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The problem of chronic rejection: Influence of leukocyte-endothelial interactions
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Briscoe DM, Ganz P, Alexander SI, Melder RJ, Jain RK, Cotran RS, Lichtman AH. The problem of chronic rejection: influence of leukocyte-endothelial interactions. Kidney Int. 58:1997;S22-S27.
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Briscoe, D.M.1
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Can graft endothelial cells initiate a host anti-graft immune response?
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Pober JS, Orosz CG, Rose ML, Savage COS. Can graft endothelial cells initiate a host anti-graft immune response? Transplantation. 61:1996;343-349.
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Pober, J.S.1
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Traffic signals for lymphocyte recirculation and leukocyte emigration: The multistep paradigm
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Lymphocyte migration into tissue: The paradigm derived from CD4 subsets
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Bradley LM, Watson SR. Lymphocyte migration into tissue: the paradigm derived from CD4 subsets. Curr Opin Immunol. 8:1996;312-320.
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Bradley, L.M.1
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Predictive value of inducible endothelial cell adhesion molecule expression for acute rejection of human cardiac allografts
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Briscoe DM, Yeung AC, Schoen FJ, Alfred EN, Stavrakis G, Ganz P, Cotran RS, Pober JS. Predictive value of inducible endothelial cell adhesion molecule expression for acute rejection of human cardiac allografts. Transplantation. 59:1995;204-211.
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Briscoe, D.M.1
Yeung, A.C.2
Schoen, F.J.3
Alfred, E.N.4
Stavrakis, G.5
Ganz, P.6
Cotran, R.S.7
Pober, J.S.8
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6
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0031569453
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CD45RA-RO+ (memory) but not CD45RA+RO- (naive) T cells roll efficiently on E- And P-selectin and vascular cell adhesion molecule-1 under flow
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+ cells do not. The binding of T cells to selectins was assessed under flow conditions and the in vitro acquisition of functional selectin ligands was shown to be induced by stimulation of the T cell antigen receptor plus costimulatory signals. Both naïve and activated T cells were shown to expres PSGL-1 (P-selectin glycoprotein ligand 1) protein, implying that post-translational modifications required for function were restricted to the activated T cells.
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+ cells do not. The binding of T cells to selectins was assessed under flow conditions and the in vitro acquisition of functional selectin ligands was shown to be induced by stimulation of the T cell antigen receptor plus costimulatory signals. Both naïve and activated T cells were shown to expres PSGL-1 (P-selectin glycoprotein ligand 1) protein, implying that post-translational modifications required for function were restricted to the activated T cells.
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(1997)
J Immunol
, vol.158
, pp. 3640-3650
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Lichtman, A.H.1
Ding, H.2
Henault, L.3
Vachino, G.4
Camphausen, R.5
Cumming, D.6
Luscinskas, F.W.7
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7
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0031127143
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T-cell subsets: Recruiting the right kind of help
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Lichtman AH, Abbas AK. T-cell subsets: recruiting the right kind of help. Curr Biol. 7:1997;R242-R244.
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Curr Biol
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Lichtman, A.H.1
Abbas, A.K.2
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8
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0031054445
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P-selectin glycoprotein ligand-1 (PSGL-1) on T helper 1 but not on T helper 2 cells binds to P-selectin and supports migration into inflammed skin
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of special interest. This paper demonstrates that post-translational modifications, required for functional PSGL-1 expression, occur in mouse Th1 but not Th2 cells. Together with [9], it establishes that the Th1 and Th2 subsets have different abilities to home to peripheral inflammatory site, based in part differences on selectin-ligand expression.
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Borges E, Tietz W, Steegmaier M, Moll T, Hallmann R, Hamann A, Vestweber D. P-selectin glycoprotein ligand-1 (PSGL-1) on T helper 1 but not on T helper 2 cells binds to P-selectin and supports migration into inflammed skin. of special interest J Exp Med. 185:1997;573-578 This paper demonstrates that post-translational modifications, required for functional PSGL-1 expression, occur in mouse Th1 but not Th2 cells. Together with [9], it establishes that the Th1 and Th2 subsets have different abilities to home to peripheral inflammatory site, based in part differences on selectin-ligand expression.
