Cyclic-AMP Modulates Downstream Events in CD40-Mediated Signal Transduction, but Inhibition of Protein Kinase A has no Direct Effect on CD40 Signaling

Journal of Immunology

Volumn 159, Issue 12, 1997, Pages 5871-5880

  Goldstein, Marni D ^a   Cochrane, Alan ^a   Watts, Tania H ^a  

^a UNIVERSITY OF TORONTO   (Canada)

Author keywords

[No Author keywords available]

Indexed keywords

B7 ANTIGEN; CARRIER PROTEIN; CD40 ANTIGEN; CD86 ANTIGEN; CD86 PROTEIN, HUMAN; CD86 PROTEIN, MOUSE; CYCLIC AMP; CYCLIC AMP DEPENDENT PROTEIN KINASE; FAS ANTIGEN; GROWTH INHIBITOR; IMMUNOGLOBULIN E RECEPTOR; IMMUNOLOGICAL ADJUVANT; INTERCELLULAR ADHESION MOLECULE 1; LEUKOCYTE ANTIGEN; LYMPHOCYTE FUNCTION ASSOCIATED ANTIGEN 1; MEMBRANE PROTEIN; PROTEIN KINASE MODULATOR; RNA; SIGNAL PEPTIDE; TETRACYCLINE;

ANIMAL; ARTICLE; BIOSYNTHESIS; CELL DIVISION; CELL LINE; DRUG ANTAGONISM; DRUG EFFECT; GENETICS; HUMAN; IMMUNOLOGY; MOUSE; PHYSIOLOGY; SIGNAL TRANSDUCTION;

ADJUVANTS, IMMUNOLOGIC; ANIMALS; ANTIGENS, CD; ANTIGENS, CD40; ANTIGENS, CD80; ANTIGENS, CD86; ANTIGENS, CD95; CARRIER PROTEINS; CELL DIVISION; CELL LINE; CYCLIC AMP; CYCLIC AMP-DEPENDENT PROTEIN KINASES; GROWTH INHIBITORS; HUMANS; INTERCELLULAR ADHESION MOLECULE-1; INTRACELLULAR SIGNALING PEPTIDES AND PROTEINS; LYMPHOCYTE FUNCTION-ASSOCIATED ANTIGEN-1; MEMBRANE GLYCOPROTEINS; MICE; RECEPTORS, IGE; RNA; SIGNAL TRANSDUCTION; TETRACYCLINE;

EID: 0031573688     PISSN: 00221767     EISSN: None     Source Type: Journal    
DOI: None     Document Type: Article

References (77)

