Induction of interleukin-12 p40 transcript by CD40 ligation via activation of nuclear factor-χB

European Journal of Immunology

Volumn 27, Issue 12, 1997, Pages 3461-3470

  Yoshimoto, Takayuki ^a   Nagase, Hisashi ^a   Ishida, Takaomi ^a   Inoue, Jun Ichiro ^a   Nariuchi, Hideo ^a  

^a UNIVERSITY OF TOKYO   (Japan)

Author keywords

CD40; Interleukin 12 p40; NF B

Indexed keywords

CD40 ANTIGEN; CHLORAMPHENICOL ACETYLTRANSFERASE; IMMUNOGLOBULIN ENHANCER BINDING PROTEIN; INTERLEUKIN 12; MESSENGER RNA; MONOCLONAL ANTIBODY; THYMIDINE KINASE;

ACUTE MONOCYTIC LEUKEMIA; ARTICLE; BINDING SITE; CONTROLLED STUDY; DAUDI CELL; ELECTROPHORETIC MOBILITY; ENZYME ACTIVITY; EXPRESSION VECTOR; GENE INDUCTION; GENETIC TRANSCRIPTION; GENETIC TRANSFECTION; HUMAN; HUMAN CELL; LEUKEMIA CELL LINE; PLASMID; PRIORITY JOURNAL; PROMOTER REGION; REPORTER GENE; SEQUENCE ANALYSIS; TRANSCRIPTION INITIATION;

ANIMALS; ANTIGENS, CD40; B-LYMPHOCYTES; BASE SEQUENCE; CATS; CELL LINE; HUMANS; INTERLEUKIN-12; MICE; MOLECULAR SEQUENCE DATA; NF-KAPPA B; PROMOTER REGIONS (GENETICS); SEQUENCE ALIGNMENT; SIGNAL TRANSDUCTION; TRANSFECTION;

EID: 0031474271     PISSN: 00142980     EISSN: None     Source Type: Journal    
DOI: 10.1002/eji.1830271247     Document Type: Article

References (52)

