CD40 expressed on thymic epithelial cells provides costimulation for proliferation but not for apoptosis of human thymocytes

Journal of Immunology

Volumn 156, Issue 10, 1996, Pages 3737-3746

  Ruggiero, Giuseppina ^a,c   Cáceres, Eva Martinez ^a   Voordouw, Arie ^a   Noteboom, Eric ^a   Graf, Daniel ^b   Kroczek, Richard A ^b   Spits, Hergen ^a  

^a NETHERLANDS CANCER INSTITUTE   (Netherlands)

^b ROBERT KOCH INSTITUTE   (Germany)

^c UNIVERSITY OF NAPLES FEDERICO II   (Italy)

Author keywords

[No Author keywords available]

Indexed keywords

CD40 ANTIGEN;

ANTIGEN EXPRESSION; APOPTOSIS; ARTICLE; EPITHELIUM CELL; HUMAN; HUMAN CELL; IMMUNOSTIMULATION; LEUKEMIA CELL LINE; PRIORITY JOURNAL; T LYMPHOCYTE ACTIVATION; THYMOCYTE;

ANTIBODIES, MONOCLONAL; ANTIGENS, CD3; ANTIGENS, CD40; ANTIGENS, CD80; APOPTOSIS; CD40 LIGAND; CELL DEATH; CHILD, PRESCHOOL; EPITHELIUM; FETUS; HUMANS; INFANT; INTERCELLULAR ADHESION MOLECULE-1; LEUKEMIA, T-CELL; LYMPHOCYTE ACTIVATION; MEMBRANE GLYCOPROTEINS; T-LYMPHOCYTES; THYMUS GLAND; TUMOR CELLS, CULTURED;

EID: 0029870459     PISSN: 00221767     EISSN: None     Source Type: Journal    
DOI: None     Document Type: Article

References (65)