1. + T-cell responses. Immunol. Today 17:410.
2. Noelle, R. J. 1996. CD40 and its ligand in host defense. Immunity 4:415.
3. Kawabe, T., T. Naka, K. Yoshida, T. Tanaka, H. Fujiwara, S. Suematsu, N. Yoshida, T. Kishimoto, and H. Kikutani. 1994. The immune responses in CD40-deficient mice: impaired immunoglobulin class switching and germinal center formation. Immunity 1:167.
4. Xu, J., T. M. Foy, J. D. Laman, E. A. Elliott, J. J. Dunn, T. J. Waldschmidt, J. Elsemore, R. J. Noelle, and R. A. Flavell. 1994. Mice deficient for the CD40 ligand. Immunity 1:423.
5. Castigli, E., F. W. Alt, L. Davidson, A. Bottaro, E. Mizoguchi, A. K. Bhan, and R. S. Geha. 1994. CD40-deficient mice generated by recombination-activating gene-2-deficient blastocyst complementation. Proc. Natl. Acad. Sci. USA 91:12135.
6. Callard, R. E., R. J. Armitage, W. C. Fanslow, and M. K. Spriggs. 1993. CD40 ligand and its role in X-linked hyper-IgM syndrome. Immunol. Today 14:559.
7. Paulie, S., A. Rosén, B. Ehlin-Henriksson, S. Braesch-Andersen, E. Jakobson, H. Koho, and P. Perlmann. 1989. The human B lymphocyte and carcinoma antigen, CDw40, is a phosphoprotein involved in growth signal transduction. J. Immunol. 142:590.
8. Jabara, H. H., S. M. Fu, R. S. Geha, and D. Vercelli. 1990. CD40 and IgE: synergism between anti-CD40 monoclonal antibody and interleukin 4 in the induction of IgE synthesis by highly purified human B cells. J. Exp. Med. 172: 1861.
9. Barrett, T. B., G. Shu, and E. A. Clark. 1991. CD40 signaling activates CD11a/ CD18 (LFA-1)-mediated adhesion in B cells. J. Immunol. 146:1722.
10. Burlinson, E. L., P. Graber, J.-Y. Bonnefoy, B. W. Ozanne, and W. Cushley. 1996. Soluble CD40 ligand induces expression of CD25 and CD23 in resting human tonsillar B lymphocytes. Eur. J. Immunol. 26:1069.
11. Schattner, E. J., K. B. Elkon, D.-H. Yoo, J. Tumang, P. H. Krammer, M. K. Crow, and S. M. Friedman. 1995. CD40 ligation induces Apo-1/Fas expression on human B lymphocytes and facilitates apoptosis through the Apo-1/Fas pathway. J. Exp. Med. 182:1557.
12. Ranheim, E. A., and T. J. Kipps. 1993. Activated T cells induce expression of B7/BB1 on normal or leukemic B cells through a CD40-dependent signal. J. Exp. Med. 177:925.
13. Azuma, M., D. Ito, H. Yagita, K. Okamura, J. H. Phillips, L. L. Lanier, and C. Somoza. 1993. B70 antigen is a second ligand for CTLA-4 and CD28. Nature 366:76.
14. Kennedy, M. K., K. M. Mohler, K. D. Shanebeck, P. R. Baum, K. S. Picha, C. A. Otten-Evans, C. A. Janeway Jr., and K. H. Grabstein. 1994. Induction of B cell costimulatory function by recombinant murine CD40 ligand. Eur. J. Immunol. 24:116.
15. Yellin, M. J., J. Sinning, L. R. Covey, W. Sherman, J. J. Lee, E. Glickman-Nir, K. C. Sippel, J. Rogers, A. M. Cleary, M. Parker, L. Chess, and S. Lederman. 1994. T lymphocyte T cell-B cell-activating molecule/CD40-L molecules induce normal B cells or chronic lymphocytic leukemia B cells to express CD80 (B7/ BB-1) and enhance their costimulatory activity. J. Immunol. 153:666.
16. Hasbold, J., C. Johnson-Léger, C. J. Atkins, E. A. Clark, and G. G. B. Klaus. 1994. Properties of mouse CD40: cellular distribution of CD40 and B cell activation by monoclonal anti-mouse CD40 antibodies. Eur. J. Immunol. 24:1835.
17. Guo, Y., Y. Wu, S. Shinde, M.-S. Sy, A. Aruffo, and Y. Liu. 1996. Identification of a costimulatory molecule rapidly induced by CD40L as CD44H. J. Exp. Med. 184:955.
18. - T lymphocytes by 4-1BB ligand. J. Immunol. 158:551.
19. Inui, S., T. Kaisho, H. Kikutani, I. Stamenkovic, B. Seed, E. A. Clark, and T. Kishimoto. 1990. Identification of the intracytoplasmic region essential for signal transduction through a B cell activation molecule, CD40. Eur. J. Immunol. 20:1747.
20. Heath, A. W., R. Chang, N. Harada, L. Santos-Argumedo, J. Gordon, C. Hannum, D. Campbell, A. B. Shanafelt, E. A. Clark, R. Torres, and M. Howard. 1993. Antibodies to murine CD40 stimulate normal B lymphocytes but inhibit proliferation of B lymphoma cells. Cell. Immunol. 152:468.
