CD40 induces resistance to TNF-mediated apoptosis in a fibroblast cell line

European Journal of Immunology

Volumn 28, Issue 11, 1998, Pages 3594-3604

  Hess, Sigrun ^a,b   Gottfried, Eva ^a   Smola, Hans ^b   Grunwald, Ulrich ^a   Schuchmann, Marcus ^a   Engelmann, Hartmut ^a  

^a UNIVERSITY OF MUNICH   (Germany)

^b UNIVERSITY OF COLOGNE   (Germany)

Author keywords

Apoptosis; CD40; CD40 ligand; Cell death; Resistance; TNF receptor family

Indexed keywords

CD40 ANTIGEN; CYCLOHEXIMIDE; CYTOKINE; GLYCOPROTEIN GP 39; IMMUNOGLOBULIN ENHANCER BINDING PROTEIN; TUMOR NECROSIS FACTOR; ZINC FINGER PROTEIN;

ANIMAL CELL; APOPTOSIS; ARTICLE; B LYMPHOCYTE; CELL ADHESION; CELL DEATH; CONTROLLED STUDY; FIBROBLAST CULTURE; HUMAN; HUMAN CELL; LYMPHOCYTE PROLIFERATION; NONHUMAN; PRIORITY JOURNAL;

ANIMALS; ANTIGENS, CD; ANTIGENS, CD40; APOPTOSIS; CELL LINE; CRICETINAE; CYCLOHEXIMIDE; FIBROBLASTS; HUMANS; NF-KAPPA B; RECEPTORS, TUMOR NECROSIS FACTOR; RECEPTORS, TUMOR NECROSIS FACTOR, TYPE I; RNA, MESSENGER; TUMOR NECROSIS FACTOR-ALPHA; ZINC FINGERS;

EID: 0031767114     PISSN: 00142980     EISSN: None     Source Type: Journal    
DOI: 10.1002/(SICI)1521-4141(199811)28:11<3594::AID-IMMU3594>3.0.CO;2-D     Document Type: Article

References (67)

