Anti-tumor immunity induced by in vivo adenovirus vector-mediated expression of CD40 ligand in tumor cells

Human Gene Therapy

Volumn 10, Issue 8, 1999, Pages 1375-1387

  Kikuchi, Toshiaki ^a   Crystal, Ronald G ^a  

^a WEILL CORNELL MEDICAL COLLEGE   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

GLYCOPROTEIN GP 39; VIRUS VECTOR;

ADENOVIRUS; ANIMAL CELL; ANIMAL EXPERIMENT; ARTICLE; COLON CANCER; CONTROLLED STUDY; CYTOTOXIC T LYMPHOCYTE; FEMALE; GENE TRANSFER; LEWIS CARCINOMA; MELANOMA B16; MOUSE; NONHUMAN; TUMOR CELL; TUMOR IMMUNITY; TUMOR REGRESSION;

ADENOVIRUSES, HUMAN; ANIMALS; ANTIGENS, CD40; CD40 LIGAND; COLONIC NEOPLASMS; DISEASE MODELS, ANIMAL; FEMALE; GENE EXPRESSION; GENE THERAPY; GENETIC VECTORS; HUMANS; LUNG NEOPLASMS; MELANOMA, EXPERIMENTAL; MEMBRANE GLYCOPROTEINS; MICE; MICE, INBRED BALB C; MICE, INBRED C57BL; T-LYMPHOCYTES, CYTOTOXIC; TRANSFECTION; TUMOR CELLS, CULTURED;

ADENOVIRIDAE; ANIMALIA; MURINAE;

EID: 0033587141     PISSN: 10430342     EISSN: None     Source Type: Journal    
DOI: 10.1089/10430349950018049     Document Type: Article

References (48)