21. Funakoshi, S., D. L. Longo, M. Beckwith, D. K. Conley, G. Tsarfaty, I. Tsarfaty, R. J. Armitage, W. C. Fanslow, M. K. Spriggs, and W. J. Murphy. 1994. Inhibition of human B-cell lymphoma growth by CD40 stimulation. Blood 81:2787.
22. Uckun, F. M., G. L. Schieven, I. Dibirdik, M. Chandan-Langlie, L. Tuel-Ahlgren, and J. A. Ledbetter. 1991. Stimulation of protein tyrosine phosphorylation, phosphoinositide turnover, and multiple previously unidentified serine/threonine-specific protein kinases by the pan-B-cell receptor CD40/Bp50 at discrete developmental stages of human B-cell ontogeny. J. Biol. Chem. 266:17478.
23. Kansas, G. S., and T. F. Tedder. 1991. Transmembrane signals generated through MHC class II, CD19, CD20, CD39, and CD40 antigens induce LFA-1-dependent and independent adhesion in human B cells through a tyrosine kinase-dependent pathway. J. Immunol. 147:4094.
24. Knox, K. A., and J. Gordon. 1993. Protein tyrosine phosphorylation is mandatory for CD40-mediated rescue of germinal center B cells from apoptosis. Eur. J. Immunol. 23:2578.
25. Ren, C. L., T. Morio, S. M. Fu, and R. S. Geha. 1994. Signal transduction via CD40 involves activation of lyn kinase and phosphatidylinositol-3-kinase, and phosphorylation of phospholipase Cγ2. J. Exp. Med. 179:673.
26. Faris, M., F. Gaskin, J. T. Parsons, and S. M. Fu. 1994. CD40 signaling pathway: anti-CD40 monoclonal antibody induces rapid dephosphorylation and phosphorylation of tyrosine-phosphorylated proteins including protein tyrosine kinase lyn, fyn, and syk and the appearance of a 28-kD tyrosine phosphorylated protein. J. Exp. Med. 179:1923.
27. Hasbold, J., and G. G. B. Klaus. 1994. B cells from CBA/N mice do not proliferate following ligation of CD40. Eur. J. Immunol. 24:152.
28. Gulbins, E., B. Brenner, K. Schlottmann, U. Koppenhoefer, O. Linderkamp, K. M. Coggeshall, and F. Lang. 1996. Activation of the Ras signaling pathway by the CD40 receptor. J. Immunol. 157:2844.
29. Sakata, N., H. R. Patel, N. Terada, A. Aruffo, G. L. Johnson, and E. W. Gelfand. 1995. Selective activation of c-Jun kinase mitogen-activated protein kinase by CD40 on human B cells. J. Biol. Chem. 270:30823.
30. Berberich, I., G. Shu, F. Siebelt, J. R. Woodgett, J. M. Kyriakis, and E. A. Clark. 1996. Cross-linking CD40 on B cells preferentially induces stress-activated protein kinases rather than mitogen-activated protein kinases. EMBO J. 15:92.
31. ++-dependent, FK506-sensitive pathway. Eur. J. Immunol. 24:3229.
32. Knox, K. A., G. D. Johnson, and J. Gordon. 1993. Distribution of cAMP in secondary follicles and its expression in B cell apoptosis and CD40-mediated survival. Int. Immunol. 5:1085.
33. Kato, T., T. Kokuho, T. Tamura, and H. Nariuchi. 1994. Mechanisms of T cell contact-dependent B cell activation. J. Immunol. 152:2130.
34. Rothe, M., V. Sarma, V. M. Dixit, and D. V. Goeddel. 1995. TRAF2-mediated activation of NF-κB by TNF receptor 2 and CD40. Science 269:1424.
35. Hu, H. M., K. O'Rourke, M. S. Boguski, and V. M. Dixit. 1994. A novel RING finger protein interacts with the cytoplasmic domain of CD40. J. Biol. Chem. 269:30069.
36. Mosialos, G., M. Birkenbach, R. Yalamanchili, T. VanArsdale, C. Ware, and E. Kieff. 1995. The Epstein-Barr virus transforming protein LMP1 engages signaling proteins for the tumor necrosis factor receptor family. Cell 80:389.
37. Cheng, G., A. M. Cleary, Z. Ye, D. I. Hong, S. Lederman, and D. Baltimore. 1995. Involvement of CRAF1, a relative of TRAF, in CD40 signaling. Science 267:1494.
38. Sato, T., S. Irie, and J. C. Reed. 1995. A novel member of the TRAF family of putative signal transducing proteins binds to the cytosolic domain of CD40. FEBS Lett. 358:113.
39. Ishida, T., T. Tojo, T. Aoki, N. Kobayashi, T. Ohishi, T. Watanabe, T. Yamamoto, and J.-I. Inoue. 1996. TRAF5, a novel tumor necrosis factor receptor-associated factor family protein, mediates CD40 signaling. Proc. Natl. Acad. Sci. USA 93:9437.
