CD40 engagement triggers switching to IgA1 and IgA2 in human B cells through induction of endogenous TGF-β: Evidence for TGF-β but not IL-10- dependent direct sμ→sα and sequential Sμ→Sγ, Sγ→Sα DNA recombination

Journal of Immunology

Volumn 161, Issue 10, 1998, Pages 5217-5225

  Zan, Hong ^a   Cerutti, Andrea ^a   Dramitinos, Patricia ^a   Schaffer, András ^a,b   Casali, Paolo ^a,b  

^a WEILL CORNELL MEDICAL COLLEGE   (United States)

^b Weill Cornell Medical Center   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

CD40 ANTIGEN; IMMUNOGLOBULIN A1; IMMUNOGLOBULIN A2; INTERLEUKIN 10; TRANSFORMING GROWTH FACTOR BETA;

ARTICLE; B LYMPHOCYTE ACTIVATION; B LYMPHOCYTE DIFFERENTIATION; CELL SPECIFICITY; DNA RECOMBINATION; GERMINAL CENTER; GROWTH REGULATION; HUMAN; HUMAN CELL; IMMUNOSTIMULATION; PRIORITY JOURNAL; TRANSCRIPTION REGULATION;

ANTIGENS, CD40; B-LYMPHOCYTES; BASE SEQUENCE; CD40 LIGAND; GENE REARRANGEMENT, B-LYMPHOCYTE; GENES, IMMUNOGLOBULIN; HUMANS; IMMUNOGLOBULIN A; IMMUNOGLOBULIN ALPHA-CHAINS; IMMUNOGLOBULIN CLASS SWITCHING; IMMUNOGLOBULIN CONSTANT REGIONS; IMMUNOGLOBULIN GAMMA-CHAINS; IMMUNOGLOBULIN HEAVY CHAINS; IMMUNOGLOBULIN MU-CHAINS; IMMUNOGLOBULIN VARIABLE REGION; INTERLEUKIN-10; LIGANDS; LYMPHOCYTE ACTIVATION; MEMBRANE GLYCOPROTEINS; MOLECULAR SEQUENCE DATA; RECEPTORS, ANTIGEN, B-CELL; TRANS-ACTIVATION (GENETICS); TRANSCRIPTION, GENETIC; TRANSFORMING GROWTH FACTOR BETA;

EID: 0032534070     PISSN: 00221767     EISSN: None     Source Type: Journal    
DOI: None     Document Type: Article

References (42)