1. Clark, E. A. and Ledbetter, J. A., Activation of human B cells mediated through two distinct cell surface differentiation antigens, Bp35 and Bp50. Proc. Natl. Acad. Sci. USA 1986. 83: 4494-4498.
2. Bancherau, J., de Paoli, P., Valle, A., Garcia, E. and Rousset, F., Long-term human B cell lines dependent on interleukin-4 and antibody to CD40. Science 1991. 251: 70-72.
3. Barrett, T. B., Shu, G. and Clark, E. A., CD40 signaling activates CD11a/CD18 (LFA-1)-mediated adhesion in B cells. J. Immunol. 1991. 146: 1722-1729.
4. Jabara, H. H., Fu, S. M., Geha, R. S. and Vercelli, D., CD40 and IgE: synergism between anti-CD40 monoclonal antibody and interleukin 4 in the induction of IgE synthesis by highly purified human B cells. J. Exp. Med. 1990. 172: 1861-1864.
5. Aruffo, A., Farrington, M., Hollenbaugh, D., Li, X., Milatovich, A., Nonoyama, S., Bajorath, J., Grosmaire, L. S., Stenkamp, R., Neubauer, M., Roberts, R. L., Noelle, R. J., Ledbetter, J. A., Francke, U. and Ochs, H. D., The CD40 ligand, gp39, is defective in activated T cells from patients with X-linked hyper-IgM syndrome. Cell 1993. 72: 291-300.
6. Allen, R. C., Armitage, R. J., Conley, M. E., Rosenblatt, H., Jenkins, N. A., Copeland, N. G., Bedell, M. A., Edelhoff, S., Disteche, C. M., Simoneaux, D. K., Fanslow, W. C., Belmont, J. and Spriggs, M. K., CD40 ligand gene defects responsible for X-linked hyper-IgM syndrome. Science 1993. 259: 990-993.
7. DiSanto, J. P., Bonnefoy, J. Y., Gauchat, J. F., Fischer, A. and de Saint Basile, G., CD40 ligand mutations in X-linked immunodeficiency with hyper-IgM. Nature 1993. 361: 541-543.
8. Korthäuer, U., Graf, D., Mages, H. W., Briere, F., Padayachee, M., Malcolm, S., Ugazio, A. G., Notarangelo, L. D., Levinsky, R. J. and Kroczek, R. A., Defective expression of T-cell CD40 ligand causes X-linked immunodeficiency with hyper-IgM. Nature 1993. 361: 539-541.
9. Kawabe, T., Naka, T., Yoshida, K., Tanaka, T., Fujiwara, H., Suematsu, S., Yoshida, N., Kishimoto, T. and Kikutani, H., The immune responses in CD40-deficient mice: Impaired immunoglobulin class switching and germinal center formation. Immunity 1994. 1: 167-178.
10. Xu, J., Foy, T. M., Laman, J. D., Elliott, E. A., Dunn, J. J., Waldschmidt, T. J., Elsemore, J., Noelle, R. J. and Flavell, R. A., Mice deficient for the CD40 ligand. Immunity 1994. 1: 423-431.
11. Rathmell, J. C., Townsend, S. E., Xu, J. C., Flavell, R. A. and Goodnow, C. C., Expansion or elimination of B cells in vivo: Dual role for CD40- and Fas (CD95)-ligands modulated by the B cell antigen receptor. Cell 1996. 87: 319-329.
12. Liu, Y. J., Joshua, D. E., Williams, G. T., Smith, C. A., Gordon, J. and MacLennan, I. C., Mechanism of antigen-driven selection in germinal centres. Nature 1989. 342: 929-931.
13. Gregory, C. D., Dive, C., Henderson, S., Smith, C. A., Williams, G. T., Gordon, J. and Rickinson, A. B., Activation of Epstein-Barr virus latent genes protects human B cells from death by apoptosis. Nature 1991. 349: 612-614.
14. Valentine, M. A. and Licciardi, K. A., Rescue from anti-IgM-induced programmed cell death by the B cell surface proteins CD20 and CD40. Eur. J. Immunol. 1992. 22: 3141-3148.
15. Rothstein, T. L., Wang, J. K. M., Panka, D. J., Foote, L. C., Wang, Z., Stanger, B., Cui, H., Ju, S.-T. and Marshak-Rothstein, A., Protection against Fas-dependent Th1-mediated apoptosis by antigen receptor engagement in B cells. Nature 1995. 374: 163-165.
16. Garrone, P., Neidhardt, E.-M., Garcia, E., Galibert, L., van Kooten, C. and Banchereau, J., Fas ligation induces apoptosis of CD40-activated human B lymphocytes. J. Exp. Med. 1995. 182: 1265-1273.