1. ARMITAGE, R.J., FANSLOW, W.C., STROCKBINE, L., SATO, T.A., CLIFFORD, K.M., MACDUFF, B.M., ANDERSON, D.M., GIMPEL, S.D., DAVIS-SMITH, T., MALISZEWSKI, C.R., CLARK, E.A., SMITH, C.A., GRABSTEIN, K.H., COSMAN, D., and SPRIGGS, M.K. (1992). Molecular and biological characterization of a murine ligand for CD40. Nature (London) 357, 80-82.
2. + T cell help. J. Exp. Med. 186, 65-70.
3. BENNETT, S.R.M., CARBONE, F.R., KARAMALIS, F., FLAVELL, R.A., MILLER, J.F.A.P., and HEATH, W.R. (1998). Help for cytotoxic-T-cell responses is mediated by CD40 signaling. Nature (London) 393, 478-480.
4. CAUX, C., MASSACRIER, C., VANBERVLIET, B., DUBOIS, B., VAN KOOTEN, C., DURAND, I., and BANCHEREAU, J. (1994). Activation of human dendritic cells through CD40 cross-linking. J. Exp. Med. 180, 1263-1272.
5. CELLA, M., SCHEIDEGGER, D., PALMER-LEHMANN, K., LANE, P., LANZAVECCHIA, A., and ALBER, G. (1996). Ligation of CD40 on dendritic cells triggers production of high levels of interleukin-12 and enhances T cell stimulatory capacity: T-T help via APC activation. J. Exp. Med. 184, 747-752.
6. CHEN, L., ASHE, S., BRADY, W.A., HELLSTRÖM, I., HELLSTRÖM, K.E., LEDBETTER, J.A., MCGOWAN, P., and LINSLEY, P.S. (1992). Costimulation of antitumor immunity by the B7 counterreceptor for the T lymphocyte molecules CD28 and CTLA-4. Cell 71, 1093-1102.
7. CHEN, S.H., SHINE, H.D., GOODMAN, J.C., GROSSMAN, R.G., and WOO, S.L.C. (1994). Gene therapy for brain tumors: regression of experimental gliomas by adenovirus-mediated gene transfer in vivo. Proc. Natl. Acad. Sci. U.S.A. 91, 3054-3057.
8. COUDERC, B., ZITVOGEL, L., DOUIN-ECHINARD, V., DJENNANE, L., TAHARA, H., FAVRE, G., LOTZE, M.T., and ROBBINS, P.D. (1998). Enhancement of antitumor immunity by expression of CD70 (CD27 ligand) or CD154 (CD40 ligand) costimulatory molecules in tumor cells. Cancer Gene Ther. 5, 163-175.
9. DILLOO, D., BROWN, M., ROSKROW, M., ZHONG, W., HOLLADAY, M., HOLDEN, W., and BRENNER, M. (1997). CD40 Ligand induces an antileukemia immune response in vivo. Blood 90, 1927-1933.
10. DRANOFF, G., JAFFEE, E., LAZENBY, A., GOLUMBEK, P., LEVITSKY, H., BROSE, K., JACKSON, V., HAMADA, H., PARDOLL, D., and MULLIGAN, R.C. (1993). Vaccination with irradiated tumor cells engineered to secrete murine granulocyte-macrophage colony-stimulating factor stimulates potent, specific, and long-lasting anti-tumor immunity. Proc. Natl. Acad. Sci. U.S.A. 90, 3539-3543.
11. FEARON, E.R., PARDOLL, D.M., ITAYA, T., GOLUMBEK, P., LEVITSKY, H.I., SIMONS, J.W., KARASUYAMA, H., VOGELSTEIN, B., and FROST, P. (1990). Interleukin-2 production by tumor cells bypasses T helper function in the generation of an antitumor response. Cell 60, 397-403.
12. FOY, T.M., SHEPHERD, D.M., DURIE, F.H., ARUFFO, A., LEDBETTER, J.A., and NOELLE, R.J. (1993). In vivo CD40-gp39 interactions are essential for thymus-dependent humoral immunity. II. Prolonged suppression of the humoral immune response by an antibody to the ligand for CD40, gp39. J. Exp. Med. 178, 1567-1575.
13. GANSBACHER, B., BANNERJI, R., DANIELS, B., ZIER, K., CRONIN, K., and GILBOA, E. (1990). Retroviral vector-mediated γ-interferon gene transfer into tumor cells generates potent and long lasting antitumor immunity. Cancer Res. 50, 7820-7825.
14. GONG, J., CHEN, L., CHEN, D., KASHIWABA, M., MANOME, Y., TANAKA, T., and KUFE, D. (1997). Induction of antigen-specific antitumor immunity with adenovirus-transduced dendritic cells. Gene Ther. 4, 1023-1028.
15. GREWAL, I.S., and FLAVELL, R.A. (1998). CD40 and CD154 in cell-mediated immunity. Annu. Rev. Immunol. 16, 111-135.
16. GROSSMANN, M.E., BROWN, M.P., and BRENNER, M.K. (1997). Antitumor responses induced by transgenic expression of CD40 ligand. Hum. Gene Ther. 8, 1935-1943.
