Cellular and Molecular Factors That Regulate the Differentiation and Apoptosis of Germinal Center B Cells: Anti-Ig Down-Regulates Fas Expression on CD40 Ligand-Stimulated Germinal Center B Cells and Inhibits Fas-Mediated Apoptosis

Journal of Immunology

Volumn 157, Issue 3, 1996, Pages 1006-1016

  Choe, Jongseon ^a   Kim, Han Soo ^a   Zhang, Xinhong ^a   Armitage, Richard J ^b   Choi, Yong Sung ^a  

^a OCHSNER MEDICAL CENTER   (United States)

^b AMGEN INC   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

ADENOSINE DIPHOSPHATE RIBOSYL CYCLASE; CD20 ANTIGEN; CD38 ANTIGEN; CD38 PROTEIN, HUMAN; CD40 ANTIGEN; DIFFERENTIATION ANTIGEN; FAS ANTIGEN; GLYCOSIDASE; HERMES ANTIGEN; INTERLEUKIN 2; INTERLEUKIN 4; LEUKOCYTE ANTIGEN; MEMBRANE ANTIGEN; MEMBRANE PROTEIN;

APOPTOSIS; ARTICLE; B LYMPHOCYTE; BIOSYNTHESIS; CELL DIFFERENTIATION; CELL SURVIVAL; CYTOLOGY; DENDRITIC CELL; DRUG EFFECT; GERMINAL CENTER; HUMAN; IMMUNOLOGY; PHYSIOLOGY; T LYMPHOCYTE SUBPOPULATION;

ADP-RIBOSYL CYCLASE; ANTIGENS, CD; ANTIGENS, CD20; ANTIGENS, CD38; ANTIGENS, CD40; ANTIGENS, CD44; ANTIGENS, CD95; ANTIGENS, DIFFERENTIATION; ANTIGENS, SURFACE; APOPTOSIS; B-LYMPHOCYTES; CELL DIFFERENTIATION; CELL SURVIVAL; DENDRITIC CELLS; GERMINAL CENTER; HUMANS; INTERLEUKIN-2; INTERLEUKIN-4; MEMBRANE GLYCOPROTEINS; N-GLYCOSYL HYDROLASES; T-LYMPHOCYTE SUBSETS;

EID: 0030209983     PISSN: 00221767     EISSN: None     Source Type: Journal    
DOI: None     Document Type: Article

References (65)