17. Schattner, E. J., Elkon, K., Yoo, D.-H., Tumang, J., Krammer, P. H., Crow, M. K. and Friedman, S. M., CD40 ligation induces Apo-1/Fas expression on human B lymphocytes and facilitates apoptosis through the Apo-1/Fas pathway. J. Exp. Med. 1995. 182: 1557-1565.
18. Liu, Y. J., Mason, D. Y., Johnson, G. D., Abbot, S., Gregory, C. D., Hardie, D. L., Gordon, J. and MacLennan, I. C., Germinal center cells express bcl-2 protein after activation by signals which prevent their entry into apoptosis. Eur. J. Immunol. 1991. 21: 1905-1910.
19. Ishida, T., Kobayashi, N., Tojo, T., Ishida, S., Yamamoto, T. and Inoue, J., CD40 signaling-mediated induction of Bel-XL, Cdk4, and Cdk6. Implication of their cooperation in selective B cell growth. J. Immunol. 1995. 155: 5527-5535.
20. Merino, R., Grillot, D. A., Simonian, P. L., Muthukkumar, S., Fanslow, W. C., Bondada, S. and Nunez, G., Modulation of anti-IgM-induced B cell apoptosis by Bcl-xL and CD40 in WEHI-231 cells. Dissociation from cell cycle arrest and dependence on the avidity of the antibody-IgM receptor interaction. J. Immunol. 1995. 155: 3830-3838.
21. Wang, Z., Karras, J. G., Howard, R. G. and Rothstein, T. L., Induction of bcl-x by CD40 engagement rescues slg-induced apoptosis in murine B cells. J. Immunol. 1995. 155: 3722-3725.
22. Holder, M. J., Wang, H., Milner, A. E., Casamayor, M., Armitage, R., Spriggs, M. K., Fanslow, W. C., MacLennan, I. C., Gregory, C. D. and Gordon, J., Suppression of apoptosis in normal and neoplastic human B lymphocytes by CD40 ligands is independent of Bcl-2 induction. Eur. J. Immunol. 1993. 23: 2368-2371.
23. Sarma, V., Lin, Z., Clark, L., Rust, B. M., Tewari, M., Noelle, R. J. and Dixit, V. M., Activation of the B-cell surface receptor CD40 induces A20, a novel zinc finger protein that inhibits apoptosis. J. Biol. Chem. 1995. 270: 12343-12346.
24. Opipari, A. W., Hu, H. M., Yabkowitz, R. and Dixit, V. M., The A20 zinc finger protein protects cells from tumor necrosis factor cytotoxicity. J. Biol. Chem. 1992. 267: 12424-12427.
25. Jäättelä, M., Mouritzen, H., Elling, F. and Bastholm, L., A20 zinc finger protein inhibits TNF anf IL-1 signaling. J. Immunol. 1996. 156: 1166-1173.
26. Rothe, M., Sarma, V., Dixit, V. M. and Goeddel, D. V., TRAF2-mediated activation of NF-(greek small letter script kappa)B by TNF receptor 2 and CD40. Science 1995. 269: 1424-1427.
27. Ishida, T., Tojo, T., Aoki, T., Kobayashi, N., Ohishi, T., Watanabe, T., Yamamoto, T. and Inoue, J.-I., TRAF5, a novel tumor necrosis factor receptor-associated factor family protein, mediates CD40 signaling. Proc. Natl. Acad. Sci. USA 1996. 93: 9437-9442.
28. Ishida, T., Mizushima, S.-I., Azuma, S., Kobayashi, N., Tojo, T., Suzuki, K., Aizawa, S., Watanabe, T., Mosialos, G., Kieff, E., Yamamoto, T. and Inoue, J.-I., Identification of TRAF6, a novel tumor necrosis factor receptor-associated factor protein that mediates signaling from an amino-terminal domain of the CD40 cytoplasmic region. J. Biol. Chem. 1996. 271: 28745-28748.
29. Nakano, H., Oshima, H., Chung, W., Williams-Abbot, L., Ware, C. F., Yagita, H. and Okumura, K.. TRAF5, an activator of NF-(greek small letter script kappa)B and putative signal transducer for the lymphotoxin-β receptor. J. Biol. Chem. 1996. 271: 14661-14664.
30. Hanissian, S. and Geha, R. S., Jak3 is associated with CD40 and is critical for CD40 induction of gene expression in B cells. Immunity 1997. 6: 379-387.
31. Malinin, N. L., Boldin, M. P., Kovalenko, A. V. and Wallach, D., MAP3K-related kinase involved in NF-(greek small letter script kappa)B induction by TNF, CD95 and IL-1. Nature 1997. 385: 540-544.
32. Alderson, M. R., Armitage, R. J., Tough, T. W., Strockbine, L., Fanslow, W. C. and Spriggs, M. K., CD40 expression by human monocytes: regulation by cytokines and activation of monocytes by the ligand for CD40. J. Exp. Med. 1993. 178: 669-674.