1. Janeway, C. A., and K. Bottomly. 1994. Signals and signs for lymphocyte responses Cell 76:275.
2. Linsey, P. S., W. Brady, M. Urnes, L. S. Grosmaire, N K Damle, and J. A. Ledbetter. 1991. CTLA-4 is a second receptor for the B cell activation antigen B7. J. Exp. Med. 174.561.
3. Linsley, P. S., W. Brady, L. S. Grosmaire, A. Aruffo, N. R Damle, and J. A Ledbetter. 1991. Binding of the B cell activation antigen B7 to CD28 costimulates T cell proliferation and interleukin-2 mRNA accumulation. J. Exp. Med. 173:721.
4. Freeman, G. J., J. G. Gribben, V. A Boussiotis. J W. Ng, V. A J Restivo, L. A Lombard, G S. Gray, and L. M. Nadler. 1993. Cloning of B7.2: CTLA-4 counter receptor that costimulates human T cell proliferation. Science 262:909
5. Azuma, M , D Ito, H. Yagita, K. Okumura, J. H. Phillips, L. L. Lanier, and C. Somoza. 1994. B70 antigen is a second ligand for CTLA-A and CD28. Nature 366.76.
6. + T lymphocytes. J. Immunol. 152:1523.
7. Goodwin, R. G., M. R. Alderson, C. A. Smith, R J. Armitage, T. Van den Bos, R. Jerzy, T. W. Tough, M. A. Schoenborn, T. Davis-Smith, K. Hennen, B Falk, D. Cosman, E. Baker, G. R Sutherland. K. H. Grabstein, T. Farrah, J. G. Giri, and M. P Beckman. 1993. Molecular and biological characterization of a ligand for CD27 defines a new family of cytokines with homology to tumor necrosis factor. Cell 73:447
8. Bowman, M. R., M. A. V. Crimmins, J. Yetz-Aldape, R. Kriz, K. Kelleher, and S Herrman. 1994 Cloning of CD70 and its identification as the ligand for CD27. J. Immunol. 152:2756
9. Hintzen, R Q., M. A. Lens, G. Koopman, S. T. Pals, H. Spits, and R. A W. van Lier. 1994. CD70 represents the human ligand for CD27. Int Immunol. 6:477.
10. Yang, S. Y., S. M. Denning, S. Mizuno, B Dupont, and B. F. Haynes. 1988. A novel activation pathway for mature thymocytes. Costimulation of CD2 (T,p50) and CD28 (Tp44) induces autocrine interleukin 2/interleukin 2 receptor-mediated cell proliferation. J Exp. Med. 168:1457.
11. low" human thymocyte populations can readily be triggered via the CD2 and/or CD28 activation pathways whereas the CD3 pathway remains nonfunctional. J. Immunol 144:1202.
12. + thymocytes by T cell receptor-induced apoptosis requires a costimulatory signal that can be provided by CD28 J. Exp. Med. 179:709.
13. Galy, A., and H. Spits. 1992. CD40 is functionally expressed on human thymic epithelial cells. J. Immunol. 149:775.
14. Clark, E A. 1990. CD40: a cytokine receptor in search of a ligand. Tissue Antigens 36:33
15. Schiever, F., A. S. Freeman, G. Freeman, E Messner, D. Lee, J. Daley, and L. M. Nadler. 1989. Isolated human dendritic cells display a unique antigenic phenotype. J. Exp. Med. 169.2043.
16. Alderson, M. R., R. J Armitage, T. W. Tough, L. Strockbine, W. C. Fanslow, and M. K. Spriggs. 1993. CD40 expression by human monocytes: regulation by cytokines and activation of monocytes by the ligand for CD40. J Exp. Med 178: 669.
17. Lane, P., T. Brocker, S. Hubele, E. Padovan, A. Lanzavecchia, and F McConnell. 1993. Soluble CD40 ligand can replace the normal derived CD40 ligand signal to B cells in T cell dependent activation. J. Exp. Med. 177:1209.
18. Smith, C. A., T. Farrah, and G. R. Goodwin. 1994. The TNF receptor superfamily of cellular and viral proteins: activation, costimulation and death Cell 76:959.
19. Camerini, D., G. Walz, W. A. M. Loenen, J. Borst, and B. Seed. 1991. The T cell activation antigen CD27 is a member of the NGF/TNF receptor gene family. J. Immunol. 147:3165.
20. Mallet, S., S. Fossum, and A N. Barclay. 1990. Characterization of the MRC OX14 antigen of activated CD4 positive T lymphocytes: a molecule related to nerve growth factor receptor. EMBO J. 9:1063.
21. Kwon, B. S., and S. M. Weissman 1989. cDNA sequences of two inducible T cell genes. Proc Natl. Acad. Sci. USA 86:1963
22. Durkop, H. J , U. Latza, M Hummel, F Eitelbach, B. Sead, and H. Stem 1992. Molecular cloning and expression of a new member of nerve growth factor receptor family that is characteristic for Hodgkin's disease. Cell 68:421.
23. Itoh, N., S. Yonehara, A. Ishii, M. Yonehara, S. Mizushima, M. Sameshima, A. Hase, Y. Seto, and S. Nagata. 1991. The polypeptide encoded by the cDNA for human cell surface antigen Fas can mediate apoptosis. Cell 66:233.
