The evolutionarily conserved sequence upstream of the human Ig heavy chain Sγ3 region is an inducible promoter: Synergistic activation by CD40 ligand and IL-4 via cooperative NF-κB and STAT-6 binding sites

Journal of Immunology

Volumn 162, Issue 9, 1999, Pages 5327-5336

  Schaffer, András ^a,b   Cerutti, Andrea ^a   Shah, Shefali ^a   Zan, Hong ^a   Casali, Paolo ^a,b  

^a WEILL CORNELL MEDICAL COLLEGE   (United States)

^b Weill Cornell Graduate School of Biomedical Sciences   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

CD40 ANTIGEN; IMMUNOGLOBULIN ENHANCER BINDING PROTEIN; INTERLEUKIN 4; LUCIFERASE; STAT6 PROTEIN;

ARTICLE; BINDING SITE; CONTROLLED STUDY; DNA RECOMBINATION; GENETIC TRANSCRIPTION; HUMAN; HUMAN CELL; MOLECULAR EVOLUTION; NUCLEOTIDE SEQUENCE; PRIORITY JOURNAL; PROMOTER REGION; PROTEIN INDUCTION; REPORTER GENE; TRANSCRIPTION REGULATION;

5' UNTRANSLATED REGIONS; ANTIGENS, CD40; B-LYMPHOCYTE SUBSETS; BASE SEQUENCE; BINDING SITES; CD40 LIGAND; CONSERVED SEQUENCE; DRUG SYNERGISM; EVOLUTION, MOLECULAR; GENE EXPRESSION REGULATION; HUMANS; IMMUNOGLOBULIN CONSTANT REGIONS; IMMUNOGLOBULIN D; IMMUNOGLOBULIN GAMMA-CHAINS; IMMUNOGLOBULIN HEAVY CHAINS; IMMUNOGLOBULIN M; IMMUNOGLOBULIN SWITCH REGION; IMMUNOGLOBULIN VARIABLE REGION; INTERLEUKIN-4; LIGANDS; MEMBRANE GLYCOPROTEINS; MOLECULAR SEQUENCE DATA; NF-KAPPA B; PROMOTER REGIONS (GENETICS); PROTO-ONCOGENE PROTEINS; PROTO-ONCOGENE PROTEINS C-REL; RESPONSE ELEMENTS; SIGNAL TRANSDUCTION; STAT6 TRANSCRIPTION FACTOR; TRANS-ACTIVATORS; TRANSCRIPTION, GENETIC;

EID: 0033136276     PISSN: 00221767     EISSN: None     Source Type: Journal    
DOI: None     Document Type: Article

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