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(1997)
J Exp Med
, vol.185
, pp. 573-578
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Borges, E.1
Tietz, W.2
Steegmaier, M.3
Moll, T.4
Hallmann, R.5
Hamann, A.6
Vestweber, D.7
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9
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0031012138
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P- And E-selectin mediate recruitment of T-helper-1 but not T-helper-2 cells into inflammed tissues
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of special interest. This is the first study to show that Th1 and Th2 cells have different capabilities to home to sites of immune-mediated inflammation. The paper shows that mouse Th1 cells bind soluble P-selectin while Th2 cells do not. In addition, adoptive transfer experiments in mice indicate that Th1 cells, but not Th2 cells, accumulate at sites of delayed-type hypersensitivity in the skin and in joints with adjuvant-induced arthritis. The Th1 recruitment to these sites could be blocked by a combination of antibodies to E-selectin and to P-selectin.
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Austrup F, Vestweber D, Borges E, Lohning M, Brauer R, Herz U, Renz H, Hallmann R, Scheffold A, Rdbruch A, et al. P- and E-selectin mediate recruitment of T-helper-1 but not T-helper-2 cells into inflammed tissues. of special interest Nature. 385:1997;81-83 This is the first study to show that Th1 and Th2 cells have different capabilities to home to sites of immune-mediated inflammation. The paper shows that mouse Th1 cells bind soluble P-selectin while Th2 cells do not. In addition, adoptive transfer experiments in mice indicate that Th1 cells, but not Th2 cells, accumulate at sites of delayed-type hypersensitivity in the skin and in joints with adjuvant-induced arthritis. The Th1 recruitment to these sites could be blocked by a combination of antibodies to E-selectin and to P-selectin.
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(1997)
Nature
, vol.385
, pp. 81-83
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Austrup, F.1
Vestweber, D.2
Borges, E.3
Lohning, M.4
Brauer, R.5
Herz, U.6
Renz, H.7
Hallmann, R.8
Scheffold, A.9
Rdbruch, A.10
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10
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0032543299
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Differential expression of alpha3 fucosyltransferases in Th2 cells correlates with their ability to bind P-selectin
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of special interest. The restricted expression of functional selectin ligands in Th1 cells but not Th2 cells (see [8] and [9]) is partially explained by this brief study of fucosyltransferase expression; mRNA expression and functional enzyme activities of fucosyltransferase IV and VII were significantly higher in mouse Th1 cells compared to Th2 cells. Both enzymes have been shown in the past to be involved in the production of selectin ligands in different cells types.
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Van Wely CA, Blanchard AD, Britten CJ. Differential expression of alpha3 fucosyltransferases in Th2 cells correlates with their ability to bind P-selectin. of special interest Biochem Biophys Res Commun. 247:1998;307-311 The restricted expression of functional selectin ligands in Th1 cells but not Th2 cells (see [8] and [9]) is partially explained by this brief study of fucosyltransferase expression; mRNA expression and functional enzyme activities of fucosyltransferase IV and VII were significantly higher in mouse Th1 cells compared to Th2 cells. Both enzymes have been shown in the past to be involved in the production of selectin ligands in different cells types.
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(1998)
Biochem Biophys Res Commun
, vol.247
, pp. 307-311
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Van Wely, C.A.1
Blanchard, A.D.2
Britten, C.J.3
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11
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0030027421
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Cytokine and alloantibody networks in long term cardiac allografts in rat recipients treated with rapamycin
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Wasowska B, Wieder KJ, Hancock WW, Zheng XX, Berse B, Binder J, Strom TB, Kupiec-Weglinski JW. Cytokine and alloantibody networks in long term cardiac allografts in rat recipients treated with rapamycin. J Immunol. 156:1996;395-404.
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(1996)
J Immunol
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Wasowska, B.1
Wieder, K.J.2
Hancock, W.W.3
Zheng, X.X.4
Berse, B.5
Binder, J.6
Strom, T.B.7
Kupiec-Weglinski, J.W.8
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12
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0031056012
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Manipulation of cytokine networks in transplantation: False hope or realistic opportunity for tolerance?
