rescue of germinal center B cells from apoptosis
232. CD40 signaling pathway: Anti-CD40 monoclonal antibody induces rapid dephosphorylation and phosphorylation of tyrosine-phosphorylated proteins including protein tyrosine kinase Lyn, Fyn, and Syk and the appearance of a 28-kD tyrosine phosphorylated protein
233. Involvement of CRAFI, a relative of TRAF, in CD40 signaling
234. The Epstein-Barr virus transforming protein LMPi engages signaling proteins for the tumor necrosis factor receptor family
235. A novel member of the TRAF family of putative signal transducing proteins binds to the cytosolic domain of CD40
236. Comparative analysis identifies conserved tumor necrosis factor receptor-associated factor 3 binding sites in the human and simian Epstein-Barr virus oncogene LMP1
237. A single gene for human TRAF-3 at chromosome 14q32.3 encodes a variety of mRNA species by alternative polyadenylation, mRNA splicing and transcription initiation
238. TRAF2-mediated activation of NF-kappa B by TNF receptor 2 and CD40
239. Phosphorylation of TRAF2 inhibits binding to the CD40 cytoplasmic domain
240. CD40-mediated signals inhibit the binding of TNF receptorassociated factor 2 to the CD40 cytoplasmic domain
241. 1-TRAF is a novel TRAF-inter-acting protein that regulates TRAF-mediated signal transduction
242. TRAF5, a novel tumor necrosis factor receptor-associated factor family protein, mediates CD40 signaling
243. Identification of TRAF6, a novel tumor necrosis factor receptor-associated factor protein that mediates signaling from an amino-terminal domain of the CD40 cytoplasmic region
244. CD40-tumor necrosis factor receptor-associated factor (TRAF) interactions: Regulation of CD40 signaling through multiple TRAF binding sites and TRAF hetero-oligomerization
245. TRAF5, an activator of NF-kappaB and putative signal transducer for the lympbotoxin-beta receptor
246. High-affinity interactions of tumor necrosis factor receptor-associated factors (TRAFs) and CD40 require TRAF trimerization and CD40 multimerization
247. An 11-amino acid seqluence in the cytoplasmic domain of CD40 is sufficient for activation of c-Jun N-terminal kinase, activation of MAPKAP kinse-2, phosphorylation of I kappa B alpha, and protection of WEHI-231 cells from anti-lgM-induced growth arrest
248. An intact zinc ring finger is required for tumor necrosis tactor receptor-associated factor-mediated nuclear factor-kappaB activatin but is dispensable for c-Jun N-terminal kinase signaling
249. TNF receptor-associated factor-3 signaling mediates activation of p38 and Jun N-terminal kinase, cytokine secretion, and Ig production following ligation of CD40 on human B cells
250. Two differently regulated nuclear factor kappaB activation pathways triggered by the cytoplasmic tail of CD40
251. CD40 signaling through tumor necrosis factor reptor-associated factors (TRAFs): Binding site specificity and activation of downstream pathways by distinct trafs
252. Specificities of CD40 signaling: Involvement of TRAF2 in CD40-induced NF-kappaB activation and intercellular adhesion molecule-1 up-regulation
253. RIP2 is a novel NF-kappaB-activating and cell death-inducing kinase
254. The involement of multiple tumor necrosis factor receptor (TNFR)-associated factors in the signaling mechanisms of receptor activator of NF-kappaB, a member of the TNFR superfamily
255. Jak-STAT pathways and transcriptional action in response to IFNs and other extracellular signaling proteins
256. Induction of STAT protein signaling through the CD40 receptor in B lymphocytes: Distinct STAT activation following surface Ig and CD40 receptor engagement
257. Regulation of JAK3 expression and activation in human B cells and B cell malignancies
258. Role of JAK3 in CD40-mediated signaling
259. CD40 ligation and IL-4 use different mechanisms of transcriptional actiwttion of the human lymphotoxin alpha promoter in B cells
260. The evolutionarily conserved sequence upstream of the human lg heavy chain S gamma 3 region is an inducible promoter: Synergistic activation by CD40 ligand and IL-4 via cooperative NF-kappa B and STAT-6 binding sites
261. T cell-dependent induction of NFkappa B in B cells
262. Cross-linking CD40 on B cells rapidly activates nuclear factor-kappa B
263. Activation and regulation of the IkappaB kinase in human B ells by CD40 signaling
264. The CD40 TRAF family member inter-acting motif carries the information to rescue WEHI 231 cells from anti-IgM-induced growth arrest
265. Requirement for dual signals by anti-CD40 and 1L-4 for the induction of nuclear factor-kappa B, IL-6, and IgE in human B tymphocytcs
