Functional CD40 ligand is expressed by T cells in rheumatoid arthritis

Journal of Clinical Investigation

Volumn 100, Issue 9, 1997, Pages 2404-2414

  MacDonald, Kelli P A ^a   Nishioka, Yuichi ^b   Lipsky, Peter E ^b   Thomas, Ranjeny ^a  

^a UNIVERSITY OF QUEENSLAND   (Australia)

^b UNIVERSITY OF TEXAS AT DALLAS   (United States)

Author keywords

Autoimmunity; B cells; CD4 T cells; Inflammation; T cell activation

Indexed keywords

CD40 ANTIGEN; LIGAND; MEMBRANE PROTEIN;

ANTIGEN EXPRESSION; ARTICLE; AUTOIMMUNITY; B LYMPHOCYTE; CLINICAL ARTICLE; CONTROLLED STUDY; DENDRITIC CELL; HELPER CELL; HUMAN; HUMAN CELL; HUMAN TISSUE; IMMUNOGLOBULIN PRODUCTION; INFLAMMATION; PRIORITY JOURNAL; RHEUMATOID ARTHRITIS; SYNOVITIS; T LYMPHOCYTE ACTIVATION; TUMOR NECROSIS;

EID: 0030685745     PISSN: 00219738     EISSN: None     Source Type: Journal    
DOI: 10.1172/JCI119781     Document Type: Article

References (74)