17. HERSH, J., CRYSTAL, R.G., and BEWIG, B. (1995). Modulation of gene expression after replication-deficient, recombinant adenovirus-mediated gene transfer by the product of a second adenovirus vector. Gene Ther. 2, 124-131.
18. HIRSCHOWlTZ, E.A., LEONARD, S., SONG, W., FERRIS, B., LEOPOLD, P.L., LEWIS, J.J., BOWNE, W.B., WANG, S., HOUGHTON, A.N., and CRYSTAL, R.G. (1998). Adenovirus-mediated expression of melanoma antigen gp75 as immunotherapy for metastatic melanoma. Gene Ther. 5, 975-983.
19. HOUGHTON, A.N. (1994). Cancer antigens: Immune recognition of self and altered self. J. Exp. Med. 180, 1-4.
20. HUANG, A.Y.C., GOLUMBEK, P., AHMADZADEH, M., JAFFEE, E., PARDOLL, D., and LEVITSKY, H. (1994). Role of bone marrow-derived cells in presenting MHC class I-restricted tumor antigens. Science 264, 961-965.
21. JENKINS, M.K. (1994). The ups and downs of T cell costimulation. Immunity 1, 443-446.
22. KANTOR, J., IRVINE, K., ABRAMS, S., KAUFMAN, H., DI PIETRO, J., and SCHLOM, J. (1992). Antitumor activity and immune responses induced by a recombinant carcinoembryonic antigen-vaccinia virus vaccine. J. Natl. Cancer Inst. 84, 1084-1091.
23. KOCH, F., STANZL, U., JENNEWEIN, P., JANKE, K., HEUFLER, C. KÄMPGEN, E., ROMANI, N., and SCHULER, G. (1996). High level IL-12 production by murine dendritic cells: Upregulation via MHC class II and CD40 molecules and downregulation by IL-4 and IL-10. J. Exp. Med. 184, 741-746.
24. LO, W., BERENCSI, K., BASAK, S., SOMASUNDARAM, R., RICCIARDI, R.P., GÖNCZÖL, E., ZALOUDIK, J., LINNENBACH, A., MARUYAMA, H., MINIOU, P., and HERLYN, D. (1997). Human colorectal cancer (CRC) antigen CO17-1A/GA733 encoded by adenovirus inhibits growth of established CRC cells in mice. J. Immunol. 159, 763-769.
25. MENDOZA, R.B., CANTWELL, M.J., and KIPPS, T.J. (1997). Immunostimulatory effects of a plasmid expressing CD40 ligand (CD154) on gene immunization. J. Immunol. 159, 5777-5781.
26. NAKAJIMA, A., KODAMA, T., MORIMOTO, S., AZUMA, M., TAKEDA, K., OSHIMA, H., YOSHINO, S., YAGITA, H., and OKUMURA, K. (1998). Antitumor effect of CD40 ligand: Flicitation of local and systemic antitumor responses by 11-12 and B7. J. Immunol. 161, 1901-1907.
27. OSSENDORP, F., MENGEDÉ, E., CAMPS, M., FILIUS, R., and MELIEF, C.J.M. (1998). Specific T helper cell requirement for optimal induction of cytotoxic T lymphocytes against major histocompatibility complex class II negative tumors. J. Exp. Med. 187, 693-702.
28. PARDOLL, D.M. (1993). Cancer vaccines. Trends Pharmacol. Sci. 14, 202-208.
29. RAGOT, T., FINERTY, S., WATKINS, P.E., PERRICAUDET, M., and MORGAN, A.J. (1993). Replication-defective recombinant adenovirus expressing the Epstein-Barr virus (EBV) envelope glycoprotein gp340/220 induces protective immunity against EBV-induced lymphomas in the cottontop tamarin. J. Gen. Virol. 74, 501-507.
30. + T-helper and a T-killer cell. Nature (London) 393, 474-478.
31. ROSENFELD, M.A., SIEGFRIED, W., YOSHIMURA, K, YONEYAMA, K., FUKAYAMA, M., STIER, L.E., PÄÄKKÖ, P.K., GILARDI, P., STRATFORD-PERRICAUDET, L.D., PERRICAUDET, M., JALLAT, S., PAVIRANI, A., LECOCQ, J.-P., and CRYSTAL, R.G. (1991). Adenovirus-mediated transfer of a recombinant α1-antitrypsin gene to the lung epithelium in vivo. Science 252, 431-434.
32. ROSENFELD, M.A., YOSHIMURA, K., TRAPNELL, B.C., YONEYAMA, K., ROSENTHAL, E.R. DALEMANS, W., FUKAYAMA, M., BARGON, J., STIER, L.E., STRATFORD-PERRICAUDET, L., PERRICAUDET, M., GUGGINO, W.B., PAVIRANI, A., LECOCQ, J.-P., and CRYSTAL, R.G. (1992). In vivo transfer of the human cystic fibrosis transmembrane conductance regulator gene to the airway epithelium. Cell 68, 143-155.
