CD40 Ligand/CD40 stimulation regulates the production of IFN-γ from human peripheral blood mononuclear cells in an IL-12- and/or CD28-dependent manner

Journal of Immunology

Volumn 160, Issue 4, 1998, Pages 1701-1707

  McDyer, John F ^a   Goletz, Theresa J ^b   Thomas, Elaine ^c   June, Carl H ^d   Seder, Robert A ^a  

^a NATIONAL INSTITUTE OF ALLERGY AND INFECTIOUS DISEASES   (United States)

^b NATIONAL CANCER INSTITUTE   (United States)

^c AMGEN INC   (United States)

^d HENRY M JACKSON FOUNDATION FOR THE ADVANCEMENT OF MILITARY MEDICINE   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

CD28 ANTIGEN; CD40 ANTIGEN; CYTOKINE; GAMMA INTERFERON; GLYCOPROTEIN GP 39; INTERLEUKIN 12;

ANTIGEN DETECTION; ANTIGEN EXPRESSION; ARTICLE; CONTROLLED STUDY; FLOW CYTOMETRY; HUMAN; HUMAN CELL; LYMPHOCYTE ACTIVATION; MONONUCLEAR CELL; PRIORITY JOURNAL; PROTEIN DETERMINATION; T LYMPHOCYTE ACTIVATION;

ADJUVANTS, IMMUNOLOGIC; ANTIGENS, CD28; ANTIGENS, CD40; CD40 LIGAND; CELLS, CULTURED; HUMANS; INTERFERON TYPE II; INTERLEUKIN-10; INTERLEUKIN-12; LEUKOCYTES, MONONUCLEAR; LIGANDS; LYMPHOCYTE ACTIVATION; MEMBRANE GLYCOPROTEINS; PHYTOHEMAGGLUTININS;

EID: 0032519939     PISSN: 00221767     EISSN: None     Source Type: Journal    
DOI: None     Document Type: Article

References (40)