1. Fox, R.I., S. Fong, N. Sabharwal, S.A. Carstens, P.C. Kung, and J.H. Vaughan. 1982. Synovial fluid lymphocytes differ from peripheral blood lymphocytes in patients with rheumatoid arthritis. J. Immunol. 128:351-354.
2. Pitzalis, C., G. Kingsley, J.S. Lanchbury, J. Murphy, and G. Panayi. 1987. Expression of HLA-DR. DO and DP antigens and interleukin-2 receptor on synovial fluid T lymphocyte subsets in rheumatoid arthritis: evidence for "frustrated" activation. J. Rheumatol. 14:662-666.
3. Pitzalis, C., G. Kingsley, D. Haskard, and G. Panayi. 1988. The preferential accumulation of helper-inducer T lymphocytes in inflammatory lesions: evidence for regulation by selective endothelial and homotypic adhesion. Eur. J. Immunol. 18:1397-1404.
4. Cush, J.J., and P.E. Lipsky. 1988. Phenotypic analysis of synovial tissue and peripheral blood lymphocytes isolated from patients with rheumatoid arthritis. Arthritis Rheum. 31:1230-1238.
5. Potocnik, A.J., R. Kinne, H. Menninger, J. Zacher, F. Emmrich, and R.A. Kroczek. 1990. Expression of activation antigens on T cells in rheumatoid arthritis patients. Scand. J. Immunol. 31:213-224.
6. Wernick, R.M., P.E. Lipsky, E. Marban-Arcos, J.J. Maliakkal, D. Edelbaum, and M. Ziff. 1985. IgG and IgM rheumatoid factor synthesis in rheumatoid synovial membrane cell cultures. Arthritis Rheum. 28:742-752.
7. Ridley, M.G., G. Kingsley, C. Pitzalis, and G.S. Panayi. 1990. Monocyte activation in rheumatoid arthritis: evidence for in situ activation and differentiation in joints. Br. J. Rheumatol. 29:84-88.
8. Hahn, G., B. Stuhlmuller, N. Hain, J.R. Kalden, K. Pfizenmaier, and G.R. Burmester. 1993. Modulation of monocyte activation in patients with rheumatoid arthritis by leukopheresis therapy. J. Clin. Invest. 91:862-870.
9. Koch, A.E., S.L. Kunkel, L.A. Harlow, B. Johnson, H.L. Evanoff, G.K. Haines, M.D. Burdick, R.M. Pope, and R.M. Strieter. 1992. Enhanced production of monocyte chemoattractant protein-1 in rheumatoid arthritis. J. Clin. Invest. 90:772-779.
10. Thomas, R., L.S. Davis, and P.E. Lipsky. 1994. Rheumatoid synovium is enriched in mature antigen-presenting dendritic cells. J. Immunol. 152:2613-2623.
11. Thomas, R., and C. Quinn. 1996. Functional differentiation of dendritic cells in rheumatoid arthritis: role of CD86 in the synovium. J. Immunol. 156: 3074-3086.
12. Emery, P., K.C. Gentry, I.R. Mackay, K. Muirden, and M. Rowley. 1987. Deficiency of the suppressor inducer subset of T lymphocytes in rheumatoid arthritis. Arthritis Rheum. 30:849-856.
13. Morimoto, C., P.L. Romain, D.A. Fox, P. Anderson, M. Dimaggio, H. Levin, and S.F. Schlossman. 1988. Abnormalities in CD4+ T-lymphocyte subsets in inflammatory rheumatic diseases. Am. J. Med. 84:817-825.
14. Thomas, R., M. McIlraith, L.S. Davis, and P.E. Lipsky. 1992. Rheumatoid synovium is enriched in CD45RBdim mature memory T cells that are potent helpers for B cell differentiation. Arthritis Rheum. 35:1455-1465.
15. Mason, D.W., and F. Powrie. 1990. Memory CD4+ T cells in man form two distinct subpopulalions, defined by their expression of isoforms of the leucocyte common antigen. CD45. Immunology. 70:427-433.
16. Horgan, K.J., Y. Tanaka, G.E. Luce, G.A. van Seventer, T.B. Nutman, and S. Shaw. 1994. CD45RB expression defines two interconvertible subsets of human CD4+ T cells with memory function. Eur. J. Immunol. 24:1240-1243.
17. Firestein, G.S., and N.J. Zvaifler. 1990. How important are T cells in chronic rheumatoid synovitis? Arthritis Rheum. 33:768-773.
18. Kitas, G.D., M. Salmon, and P.A. Bacon. 1988. The T cell system in rheumatoid arthritis: activated or defective? Scand. J. Rheumatol. Suppl. 76: 161-173.
19. Dolhain, R.J., N.T. ter Haar, S. Hoefakker, P.P. Tak, M. de Ley, E. Claassen, F.C. Breedveld, and A.M. Miltenburg. 1996. Increased expression of interferon (IFN)-gamma together with IFN-gamma receptor in the rheumatoid synovial membrane compared with synovium of patients with osteoarthritis. Br. J. Rheumatol. 35:24-32.