1. Shockett, P., and J. Stavnezer. 1991. Effect of cytokines on switching to IgA and α germline transcripts in B lymphoma I.29μ: transforming growth factor-β activates transcription of the unrearranged Cα gene. J. Immunol. 147:4374.
2. Whitmore, A. C., D. M. Prowse, G. Haughton, and L. Arnold. 1991. Ig isotype switching in B lymphocytes: the effect of T cell-derived interleukins, cytokines, cholera toxin, and antigen on isotype switch frequency of a cloned B cell lymphoma. Int. Immunol. 3:95.
3. Iwasato, T., H. Arakawa, A. Shimizu, T. Honjo, and H. Yamagishi. 1992. Biased distribution of recombination sites within S regions upon immunoglobulin class switch recombination induced by transforming growth factor β and lipopolysaccharide. J. Exp. Med. 175:1539.
4. Lebman, D. A., M. J. Park, S. Hansen-Bundy, and A. Pandya. 1994. Mechanism for transforming growth factor β regulation of a mRNA in lipopolysaccharide-stimulated B cells. Int. Immunol. 6:113.
5. McIntyre, T. M., M. R. Kehry, and C. M. Snapper. 1995. Novel in vitro model for high rate IgA class switching. J. Immunol. 154:3156.
6. Islam, K. B., L. Nilsson, P. Sideras, L. Hammarström, and C. I. E. Smith. 1991. TGF-β1 induces germ-line transcripts of both IgA subclasses in human B lymphocytes. Int. Immunol. 3:1099.
7. Nillson, L., K. B. Islam, O. Olafsson, L. Zalcberg, C. Samakovlis, L. Hammarström, C. I. E. Smith, and P. Sideras. 1991. Structure of TGF-β1-induced human immunoglobulin Cα1 and Cα2 germ-line transcripts. Int. Immunol. 3:1107.
8. van Vlasselaer, P., J. Punnonen, and J. E. de Vries. 1992. Transforming growth factor-β directs IgA switching in human B cells. J. Immunol. 148:2062.
9. Jumper, M. D., J. B. Splawski, P. E. Lipsky, and K. Meek. 1994. Ligation of CD40 induces sterile transcripts of multiple Ig H chain isotypes in human B cells. J. Immunol. 152:438.
10. Kitani, A., and W. Strober. 1994. Differential regulation of Cα1 and Cα2 germ-line and mature transcripts in human peripheral blood B cells. J. Immunol. 153: 1466.
11. Jumper, M. D., Y. Nishioka, P. E. Lipsky, and K. Meek. 1995. Regulation of human B cell function by recombinant CD40 ligand and other TNF-related ligands. J. Immunol. 155:2369.
12. Rousset, F., E. Garcia, T. DeFrance, C. Peronne, N. Vezzio, D. Hsu, R. Kastelstein, K.W. Moore, and J. Banchereau. 1991. Human and viral IL-10 are potent growth and differentiation factors for activated human B lymphocytes. Proc. Natl. Acad. Sci. USA 89:1890.
13. DeFrance, T., B. Vanbervliet, F. Briere, I. Durand, F. Rousset, and J. Banchereau. 1992. Interleukin 10 and transforming growth factor β cooperate to induce anti-CD40-activated naive human B cells to secrete immunoglobulin A. J. Exp. Med. 175:671.
14. Arpin, C., J. Déchanet, C. Van Kooten, P. Merville, G. Grouard, F. Brière, J. Banchereau, and Y.J. Liu. 1995. Generation of memory B cells and plasma cells in vitro. Science 268:720.
15. Matthes, T., C. Werner-Favre, H. Tang, X. Zhang, V. Kindler, and R. H. Zubler. 1993. Cytokine mRNA expression during an in vitro response of human B lymphocytes: kinetics of B cell tumor necrosis factor alpha, interleukin (IL)-6, IL-10, and transforming growth factor beta 1 mRNAs. J. Exp. Med. 178:521.
16. Burdin, N., K. van Kooten, L. Galibert, J. S. Abrams, J. Banchereau, and F. Rousset. 1995. Endogenous IL-6 and IL-10 contribute to the differentiation of CD40-activated human B lymphocytes. J. Immunol. 154:2533.
17. + CL-01 cells secrete endogenous IL-6 and undergo IL-6-dependent plasmacytoid differentiation upon stimulation with CD40L and IL-10. In Molecular and Genetic Approaches to Disease: Immunology, Hematology and Oncology. Y. Niho, ed. Kyushu University Press, Fukuoka, Japan. Vol. 2.
18. Cerutti, A., A. Schaffer, S. Shah, H. Zan, H.-C. Liou, R. G. Goodwin, and P. Casali. 1998. CD30 is a CD40L-inducible molecule that negatively regulates CD40-mediated immunoglobulin class switching in non antigen-selected human B cells. Immunity 9:247.
19. Cerutti, A., H. Zan, A. Schaffer, L. Bergsagel, N. Harindranath, E. E. Max, and P. Casali. 1998. A human monoclonal B cell line as a model of IgG, IgA, and IgE class switching induced by physiological stimuli. J. Immunol. 160:2145.
20. + chronic lymphocytic leukemia B cells: a multiple time point analysis. J. Immunol. 160:820.