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Nickerson P, Steiger J, Zheng XX, Steele AW, Steurer W, Roy-Chaudhury P, Strom TB. Manipulation of cytokine networks in transplantation: false hope or realistic opportunity for tolerance? Transplantation. 63:1997;489-494.
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(1997)
Transplantation
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Nickerson, P.1
Steiger, J.2
Zheng, X.X.3
Steele, A.W.4
Steurer, W.5
Roy-Chaudhury, P.6
Strom, T.B.7
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13
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The Th1/Th2 paradigm and the allograft response
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Strom TB, Roy-Chaudhury P, Manfro R, Zheng XX, Nickerson PW, Wood K, Bushell A. The Th1/Th2 paradigm and the allograft response. Curr Opin Immunol. 8:1996;688-693.
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Strom, T.B.1
Roy-Chaudhury, P.2
Manfro, R.3
Zheng, X.X.4
Nickerson, P.W.5
Wood, K.6
Bushell, A.7
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14
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0031091771
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Blocking the CD28-B7 T cell costimulation pathway induces long term cardiac allograft acceptance in the absence of IL-4
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of outstanding interest. For many years it has been suggested that long-term allograft survival, or tolerance, results from selective activation of the Th2-cell-mediated immune pathway. Blockade of CD28-mediated costimulation induces tolerance and increased levels of IL-4. In this study the authors used knockout mice to demonstrate that blockade of CD28-mediated costimulation induces tolerance that is independent of IL-4 production. These results suggest that IL-4 production and the subsequent generation of a Th2-type immune response are not obligatory for long-term acceptance of vascularized allografts.
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Lakkis FG, Konieczny BT, Saleem S, Baddoura FK, Linsley PS, Alexander DZ, Lowry RP, Pearson TC, Larsen CP. Blocking the CD28-B7 T cell costimulation pathway induces long term cardiac allograft acceptance in the absence of IL-4. of outstanding interest J Immunol. 158:1997;2443-2448 For many years it has been suggested that long-term allograft survival, or tolerance, results from selective activation of the Th2-cell-mediated immune pathway. Blockade of CD28-mediated costimulation induces tolerance and increased levels of IL-4. In this study the authors used knockout mice to demonstrate that blockade of CD28-mediated costimulation induces tolerance that is independent of IL-4 production. These results suggest that IL-4 production and the subsequent generation of a Th2-type immune response are not obligatory for long-term acceptance of vascularized allografts.
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(1997)
J Immunol
, vol.158
, pp. 2443-2448
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Lakkis, F.G.1
Konieczny, B.T.2
Saleem, S.3
Baddoura, F.K.4
Linsley, P.S.5
Alexander, D.Z.6
Lowry, R.P.7
Pearson, T.C.8
Larsen, C.P.9
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15
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0030458601
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Acute rejection of vascularized heart allografts in the absence of IFNgamma
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Saleem S, Konieczny BT, Lowry RP, Baddoura FK, Lakkis FG. Acute rejection of vascularized heart allografts in the absence of IFNgamma. Transplantation. 62:1996;1908-1911.
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(1996)
Transplantation
, vol.62
, pp. 1908-1911
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Saleem, S.1
Konieczny, B.T.2
Lowry, R.P.3
Baddoura, F.K.4
Lakkis, F.G.5
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17
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0029947643
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Induction of chemokine gene expression during allogeneic skin graft rejection
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Kondo T, Novick AC, Toma H, Fairchild RL. Induction of chemokine gene expression during allogeneic skin graft rejection. Transplantation. 61:1996;1750-1757.
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(1996)
Transplantation
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Kondo, T.1
Novick, A.C.2
Toma, H.3
Fairchild, R.L.4
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18
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0030937276
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T cell-dependent acceleration of chemoattractant cytokine gene expression during secondary rejection of allogeneic skin grafts
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of special interest. This study extended the observations in [17] and demonstrated that there were higher levels of MIP (macrophage inflammatory protein)-1α, MIP-1β, RANTES (regulated by activation, normal-T-cell expressed and secreted) and IP-10 (IFN-γ-induced protein 10) expression in presensitized mice and during second-set skin allograft rejection than in unprimed mice; furthermore, when T cells were deleted from animals, there was no chemokine or cytokine expression in the skin allografts. Collectively, both of these studies [17 and 18] suggest a role for chemokine genes during rejection.