1. Nieuwenhuis, P., and D. Opstelten. 1984. Functional anatomy of germinal centers. Am. J. Anal. 170:421.
2. Koopman, G., and S. T. Pals. 1992. Cellular interactions in the germinal center: role of adhesion receptors and significance for the pathogenesis of AIDS and malignant lymphoma. Immunol. Rev. 126:21.
3. Gray, D. 1988. Recruitment of virgin B cells into an immune response is restricted to activation outside of follicles. Immunology 65:73.
4. Kelsoe, G. 1994. B cell diversification and differentiation in the periphery. J. Exp. Med. 180:5.
5. Jacob, J., R. Kassir, and G. Kelsoe. 1991. In situ studies of the primary immune response to (4-hydroxy-3-nitrophenyl) acetyl. I. The architecture and dynamics of responding cell populations. J. Exp. Med. 173:1165.
6. Liu, Y.-J., J. Zhang, P. J. L. Lane, E. Y.-T. Chan, and I. C. M. MacLennan. 1991. Sites of specific B cell activation in primary and secondary responses to T cell-dependent and T cell-independent antigens. Eur. J. Immunol. 21:2951.
7. MacLennan, I. C. M. 1994. Germinal centers. Annu. Rev. Immunol. 12:117.
8. Liu, Y.-J., G. D. Johnson, J. Gordon, and I. C. M. MacLennan. 1992. Germinal centres in T-cell-dependent antibody responses. Immunol. Today 13:17.
9. Jacob, J., and G. Kelsoe. 1992. In situ studies of the primary immune response to (4-hydroxy-3-nitrophenyl) acetyl. II. A common clonal origin for periarteriolar lymphoid sheath-associated foci and germinal centers. J. Exp. Med. 176:679.
10. Berek, C., A. Berger, and M. Apel. 1991. Maturation of the immune response in germinal centers. Cell 67:1121.
11. Leanderson, T., E. Kallberg, and D. Gray. 1992. Expansion, selection and mutation of antigen-specific B cells in germinal centers. Immunol. Rev. 126:47.
12. MacLennan, C. M., Y.-J. Liu, and G. D. Johnson. 1992. Maturation and dispersal of B-cell clones during T cell-dependent antibody responses. Immunol. Rev. 126: 143.
13. Nossal, G. J. V., M. Karvelas, and B. Pulendran. 1993. Soluble antigen profoundly reduces memory B-cell numbers even when given after challenge immunization. Proc. Natl. Acad. Sci. USA 90:3088.
14. Liu, Y.-J., D. E. Joshua, G. T. Williams, C. A. Smith, J. Gordon, and I. C. M. MacLennan. 1989. Mechanism of antigen-driven selection in germinal centres. Nature 342:929.
15. Holder, M. J., H. Wang, A. E. Milner, M. Casamayor, R. Armitage, M. K. Spriggs, W. C. Fanslow, I. C. M. MacLennan, C. D. Gregory, and J. Gordon. 1993. Suppression of apoptosis in normal and neoplastic human B lymphocytes by CD40 ligand is independent of Bcl-2 induction. Eur. J. Immunol. 23:2368.
16. Kim, H.-S., X. Zhang, and Y. S. Choi. 1994. Activation and proliferation of follicular dendritic cell-like cells by activated T lymphocytes. J. Immunol. 153: 2951.
17. Kim, H.-S., X. Zhang, E. Klyushnenkova, and Y. S. Choi. 1995. Stimulation of germinal center B lymphocyte proliferation by an FDC-like cell line, HK. J. Immunol. 155:1101.
18. Jacobson, E. B., L. H. Caporale, and G. J. Thorbecke. 1974. Effect of thymus cell injections on germinal center formation in lymphoid tissues of nude (thymusless) mice. Cell. Immunol. 13:416.
19. Kapasi, Z. F., G. F. Burton, L. D. Shultz, J. G. Tew, and A. K. Szakal. 1993. Induction of functional follicular dendritic cell development in severe combined immunodeficiency mice. J. Immunol. 150:2648.
20. Schmitz, J., S. Petrash, J. van Lunzen, P. Racz, H.-D. Kleine, F. Hufert, P. Kern, H. Schmitz, and K. Tenner-Racz. 1993. Optimizing follicular dendritic cell isolation by discontinuous gradient centrifugation and use of the magnetic cell sorter (MACS). J. Immunol. Methods 159:189.
21. Xia, X., H. K. Lee, S. C. Clark, and Y. S. Choi. 1989. Recombinant interleukin (IL) 2-induced human B cell differentiation is mediated by autocrine IL 6. Eur. J. Immunol. 19:2275.
22. Möller, S. A., and C. A. K. Borrebaeck. 1985. A filter immuno-plaque assay for the detection of antibody-secreting cells in vivo. J. Immunol. Methods 79:195.
23. + thymocytes by flow cytometry. J. Immunol. Methods 137:79.