1. Trinchieri, G., Interleukin-12: a cytokine produced by antigen-presenting cells with immunoregulatory functions in the generation of T-helper cells type 1 and cytotoxic lymphocytes. Blood 1994. 84: 4008-4027.
2. Hendrzak, J. A. and Brunda, M. J., Interleukin-12. Biologic activity, therapeutic utility, and role in disease. Lab. Invest. 1995. 72: 619-637.
3. Manetti, R., Parronchi, P., Guidizi, M. G., Piccinni, M., Maggi, E., Trinchieri, G. and Romagnani, S., Natural killer cell stimulatory factor (interleukin 12 [IL-12]) induces T helper type 1 (Th1)-specific immune responses and inhibits the development of IL-4-producing Th cells. J. Exp. Med. 1993. 177: 1199-1204.
4. + T cells through IL-12 produced by Listeria-induced macrophages. Science 1993. 260: 547-549.
5. Murphy, E. E., Terres, G., Macatonia, S. E., Hsieh, C. S., Mattson, J., Lanier, L., Wysocka, M., Trinchieri, G., Murphy, K. and O'Garra, A., B7 and interleukin 12 cooperate for proliferation and interferon γ production by mouse T helper clones that are unresponsive to B7 costimulation. J. Exp. Med. 1994. 180: 223-231.
6. D'Andrea, A., Rengaraju, M., Valiante, N. M., Chehimi, J., Kubin, M., Aste, M., Chan, S. H., Kobayashi, M., Young, D., Nickbarg, E., Chizzonite, R., Wolf, S. F. and Trinchieri, G., Production of natural killer cell stimulatory factor (interleukin 12) by peripheral blood mononuclear cells. J. Exp. Med. 1992. 176: 1387-1398.
7. Kubin, M., Chow, J. M. and Trinchieri, G., Differential regulation of interleukin-12 (IL-12), tumor necrosis factor α, and IL-1β production in human myeloid leukemia cell lines and peripheral blood mononuclear cells. Blood 1994. 83: 1847-1855.
8. Shu, U., Kiniwa, M., Wu, C. Y., Maliszewski, C., Vezzio, N., Hakimi, J., Gately, M. and Delespesse, G., Activated T cells induce interleukin-12 production by monocytes via CD40-CD40 ligand interaction. Eur. J. Immunol. 1995. 25: 1125-1128.
9. Kato, T., Hakamada, R., Yamane, H. and Nariuchi, H., Induction of IL-12 p40 messenger RNA expression and IL-12 production of macrophages via CD40-CD40 ligand interaction. J. Immunol. 1996. 156: 3932-3938.
10. Yoshimoto, T., Kojima, K., Funakoshi, T., Endo, Y., Fujita, T. and Nariuchi, H., Molecular cloning and characterization of murine interleukin-12 genes. J. Immunol. 1996. 156: 1082-1088.
11. Murphy, T. L., Cleveland, M. G., Kulesza, P., Magram, J. and Murphy, K. M., Regulation of interleukin 12 p40 expression through an NF-NB half-site. Mol. Cell. Biol. 1995. 15: 5258-5267.
12. Ma, X., Chow, J. M., Gri, G., Carra, G., Gerosa, F., Wolf, S. F., Dzialo, R. and Trinchieri, G., The interleukin 12 p40 gene promoter is primed by interferon γ in monocytic cells. J. Exp. Med. 1996. 183: 147-157.
13. Koch, F., Stanzl, U., Jennewein, P., Janke, K., Heufler, C., Kampgen, E., Romani, N. and Schuler, G., High level IL-12 production by murine dendritic cells: upregulation via MHC class II and CD40 molecules and downregulation by IL-4 and IL-10. J. Exp. Med. 1996. 184: 741-746.
14. Cella, M., Scheidegger, D., Palmer, L. K., Lane, P., Lanzavecchia, A. and Alber, G., Ligation of CD40 on dendritic cells triggers production of high levels of interleukin-12 and enhances T cell stimulatory capacity: T-T help via APC activation. J. Exp. Med. 1996. 184: 747-752.
15. Valle, A., Zuber, C. E., Defrance, T., Djossou, O., Rie, M. D. and Banchereau, J., Activation of human B lymphocytes through CD40 and interleukin 4. Eur. J. Immunol. 1989. 19: 1463-1467.
16. Devereux, J., Haeberli, P. and Smithies, O., A comprehensive set of sequence analysis programs for the VAX. Nucleic Acids Res. 1984. 12: 387-395.
17. Lenardo, M. J. and Baltimore, D., NF-NB: a pleiotropic mediator of inducible and tissue-specific gene control. Cell 1989. 58: 227-229.
18. Wasylyk, B., Hahn, S. L. and Giovane, A., The Ets family of transcription factors. J. Biochem. 1993. 211: 7-18.
19. Klemsz, M. J., McKercher, S. R., Celeda, A., Van Beveran, C. and Maki, R., The macrophage and B cell-specific transcription factor PU.1 is related to the ets oncogene. Cell 1990. 61: 113-124.
20. Akira, S., Isshiki, H., Sugita, T., Tanabe, O., Kinoshita, S., Nishino, Y., Nakajima, T., Hirano, T. and Kishimoto, T., A nuclear factor for IL-6 expression (NF-IL6) is a member of a C/EBP family. EMBO J. 1990. 9: 1897-1906.