20. Aaron, S., and V. Paetkau. 1991. Synovial cell secretion of IL-2 in vitro, a limiting dilution analysis. Clin. Exp. Rheumatol. 9:113-118.
21. Chen, E., E.C. Keystone, and E.N. Fish. 1993. Restricted cytokine expression in rheumatoid arthritis. Arthritis Rheum. 36:901-910.
22. Burmester, G.R., and F. Emmrich. 1993. Anti-CD4 therapy in rheumatoid arthritis. Clin. Exp. Rheumatol. 11:S139-S145.
23. Panayi, G.S., and P. Tugwell. 1994. The use of cyclosporin A in rheumatoid arthritis: conclusions of an international review. Br. J. Rheumatol. 33:967-969.
24. Tak, P.P., P.A. van der Lubbe, A. Cauli, M.R. Daha, T.J. Smeets, P.M. Kluin, A.E. Meinders, G. Yanni, G.S. Panayi, and F.C. Breedveld. 1995. Reduction of synovial inflammation after anti-CD4 monoclonal antibody treatment in early rheumatoid arthritis. Arthritis Rheum. 38:1457-1465.
25. Moreland, L.W., P.W. Pratt, M.D. Mayes, A. Postlethwaite, M.H. Weisman, T. Schnitzer, R. Lightfoot, L. Calabrese, D.J. Zelinger, J.N. Woody, et al. 1995. Double-blind, placebo-controlled multicenter trial using chimeric monoclonal anti-CD4 antibody. cM-T412, in rheumatoid arthritis patients receiving concomitant methotrexate. Arthritis Rheum. 38:1581-1588.
26. Elliott, M.J., R.N. Maini, M. Feldmann, A. Long-Fox, P. Charles, P. Katsikis, F.M. Brennan, J. Walker, H. Bijl, J. Ghrayeb, and J.N. Woody. 1993. Treatment of rheumatoid arthritis with chimeric monoclonal antibodies to tumor necrosis factor alpha. Arthritis Rheum. 12:1681-1690.
27. Rankin, E.C., E.H. Choy, D. Kassimos, G.H. Kingsley, A.M. Sopwith, D.A. Isenberg, and G.S. Panayi. 1995. The therapeutic effects of an engineered human anti-tumour necrosis factor alpha antibody (CDP571) in rheumatoid arthritis. Br. J. Rheumatol. 34:334-342.
28. Maini, R.N., M.J. Elliott, F.M. Brennan, R.O. Williams, C.Q. Chu, E. Paleolog, P.J. Charles, P.C. Taylor, and M. Feldmann. 1995. Monoclonal anti-TNF alpha antibody as a probe of pathogenesis and therapy of rheumatoid disease. Immunol. Rev. 144:195-223.
29. Mulherin, D., O. Fitzgerald, and B. Bresnihan. 1996. Synovial tissue macrophage populations and articular damage in rheumatoid arthritis. Arthritis Rheum. 39:115-124.
30. Hollenbaugh, D., L.S. Grosmaire, C.D. Kullas, N.J. Chalupny, S. Braesch-Andersen, R.J. Noelle, I. Stamenkovic, J.A. Ledbetter, and A. Aruffo. 1992. The human T cell antigen gp39, a member of the TNF gene family, is a ligand for the CD40 receptor: expression of a soluble form of gp39 with B cell co-stimulatory activity. EMBO (Eur. Mol. Biol. Organ.) J. 11:4313-4321.
31. Fanslow, W.C., S. Srinivasan, R. Paxton, M.G. Gibson, M.K. Spriggs, and R.J. Armitage. 1994. Structural characteristics of CD40 ligand that determine biological function. Semin. Immunol. 6:267-278.
32. Peitsch, M.C., and J. Tschopp. 1995. Comparative molecular modelling of the Fas-ligand and other members of the TNF family. Mol. Immunol. 32:761-772.
33. Mazzei, G.J., M.D. Edgerton, C. Losberger, S. Lecoanet Henchoz, P. Graber, A. Durandy, J.F. Gauchat, A. Bernard, B. Allet, and J.Y. Bonnefoy. 1995. Recombinant soluble trimeric CD40 ligand is biologically active. J. Biol. Chem. 270:7025-7028.
34. Spriggs, M.K., W.C. Fanslow, R.J. Armitage, and J. Belmont. 1993. The biology of the human ligand for CD40. J. Clin. Immunol. 13:373-380.
35. Caux, C., C. Massacrier, B. Vanbervliet, B. Dubois, C. Van-Kooten, I. Durand, and J. Banchereau. 1994. Activation of human dendritic cells through CD40 cross-linking. J. Exp. Med. 180:1263-1272.
36. Alderson, M.R., R.J. Armitage, T.W. Tough, L. Strockbine, W.C. Fanslow, and M.K. Spriggs. 1993. CD40 expression by human monocytes: regulation by cytokines and activation of monocytes by the ligand for CD40. J. Exp. Med. 178:669-674.
37. Kiener, P.A., P. Moran Davis, B.M. Rankin, A.F. Wahl, A. Aruffo, and D. Hollenbaugh. 1995. Stimulation of CD40 with purified soluble gp39 induces proinflammatory responses in human monocytes. J. Immunol. 155:4917-4925.