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Kondo T, Watarai Y, Novick AC, Toma H, Fairchild RL. T cell-dependent acceleration of chemoattractant cytokine gene expression during secondary rejection of allogeneic skin grafts. of special interest Transplantation. 63:1997;732-742 This study extended the observations in [17] and demonstrated that there were higher levels of MIP (macrophage inflammatory protein)-1α, MIP-1β, RANTES (regulated by activation, normal-T-cell expressed and secreted) and IP-10 (IFN-γ-induced protein 10) expression in presensitized mice and during second-set skin allograft rejection than in unprimed mice; furthermore, when T cells were deleted from animals, there was no chemokine or cytokine expression in the skin allografts. Collectively, both of these studies [17 and 18] suggest a role for chemokine genes during rejection.
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(1997)
Transplantation
, vol.63
, pp. 732-742
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Kondo, T.1
Watarai, Y.2
Novick, A.C.3
Toma, H.4
Fairchild, R.L.5
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19
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0030914381
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Expression of chemokine genes during rejection and long-term acceptance of cardiac allografts
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of special interest. This study demonstrated that IP-10 (IF-γ-induced protein 10), MCP (monocyte chemotactic protein)-1 and KC were prominent by day three after transplantation in cardiac allograft rejection. RANTES (regulated by activation, normal-T-cell expressed and secreted) was expressed later, by day eight. There was little chemokine expression in isografts. This is one of the first studies to demonstrate a potential role for chemokines in acute cardiac allograft rejection.
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Fairchild RL, VanBuskirk AM, Kondo T, Wakely ME, Orosz CG. Expression of chemokine genes during rejection and long-term acceptance of cardiac allografts. of special interest Transplantation. 63:1997;1807-1812 This study demonstrated that IP-10 (IF-γ-induced protein 10), MCP (monocyte chemotactic protein)-1 and KC were prominent by day three after transplantation in cardiac allograft rejection. RANTES (regulated by activation, normal-T-cell expressed and secreted) was expressed later, by day eight. There was little chemokine expression in isografts. This is one of the first studies to demonstrate a potential role for chemokines in acute cardiac allograft rejection.
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(1997)
Transplantation
, vol.63
, pp. 1807-1812
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Fairchild, R.L.1
Vanbuskirk, A.M.2
Kondo, T.3
Wakely, M.E.4
Orosz, C.G.5
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20
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0029086366
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Sequential cytokine dynamics in chronic rejection of rat renal allografts: Roles for cytokines RANTES and MCP-1
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Nadeau KC, Azuma H, Tilney NL. Sequential cytokine dynamics in chronic rejection of rat renal allografts: roles for cytokines RANTES and MCP-1. Proc Natl Acad Sci USA. 92:1995;8729-8733.
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Nadeau, K.C.1
Azuma, H.2
Tilney, N.L.3
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21
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0030892738
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Sequential cellular and molecular kinetics in acutely rejecting renal allografts in rats
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Nagano H, Nadeau KC, Takada M, Kusaka M, Tilney NL. Sequential cellular and molecular kinetics in acutely rejecting renal allografts in rats. Transplantation. 63:1997;1101-1108.
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Transplantation
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Nagano, H.1
Nadeau, K.C.2
Takada, M.3
Kusaka, M.4
Tilney, N.L.5
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22
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0032556858
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CCR5 is characteristic of Th1 lymphocytes
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of outstanding interest. This study, of chemokine receptors on lymphocytes, demonstrated that CCR5 is expressed and is functional on Th1 lymphocytes but not on Th2 lymphocytes. Th2 cells but not Th1 cells were noted to express moderate levels of CCR3. In addition, lymphocytes infiltrating human rheumatoid synovium, know to be a Th1-like inflammatory site, were shown to express high levels of CCR5 and borderline levels of CCR3 by immunohistochemistry. This study, together with [23] and [24], provides evidence that selective recruitment patterns of Th1 and Th2 lymphocytes is regulated in part by differential expression of chemokoine receptors.
