IL-4 and IL-10 Modulation of CD40-Mediated Signaling of Monocyte IL-1β Synthesis and Rescue from Apoptosis

Journal of Immunology

Volumn 159, Issue 2, 1997, Pages 846-852

  Poe, Jonathan C ^a   Wagner, David H ^a,b   Miller, Robert W ^a   Stout, Robert D ^a   Suttles, Jill ^a,c  

^a East Tennessee State University   (United States)

^b NATIONAL JEWISH MEDICAL AND RESEARCH CENTER   (United States)

^c EAST TENNESSEE STATE UNIVERSITY   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

CD40 ANTIGEN; INTERLEUKIN 10; INTERLEUKIN 4;

APOPTOSIS; ARTICLE; CELL CULTURE; DRUG EFFECT; FLOW CYTOMETRY; HUMAN; METABOLISM; MONOCYTE; PATHOLOGY; SIGNAL TRANSDUCTION;

ANTIGENS, CD40; APOPTOSIS; CELLS, CULTURED; FLOW CYTOMETRY; HUMANS; INTERLEUKIN-10; INTERLEUKIN-4; MONOCYTES; SIGNAL TRANSDUCTION;

EID: 0031570827     PISSN: 00221767     EISSN: None     Source Type: Journal    
DOI: 10.4049/jimmunol.159.2.846     Document Type: Article

References (36)