40. Ishida, T., S. Mizushima, S. Azuma, N. Kobayashi, T. Tojo, K. Suzuki, S. Aizawa, T. Watanabe, G. Mosialos, E. Kieff, T. Yamamoto, and J. Inoue. 1996. Identification of TRAF6, a novel tumor necrosis factor receptor-associated factor protein that mediates signaling from an amino-terminal domain of the CD40 cytoplasmic region. J. Biol. Chem. 271:28745.
41. Morio, T., S. Hanissian, and R. S. Geha. 1995. Characterization of a 23-kDa protein associated with CD40. Proc. Natl. Acad. Sci. USA 92:11633.
42. Pollok, K. E., V. O'Brien, L. Marshall, J. W. Olson, R. J. Noelle, and E. C. Snow. 1991. The development of competence in resting B cells: the induction of cyclic AMP and ornithine decarboxylase activity after direct contact between B and T helper cells. J. Immunol. 146:1633.
43. Lapointe, R., R. Lemieux, M. Olivier, and A. Darveau. 1996. Tyrosine kinase and cAMP-dependent protein kinase activities in CD40-activated human B lymphocytes. Eur. J. Immunol. 26:2376.
44. Marshall, L. S., D. M. Shepherd, J. A. Ledbetter, A. Aruffo, and R. J. Noelle. 1994. Signaling events during helper T cell-dependent B cell activation. I. Analysis of the signal transduction pathways triggered by activated helper T cells in resting B cells. J. Immunol. 152:4816.
45. Kammer, G. M. 1988. The adenylate cyclase-cAMP-protein kinase A pathway and regulation of the immune response. Immunol. Today 9:222.
46. Taylor, S. S., J. A. Buechler, and W. Yonemoto. 1990. cAMP-dependent protein kinase: framework for a diverse family of regulatory enzymes. Annu. Rev. Biochem. 59:971.
47. McKnight, G. S. 1991. Cyclic AMP second messenger systems. Curr. Opin. Cell Biol. 3:213.
48. Lee, K. A. W. 1991. Transcriptional regulation by cAMP. Curr. Opin. Cell Biol. 3:953.
49. Clegg, C. H., L. A. Correll, G. G. Cadd, and G. S. McKnight. 1987. Inhibition of intracellular cAMP-dependent protein kinase using mutant genes of the regulatory type 1 subunit. J. Biol. Chem. 262:13111.
50. Steinberg, R. A., K. B. Gorman, D. Øgreid, S. O. Døskeland, and I. T. Weber. 1991. Mutations that alter the charge of type I regulatory subunit and modify activation properties of cyclic AMP-dependent protein kinase from S49 mouse lymphoma cells. J. Biol. Chem. 266:3547.
51. Olson, M. F., A. J. Krolczyk, K. B. Gorman, R. A. Steinberg, and B. P. Schimmer. 1993. Molecular basis for the 3′,5′-cyclic adenosine monophosphate resistance of Kin mutant Y1 adrenocortical tumor cells. Mol. Endocrinol. 7:477.
52. Hostager, B. S., Y. Hsing, D. E. Harms, and G. A. Bishop. 1996. Different CD40-mediated signaling events require distinct CD40 structural features. J. Immunol. 157:1047.
53. Goldstein, M. D., and T. H. Watts. 1996. Identification of distinct domains in CD40 involved in B7-1 induction or growth inhibition. J. Immunol. 157:2837.
54. Gossen, M., and H. Bujard. 1992. Tight control of gene expression in mammalian cells by tetracycline-responsive promoters. Proc. Natl. Acad. Sci. USA 89:5547.
55. Hollenbaugh, D., L. S. Grosmaire, C. D. Kullas, N. J. Chalupny, S. Braesch-Andersen, R. J. Noelle, I. Stamenkovic, J. A. Ledbetter, and A. Aruffo. 1992. The human T cell antigen gp39, a member of the TNF gene family, is a ligand for the CD40 receptor: expression of a soluble form of gp39 with B cell co-stimulatory activity. EMBO J. 11:4313.
56. Razi-Wolf, Z., G. J. Freeman, F. Calvin, B. Benacerraf, L. Nadler, and H. Reiser. 1992. Expression and function of the murine B7 antigen, the major costimulatory molecule expressed by peritoneal exudate cells. Proc. Natl. Acad. Sci. USA 89: 4210.
57. Ledbetter, J. A., and L. A. Herzenberg. 1979. Xenogeneic monoclonal antibodies to mouse lymphoid differentiation antigens. Immunol. Rev. 47:63.
58. Takei, F. 1985. Inhibition of mixed lymphocyte response by a rat monoclonal antibody to a novel murine lymphocyte activation antigen (MALA-2). J. Immunol. 134:1403.