1. Noelle, R. J. 1996. CD40 and its ligand in host defense. Immunity 4:415.
2. van Essen, D., H. Kikutani, and D. Gray. 1995. CD40 ligand-transduced costimulation of T cells in the development of helper function. Nature 378:620.
3. Grewal, I. S., J. Xu, and R. A. Flavell. 1995. Impairment of antigen-specific T-cell priming in mice lacking CD40 ligand. Nature 378:617.
4. Shu, U., M. Kiniwa, C. Y. Wu, C. Maliszewski, N. Vezzio, J. Hakimi, M. Gately, and G. Delespesse. 1995. Activated T cells induce IL-12 production by monocytes via CD40-CD40 ligand interaction. Eur. J. Immunol. 25:1125.
5. Koch, F., U. Stanzl, P. Jennewein, K. Janke, C. Heufler, E. Kämpgen, N. Romani, and G. Schuler. 1996. High level IL-12 production by murine dendritic cells: upregulation via MHC class II and CD40 molecules and downregulation by IL-4 and IL-10. J. Exp. Med. 184:741.
6. Cella, M., D. Scheidegger, K. Palmer-Lehmann, P. Lane, A. Lanzavecchia, and G. Alber. 1996. Ligation of CD40 on dendritic cells triggers production of high levels of IL-12 and enhances T cell stimulatory capacity: T-T help via APC activation. J. Exp. Med. 184:747.
7. Kennedy, M. K., K. S. Picha, W. C. Fanslow, K. H. Granstein, M. R. Alderson, K. N. Clifford, W. A. Chin, and K. M. Mohler. 1996. CD40/CD40 ligand interactions are required for T cell-dependent production of IL-12 by mouse macrophages. Eur. J. Immunol. 26:370.
8. Kiener, P. A., P. Moran-Davis, B. M. Rankin, A. F. Wahl, A. Aruffo, and D. Hollenbaugh. 1995. Stimulation of CD40 with purified soluble gp39 induces proinflammatory responses in human monocytes. J. Immunol. 155:4917.
9. Wu, Y., J. Xu, S. Shinde, I. Grewal, T. Henderson, R. A. Flavell, and Y. Liu. 1995. Rapid induction of a novel costimulatory activity on B cells by CD40 ligand. Curr. Biol. 5:1303.
10. Shinde, S., Y. Wu, Y. Guo, Q. Niu, J. Xu, I. S. Grewal, R. Flavell, and Y. Liu. 1996. CD40L is important for induction of, but not response to, costimulatory activity: ICAM-1 as the second costimulatory molecule rapidly up-regulated by CD40L. J. Immunol. 157:2764.
11. Meenakshi, R., A. Aruffo, J. Ledbetter, P. Linsley, M. Kehry, and R. Noelle. 1995. Studies on the interdependence of gp39 and B7 expression and function during antigen-specific immune responses. Eur. J. Immunol. 25:596.
12. Ranheim, E. A., and T. J. Kipps. 1993. Activated T cells induce expression of B7/BB1 on normal or leukemic B cells through a CD40-dependent signal. J. Exp. Med. 177:925.
13. Yang, Y., and J. M. Wilson. 1996. CD40 ligand-dependent T cell activation: requirement of B7-CD28 signaling through CD40. Science 273:1862.
14. Grewal, I. S., H. G. Foellmer, K. D. Grewal, J. Xu, F. Hardardottir, J. L. Baron, C. A. Janeway, and R. A. Flavell. 1996. Requirement for CD40 ligand in costimulation induction, T cell activation, and experimental allergic encephalomyelitis. Science 273:1964.
15. Armitage, R. J., T. A. Sato, B. M. Macduff, K. N. Clifford, A. R. Alpert, C. A. Smith, and W. C. Fanslow. 1992. Identification of a source of biologically active CD40 ligand. Eur. J. Immunol. 22:2071.
16. Fanslow, W. C., S. Srinivasan, R. Paxton, M. G. Gibson, M. K. Spriggs, and R. J. Armitage. 1994. Structural characteristics of CD40 ligand that determine biological function. Semin. Immunol. 6:267.
17. + T cells and induce similar patterns of cytokine secretion in vitro. Int. Immunol. 7:891.
18. D'Andrea, A., M. Aste-Amezaga, N. M. Valiante, X. Ma, M. Kubin, and G. Trinchieri. 1993. IL-10 inhibits human lymphocyte IFN-γ production by suppressing natural killer cell stimulatory factor/IL-12 synthesis in accessory cells. J. Exp. Med. 178:1041.
19. Alderson, M. R., R. J. Armitage, T. W. Tough, L. Strockbine, W. C. Fanslow, and M. K. Spriggs. 1993. CD40 expression by human monocytes: regulation by cytokines and activation of monocytes by the ligand for CD40. J. Exp. Med. 178: 669.
20. DeKruyff, R. H., R. S. Gieni, and D. T. Umetsu. 1997. Antigen-driven but not lipopolysaccharide-driven IL-12 production in macrophages requires triggering of CD40. J. Immunol. 158:359.
21. Ding, L., P. S. Linsley, L. Y. Huang, R. N. Germain, and E. M. Shevach. 1993. IL-10 inhibits macrophage costimulatory activity by selectively inhibiting the up-regulation of B7 expression. J. Immunol. 151:1224.