266. Receptor-specific induction of individual AP-I components in B lymphocytes
267. Induction of NF-AT in normal B lymphocytes by anti-immuuoglobulin or CD40 ligand in conjunction with 11-4
268. Properties of mousc CD40: Ligation of CD40 activates B cells via a Ca(+ +)-dependent, FK506-sensitive pathway
269. Modulation of E2F activity via signaling through surface lgM and CD40 receptors in WEHI-231 B lymphoma cells
270. Production of reactive oxygen intermediates following CD40 ligation correlates with c-Jun N-terminal kinase activation and IL-6 secretion in murine B lymphocytes
271. CD40 function in nonhematopoietic cells: Nuclear factor kappa B mobilization and induction of IL-6 production
272. CD40-induced growth inhibition in epithelial cells is mimicked by Epstein-Barr virus-encoded LMPI: Involvement of TRAF3 as a common mediator
273. CD40 and its ligand in the regulation of humoral immunity
274. The role of CD40 in the regulation of humoral and cell-mediated immunity
275. The role of CD40 and its ligand in the regulation of the immune response
276. Functions of CD40 and its ligand, gp39 (CD40L)
277. Immune regulation by CD40 and its ligand GP39
278. Functional role of CD40 and its ligand
279. Analysis of CD40-CD40 ligand interactions in the regulation of human B cell function
280. CD40 signaling activates CD11a/CD18 (LFA-1)-mediated adhesion in B cells
281. Anti-CD40 antibody stimulates the VLA-4-dependent adhesion of normal and LFA-1-deficient B cells to endothelium
282. CD30 is a CD40-inducible molecule that negatively regulates CD40-mediated immunoglobulin class switching in non-antigen-selected human B cells
283. Memory B cells from human tonsils colonize mucosal epithelium and directly present antigen to T cells by rapid up-regulation of B7-1 and B7-2
284. Activated T cells induce expression of B7/BB1 on normal or leukemic B cells through a CD40-dependent signal
285. T lymphocyte T cell-B cell-activating molecule/CD40-L molecules induce normal B cells or chronic lymphocytic leukemia B cells to express CD80 (B7/BB-1) and enhance their costimulatory activity
286. Fas ligation induces apoptosis of CD40-activated human B lymphocytes
287. CD40 ligation induces Apo-1/Fas expression on human B lymphocytes and facilitates apoptosis through the Apo-1/Fas expression on human B lymphocytes and facilitates apoptosis through the Apo-1/Fas pathway
288. CD40 engagement triggers switching to lgA1 and IgA2 in human B cells through induction of endogenous TGF-beta: Evidence for TGF-beta but not IL-10-dependent direct S mu→S alpha and sequential S mu→gamma, S gamma→alpha DNA recombination
289. Epstein-Barr virus transformation induces B lymphocytes to produce human interleukin 10
290. Tumor necrosis factor alpha is an autocrine growth factor for normal human B cells
291. Surface expression and release of soluble forms of CD8 and CD23 in CD40- and IL-4-activated mononuclear cells from patients with Graves' disease (GD)
292. Proliferation and differentiation of human CD5 + and CD5 - B cell subsets activated through their antigen receptors or CD40 antigens
293. Generation of memory B cells and plasma cells in vitro
294. Soluble CD40 ligand can replace the normal T cell-derived CD40 ligand signal to B cell in T cell-dependent activation
295. Multivalent, but not divalent, antigen receptor crosslinkers synergize with CD40 ligand for induction of lg synthesis and class switching in normal murine B cells: A redefinition of the TI-2 vs T cell-dependent antigen dichotomy
296. Growing human B lymphocytes in the CD40 system
297. Cytokine-induced proliferation and immunoglobulin production of human B lymphocytes triggered through their CD40 antigen
298. Interleukin 10 is a potent growth and differentiation factor for activated human B lymphocytes
299. Recombinant human CD40 ligand stimulates B cell proliferation and immunoglobulin E secretion
300. IFN-alpha stimulates proliferation and cytokine secretion of CD40-stimulated B cell chronic lymphocytic leukemia cells in vitro
301. The p65 subunit of NF-kappa B is redundant with p50 during B cell proliferative responses, and is required for germline CH transcription and class switching to IgG3
302. Impaired B cell development and proliferation in absence of phosphoinositide 3-kinase p85alpha
303. T helper cell membranes promote IL-4-independent expression of germ-line C gamma 1 transcripts in B cells
304. B cell differentiation induced by helper T cell membranes: Evidence for sequential isotype switching and a requirement for lymphokines during proliferation