33. + T cells. J. Immunol. 151, 2497-2510.
34. SCHOENBERGER, S.P., TOES, R.E.M., VAN DER VOORT, E.I.H., OFFRINGA, R., and MELIEF, C.J.M. (1998). T-cell help for cytotoxic T lymphocytes is mediated by CD40-CD40L interactions. Nature (London) 393, 480-483.
35. SMITH, C.A., FARRAH, T., and GOODWIN, R.G. (1994). The TNF receptor superfamily of cellular and viral proteins: Activation, costimulation, and death. Cell 76, 959-962.
36. SOIFFER, R., LYNCH, T., MIHM, M., JUNG, K., RHUDA, C., SCHMOLLINGER, J.C., HODI, F.S., LIEBSTER, L., LAM, P., MENTZER, S., SINGER, S., TANABE, K.K., COSIMI, A.B., DUDA, R., SOBER, A., BHAN, A., DALEY, J., NEUBERG, D., PARRY, G., ROKOVICH, J., RICHARDS, L., DRAYER, J., BERNS, A., CLIFT, S., COHEN, L.K., MULLIGAN, R.C., and DRANOFF, G. (1998). Vaccination with irradiated autologous melanoma cells engineered to secrete human granulocyte-macrophage colony-stimulating factor generates potent antitumor immunity in patients with metastatic melanoma. Proc. Natl. Acad. Sci. U.S.A. 95, 13141-13146.
37. SONG, W., KONG, H.L., CARPENTER, H., TORII, H., GRANSTEIN, R., RAFII, S., MOORE, M.A.S., and CRYSTAL, R.G. (1997a). Dendritic cells genetically modified with an adenovirus vector encoding the cDNA for a model antigen induce protective and therapeutic antitumor immunity. J. Exp. Med. 186, 1247-1256.
38. SONG, W., KONG, H.L., TRAKTMAN, P., and CRYSTAL, R.G. (1997b). Cytotoxic T lymphocyte responses to proteins encoded by heterologous transgenes transferred in vivo by adenoviral vectors. Hum. Gene Ther. 8, 1207-1217.
39. SPECHT, J.M., WANG, G., DO, M.T., LAM, J.S., ROYAL, R.E., REEVES, M.E., ROSENBERG, S.A., and HWU, P. (1997). Dendritic cells retrovirally transduced with a model antigen gene are therapeutically effective against established pulmonary metastases. J. Exp. Med. 186, 1213-1221.
40. SZABOLCS, P., GALLARDO, H.F., CIOCON, D.H., SADELAIN, M., and YOUNG, J.W. (1997). Retrovirally transduced human dendritic cells express a normal phenotype and potent T-cell stimulatory capacity. Blood 90, 2160-2167.
41. TAHARA, H., ZEH, H.J., STORKUS, W.J., PAPPO, I., WATKINS, S.C., GUBLER, U., WOLF, S.F., ROBBINS, P.D., and LOTZE, M.T. (1994). Fibroblasts genetically engineered to secrete interleukin 12 can suppress tumor growth and induce antitumor immunity to a murine melanoma in vivo. Cancer Res. 54, 182-189.
42. + T cells in response to MIP-1α and MIP-1β Science 260, 355-358.
43. TEPPER, R.I., PATTENGALE, P.K., and LEDER, P. (1989). Murine interleukin-4 displays potent anti-tumor activity in vivo. Cell 57, 503-512.
44. TOPF, N., WORGALL, S., HACKETT, N.R., and CRYSTAL, R.G. (1998). Regional "pro-drug" gene therapy: Intravenous administration of an adenoviral vector expressing the E. coli cytosine deaminase gene and systemic administration of 5-fluorocytosine suppresses growth of hepatic metastasis of colon carcinoma. Gene Ther. 5, 507-513.
45. + T cells by B7-transfected melanoma cells. Science 259, 368-370.
46. TRINCHIERI, G. (1995). Interleukin-12: A proinflammatory cytokine with immunoregulatory functions that bridge innate resistance and antigen-specific adaptive immunity. Annu. Rev. Immunol. 13, 251-276.
47. WILEY, J.A., GEHA, R., and HARMSEN, A.G. (1997). Exogenous CD40 ligand induces a pulmonary inflammation response. J. Immunol. 158, 2932-2938.
48. ZHAI, Y., YANG, J.C., KAWAKAMI, Y., SPIESS, P., WADSWORTH, S.C., CARDOZA, L.M., COUTURE, L.A., SMITH, A.E., and ROSENBERG, S.A. (1996). Antigen-specific tumor vaccines. Development and characterization of recombinant adenoviruses encoding MART1 or gp100 for cancer therapy. J. Immunol. 156, 700-710.