1. Clark, E. A. 1990. CD40: a cytokine receptor in search of a ligand. Tissue Antigens 36:33.
2. + T cell contact-dependent activation of monocyte IL-1 synthesis. Eur. J. Immunol. 24:3148.
3. Alderson, M. R., R. J. Armitage, T. W. Tough, L. Strockbine, W. C. Fanslow, and M. K. Spriggs. 1993. CD40 expression by human monocytes: regulation by cytokines and activation of monocytes by the ligand for CD40. J. Exp. Med. 178: 669.
4. Galy, A. H., and H. Spits. CD40 is functionally expressed on human thymic epithelial cells. J. Immunol. 149:775.
5. Caux, C., C. Massacrier, B. Banbervliet, B. Dubois, C. Van Kooten, I. Durand, and J. Banchereau. 1994. Activation of human dendritic cells through CD40 cross-linking. J. Exp. Med. 180:1263.
6. Yellin, M. J., J. Brett, D. Baum, A. Matsushima, M. Szabolcs, D. Stern, and L. Chess. 1995. Functional interactions of T cells with endothelial cells: the role of CD40L-CD40 mediated signals. J. Exp. Med. 182:1857.
7. Stout, R. D., and J. Sutties. 1996. The many roles of CD40 in cell-mediated inflammatory responses. Immunol. Today 17:487.
8. Tian, L., R. J. Noelle, and D. A. Lawrence. 1995. Activated T cells enhance nitric oxide production by murine splenic macrophages through gp39 and LFA-1. Eur. J. Immunol. 25:306.
9. Stout, R., J. Sullies, J. Xu, I. Grewal, and R. Flavell. 1996. Impaired T cell-mediated macrophage activation in CD40 ligand-deficient mice. J. Immunol. 156:8.
10. Suttles, J., M. Evans, R. W. Miller, J. C. Poe, R. D. Stout, and L. M. Wahl. 1996. T cell rescue of monocytes from apoptosis: role of ine CD40-CD40L interaction and requirement for CD40-mediated induction of protein tyrosine kinase activity. J. Leukocyte Biol. 60:651.
11. Uckun, F., G. Schieven, I. Dihirdik, M. Chandan-Langlie, L. Tuel-Ahlgren, and J. Ledbetter. 1991. Stimulation of protein tyrosine phosphorylation, phosphoinositide turnover, and multiple previously unidentified serine/threonine-specific protein kinases by the pan-B-cell receptor CD40/Bp50 at discrete developmental stages of human B-cell ontogeny. J. Biol. Chem. 266:17478.
12. Faris, M., F. Gaskin, T. Parsons, and S. Fu. 1994. CD40 signaling pathway: anti-CD40 monoclonal antibody induces rapid dephosphorylation and phosphorylation of tyrosine-phosphorylated proteins including protein tyrosine kinase lyn, fyn, and syk and the appearance of a 28-kD tyrosine phosphorylated protein. J. Exp. Med. 179:1923.
13. Mosmann, T. R., and K. W. Moore. 1991. The role of IL-10 in crossregulation of TH1 and TH2 responses. Immunol. Today 12:49.
14. + T lymphocytes correlates with down-regulation of Th1 cytokine synthesis in helminth infection. J. Immunol. 147:2713.
15. Sher, A., R. T. Gazzinelli, I. P. Oswald, M. Clerici, M. Kullberg, E. J. Pearce, J. A. Berzofsky, T. R. Mosmann, S. L. James, and H. C. Morse. 1992. Role of T-cell derived cytokines in the downregulation of immune responses in parasitic and retroviral infection. Immunol. Rev. 127:183.
16. Chatelain, R., K. Varkila, and R. L. Coffman. 1992. IL-4 induces a Th2 response in Leishmania major-infected mice. J. Immunol. 148:1182.
17. Maggi, E., P. Parronchi, R. Manetti, C. Simonelli, M. P. Piccinni, F. S. Rugiu, M. DeCarli, M. Ricci, and S. Romagnani. 1992. Reciprocal regulatory effects of IFN-gamma and IL-4 on the in vitro development of human Th1 and Th2 clones. J. Immunol. 148:2142.
18. Mocci, S., and R. L. Coffman. 1995. Induction of a Th2 population from a polarized Leishmania-specific Th1 population by in vitro culture with IL-4. J. Immunol. 154:3779.
19. 2. Proc. Natl. Acad. Sci. USA 86:3803.
20. de Waal Malefyt, R., J. Abrams, B. Bennett, C. Figdor, and J. de Vries. 1991. Interleukin-10 (IL-10) inhibits cytokine synthesis by human monocytes: an autoregulatory role of IL-10 produced by monocytes. J. Exp. Med. 174:1209.
21. Donnelly, R. P., M. J. Fenton, D. S. Finbloom, and T. L. Gerrard. 1990. Differential regulation of IL-1 production in human monocytes. J. Immunol. 145:569.
22. te Velde, A. A., R. F. J. Huijbens, K. Heije, J. E. de Vries, and C. G. Figdor. 1990. Interleukin-4 (IL-4) inhibits secretion of IL-1β, TNFα, and IL-6 by human monocytes. Blood 76:1392.
23. Fiorentino, D. F., A. Zlotnik, T. R. Mosmann, M. Howard, and A. O'Garra. 1991. IL-10 inhibits cytokine production by activated macrophages. J. Immunol. 147: 3815.
24. Oswald, I. P., R. T. Gazzinelli, A. Sher, and S. L. James. 1992. IL-10 synergizes with IL-4 and transforming growth factor-beta to inhibit macrophage cytotoxic activity. J. Immunol. 148:3578.
25. Mangan, D. F., R. Robertson, and S. M. Wahl. 1992. IL-4 enhances programmed cell death (apoptosis) in stimulated human monocytes. J. Immunol. 148:1812.
26. Noelle, R., J. Daum, W. Bartlett, J. McCann, and D. Shepherd. 1991. Cognate interactions between helper T cells and B cells. J. Immunol. 146:1118.
27. Swarup, G., S. Cohen, and D. L. Garbers. 1982. Inhibition of membrane phosphotyrosyl-protein phosphatase activity by vanadate. Biochem. Biophys. Res. Commun. 107:1104.
28. Posner, B. I., R. Faure, J. W. Burgess, A. P. Bevan, D. Lachance, G. Zhang-Sun, I. G. Fauntus, J. B. Ng, D. A. Hall, B. Soo Lum, and A. Shaver. 1994. Peroxovanadium compounds. A new class of potent phosphotyrosine phosphatase inhibitors which are insulin mimetics. J. Biol. Chem. 269:4596.
29. Hu, H. M., K. O'Rourke, M. S. Boguski, and V. M. Dixit. 1994. A novel RING Finger protein interacts with the cytoplasmic domain of CD40. J. Biol. Chem. 269:30069.
30. Cheng, G., A. M. Cleary, Z. Ye, D. I. Hong, S. Lederman, and D. Baltimore. 1995. Involvement of CRAF1, a relative of TRAF, in CD40 signaling. Science 267:1494.
31. Rothe, M., V. Sarma, V. M. Dixit, and D. V. Goeddel. 1995. TRAF2-mediated activation of NF-κB by TNF receptor 2 and CD40. Science 269:1424.
32. Cheng, G., and D. Baltimore. 1996. TANK, a co-inducer with TRAF2 of TNF-and CD40-mediated NF-κB activation. Genes Dev. 10:963.
33. Shapira, L., S. Takahiba, C. Champagne, S. Amar, and T. E. Van Dyke. 1994. Involvement of protein kinase C and protein tyrosine kinase in lipopolysaccharide-induced TNF-alpha and IL-1 beta production by human monocytes. J. Immunol. 153:1818.
34. Wang, P., P. Wu. M. I. Siegel, R. W. Egan, and M. M. Billah. 1995. Interleukin (IL)-10 inhibits nuclear factor κB (NFκB) activation in human monocytes: IL-10 and IL-4 suppress cytokine synthesis by different mechanisms. J. Biol. Chem. 270:9558.
35. Takeshita, S., J. R. Gage, T. Kishimoto, D. L. Vredevoe, and O. Martinez-Maza. 1996. Differential regulation of IL-6 gene transcription and expression by IL-4 and IL-10 in human monocytic cell lines. J. Immunol. 156:2591.
36. Powrie, F., S. Menton, and R. L. Coffman. 1993. Interleukin-4 and Interleukin-10 synergize to inhibit cell-mediated immunity in vivo. Eur. J. Immunol. 23:2223.