305. Efficient recombination of a switch substrate retrovector in CD40-activated B lymphocytes: Implications for the control of CH gene switch recombination
306. Immunoregulatory role of D40 in human B cell differentiation
307. Interleukin 10 and transforming growth factor beta cooperate to induce anti-CD40-activate naïve human B cells to secrete immunoglobulin A
308. Human interleukin 10 induces naïve surface immunoglobulin D + (slgD +) B cells to secrete IgGl and IgG3
309. IL-4 plus CD40 monoclonal antibody induces human B cells gamma subclass-specific isotype switch: Switching to gamma 1, gamma 3, and gamma 4, but not gamma 2
310. Human B cell proliferation and Ig secretion induccd by recombinant CD40 ligand are modulated by soluble cytokines
311. Cognate interaction between T helper cells and B cells. VII. Role of contact and lymphokines in the expression of germ-line and mature gamma 1 Transcripts
312. Recombinant CD40 ligand stimulation of murine B ccll growth and differentiation: Cooperative effects of cytokines
313. Endogenous interleukin 6 plays an obligatory role in interleukin 4-dependent human IgE synthesis
314. Human B cell clones can be induced to proliferate and to switch to IgE and IgG4 synthesis by interleukin 4 and a signal provided by activated CD4 + T cell clones
315. Structure and expression of germline epsilon transcripts in human B cells induced by interleukin 4 to switch to lgE production
316. Sequential switching from mu to epsilon via gamma 4 in human B cells stimulated with IL-4 and hydrocortisone
317. The relative contribution of IL-4 and hydrocortisone
318. Regulation of the expression of human C epsilon germline transcript: Identification of a novel IL-4 responsive element
319. IFN-gamma represses epsilon germline transcription and subsequently down-regulates switch recombination to epsilon
320. Regulation of germ-line epsilon transcription and induction of epsilon switching in cloned EBV-transformed and malignant human B cell lines by cytokines and CD4 + T cells
321. IgE production by normal human B cells induced by alloreactive T cell clones is mediated by IL-4 and suppressed by IFN-gamma
322. Retinoic acid inhibits CD40 + interleukin-4-mediated IgE production in vitro
323. IL-6 antisense oligonucleotides inhibit IgE production in IL-4 and anti-CD40-stimulated human Blymphocytes
324. CD40 cross-linking induces Ig epsilon germline transcripts in B cells via activation of NF-kappaB: Synergy with 1L-4 induction
325. The transcription factor B cell-specific activator protein (BSAP) enhances both IL-4- and CD40-mediated activation of the human epsilon germline promoter
326. Germinal centers
327. Maintenance of human germinal center B cells in vitro
328. Observations on memory B-cell development
329. Memory, but not naïve, peripheral blood B lymphocytes differentiate into Ig-secreting cells alter CD40 ligation and costimulation with IL-4 and the differentiation factors IL-2, IL-10, and IL-3
330. Cross-linking of the CD40 ligand on human CD4 + T lymphocytes generates a costimulatory signal that up-regulates IL-4 synthesis
331. CD40 ligand-transduces co-stimulation of T cells in the development of helper function
332. Lymphotoxinalpha is an important autocrine factor for CD40 interleukin-4-mediated B-cell activation in normal and atopic donors
333. Interleukin-2 secretion by human B lymphocytes occurs as a late event and requires additional stimulation after CD40 cross-linking
334. Activation of tumor necrosis factor-alpha and lymphotoxin-alpha via anti-CD40 in human B cells
335. Differential induction of cytokine genes and actiwttion of mitogcn-activated protein kinase family by soluble CD40 ligand and TNF in a human follicular dendritic cell line
336. CD40 ligand triggered interleukin-6 secretion in multiple myeloma
337. High level IL-12 production by murine dendritic cells: Upregulation via MHC class II and CD40 molecules and downregulation by IL-4 and IL-10
338. Ligation of CD40 on dendritic cells triggers production of high levels of interleukin 12 and enhances T cell stimulatory capacity: T-T help via APC activation
339. Induction of interleukin-12 p40 transcript by CD40 ligation via activation of nuclear factor-kappaB
340. Interleukin-12 production by dendritic cell: The role of CD40-CD40L interactions in Thl T-cell responses
341. CD40 ligand/CD40 stimulation regulates the production of IFN-gamma from human peripheral blood mononuclear cells in an IL-12- and/or CD28-dependent manner