24. Naiem, M., J. Gerdes, Z. Abdulaziz, H. Stein, and D. Y. Mason. 1983. Production of a monoclonal antibody reactive with human dendritic reticulum cells and its use in the immunohistological analysis of lymphoid tissue. J. Clin. Pathol. 36: 167.
25. Schriever, F., and L. M. Nadler. 1992. The central role of follicular dendritic cells in lymphoid tissues. Adv. Immunol. 51:243.
26. Clark, E. A., K. H. Grabstein, and G. L. Shu. 1992. Cultured human follicular dendritic cells: growth characteristics and interactions with B lymphocytes. J. Immunol. 148:3327.
27. Lindhout, E., A. Lakeman, M. L. C. M. Mevissen, and C. de Groot. 1994. Functionally active Epstein-Barr virus-transformed follicular dendritic cell-like cell lines. J. Exp. Med. 179:1173.
28. Parwaresch, M. R., H. J. Radzun, M.-L. Hansmann, and K.-P. Peters. 1983. Monoclonal antibody Ki-M4 specifically recognizes human dendritic reticulum cells (follicular dendritic cells) and their possible precursor in blood. Blood 62: 585.
29. Grouard, G., O. de Bouteiller, J. Banchereau, and Y.-J. Liu. 1995. Human follicular dendritic cells enhance cytokine-dependent growth and differentiation of CD40-activated B cells. J. Immunol. 155:3345.
30. Butch, A. W., B. A. Hug, and M. H. Nahm. 1994. Properties of human follicular dendritic cells purified with HJ2, a new monoclonal antibody. Cell. Immunol. 155:27.
31. Pascual, V., Y.-J. Liu, A. Magalski, O. de Bouteiller, J. Banchereau, and J. D. Capra. 1994. Analysis of somatic mutation in five B cell subsets of human tonsil. J. Exp. Med. 180:329.
32. Liu, Y.-J., C. Barthelemy, O. de Bouteiller, C. Arpin, I. Durand, and J. Banchereau. 1995. Memory B cells from human tonsils colonize mucosal epithelium and directly present antigen to T cells by rapid up-regulation of B7-1 and B7-2. Immunity 2:239.
33. Miltenyi, S., W. Müller, W. Weichel, and A. Radbruch. 1990. High gradient magnetic cell separation with MACS. Cytometry 11:231.
34. Koopman, G., H. K. Parmentier, H.-J. Schuurman, W. Newman, C. J. L. M. Meijer, and S. T. Pals. 1991. Adhesion of human B cells to follicular dendritic cells involves both the lymphocyte function-associated antigen 1/intercellular adhesion molecule 1 and very late antigen 4/vascular cell adhesion molecule 1 pathways. J. Exp. Med. 173:1297.
35. Kosco, M. H., E. Pflugfelder, and D. Gray. 1992. Follicular dendritic cell-dependent adhesion and proliferation of B cells in vitro. J. Immunol. 148:2331.
36. Holder, M. J., Y.-J. Liu, T. Defrance, L. Flores-Romo, I. C. M. MacLennan, and J. Gordon. 1991. Growth factor requirements for the stimulation of germinal center B cells: evidence for an IL-2-dependent pathway of development. Int. Immunol. 3:1243.
37. Harada, H., M. M. Kawano, N. Huang, Y. Harada, K. Iwato, O. Tanabe, H. Tanaka, A. Sakai, H. Asaoku, and A. Kuramoto. 1993. Phenotypic difference of normal plasma cells from mature myeloma cells. Blood 81:2658.
38. Korsmeyer, S. J. 1992. Bcl-2: a repressor of lymphocyte death. Immunol. Today 13:285.
39. Ramsdell, F., M. S. Seaman, R. E. Miller, K. S. Picha, M. K. Kennedy, and D. H. Lynch. 1994. Differential ability of Th1 and Th2 T cells to express Fas ligand and to undergo activation-induced cell death. Int. Immunol. 6:1545.
40. Ju, S.-T., D. J. Panka, H. Cui, R. Ettinger, M. El-Khatib, D. H. Sherr, B. Z. Stanger, and A. Marshak-Rothstein. 1995. Fas(CD95)/FasL interactions required for programmed cell death after T-cell activation. Nature 373:444.
41. Schattner, E. J., K. B. Elkon, D.-H. Yoo, J. Tumang, P. H. Krammer, M. K. Crow, and S. M. Friedrnan. 1995. CD40 ligation induces Apo-1/Fas expression on human B lymphocytes and facilitates apoptosis through the Apo-1/Fas pathway. J. Exp. Med. 182:1557.
42. Lagresle, C., C. Bella, P. T. Daniel, P. H. Krammer, and T. Defrance. 1995. Regulation of germinal center B cell differentiation. J. Immunol. 154:5746.
43. Rothstein, T. L., J. K. M. Wang, D. J. Panka, L. C. Foote, Z. Wang, and A. Marshak-Rothstein. 1995. Protection against Fas-dependent Th1-mediated apoptosis by antigen receptor engagement in B cells. Nature 374:163.