21. Kasaian, M. T., H. Ikematsu, and P. Casali. 1992. Identification and analysis of a novel human surface CD5-B lymphocyte subset producing natural antibodies. J. Immunol. 148:2690.
22. McCaffrey, T. A., S. Consigli, B. Du, D. J. Falcone, T. A. Sanborn, A. M. Spokojny, and J. H. L. Bush. 1995. Decreased type II/type I TGF-β receptor ratio in cells derived from human atherosclerotic lesions: conversion from an antiproliferative to profibrotic response to TGF-β1. J. Clin. Invest. 96:2667.
23. Kasaian, M. T., H. Ikematsu, J. E. Balow, and P. Casali. 1994. Structure of the VH and VL segments of monoreactive and polyreactive IgA autoantibodies to DNA in patients with systemic lupus erythematosus. J. Immunol. 152:3137.
24. Young, I. T. 1977. Use of the Kolmogorov-Smirnov test for analysis of histograms from flow systems and other sources. J. Histochem. Cytochem. 25:935.
25. Malisan, F., F. Briere, J. M. Bridon, N. Harindranath., F. C. Mills, E. E. Max, J. Bancherau, and H. Martinez-Valdez. 1996. Interleukin-10 induces immunoglobulin G isotype switch recombination in human CD40-activated naive B lymphocytes. J. Exp. Med. 183:937.
26. Stavnezer, J. 1995. Regulation of antibody production and class switching by TGF-β. J. Immunol. 55:1647.
27. Stavnezer, J. 1996. Antibody class switching. Adv. Immunol. 61:79.
28. Mill, F. C., G. Thyphronitis, F. D. Finkelman, and E. E. Max. 1992. Iγ μ-ε isotype switch in IL-4 treated human B lymphoblastoid cells: evidence for sequential switch. J. Immunol. 149:1075.
29. Kinashi, T., T. Godal, Y. Noma, N. R. Ling, Y. Yaoita, and T. Honjo. 1987. Human neoplastic B cells express more than two isotypes of immunoglobulins without deletion of heavy-chain constant-region genes. Genes Dev. 1:465.
30. Kunimoto, D. Y., M. C. Sneller, L. Clafin, J. F. Mushinski, and W. Strober. 1993. Molecular analysis of double isotype expression in IgA switching. J. Immunol. 150:1338.
31. Fayette, J., B. Dubois, S. Vandenabeele, J. M. Bridon, B. Vanderbliet, I. Durand, J. Banchereau, C. Caux, and F. Brière. 1997. Human dendritic cells skew isotype switching of CD40-activated naive B cells towards IgA1 and IgA2. J. Exp. Med. 11:1909.
32. + (sIgD) B cells to secrete IgG1 and IgG3. J. Exp. Med. 179:757.
33. Fujieda, S., J. A. Waschek, K. Zhang, and A. Saxon. 1996. Vasoactive intestinal peptide induces Sα/Sμ switch circular DNA in human B cells. J. Clin. Invest. 98:1527.
34. Islam, K. B., B. Baskin, L. Nilsson, L. Hammarstrom, P. Sideras, and C. I. E. Smith. 1994. Molecular analysis of IgA deficiency: evidence of impaired switching to IgA. J. Immunol. 152:1442.
35. McIntyre, T. M., D. R. Klinmann, P. Rothman, M. Lugo, J. R. Dasch, J. J. Mond, and C. M. Snapper. 1993. Transforming growth factor β 1 selectively stimulates immunoglobulin G2b secretion by lipopolysaccharide-activated murine B cells. J. Exp. Med. 177:1031.
36. Snapper, C. M., W. Waegell, H. Beerninink, and J. R. Dasch. 1993. Transforming growth factor-β1 is required for secretion of IgG of all subclass by LPS-activated murine B cell in vitro. J. Immunol. 151:4625.
37. Nilsson, L., and P. Sideras. 1993. The human Iα1 and Iα2 germline promoter elements: proximal positive and distal negative elements may regulate the tissue specific expression of Cα1 and Cα2 germline transcripts. Int. Immunol. 5:271.
38. Chou, C., and S. L. Morrison. 1993. A common sequence motif near nonhomologous recombination breakpoints involving Ig sequences. J. Immunol. 150: 5350.
39. Nilsson, L., P. Grant, I. Larsson, S. Pettersson, and P. Sideras. 1995. The human Iα1 region contains a TGF-β1 responsive enhancer and a putative recombination hotspot. Int. Immunol. 8:1191.
40. Gauchat, J.-F., S. Henchoz, G. Mazzei, J.P. Aubry, T. Brunner, H. Blasey, P. Life, D. Talabot, L. Flores-Romo, J. Thompson, K. Kishi, J. Butterfield, C. Dahinden, and J.-Y. Bonnefoy. 1993. Induction of IgE synthesis in B cells by mast cells and basophils. Nature 365:340.
41. Pinchuk, L. M., S. J. Klaus, D. M. Magaletti, G. V. Pinchuk, J. P. Norsen, and E. A. Clark. 1996. Functional CD40 ligand expressed by human blood dendritic cells is up-regulated by CD40 ligation. J. Immunol. 157:4363.
42. Mach, F., U. Schombeck, G.K. Sukhova, T. Bourcier, J. Y. Bonnefoy, J. S. Pober, and P. Libby. 1997. Functional CD40 ligand is expressed on vascular endothelial cells, smooth muscle cells, and macrophages: implication for CD40-CD40 ligand signaling in atherosclerosis. Proc. Natl. Acad. Sci. USA 94:1931.