342. CD40 ligand is not essential for induction of type 1 cytokine responses or protective immunity after primary or secondary infection with Histoplasma capsulatum
343. Possible role CD40-CD40L in the regulation of interstitial in the kidney
344. CD40 ligand (CD154) stimulation of macrophages to produce HIV-1 suppressive beta-chemokines
345. Differential effects of CD40 ligand/trimer stimulation on the ability of dendritic cells to replicate and transmit HIV infection: Evidence for CC-chemokine-dependent and -independent mechanisms
346. Activated murine B lymphocytes and dendritic cells produce a novel CC chemokine which acts selectively on activated T cells
347. IL-4 and ILl3 augment cytokine-and CD40-induced RANTES production by human renal tubular epithelial cells in vitro
348. Demdritic cells and MPIF-I chemotactic activity and inhibition of endogenous chemokine production by IFN-gamma and CD40 ligation
349. Differential regulation of chemokine receptors during dendritic cell maturation: A model for their trafficking properties
350. Rapid and coordinated switch in chemokine receptor expression during dendritic cell maturation
351. B cell-B cell interaction through intercellular adhesion molecule-1 and lymphocyte functional antigen-1 regulates immunoglobulin E synthesis by B cells stimulated with interleukin-4 and anti-CD40 antibody
352. Activation and homologous desensitization of human endothelial cells by CD40 ligand, tumor necrosis factor, and interleukin 1
353. The CD30 ligand and CD40 ligand regulate CD54 surface expression and release of its soluble form by cultured Hodgkin and Reed-Sternberg cells
354. CD1 la-CD18 and CD102 interactions mediate human myeloma cell growth arrest induced by CD40 stimnlation
355. The 86-kD subunit of Ku autoantigen mediates homotypic and heterotypic adhesion of multiple myeloma cells
356. T lymphocytes induce endothelial cell matrix metalloproteinase expression by a CD40L-dependent mechanism: Implications for tubule formation
357. Evidence for increased collagenolysis by interstitial collagenases-1 and -3 in vulnerable human atheromatous plaques
358. CD40 in clinical inflammation: From multiple sclerosis to athcrosclerosis
359. CD40 signaling in vascular cells: A key rote in atherosclerosis?
360. Platelet effects on tissue factor and fibrinolytic inhibition of cultured human fibroblasts and vascular cells
361. Tissue factor induction in human monocytes: Two distinct mechanisms displayed by different alloantigen-responsive T cell clones
362. CD40 engagement induces monocyte procoagulant activity through an interleukin-10 resistant pathway
363. CD40L-CD40 interactions regulate endothelial cell surface tissue factor and thrombomodulin expression
364. CD40 engagement on endothelial cells promotes tissue factor-dependent procoagulant activity
365. Disruption of the CD40-CD40 ligand system prevents an oxygen-induced respiratory distress syndrome
366. Augmented expression of cyclooxygenase-2 in human atherosclerotic lesions
367. Activated T cells enhance nitric oxide production by murine splenic macrophages through gp39 and LFA-1
368. Imparied T cell-mediated macrophage activation in CD40 ligand-deficient mice
369. Induction of nitric oxide synthase in mouse dendritic cells by IFN-gamma, endotoxin, and interaction with allogeneic T cells: Nitric oxide production is associated with dendritic cell apoptosis
370. Mechanism of antigen-driven selection in germinal centres
371. Protection against Fas-dependent Thl-mediated apoptosis by antigen receptor engagement in B cells
372. Rescue from anti-lgM-induced programmed cell death by the B cell surface proteins CD20 and CD40
373. B-cell apoptosis induced by antigen receptor crosslinking is blocked by a T-cell signal through CD40
374. T-BAM/CD40-L on helper T lymphocytes augments lymphokine-induced B cell lg iso-type switch recombinatioon and rescues B cells from programmed cell death
375. Hypercross-linking surface IgM or IgD receptors on mature B cells induces apoptosis that is reversed by costimulated with IL-4 and anti-CD40
376. A role for deregulated c-Myc expression in apoptosis of Epstein-Barr virus-immortalized B cells
377. Modulation of anti-IgM-induced B cell apoptosis by Bcl-xL and CD40 in WEHI-231 cells: Dissociation from cell cycle arrest and dependence on the avidity of the antibody-lgM receptor inter-action
378. Maintenance of nuclear factor-kappa B/Rel and c-myc expression during CD40 ligand rescue of WEHI 231 early B cells from receptor-mediated apoptosis through modulation of I kappa B proteins