38. Ludewig, B., D. Graf, H.R. Gelderblom, Y. Becker, R.A. Kroczek, and G. Pauli. 1995. Spontaneous apoptosis of dendritic cells is efficiently inhibited by TRAP (CD40-ligand) and TNF-alpha, but strongly enhanced by interleukin-10. Eur. J. Immunol. 25:1943-1950.
39. Arnett, F.C., S.M. Edworthy, D.A. Bloch, D.J. McShane, J.F. Fries, N.S. Cooper, L.A. Healey, S.R. Kaplan, M.H. Liang, H.S. Luthra, et al. 1988. The American Rheumatism Association 1987 revised criteria for the classification of rheumatoid arthritis. Arthritis Rheum. 31:315-324.
40. Goding, J.W. 1986. Monoclonal Antibodies: Principles and Practice. Academic Press Limited, London.
41. Thomas, R., and P.E. Lipsky. 1994. Human peripheral blood dendritic cell subsets: isolation and characterization of precursor and mature antigen-presenting cells. J. Immunol. 153:4016-4028.
42. Romani, N., S. Gruner, D. Brang, E. Kampgen, A. Lenz, B. Trockenbacher, G. Konwalinka, P.O. Fritsch, R.M. Steinman, and G. Schuler. 1994. Proliferating dendritic cell progenitors in human blood. J. Exp. Med. 180:83-93.
43. Thiele, D.L., M. Kurosaka, and P.E. Lipsky. 1983. Phenotype of the accessory cell necessary for mitogen-stimulated T and B cell responses in human peripheral blood: delineation by its sensitivity to the lysosomotropic agent, L-leucine methyl ester. J. Immunol. 131:2282-2290.
44. Thiele, D.L., and P.E. Lipsky. 1985. Modulation of human natural killer cell function by L-leucine methyl ester: monocyte-dependent depletion from human peripheral blood mononuclear cells. J. Immunol. 134:786-793.
45. Wysocki, L.J., and V.L. Sato. 1978. "Panning" for lymphocytes: a method for cell selection. Proc. Natl. Acad. Sci. USA. 75:2844-2848.
46. Shimadzu, M., H. Nunoi, H. Terasaki, R. Ninomiya, M. Iwata, S. Kanegasaka, and I. Matsuda. 1995. Structural organization of the gene for CD40 ligand: molecular analysis for diagnosis of X-linked hyper-IgM syndrome. Biochim. Biophys. Acta. 1260:67-72.
47. de Waal Malefyt, R., J. Abrams, B. Bennett, C.G. Figdor, and J.E. De Vries. 1991. Interleukin 10 (IL-10) inhibits cytokine synthesis by human monocytes: an autoregulatory role of IL-10 produced by monocytes. J. Exp. Med. 174:1209-1220.
48. Tohma, S., and P.E. Lipsky. 1991. Analysis of the mechanisms of T cell-dependent polyclonal activation of human B cells. Induction of human B cell responses by fixed activated T cells. J. Immunol. 146:2544-2552.
49. 4. Nature (Lond.). 227:680-685.
50. Casamayor Palleja, M., M. Khan, and I.C. Maclennan. 1995. A subset of CD4+ memory T cells contains preformed CD40 ligand that is rapidly but transiently expressed on their surface after activation through the T cell receptor complex. J. Exp. Med. 181:1293-1301.
51. Nishioka, Y., and P.E. Lipsky. 1994. The role of CD40-CD40 ligand interaction in human T cell-B cell collaboration. J. Immunol. 153:1027-1036.
52. Cella, M., D. Scheidegger, K. Palmer-Lehmann, P. Lane, A. Lanzavecchia, and G. Alber. 1996. Ligation of CD40 on dendritic cells triggers production of high levels of interleukin-12 and enhances T cell stimulatory capacity: T-T help via APC activation. J. Exp. Med. 184:747-752.
53. Yellin, M.J., K. Sippel, G. Inghirami, L.R. Covey, J.J. Lee, J. Sinning, E.A. Clark, L. Chess, and S. Lederman. 1994. CD40 molecules induce down-modulation and endocytosis of T cell surface T cell-B cell activating molecule/ CD40-L: potential role in regulating helper effector function. J. Immunol. 152: 598-608.
54. Graf, D., S. Muller, U. Korthauer, C. van Kooten, C. Weise, and R.A. Kroczek. 1995. A soluble form of TRAP (CD40 ligand) is rapidly released after T cell activation. Eur. J. Immunol. 25:1749-1754.
55. Calin, A., J. Elswood, and P.T. Klouda. 1989. Destructive arthritis, rheumatoid factor, and HLA-DR4. Susceptibility versus severity, a case-control study. Arthritis Rheum. 32:1221-1225.
56. van Zeben, D., J.M. Hazes, A.H. Zwinderman, J.P. Vandenbroucke, and F.C. Breedveld. 1993. Factors predicting outcome of rheumatoid arthritis: results of a follow-up study. J. Rheumatol. 20:1288-1296.