22. Seder, R. A., B. L. Kelsall, and D. Jankovic. 1996. Differential roles for IL-12 in the maintenance of immune responses in infectious versus autoimmune disease. J. Immunol. 157:2745.
23. Magram, J., S. E. Connaughton, R. R. Barrier, D. M. Carvajal, C.-Y. Wu, J. Ferrante, C. Stewart, U. Sarmiento, D. A. Faherty, and M. K. Gately. 1996. IL-12-deficient mice are defective in IFN-γ production and type 1 cytokine responses. Immunity 4:471.
24. Mattner, F., J. Magram, J. Ferrante, P. Launois, K. Di Padova, R. Behin, M. K. Gately, J. A. Louis, and G. Alber. 1996. Genetically resistant mice lacking IL-12 are susceptible to infection with Leishmania major and mount a polarized Th2 cell response. Eur. J. Immunol. 26:1553.
25. Magram, J., J. Sfarra, S. Connaughton, D. Faherty, R. Warrier, D. Cavajal, C.-Y. Wu, C. Stewart, U. Sarmiento, and M. K. Gately. 1996. IL-12-deficient mice are defective but not devoid of type 1 cytokine responses. Ann. NY Acad. Sci. 795:60.
26. Flesch, I. E. A., J. H. Hess, S. Huang, M. Aguet, J. Rothe, H. Bluethmann, and S. H. E. Kaufmann. 1995. Early IL-12 production by macrophages in response to mycobacterial infection depends on IFN-γ and TNF-α. J. Exp. Med. 181: 1615.
27. Ma, X., J. M. Chow, G. Gri, G. Carra, F. Gerosa, S. F. Wolf, R. Dzialo, and G. Trinchieri. 1996. The IL-12 p40 gene promoter is primed by IFN-γ in monocytic cells. J. Exp. Med. 183:147.
28. Hayes, M. P., J. Wang, and M. A. Norcross. 1995. Regulation of IL-12 expression in human monocytes: selective priming by IFN-γ of lipopolysaccharide-inducible p35 and p40 genes. Blood 86:646.
29. Szabo, S. J., A. S. Dighe, U. Gubler, and K. M. Murphy. 1997. Regulation of the IL-12Rβ2 subunit expression in developing Th1 and Th2 cells. J. Exp. Med. 185:817.
30. Wu, C.-Y., R. R. Warrier, X. Wang, D. H. Oresky, and M. K. Gately. 1997. Regulation of IL-12 receptor β1 chain expression and IL-12 binding by human peripheral blood mononuclear cells. Eur. J. Immunol. 27:147.
31. Murphy, E. E., G. Terres, S. E. Macatonia, C.-S. Hsieh, J. Mattson, L. Lanier, M. Wysocka, G. Trinchieri, K. Murphy, and A. O'Garra. 1994. B7 and IL-12 cooperate for proliferation and IFN-γ production by mouse T helper clones that are unresponsive to B7 costimulation. J. Exp. Med. 180:223.
32. Kubin, M., M. Kamoun, and G. Trinchieri. 1994. IL-12 synergizes with B7/CD28 interaction in inducing efficient proliferation and cytokine production of human T cells. J. Exp. Med. 180:211.
33. Ding, L., J. M. Green, C. G. Thompson, and E. M. Shevach. 1995. By/CD28-dependent and -independent induction of CD40 ligand expression. J. Immunol. 155:5124.
34. Guo, Y., Y. Wu, S. Shinde, M.-S. Sy, A. Aruffo, and Y. Liu. 1996. Identification of a costimulatory molecule rapidly induced by CD40L as CD44H. J. Exp. Med. 184:955.
35. Soong, L., J.-C. Xu, I. S. Grewal, P. Kima, J. Sun, B. J. Longley, N. H. Ruddle, D. McMahon-Pratt, and R. A. Flavell. 1996. Disruption of CD40-CD40 ligand interactions results in an enhanced susceptibility to Leishmania amazonensis infection. Immunity 4:263.
36. Kamanaka, M., P. Yu, T. Yasul, K. Yoshida, T. Kawabe, T. Horii, T. Kishimoto, and H. Kikutani. 1996. Protective role of CD40 in Leishmania major infection at two distinct phases of cell-mediated immunity. Immunity 4:275.
37. Campbell, K. A., P. J. Ovendale, M. K. Kennedy, W. C. Fanslow, S. G. Reed, and C. R. Maliszewski. 1996. CD40 ligand is required for protective cell-mediated immunity to Leishmania major. Immunity 4:283.
38. Brown, D. R., J. M. Green, N. H. Moskowitz, M. Davis, C. B. Thompson, and S. L. Reiner. 1996. Limited role of CD28-mediated signals in T helper subset differentiation. J. Exp. Med. 184:803.
39. Renshaw, B. R., W. C. Fanslow, R. J. Armitage, K. A. Campbell, D. Liggitt, B. Wright, B. L. Davison, and C. R. Maliszewski. 1994. Humoral immune responses in CD40 ligand-deficient mice. J. Exp. Med. 180:1889.
40. Spriggs, M. K., R. J. Armitage, L. Strockbine, K. N. Clifford, B. M. Macduff, T. A. Sato, C. R. Maliszewski, and W. C. Fanslow. 1992. Recombinant human CD40 ligand stimulates B cell proliferation and immunoglobulin E secretion. J. Exp. Med. 176:1543.