44. Schriever, F., A. S. Freedman, G. Freeman, E. Messner, G. Lee, J. Daley, and L. M. Nadler. 1989. Isolated human follicular dendritic cells display a unique antigenic phenotype. J. Exp. Med. 169:2043.
45. Notarangelo, L. D., M. Duse, and A. G. Ugazio. 1992. Immunodeficiency with hyper-IgM (HIM). Immunodefic. Rev. 3:101.
46. Kawabe, T., T. Naka, K. Yoshida, T. Tanaka, H. Fujiwara, S. Suematsu, N. Yoshida, T. Kishimoto, and H. Kikutani. 1994. The immune responses in CD40-deficient mice: impaired immunoglobulin class switching and germinal center formation. Immunity 1:167.
47. Xu, J., T. M. Foy, J. D. Laman, E. A. Elliott, J. J. Dunn, T. J. Waldschmidt, J. Elsemore, R. J. Noelle, and R. A. Flavell. 1994. Mice deficient for the CD40 ligand. Immunity 1:423.
48. Renshaw, B. R., W. C. Fanslow III, R. J. Armitage, K. A. Campbell, D. Liggitt, B. Wright, B. L. Davison, and C. R. Maliszewski. 1994. Humoral immune responses in CD40 ligand-deficient mice. J. Exp. Med. 180:1889.
49. Foy, T. M., J. D. Laman, J. A. Ledbetter, A. Aruffo, E. Claassen, and R. J. Noelle. 1994, gp39-CD40 interactions are essential for germinal center formation and the development of B cell memory. J. Exp. Med. 180:157.
50. Han, S., K. Hathcock, B. Zheng, T. B. Kepler, R. Hodes, and G. Kelsoe. 1995. Cellular interaction in germinal centers. J. Immunol. 155:556.
51. + memory T cells contains preformed CD40 ligand that is rapidly but transiently expressed on their surface after activation through the T cell receptor complex. J. Exp. Med. 181:1293.
52. Fuller, K. A., O. Kanagawa, and M. H. Nahm. 1993. T cells within germinal centers are specific for the immunizing antigen. J. Immunol. 151:4505.
53. Zheng, B., W. Xue, and G. Kelsoe. 1994. Locus-specific somatic hypermutation in germinal centre T cells. Nature 372:556.
54. Roussel, F., E. Garcia, T. Defrance, C. Peronne, N. Vezzio, D.-H. Hsu, R. Kastelein, K. W. Moore, and J. Banchereau. 1992. Interleukin 10 is a potent growth and differentiation factor for activated human B lymphocytes. Immunology 89:1890.
55. Armitage, R. J., B. M. Macduff, M. K. Spriggs, and W. C. Fanslow. 1993. Human B cell proliferation and Ig secretion induced by recombinant CD40 ligand are modulated by soluble cytokines. J. Immunol. 150:3671.
56. Fluckiger, A.-C., P. Garrone, I. Durand, J.-P. Galizzi and J. Banchereau. 1993. Interleukin 10 (IL-10) upregulates functional high affinity IL-2 receptors on normal and leukemic B lymphocytes. J. Exp. Med. 178:1473.
57. Galibert, L., I. Durand, J. Banchereau, and F. Roussel. 1994. CD40-activated surface IgD-positive lymphocytes constitute the long term IL-4-dependent proliferating B cell pool. J. Immunol. 152:22.
58. Butch, A. W., G.-H. Chung, J. W. Hoffman, and M. H. Nahm. 1993. Cytokine expression by germinal center cells. J. Immunol. 150:39.
59. Levy, Y., and J.-C. Brouet. 1994. Interleukin-10 prevents spontaneous death of germinal center B cells by induction of the Bcl-2 protein. J. Clin. Invest. 93:424.
60. Arpin, C., J. Dechanet, C. van Kooten, P. Merville, G. Grouard, F. Briere, J. Banchereau, and Y.-J. Liu. 1995. Generation of memory B cells and plasma cells in vitro. Science 268:720.
61. Pulendran, B., G. Kannourakis, S. Nouri, K. G. C. Smith, and G. J. V. Nossal. 1995. Soluble antigen can cause enhanced apoptosis of germinal-centre B cells. Nature 375:331.
62. Shokat, K. M., and C. C. Goodnow. 1995. Antigen-induced B-cell death and elimination during germinal-centre immune responses. Nature 375:334.
63. Veis, D. J., C. M. Sorenson, J. R. Shutter, and S. J. Korsmeyer. 1993. Bcl-2-deficient mice demonstrate fulminant lymphoid apoptosis, polycystic kidneys, and hypopigmented hair. Cell 75:229.
64. Smith, K. G. C., U. Weiss, K. Rajewsky, G. J. V. Nossal, and D. M. Tarlinton. 1994. Bcl-2 increases memory B cell recruitment but does not perturb selection in germinal centers. Immunity 1:803.
65. Garrone, P., E.-M. Neidhardt, E. Garcia, L. Galibert, C. van Kooten, and J. Banchereau. 1995. Fas ligation induces apoptosis of CD40-activated human B lymphocytes. J. Exp. Med. 182:1265.