57. Matthews, N., P. Emery, D. Pilling, A. Akbar, and M. Salmon. 1993. Subpopulations of primed T helper cells in rheumatoid arthritis. Arthritis Rheum. 36:603-607.
58. Kohem, C.L., R.I. Brezinschek, H. Wisbey, C. Tortorella, P.E. Lipsky, and N. Oppenheimer Marks. 1996. Enrichment of differentiated CD45-RBdim,CD27-memory T cells in the peripheral blood, synovial fluid, and synovial tissue of patients with rheumatoid arthritis. Arthritis Rheum. 39:844-854.
59. Castle, B.E., K. Kishimoto, C. Stearns, M.L. Brown, and M.R. Kehry. 1993. Regulation of expression of the ligand for CD40 on T helper lymphocytes. J. Immunol. 151:1777-1788.
60. Grammer, A.C., M.C. Bergman, Y. Miura, K. Fujita, L.S. Davis, and P.E. Lipsky. 1995. The CD40 ligand expressed by human B cells costimulates B cell responses. J. Immunol. 154:4996-5010.
61. Kroszek, R.A., D. Graf, D. Brugnoni, S. Gilliani, U. Korthauer, A.G. Ugazio, G. Senger, H.W. Mages, A. Villa, and L.D. Notarangelo. 1994. Defective expression of CD40 ligand on T cells causes X-linked immunodeficiency with hyper IgM (HIGMI). Immunol. Rev. 138:39-59.
62. Patel, H.R., A. Oshiba, J.D. Jeppson, and E.W. Gelfand. 1996. Differential expression of CD40 ligand on T cell subsets. Implications for different roles of CD45RA+ and CD45RO+ cells in IgE production. J. Immunol. 156:1781-1787.
63. Hollenbaugh, D., L.H. Wu, H.D. Ochs, S. Nonoyama, L.S. Grosmaire, J.A. Ledbetter, R.J. Noelle, H. Hill, and A. Aruffo. 1994. The random inactivation of the X chromosome carrying the defective gene responsible for X-linked hyper IgM syndrome (X-HIM) in female carriers of HIGM1. J. Clin. Invest. 94: 616-622.
64. Mach, F., U. Schönbeck, G.K. Sukhova, T. Bourcier, J.Y. Bonnefoy, J.S. Pober, and P. Libby. 1997. Functional CD40 ligand is expressed on human vascular endothelial cells, smooth muscle cells, and macrophages: implications for CD40-CD40 ligand signaling in atherosclerosis. Proc. Natl. Acad. Sci. USA. 94: 1931-1936.
65. van Kooten, C., C. Gaillard, J.P. Galizzi, P. Hermann, F. Fossiez, J. Banchereau, and D. Blanchard. 1994. B cells regulate expression of CD40 ligand on activated T cells by lowering the mRNA level and through the release of soluble CD40. Eur. J. Immunol. 24:787-792.
66. Durie, F.H., T.M. Foy, S.R. Masters, J.D. Laman, and R.J. Noelle. 1994. The role of CD40 in the regulation of humoral and cell-mediated immunity. Immunol. Today. 15:406-411.
67. Hoxie, J.A., D.M. Matthews, K.J. Callahan, D.L. Cassel, and R.A. Cooper. 1986. Transient modulation and internalization of T4 antigen induced by phorbol esters. J. Immunol. 137:1194-1201.
68. Howell, M., J. Smith, and M. Cawley. 1992. The rheumatoid synovium: a model for T cell anergy? Immunol. Today. 13:191.
69. Schwartz, R.H. 1996. Models of T cell anergy: is there a common molecular mechanism? J. Exp. Med. 184:1-8.
70. Tortorella, C., H. Schulze-Koops, R. Thomas, J.B. Splawski, L.S. Davis, L.J. Picker, and P.E. Lipsky. 1995. Expression of CD45RB and CD27 identifies subsets of CD4+ memory T cells with different capacities to induce B cell differentiation. J. Immunol. 155:149-162.
71. Desai Mehta, A., L. Lu, R. Ramsey Goldman, and S.K. Datta. 1996. Hyperexpression of CD40 ligand by B and T cells in human lupus and its role in pathogenic autoantibody production. J. Clin. Invest. 97:2063-2073.
72. Gerritse, K., J.D. Laman, R.J. Noelle, A. Aruffo, J.A. Ledbetter, W.J. Boersma, and E. Claassen. 1996. CD40-CD40 ligand interactions in experimental allergic encephalomyelitis and multiple sclerosis. Proc. Natl. Acad. Sci. USA. 93:2499-2504.
73. Durie, F.H., R.A. Fava, T.M. Foy, A. Aruffo, J.A. Ledbetter, and R.J. Noelle. 1993. Prevention of collagen-induced arthritis with an antibody to gp39, the ligand for CD40. Science (Wash. DC). 261:1328-1330.
74. Larsen, C.P., E.T. Elwood, D.Z. Alexander, S.C. Ritchie, R. Hendrix, C. Tucker Burden, H.R. Cho, A. Aruffo, D. Hollenbaugh, P.S. Linsley, et al. 1996. Long-term acceptance of skin and cardiac allografts after blocking CD40 and CD28 pathways. Nature (Lond.). 381:434-438.