379. Anti-lgM-mediated regulation of c-myc and its possible relationship to apoptosis
380. Down-modulation of c-myc expression induces apoptosis of B lymphocyte models of tolerance via clonal deletion
381. Increase ill Bcl-2 level promoted by CD40 ligation correlates with inhibition of B Cell apoptosis induced by vacular type H(+)-ATPase inhibitor
382. Bcl-2+ tonsillar plasma cells are rescued from apoptosis by bone marow fibroblasts
383. Elevated levels of biologically active soluble CD40 ligand in the serum of patients with chronic lymphocytic lcukaemia
384. Suppression of apoptosis in normal and neoplastic human B lymphocytes by CD40 ligand is independent of Bcl-2 induction
385. Repression of apoptosis in human B-lymphoma cells by CD40-ligand and Bcl-2: Relationship to the cell-cycle and role of the retinoblastoma protein
386. T-B cell interaction inhibits spontaneous apoptosis of mature lymphocytcs in Bcl-2 deficient mice
387. Bcl-x exhibits regulated expression during B cell development and activation and modulates lymphocyte survival in transgenic mice
388. Bcl-x rather than Bcl-2 mediates CD40-dependent centrocyte survival in the germinal center
389. CD40 signaling-mediated induction of BcI-XL, Cdk4, and Cdk6: Implication of their cooperation in selective B cell growth
390. Expression of blc-x during mouse B cell differentiation and following activation by various stimuli
391. Human germinal center B cells express the apoptosJs-inducing genes Fas, c-myc, P53, and Bax but not the survival gene bcl-2
392. Up-regulation of Bcl-xL expression protects CD40-activated human B cells from Fas-mediated apoptosis
393. Regulation of bcl-xL expression and Fas susceptibility in mouse B cells by CD40 ligation, surface IgM crosslinking and IL-4
394. CD40 inhibits B cell apoptosis by upregulating bcl-xL expression and blocking oxidant accumulation
395. Unbalanced expression of bcl-2 family proteins in follicular lylnphoma: Contribution of CD40 signaling in promoting survival
396. Induction of bcl-x by CD40 engagement rescues slg-induced apoptosis in murine B cells
397. Ligation of CD40 rescues Ramos-Burkitt lymphoma B cells from calcium ionophore- and antigen receptor-triggered apoptosis by inhibiting activation of the cysteine protease CPP32/Yama and cleavage of its substrate PARP
398. Ligation of CD40 potentiates Fas-mediated activation of the cysteine protease CPP32, cleavage of its death substrate PARP, and apoptosis in Ramos-Burkitt lymphoma B cells
399. Opposing roles of CD95 (Fas/APO-1) and CD40 in the death and rescue of human low density tonsillar B cells
400. CD95 (Fas)-dependent elimination of self-reactive B cells upon interaction with CD4+ T cells
401. Concurrent engagement of CD40 and the antigen receptor protects naive and memory human B cells from APO-1/Fas-mediated apoptosis
402. IL-4 and anti-CD40 protect against Fas-mediated B cell apoptosis and induce B cell growth and differentiation
403. Antibodies to murine CD40 stimulate normal B lymphocytes but inhibit proliferation of B lymphoma cells
404. Activation mediated by RP105 but not CD40 makes normal B cells susceptible to anti-lgM-induced apoptosis: A role for Fc receptor coligation
405. Cellular and molecular factors that regulate the differentiation and apoptosis of germinal center B cells: Anti-lg down-regulates Fas expression of CD40 ligand-stimulated germinal center B cells and inhibits Fas-mediated apoptosis
406. Antigen receptor-induced apoptosis of human germinal center B cells is targeted to a eentrocytic subset
407. T cell rescue of monocytes from apoptosis: Role of the CD40-CD40L interaction and requirement for CD40-mediated induction of protein tyrosine kJnase activity
408. CD40 ligation counteracts Fas-induced apoptosis of human dendritic cells
409. CD40 induces resistance to TNF-mediated apoptosis in a fibroblast cell line
410. Expression of CD40 induces neural apoptosis
411. A novel function of CD40: Induction of cell death in transformed cells
412. Role of the CD40 and CD95 (APO-1/Fas) antigens in the apoptosis of human B-cell malignancies
413. CD40 ligand inhibits Fas/CD95-mediated apoptosis of human blood-derived dendritic cells
414. Germinal center-derived signals act with Bcl-2 to decrease apoptosis and increase clonogenicity of drug-treated human B lymphoma cells
415. Resistance to cytotoxic chemotherapy induced by CD40 ligand in lymphoma cells
416. Sensitivity to Fas-mediated apoptosis is null or weak in B-cell non-Hodgkin's lymphomas and is moderately increased by CD40 ligation