24. Barret, J B., G Shu, and E A. Clark 1991. CD40 signaling activates CD11a/CD18 (LFA-1)-mediated adhesion in B cells. J Immunol 146:1722.
25. Clark, E. A , and J Ledbetter. 1986. Activation of human B cells mediated through two distinct cell surface differentiation antigens Bp35 and Bp50. Proc. Natl Acad Sci. USA 83.4494.
26. Jabara, H. H , S M. Fu, R. S. Geha, and D. Vercelli 1990 CD40 and IgE: synergism between anti-CD40 monoclonal antibody and interleukin 4 in the induction of IgE synthesis by highly purified human B cells. J. Exp Med. 172: 1861.
27. Tsubata, T , J. Wu, and T. Honjo. 1993. B cell apoptosis induced by antigen receptor crosslinking is blocked by a T cell signal through CD40. Nature 364: 645.
28. Armitage, R J., W. C. Fanslow, L. Strockbine, T. A. Sato, K. N. Clifford, B. M Macduff, D. M. Anderson, S. D. Gimpel, T. Davis-Smith, C. R. Maliszewski, E. A. Clark, C. A. Smith, K. H. GrAbtein, D. Cosman, and M K. Spriggs 1992. Molecular and biological characterization of a murine ligand for CD40. Nature 357:80.
29. Hollenbough, D., L S. Grosmaire, C. D. Kullas, N. J. Chalupny, S. Braesch-Anderson, R. J. Noelle, I. Stamenkowic, J. A. Ledbetter, and A Aruffo. 1992 The human antigen gp39, a member of the TNF gene family, is a ligand for the CD40 receptor: expression of a soluble form of gp39 with B cell co-stimulatory activity. EMBO J. 11:4313.
30. Graf, D., U. Korthàuer, H W Mages, G Senger, and R. A. Kroczek 1992. Cloning of TRAP, a ligand for CD40 on human T cells. Eur. J. Immunol. 22: 3191.
31. Lane, P , A. Traunecker, S. Hubele. S. Inui, A. Lanzavecchia, and D. Gray. 1992. Activated T cells express a ligand for human B cell-associated antigen CD40 which participates in T cell-independent activation of B lymphocytes. Eur. J Immunol 22:2573.
32. Noelle, R. J., M. Roy, D. M. Shepherd, I. Stamenkovic, J. A. Ledbetter, and A Aruffo. 1992. A 39-KDa protein on activated helper T cells binds CD40 and tranduces a signal for cognate activation of B cells. Proc. Natl. Acad. Sci. USA 89:6550.
33. Fuleihan, R . N. Ramesh, R. Loh, H. Jabara, F S. Rosen, T. Chaula, S. M. Fu, I Stamenkovic, and R. S. Geha. 1993. Defective expression of the CD40 ligand m X chromosome linked immunoglobulin deficiency with normal or elevated IgM. Proc. Natl Acad Sci. USA 90:2170.
34. Farrington, M., L. S. Grosmaire, S. Nonoyama, S. H. Fisher, D. Hollenbaugh, J. A. Ledbetter, R. Noelle, J. A. Aruffo, and H. D. Ochs. 1994. CD40 ligand expression is defective in a subset of patients with common variable immunodeficiency. Proc. Natl Acad. Sci. USA 91:1099.
35. Callard, R. E., R. J. Armitage, W. C. Fanslow, and M. K. Spriggs. 1993. CD40 ligand and its role in X-linked hyper-IgM syndrome. Immunol. Today 14:559.
36. Durie, F. H., T. M. Foy, S R. Masters, J. D. Laman, and R. J. Noelle. 1994 The expanding role of CD40 in the regulation of humoral-, cell-mediated immunity and T cell education. Immunol. Today 15.406.
37. Foy, T. M., D. M. Page, T. J. Waldschmidt, A. Schoneveld, J. D. Laman, S. R. Masters, L. Tygrett, J. A. Ledbetter, A. Aruffo, E. Claasen, J. C. Xu, R. A. Flavell, S. Oehen, S M. Hedrick, and R J. Noelle 1995. An essential role for gp39, the ligand for CD40, in thymic selection. J. Exp. Med. 182:1377.
38. Galy, A , and H. Spits. 1991. EL-1,IL-4, IFN-γ differentially regulate cytokine production and cell surface molecule expression in cultured human thymic epithelial cells J Immunol. 147:3823
39. Azuma, M., D Cayabyab, D. Buck, J. H. Phillips, and L. L Lanier. 1992. CD28 interaction with B7 costimulates primary allogeneic proliferative responses and cytotoxicity mediated by small resting T cells. J. Exp. Med. 175:353.
40. Vallé, A , C. E. Zuber, T. Defrance, O. Djossou, M. De Rie, and J. Banchereau. 1989. Activation of human tonsillar B lymphocytes through CD40 and interleukin 4. Eur. J. Immunol. 19:1463.
41. Spits, H , G. Keizer, J. Borst, C. Terhorst, A. Hekman, and J. E. de Vries. 1983. Characterization of monoclonal antibodies against cell surface molecules associated with cytotoxic activity of natural and activated killer cells and cloned CTL lines. Hybridoma 2:423.
42. Patarroyo, M. E. A , J. Clark, J Priet, C. Kantor, and C. G. Gahmberg. 1987. Identification of a novel adhesion molecule in human leukocytes by monoclonal antibody LB-2. FEBS Lett. 210:127.