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Loetscher P, Uguccioni M, Bordoli L, Baggiolini M, Moser B, Chizzolini C, Dayer JM. CCR5 is characteristic of Th1 lymphocytes. of outstanding interest Nature. 391:1998;344-345 This study, of chemokine receptors on lymphocytes, demonstrated that CCR5 is expressed and is functional on Th1 lymphocytes but not on Th2 lymphocytes. Th2 cells but not Th1 cells were noted to express moderate levels of CCR3. In addition, lymphocytes infiltrating human rheumatoid synovium, know to be a Th1-like inflammatory site, were shown to express high levels of CCR5 and borderline levels of CCR3 by immunohistochemistry. This study, together with [23] and [24], provides evidence that selective recruitment patterns of Th1 and Th2 lymphocytes is regulated in part by differential expression of chemokoine receptors.
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(1998)
Nature
, vol.391
, pp. 344-345
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Loetscher, P.1
Uguccioni, M.2
Bordoli, L.3
Baggiolini, M.4
Moser, B.5
Chizzolini, C.6
Dayer, J.M.7
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23
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0032536869
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Flexible programs of chemokine receptor expression on human polarized T helper 1 2 lymphocytes
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of special interest. This study was a follow-up to an earlier paper [24] and demonstrated selective expression of chemokine receptors by subsets of helper T (Th) cells. Naive T cells expressed only CXCR4, whereas the majority of memory T cells expressed CXCR3 and a small proportion expressed CCR3 and CCR5. When differentiated T cells were analyzed, CXCR3 was found to be expressed at high levels on Th0 and Th1 lymphocytes but at low levels on Th2 lymphocytes. In contrast, CCR3 and CCR4 were found on Th2 lymphocytes. Expression of chemokine receptors in T cell subsets was confirmed by functional responses.
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Sallusto F, Lenig D, Mackay CR, Lanzavecchia A. Flexible programs of chemokine receptor expression on human polarized T helper 1 2 lymphocytes. of special interest J Exp Med. 187:1998;875-883 This study was a follow-up to an earlier paper [24] and demonstrated selective expression of chemokine receptors by subsets of helper T (Th) cells. Naive T cells expressed only CXCR4, whereas the majority of memory T cells expressed CXCR3 and a small proportion expressed CCR3 and CCR5. When differentiated T cells were analyzed, CXCR3 was found to be expressed at high levels on Th0 and Th1 lymphocytes but at low levels on Th2 lymphocytes. In contrast, CCR3 and CCR4 were found on Th2 lymphocytes. Expression of chemokine receptors in T cell subsets was confirmed by functional responses.
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(1998)
J Exp Med
, vol.187
, pp. 875-883
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Sallusto, F.1
Lenig, D.2
MacKay, C.R.3
Lanzavecchia, A.4
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24
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0030769920
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Selective expression of the eotaxin receptor CCR3 by human T helper 2 cells
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of outstanding interest. This study demonstrated the relatively selective expression of CCR3 on Th2 but not Th1 cells; furthermore, in T cell differentiation assays, expression of CCR3 was found to correlate with acquisition of Th2 responses.
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Sallusto F, Mackay CR, Lanzavecchia A. Selective expression of the eotaxin receptor CCR3 by human T helper 2 cells. of outstanding interest Science. 277:1997;2005-2007 This study demonstrated the relatively selective expression of CCR3 on Th2 but not Th1 cells; furthermore, in T cell differentiation assays, expression of CCR3 was found to correlate with acquisition of Th2 responses.
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(1997)
Science
, vol.277
, pp. 2005-2007
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Sallusto, F.1
MacKay, C.R.2
Lanzavecchia, A.3
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25
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0032536046
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Chemokines and the arrest of lymphocytes rolling under flow conditions
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of special interest. In this paper, experiments are reported showing that stromal-cell-derived factor 1α, macrophage inflammatory protein 3β and 6-C-kine triggered robust, integrin-dependent adhesive interactions under flow conditions, within two minutes of activation.
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Campbell JJ, Hedrick J, Zlotnik A, Siani MA, Thompson DA, Butcher EC. Chemokines and the arrest of lymphocytes rolling under flow conditions. of special interest Science. 279:1998;381-384 In this paper, experiments are reported showing that stromal-cell-derived factor 1α, macrophage inflammatory protein 3β and 6-C-kine triggered robust, integrin-dependent adhesive interactions under flow conditions, within two minutes of activation.