417. Downregulation of the CD95 receptor and defect CD40-mediated signal transduction in B-chronic lymphocytic leukemia cells
418. Inhibition of human breast carcinoma growth by a soluble recombinant human CD40 ligand
419. CD40 stimulation inhibits cell growth and Fas-mediated apoptosis in a thyroid cancer cell line
420. CD154 inhibits tulnor-induced apoptosis in dendritic cells and tumor growth
421. Interleukin-13 in combination with CD40 ligand potently inhibits apoptosis in human B lymphocytes: Upregulation of Bcl-xL and Mcl-l
422. IL-4 and IL-10 modulation of CD40-mediated signaling of monocyte IL-I beta synthesis and rescue from apoptosis
423. Distinct mechanisms for rescue from apoptosis in Ramos human B cells by signaling through CD40 and interleukin-4 receptor: Role for inhibition of an early response gene, Berg36
424. The CD40 ligand, gp39, is defective in activated T cells froln patients with X-linked hyper-IgM syndrome
425. CD40 ligand gene defects responsible for X-linked hyper-lgM syndrome
426. The random inactivation of the X chromosome carrying the defective gene responsible for X-linked hyper IgM syndrome (X-HIM) in female carriers of HIGMI
427. CD40 ligand mutations in X-linked immunodeficiency with hyper-IgM
428. Defective expression of the CD40 ligand in X chromosome-linked immunoglobulin defciency with normal or elewtted IgM
429. Defective expression of T-cell CD40 ligand causes X-linked immunodefiency with hyper lgM
430. CD401base: A database of CD40L gene mutations causing X-linked hyper lgM syndrome
431. Mutation analysis in CD40 ligand deficiency leading to X-linked hypogammaglobulinemia with hyper IgM syndrome
432. A novel splice-site mutation in the CD40L gene in a patient with X-linked hyper-IgM syndrome
433. Mutations of the CD40 ligand gene and its effect on CD40 ligand expression in patients with X-linked hyper IgM syndrome
434. CD40 ligand mutants responsible for X-linked hyper-IgM syndrome associate with wild type CD40 ligand
435. Hyper IgM syndrome associated with defective CD40-mediated B cell activation
436. Mice deficient for the CD40 ligand
437. Humoral imlnune responses in CD40 ligand-deficient mice
438. The immune responses in CD40-deficient mice: Impaired immunoglobulin class switching and germinal center formation
439. Viral and celullar gene expression in CD4+ human lymphoid cell lines infected by the simian immunodeficiency virus, SIV/Mne
440. Membrane tumour necrosis factor-alpha is involved in the polyclonal B-cell activation induced by HIV-infected human T cells
441. HIV gp120 inhibits T cell activation by interfering with expression of costimulatory molecules CD40 ligand and CDS0 (B71)
442. CD40/CD40L interactions and cytokines regulate HIV replication in B cells in vitro
443. The role of CD40 and CD80 accessory cell molecules in dendritie cell-dependent HIV-1 infection
444. Productive infection of normal CD40-activated human B lymphocytes by HIV-1
445. CD40 ligand has potent antiviral activity
446. CD40L-deficient mice show deficits in antiviral immunity and have an impaired memory CD8 + CTL response
447. CD40 ligand-dependent T cell activation: Requirement of B7-CD28 signaling through CD40
448. The CD40-CDI54 system ill anti-infective host defense
449. CD40-CD40 ligand interaction is central to cell-mediated immunity against Toxophtsma gondii: Patients with hyper lgM syndrome have a defective type 1 immune response that can be restored by soluble CD40 ligand trimer
450. Protective role of CD40 in Leishmania major infection at two distinct phases of cell-mediated immunity
451. Disruption of CD40-CD40 ligand interactions results in all enhanced susceptibility to Leishmania amazonensis infection
452. CD40 ligand is required for protective cell-mediated immunity to Leishmania major
453. The induction of a protective response in Leishmania ma/or-infected BALB/c mice with anti-CD40 mAb
454. Protective antibodies in murine Lyme disease arise independently of CD40 ligand
455. CD40-mediated stimulation contributes to lymphocyte proliferation, antibody production, eosinophilia, and mastocytosis during an in vivo type 2 response, but is not required for T cell IL-4 produetion
456. CD40 ligand is required for resolution of Pneumocystis carinii pneumonia in mice
457. Underproduction of interleukin-12 in snsceptible mice during progressive leishmaniasis is due to deereased CD40 aetivity
458. CD40 ligand/trimer DNA enhances both humoral and cellular immune responses and induces protective immunity to infectious and tumor challenge