43. Takei, F. 1985. Inhibition of mixed lymphocyte response by a rat monoclonal antibody to a novel murine lymphocyte activation antigen (MALA-2). J Immunol 134.1403
44. De Boer, M., L. Controy, H. Y. Min, and J. J. Kwekkeboon. 1992. Generation of monoclonal antibodies to human lymphocyte cell surface antigens using insect cells expressing recombinant proteins J Immunol. Methods 152:15.
45. Borst, J., C Sluyser, E. de Vries, H. Klein, C. I. M. Melief, and R. A. W. van Lier. 1989. Alternative molecular form of human T cell specific antigen CD27 expressed upon T cell activation. Eur. J. Immunol. 19:357.
46. Van Lier, R. A., M. Brouwer and L. A. Aarden. 1988. Signals involved in T cell activation. T cell proliferation induced through the synergistic action of anti-CD28 and anti-CD2 monoclonal antibodies. Eur J. Immunol. 18:167.
47. Lanier, L. L., and D. J Recktenweld. 1991. Multicolor immunofluorescence and flow cytometry. Methods Compan. Methods Enzymol. 2:192.
48. Castle, B E , K. Kishimoto, C. Stearns, M. L. Brown, and M. R. Kehry. 1993. Regulation of expression of the ligand for CD40 on T helper lymphocytes. J. Immunol. 151:1777.
49. Curnow, S. J., M. Barad, N. Bran-Roubereau, and A. M. Schmitt-Verhulst. 1994. Flow-cytometric analysis of apoplotic and nonapoptic T cell receptor transgenic thymocytes following in vitro presentation of antigen. Cytometry 16:41.
50. Schmid, I., C H. Uittenbogaart, and J. V. Giorgi 1994. Sensitive method for measuring apoptosis and cell surface phenotype in human thymocytes by flow cytometry. Cytometry 15:12.
51. Nicoletti, L. G. Migluiorati, M. C. Pagliacci, F. Grignani, and C. Riccardi. 1991. A rapid and simple method for measuring thymocyte apoptosis by propidium iodide staining and flow cytometry. J Immunol. Methods 139:271.
52. Van Lier, R. A. W., J. H. Boot, E. R. De Groot, and L. A. Aarden. 1987. Induction of T cell proliferation with anti-CD3 switch-variant monoclonal antibodies, effects of heavy chain isotype in monocyte-dependent systems Eur. J. Immunol. 17:1599.
53. high human chymocytes are activated and already functionally differentiated in helper and cytotoxic cells. J. Immunol. 152:1738.
54. Darzynkiewicz, Z., S. Bruno, G. Del Bino, W. Gorczyca, M. A. Hotz, P. Lassota, and F. Traganos. 1992. Features of apoptotic cells measured by flow cytometry. Cytometry 13:795.
55. Telford, W. J., L. E. King, and P. I. Fraker. 1992. Comparative evaluation of several DNA binding dyes in the detection of apoptosis associated chromatin degradation by flow cytometry. Cytometry 13:137.
56. Damle, N. K., K. Klussman, G. Leytze, and P. S. Linsley. 1993. Proliferation of human T lymphocytes induced by superantigens is not dependent on costimulation by the counter-receptor B7. J. Immunol. 150:726.
57. Nickoloff, B. J., R. S. Mitra, I. Green, X.-G. Zheng, Y Shimizu, C. Thompson, and L. A. Turka 1993. Accessory cell function of keratinocytes for superantigens. J. Immunol 150:2148.
58. + thymocytes J. Immunol. 151: 1868.
59. Mazda, O. Y., Y. Watanabe, J.-I. Gyotoku, and Y. J. Katsura. 1991. Requirement of dendritic cells and B cells in clonal deletion of MIs-reactive T cells in the thymus. J. Exp. Med. 173:539.
60. Lanier, L. L., S. O'Fallon, C. Somoza, J. H. Phillips, P. S. Linsley, K. Okumura, D. Ito, and M. Azuma. 1995. CD80 (B7) and CD86 (B70) provide similar costimulatory signals for T cell proliferation, cytokine production, and generation of CTL. J. Immunol. 154:97
61. + thymocytes. J. Immunol 152:3254.
62. Shahinian, A., K. Pfeffer, K. P. Lee, T. M. Kündig, K. Kishihara, A. Wakeham, K. Kawai, P. S. Ohashi, C. B. Thompson, and T. W. Mak. 1993. Differential T cell costimulatory requirements in CD28-deficient mice Science 261:609.
63. Jones, L. A., J. D. Nieland, D. J. Izon, P. Linsley, and A. M. Kruisbeek. 1993. No role for CD28/B7 interactions in negative selection of T cells. Int. Immunol 5:503.
64. Notarangelo, L. D., M. Duse, and A. G. Ugazio. 1992. Immunodeficiency with hyper-IgM (HIM). Immunodefic Rev. 3:101.
65. Ramsdell, F., M. S. Seaman, K. N. Clifford, and W C. Fanslow. 1994. CD40 ligand acts as a costimulatory signal for neonatal thymic γδ T cells. J. Immunol. 152:2190