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(1998)
Science
, vol.279
, pp. 381-384
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Campbell, J.J.1
Hedrick, J.2
Zlotnik, A.3
Siani, M.A.4
Thompson, D.A.5
Butcher, E.C.6
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26
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0032512655
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Chemokine receptors in human endothelial cells. Functional expression of CXCR4 and its transcriptional regulation by inflammtory cytokines
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Gupta SK, Lysko PG, Pillarisetti K, Ohlstein E, Stadel JM. Chemokine receptors in human endothelial cells. Functional expression of CXCR4 and its transcriptional regulation by inflammtory cytokines. J Biol Chem. 273:1998;4282-4287.
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Gupta, S.K.1
Lysko, P.G.2
Pillarisetti, K.3
Ohlstein, E.4
Stadel, J.M.5
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27
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0030796320
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Human cytomegalovirus infection up-regulates interleukin-8 gene expression and stimulates neutrophil transendothelial migration
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Craigen JL, Yong KL, Jordan NJ, MacCormac LP, Westwick J, Akbar AN, Grundy JE. Human cytomegalovirus infection up-regulates interleukin-8 gene expression and stimulates neutrophil transendothelial migration. Immunology. 92:1997;138-145.
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Immunology
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Craigen, J.L.1
Yong, K.L.2
Jordan, N.J.3
MacCormac, L.P.4
Westwick, J.5
Akbar, A.N.6
Grundy, J.E.7
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28
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0031776873
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Intracellular signaling by the chemokine receptor US28 during human cytomegalovirus infection
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Billstrom MA, Johnson GL, Avdi NJ, Worthen GS. Intracellular signaling by the chemokine receptor US28 during human cytomegalovirus infection. J Virol. 72:1998;5535-5544.
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J Virol
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Billstrom, M.A.1
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Chemokines and leukocyte traffic
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Baggiolini M. Chemokines and leukocyte traffic. Nature. 392:1998;565-568.
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Baggiolini, M.1
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Endothelial cells augment T cell interleukin 2 production by a contact-dependent mechanism involving CD2/LFA-3 interaction
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Hughes CC, Savage CO, Pober JS. Endothelial cells augment T cell interleukin 2 production by a contact-dependent mechanism involving CD2/LFA-3 interaction. J Exp Med. 171:1990;1453-1467.
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0026046380
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Endothelial cell lymphocyte function-associated antigen-3 and an unidentified ligand act in concert to provide costimulation to human peripheral blood CD4+ T cells
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Savage CO, Hughes CC, Pepinsky RB, Wallner BP, Freedman AS, Pober JS, Hughes CC, Savage CO, Pober JS. Endothelial cell lymphocyte function-associated antigen-3 and an unidentified ligand act in concert to provide costimulation to human peripheral blood CD4+ T cells. Cell Immunol. 137:1991;150-163.
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Pober, J.S.9
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32
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Human endothelial cells effectively costimulate cytokine production by but not differentiation of naive CD4+ T cells
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This study, along with [33], demonstrates that endothelial cells can costimulate effector cytokine production, including interferon-γ and interleukin-4; nonetheless, the results indicate that endothelial costimulation is not sufficient to drive naïve T cells toward Th1 or Th2 phenotypes of outstanding interest
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Ma W, Pober JS. Human endothelial cells effectively costimulate cytokine production by but not differentiation of naive CD4+ T cells. of outstanding interest J Immunol. 1998; This study, along with [33], demonstrates that endothelial cells can costimulate effector cytokine production, including interferon-γ and interleukin-4; nonetheless, the results indicate that endothelial costimulation is not sufficient to drive naïve T cells toward Th1 or Th2 phenotypes.
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J Immunol
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Ma, W.1
Pober, J.S.2
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34
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Blockade of CD2-LFA-3 interactions protects human skin allografts in immunodeficient mouse/human chimeras
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Sultan P, Schechner JS, McNiff JM, Hochman PS, Hughes CC, Lorber MI, Askenase PW, Pober JS. Blockade of CD2-LFA-3 interactions protects human skin allografts in immunodeficient mouse/human chimeras. Nat Biotechnol. 15:1997;759-762.
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