459. CD40 ligation prevents Trypanosema cruzi infection through interleukin-12 upregulation
460. CD40 ligand is not essential for the development of cell-mediated immunity and resistance to Mycobacterium tuberctdosis
461. Survival of mouse pancreatic islet allografts in recipients treated with allogeneic small lymphocytes and antibody to CD40 ligand
462. Long-term acceptance of skin and cardiac allografts after blocking CD40 and CD28 pathways
463. Costimulatory function and expression of CD40 ligand, CD80, and CD86 in vascularized murine cardiac allograft rejection
464. Prolonged survival of mouse skin allografts in recipients treated with donor splenocytes and antibody to CD46 hgand
465. Immunologic and hematopoietic effects of CD40 stimulation after syngeneic bone marrow transplantation in mice
466. Blockade of CD40 ligand-CD40 interaction impairs CD4 + T cell-mediated alloreactivity by inhibiting mature donor T cell expansion and function after bone marrow transplantation
467. Prolonged acceptance of concordant and discordant xenografts with combined CD40 and CD28 pathway blockade
468. CTLA4-Ig and anti-CD40 ligand prevent renal allograft rejection ill primates
469. Prevention of chronic rejection in mouse aortic allografts by combined treatlnent with CTLA4lg and anti-CD40 ligand monoclonal antibody
470. Involvement of CD40 ligand-CD40 and CTLA4-B7 pathways in murine acute graft-versus-host disease induced by allogerteic T cells lacking CD28
471. Long-term survival of skin allografts induced by donor splenocytes and anti-CD 154 antibody in thymectomized mice requires CD4(+) T cells, interferon-gamlna, and CTLA4
472. Treatment with humanized monoclonal antibody against CD154 prevents acute renal allograft rejection in nonhuman primates
473. The CD40 pathway in allograft rejection, acceptance, and tolerance
474. IFN-gamma is critical for long-term allograft survival induced by blocking the CD28 and CD40 ligand T cell costimulation pathways
475. CD40 ligation prevents neonatal induction of transplantation tolerance
476. Antibody-induced transplant arteriosclerosis is prevented by graft expression of anti-oxidant and anti-apoptotic genes
477. Kupffer cell expression of CD40L (CD154) in human chronic liver allografi rejection
478. Interaction between CD40 and its ligand gp39 in the development of murine lupus nephritis
479. Antoimmune lpr/lpr mice delicicnt in CD40 ligand: Spontaneous Ig class switching with dichotomy of autoantibody responses
480. Collagen-induced arthritis as a model of rhcumatoid arthritis
481. Requirement for CD40 ligand in costimulation induction, T cell activation, and experimental allergic encephalomyelitis
482. CD40L blockade preveuts autoimmune eneephalomyelitis and hampers TH1 but not TH2 pathway of T cell differeutiation
483. CD40-CD40 ligand interactions in experimental allergic encephalomyelitis and multiple sclerosis
484. Therapy with antibodies against CD40L (CD154) and CD44-variant isoforlns reduces experimental autoimmune encephalomyelitis induced by a proteolipid protein peptide
485. CD40-CD40 ligand interaction in autoimmune disease
486. CD40 ligand-CD40 interactions are necessary for the initiation of insulitis and diabetes in nonobese diabetic mice
487. Anti-CD40 ligand antibody treatment preveuts the development of lupus-like nephritis in a subset of New Zealand black × New Zealand white mice: Response correlates with the absence of an anti-antibody response
488. Alpha beta T cell regulation and CD40 ligand dependence in murine systemic uutoimlnunity
489. Expansion or elimination of B cells in vivo: Dual roles for CD40- and Fas (CD95)-ligands modulated by the B cell antigen receptor
490. Precursor B cells for autoantibody production in genomically Fas-intact autoimmune disease are not subject to Fas-mediated immune elimination
491. Blocking the CD40L-CD40 interaction in vivo specifically prevents the priming of T helper I cells through the inhibition of interleukin 12 secretion
492. IL-12 in autoimmunity
493. Ligation of CD40 induced tumor necrosis factor-alpha in rheumatoid arthritis: A novel lnechanism of activation of synoviocytes
494. Increased expression of CD40 ligand on systemic lupus erythematosus lymphocytes
495. Expression and function of CD40 in rheulnatoid arthritis synovium
496. The role of CD8+ CD40L + T cells in the formation of germinal centers in rheumatoid synovitis
497. Functional CD40 ligand is expressed by T cells in rheumatoid arthritis
498. Hyper-lgM syndrome associated with rheumatoid arthritis: Report of RA in a patient with primary impaired CD40 pathway