33. Stout, R. D., Suttles, J., Xu, J., Grewal, I. S. and Flavell, R. A., Impaired T cell-mediated macrophage activation in CD40 ligand-deficient mice. J. Immunol. 1996. 156: 8-11.
34. Hart, D. N. J. and McKenzie, J. L., Isolation and characterization of human tonsil dendritic cells. J. Exp. Med. 1988. 168: 157-170.
35. Karmann, K., Hughes, C. C. W., Schechner, J., Fanslow, W. C. and Pober, J. S., CD40 on human endothelial cell: Inducibility by cytokines and functional regulation of adhesion molecule expression. Proc. Natl. Acad. Sci. USA 1995. 92: 4342-4346.
36. Hess, S., Rensing-Ehl, A., Schwabe, R., Bufler, P. and Engelmann, H., CD40 function in non-hematopoietic cells: mobilization of NF-(greek small letter script kappa)B and induction of IL-6 production. J. Immunol. 1995. 155: 4588-4595.
37. Kluth, B., Hess, S., Engelmann, H., Schafnitzel, S., Riehtmüller, G. and Feucht, H. E., Endothelial expression of CD40 in renal cell carcinoma. Cancer Res. 1997. 57: 891-899.
38. Stamenkovic, I., Clark, E. A. and Seed, B., A B-lymphocyte activation molecule related to the nerve growth factor receptor and induced by cytokines in carcinomas. EMBO J. 1989. 8: 1403-1410.
39. Paulie, S., Ehlin-Henriksson, B., Mellstadt, H., Koho, H., Ben-Aissa, H. and Perlmann, P., A p50 surface antigen restricted to urinary bladder carcinomas and B-lymphocytes. Cancer Immunol. Immunother. 1985. 20: 23-28.
40. Ledbetter, J. A., Clark, E. A., Norris, N. A., Shu, G. and Hellström, I., Expression of a functional B-cell receptor CDw40 (Bp50) on carconimas. In MacMichael, A. J., Beverly, P. C. L., Gilks, W. et al. (Eds.) Leucocyte typing III. White cell differentiation antigens. Oxford University Press, Oxford 1987, pp 432-435.
41. Young, L. S., Dawson, C. W., Brown, K. W. and Rickinson, A. B., Identification of a human epithelial cell surface protein sharing an epitope with the C3d/Epstein-Barr Virus receptor molecule of B lymphocytes. Int. J. Cancer 1989. 43: 786-794.
42. Eliopoulos, A. G., Dawson, C. W., Mosialos, G., Floettmann, J. E., Rowe, M., Armitage, R. J., Dawson, J., Zapata, J. M., Kerr, D. J., Wakelam, M. J., Reed, J. C., Kieff, E. and Young, L. S., CD40-induced growth inhibition in epithelial cells is mimicked by Epstein-Barr Virus-encoded LMP1: involvement of TRAF3 as a common mediator. Oncogene 1996. 13: 2243-2254.
43. Péguet-Navarro, J., Dalniez-Gauthier, C., Moulon, C., Berthier, O., Réano, A., Gaucherand, M., Banchereau, J., Rousset, F. and Scnmitt, D., CD40 ligation of human keratinocytes inhibits their proliferation and induces their differentiation. J. Immunol. 1997. 158: 144-152.
44. Hess, S. and Engelmann, H., A novel function of CD40: induction of cell death in transformed cells. J. Exp. Med. 1996. 183: 159-167.
45. Wallach, D., Preparations of lymphotoxin induce resistance to their own cytotoxic effect. J. Immunol. 1984. 132: 2464-2469.
46. Bigda, J., Beletsky, I., Brakebusch, C., Varfolomeev, Y., Engelmann, H., Bigda, J., Holtmann, H. and Wallach, D., Dual role of the p75 tumor necrosis factor (TNF) receptor in TNF cytotoxicity. J. Exp. Med. 1994. 180: 445-460.
47. Israel, S., Hahn, T., Holtmann, H. and Wallach, D., Binding of Human TNF-α to High-Affinity Cell Surface Receptors: Effect of Interferon. Immunol. Lett. 1986. 12: 217-224.
48. Liu, Z.-G., Hsu, H., Goeddel, D. V. and Karin, M., Dissection of TNF receptor 1 effector functions: JNK activation is not linked to apoptosis while NF-(greek small letter script kappa)B activation prevents cell death. Cell 1996. 87: 565-576.
49. Beg, A. A. and Baltimore, D., An essential role for NF-(greek small letter script kappa)B in preventing TNF-α-induced cell death. Science 1996. 274: 782-784.