59. Sarmiento, M., D. P. Dialynas, D. W. Lancki, K. A. Wall, M. I. Lorber, M. R. Loken, and F. W. Fitch. 1982. Cloned T lymphocytes and monoclonal antibodies as probes for cell surface molecules active in T cell-mediated cytolysis. Immunol. Rev. 68:135.
60. Hathcock, K. S., G. Laszlo, H. B. Dickler, J. Bradshaw, P. Linsley, and R. J. Hodes. 1993. Identification of an alternative CTLA-4 ligand costimulatory for T cell activation. Science 262:905.
61. Rao, M., W. T. Lee, and D. H. Conrad. 1987. Characterization of a monoclonal antibody directed against the murine B lymphocyte receptor for IgE. J. Immunol. 138:1845.
62. Ogasawara, J., R. Watanabe-Fukunaga, M. Adachi, A. Matsuzawa, T. Kasugai, Y. Kitamura, N. Itoh, T. Suda, and S. Nagata. 1993. Lethal effect of the anti-fas antibody in mice. Nature 364:806.
63. Goding, J. W. 1983. Monoclonal Antibodies: Principles and Practice. Academic Press, London, p. 230.
64. Kim, K. J., C. Kanellopoulos-Langevin, R. M. Merwin, D. H. Sachs, and R. A. Asofsky. 1979. Establishment and characterization of BALB/c lymphoma lines with B cell properties. J. Immunol. 122:549.
65. Lowry, O. H., N. J. Rosebrough, A. L. Farr, and R. J. Randall. 1951. Protein measurement with the folin phenol reagent. J. Biol. Chem. 193:265.
66. Goldstein, M. D., M. A. DeBenedette, D. Hollenbaugh, and T. H. Watts. 1996. Induction of costimulatory molecules B7-1 and B7-2 in murine B cells: the CBA/N mouse reveals a role for Bruton's tyrosine kinase in CD40-mediated B7 induction. Mol. Immunol. 33:541.
67. Baixeras, E., E. Garcia-Lozano, and C. Martinez-A. 1996. Decrease in cAMP levels promoted by CD48-CD2 interaction correlates with inhibition of apoptosis in B cells. Scand. J. Immunol. 43:406.
68. Worm, M., and R. S. Geha. 1995. CD40-mediated lymphotoxin α expression in human B cells is tyrosine kinase dependent. Eur. J. Immunol. 25:2438.
69. Loh, R. K. S., H. H. Jabara, C. L. Ren, S. M. Fu, and R. S. Geha. 1994. Role of protein tyrosine kinases in CD40/interleukin-4-mediated isotype switching to IgE. J. Allergy Clin. Immunol. 94:784.
70. Kawakami, K., and D. C. Parker. 1993. Antigen and helper T lymphocytes activate B lymphocytes by distinct signaling pathways. Eur. J. Immunol. 23:77.
71. Chijiwa, T., A. Mishima, M. Hagiwara, M. Sano, K. Hayashi, T. Inoue, K. Naito, T. Toshioka, and H. Hidaka. 1990. Inhibition of forskolin-induced neunte out-growth and protein phosphorylation by a newly synthesized selective inhibitor of cyclic AMP-dependent protein kinase, N-2[2-(p-Bromocinnamylamino)ethyl]-5-isoquinolinesulfonamide (H-89), of PC12D pheochromocytoma cells. J. Biol. Chem. 265:5267.
72. Hidaka, H., M. Inagaki, S. Kawamoto, and Y. Sasaki. 1984. Isoquinolinesulfonamides, novel and potent inhibitors of cyclic nucleotide dependent protein kinase and protein kinase C. Biochemistry 23:5036.
73. Watts, T. H., N. Alaverdi, W. F. Wade, and P. S. Linsley. 1993. Induction of costimulatory molecule B7 in M12 B lymphomas by cAMP or MHC-restricted T cell interaction. J. Immunol. 150:2192.
74. Cambier, J. C., J. K. Newell, L. B. Justement, J. C. McGuire, K. L. Leach, and Z. Z. Chen. 1987. Ia binding ligands and cAMP stimulate nuclear translocation of PKC in B lymphocytes. Nature 327:629.
75. Finney, M., G. R. Guy, R. H. Michell, J. Gordon, B. Dugas, K. P. Rigley, and R. E. Callard. 1990. Interleukin 4 activates human B lymphocytes via transient inositol lipid hydrolysis and delayed cyclic adenosine monophosphate generation. Eur. J. Immunol. 20:151.
76. Vazquez, A., M. T. Auffredou, P. Galanaud, and G. Leca. 1991. Modulation of IL-2- and IL-4-dependent human B cell proliferation by cyclic AMP. J. Immunol. 146:4222.
77. Galéa, P., G. Thibault, M. Lacord, P. Bardos, and Y. Lebranchu. 1993. IL-4, but not tumor necrosis factor-α, increases endothelial cell adhesiveness for lymphocytes by activating a cAMP-dependent pathway. J. Immunol. 151:588.