499. An aggressive form of polyarticular arthritis in a nlau with CD154 mutation (X-liuked hyper-lgM syndrolne)
500. CD40 ligation induces tissue factor expression in human vascular smooth muscle cells
501. Leucocyte recruitlnent in rupture prone regious of lipid-rich plaques: A prominent role for neowtscnhtrization?
502. Chemokines and atherosclerosis
503. Cyclooxygenase regulates angiogenesis induced by colon cancer cells
504. Requirement for CD154 in the progression of atherosclerosis
505. Enhanced levels of soluble and mcmbranc-bound CD40 ligand in patients with unstable angina: Possible reflection of T lylnphocyte and platclet involvement in thc pathogcnesis of acute coronary syndromes
506. Athcrosclerosis an inflanunatory disease
507. Lysophosphatidylcholine up-regulates CD40 ligand expression in newly activated human CD4+ T cells
508. Anti-CD40 antibody binding modnlates human multiple myeloma clonogenicity in vitro
509. CD40 ligand is constitutively expressed in a subset of T cell lymphomas and on the microenviromnental reactive T cells of follicular lympholnas and Hodgkin's disease
510. Expression of the co-stimulatory lnolecule CD40 on melanoma cells
511. CD40 expression in bladdcr cancer
512. Triggering of CD40 antigen inhibits fiudarabine-induced apoptosis in B chronic lymphocytic leukelnia cells
513. In vitro activation of leukaemic B cells by interleukin-4 and antibodies to CD40
514. Proliferation of precursor B-lineage acute lymphoblastic leukaemia by activating the CD40 antigen
515. Antibodies to routine CD40 protect normul and malignant B cells from induced growth arrest
516. CD40-ligation-mediated protection from apoptosis of a Fas-sensitive Hodgkin's-disease-derived cell line
517. Acquired CD40-ligand deficiency in chronic lymphocytic leukemia
518. Inhibition of human B-cell lymphoma growth by CD40 stimulation
519. Antibodies to CD40 prevent Epstein-Barr virus-mediated human B-cell lymphomagenesis in severe combined immune deficient mice given human peripheral blood lymphocytes
520. Protective immunity induced by tumor vaccines requires interaction between CD40 and its ligand, CD154
521. Dendritic cells require maturation via CD40 to generate protective antitumor immunity
522. CD40 antibody evokes a cytotoxic T-cell response that eradicates lymphoma and bypasses T-cell help
523. Antitumor effect of CD40 ligand: Elicitation of local and systemic antitumor responses by IL-12 and B7
524. Antitumor responses induced by transgenic expression of CD40 ligand
525. Gene transfer of CD40-ligand induces autologous immune recognition of chronic lymphocytic leukemia B cells
526. Generation of tumor immunity by bone marrow-derived dendritic cells correlates with dendritic cell maturation stage
527. Anti-tumor immunity induced by in vivo adenovirus vector-mediated expression of CD40 ligand in tumor cells
528. Enhancement of tumoricidal activity of alveolar macrophages via CD40-CD40 ligand interaction
529. Thymic lymphoproliferative disease after successful correction of CD40 ligand deficiency by gene transfer in mice
530. Activity of a single-chain immunotoxin that selectively kills lymphoma and other B-lineage cells expressing the CD40 antigen
531. In vivo efficacy and toxicity of a single-chain immunotoxin targeted to CD40
532. In situ expression of B7 and CD40 costimulatory molecules by normal human lung macrophages and epithelioid cells in tuberculoid granulomas
533. Disruption of antigen-induced inflammatory responses in CD40 ligand knockout mice
534. Exogenous CD40 ligand induces a pulmonary inflaimnation response
535. Aeroallergen-induced eosinophilic inflammation, lung damage, and airways hyperreactivity in mice can occur independently of IL-4 and allcrgcn-spccific immunoglobulins
536. Bone marrow-derived cells are required for the induction of a pulmonary inflammatory response mediated by CD40 ligation
537. Blockade of CD40-CD40 ligand interactions protects against radiation-induced pulmonary inflammation and fibrosis