50. Van Antwerp, D. J., Martin, S. J., Kafri, T., Green, D. R. and Verma, I. M., Suppression of TNF-α-induced apoptosis by NF-αB. Science 1996. 274: 787-789.
51. Wang, C.-Y., Mayo, M. W. and Baldwin Jr., A. S., TNF-and cancer therapy-induced apoptosis: potentiation by inhibition of NF-(greek small letter script kappa)B. Science 1996. 274: 784-787.
52. Wong, G. H. and Goeddel, D. V., Induction of manganous Superoxide dismutase by tumor necrosis factor: possible protective mechanism. Science 1988. 242: 941-944.
53. Kumar, S. and Baglioni, C., Protection from tumor necrosis factor-mediated cytolysis by overexpression of plasminogen activator inhibitor type-2. J. Biol. Chem. 1991. 266: 20960-20964.
54. Krikos, A., Laherty, C. and Dixit, V. M., Transcriptional activation of the tumor necrosis factor α-inducible zinc finger protein, A20, is mediated by (greek small letter script kappa)B elements. J. Biol. Chem. 1992. 267: 17971-17976.
55. Ting, A. T., Pimentel-Muinos, F. X. and Seed, B., RIP mediates tumor necrosis factor receptor 1 activation of NF-(greek small letter script kappa)B but not Fas/APO-1-initiated apoptosis. EMBO J. 1996. 15: 6189-6196.
56. Song, H. Y., Rothe, M. and Goeddel, D. V., The tumor necrosis factor-inducible zinc finger protein A20 interacts with TRAF1/TRAF2 and inhibits NF-(greek small letter script kappa)B activation. Proc. Natl. Acad. Sci. USA 1996. 93: 6721-6725.
57. Rothe, M., Pan, M. G., Henzel, W. J., Ayres, T. M. and Goeddel, D. V., The TNFR2-TRAF signaling complex contains two novel proteins related to baculoviral inhibitor of apoptosis proteins. Cell 1995. 83: 1243-1252.
58. Devereaux, Q. L., Takahashi, R., Salvesen, G. S. and Reed, J. C., X-linked IAP is a direct inhibitor of cell-death proteases. Nature 1997. 388: 300-304.
59. Chu, Z. L., McKinsey, T. A., Liu, L., Gentry, J. J., Malim, M. H. and Ballard, D. W., Suppression of tumor necrosis factor-induced cell death by inhibitor of apoptosis C-IAP2 is under NF-kappaB control. Proc. Natl. Acad. Sci. USA 1997. 94: 10057-10062.
60. Todaro, J. G., Green, H. and Swift, M. R., Susceptibility of human diploid fibroblast strains to transformation by SV40 virus. Science 1966. 153: 1252-1254.
61. Hess, S., Kurrle, R., Lauffer, L., Riethmüller, G. and Engelmann, H., A cytotoxic CD40/p55 tumor necrosis factor receptor hybrid detects CD40 ligand on Herpesvirus saimiri transformed T cells. Eur. J. Immunol. 1995. 25: 80-86.
62. Schuchmann, M., Hess, S., Bufler, P., Brakebusch, C., Wallach, D., Porter, A., Riethmüller, G. and Engelmann, H., Functional discrepancies between tumor necrosis factor and lymphotoxin α explaind by trimer stability and different receptor interactions. Eur. J. Immunol. 1995. 28: 2183-2189.
63. Bufler, P., Stiegler, G., Schuchmann, M., Hess, S., Krüger, C., Stelter, F., Eckerskorn, C., Schütt, C. and Engelmann, H., Soluble lipopolysaccharide receptor (CD14) is released via two different mechanisms from human monocytes and CD14 tranfectants. Eur. J. Immunol. 1995. 25: 604-610.
64. Finter, N. B., Dye uptake methods for assessing viral cytopathogenicity and their application to interferon assays. J. Gen. Virol. 1969. 5: 419-427.
65. Brown, T. and Mackey, K., Analysis of RNA by northern and slot blot hybridization. In Ausubel, F. M., Brent, R., Kingston, R. E., et al. (Eds.) Current protocols in molecular biology. Current Protocols, Boston, 1994, pp 4.9.1-4.9.16.
66. Dignam, J. P., Lebovitz, R. M. and Roeder, R. G., Accurate transcription initiation by RNA polymerase II in a soluble extract from isolated mammalian nuclei. Nucleic Acids Res. 1983. 11: 1475-1489.
67. Sen, R. and Baltimore, D., Multiple nuclear factors interact with the immunoglobulin enhancer sequences. Cell 1986. 46: 705-716.