21. Driggers, P. H., Ennist, D. L., Gleason, S. L., Mak, W., Marks, M. S., Levi, B., Flanagan, J. R., Appella, E. and Ozato, K., An interferon γ-regulated protein that binds the interferon-inducible enhancer element of major histocompatibility complex class I genes. Proc. Natl. Acad. Sci. USA 1990. 87: 3743-3747.
22. Tanaka, N., Kawakami, T. and Taniguchi, T., Recognition DNA sequences of interferon regulatory factor 1 (IRF-1) and IRF-2, regulators of cell growth and the interferon system. Mol. Cell. Biol. 1993. 13: 4531-4538.
23. Berberich, I., Shu, G. L. and Clark, E. A., Cross-linking CD40 on B cells rapidly activates nuclear factor-NB. J. Immunol. 1994. 153: 4357-4366.
24. Inoue, J., Kerr, L. D., Ransone, L. J., Bengal, E., Hunter, T. and Verma, I. M., c-rel activates but v-rel suppresses transcription from NB sites. Proc. Natl. Acad. Sci. USA 1991. 88: 3715-3719.
25. Johnson, D. R. and Pober, J. S., HLA class I heavy-chain gene promoter elements mediating synergy between tumor necrosis factor and interferons. Mol. Cell. Biol 1994. 14: 1322-1332.
26. Martin, E., Nathan, C. and Xie, Q.-W., Role of interferon regulatory factor 1 in induction of nitric oxide synthase. J. Exp. Med. 1994. 180: 977-984.
27. Matsusaka, T., Fujikawa, K., Nishino, Y., Mukaida, N., Matsushima, K., Kishimoto, T. and Akira, S., Transcription factors NF-IL-6 and NF-NB synergistically activate transcription of the inflammatory cytokines, interleukin 6 and interleukin 8. Proc. Natl. Acad. Sci. USA 1993. 90: 10193-10197.
28. Kuang, A. A., Novak, K. D., Kang, S., Bruhn, K. and Lenardo, M. J., Interaction between NF-NB- and serum response factor-binding elements activates an interleukin-2 receptor α-chain enhancer specifically in T lymphocytes. Mol.Cell. Biol. 1993. 13: 2536-2545.
29. Desai-Yajnik, V. and Samuels, H. H., The NF-NB and Sp1 motifs of the human immunodeficiency virus type 1 long terminal repeat function as novel thyroid hormone response elements. Mol. Cell. Biol 1993. 13: 5057-5069.
30. Stein, B., Baldwin, A. S., Jr., Ballard, D. W., Greene, W. C., Angel, P. and Herrlich, P., Cross-coupling of the NF-NB p65 and Fos/Jun transcription factors produces potentiated biological function. EMBO J. 1993. 12: 3879-3891.
31. Banchereau, J., Bazan, F., Blanchard, D., Briere, F., Galizzi, J. P., van Kooten, C., Liu, Y. J., Rousset, F. and Saeland, S., The CD40 antigen and its ligand. Annu. Rev. Immunol. 1994. 12: 881-922.
32. Lederman, S., Yellin, M. J., Cleary, A. M., Fortune, S. M. and Chess, L., The understanding of contact-dependent T-cell helper function in molecular, cellular and physiological detail. Res. Immunol. 1994. 145: 215-220.
33. Durie, F. H., Foy, T. M., Masters, S. R., Laman, J. D. and Noelle, R. J., The role of CD40 in the regulation of humoral and cell-mediated immunity. Immunol. Today 1994. 15: 406-411.
34. + T-cell responses. Immunol. Today 1996. 17: 410-414.
35. Clark, E. A. and Ledbetter, J. A., How B and T cells talk to each other. Nature 1994. 367: 425-428.
36. Alderson, M. R., Armitage, R. J., Tough, T. W., Strockbine, L., Fanslow, W. C. and Spriggs, M. K., CD40 expression by human monocytes: regulation by cytokines and activation of monocytes by the ligand for CD40. J. Exp. Med. 1993. 178: 669-674.
37. Lane, P. J., Ledbetter, J. A., McConnell, F. M., Draves, K., Deans, J., Schieven, G. L. and Clark, E. A., The role of tyrosine phosphorylation in signal transduction through surface Ig in human B cells. Inhibition of tyrosine phosphorylation prevents intracellular calcium release. J. Immunol. 1991. 146: 715-722.
38. Uckun, F. M., Schieven, G. L., Dibirdik, I., Chandan, L. M., Tuel, A. L. and Ledbetter, J. A., Stimulation of protein tyrosine phosphorylation, phosphoinositide turnover, and multiple previously unidentified serine/ threonine-specific protein kinases by the Pan-B-cell receptor CD40/Bp50 at discrete developmental stages of human B-cell ontogeny. J. Biol. Chem. 1991. 266: 17478-17485.
39. Ren, C. L., Morio, T., Fu, S. M. and Geha, R. S., Signal transduction via CD40 involves activation of lyn kinase and phosphatidylinositol-3-kinase, and phosphorylation of phospholipase Cγ2. J. Exp. Med. 1994. 179: 673-680.
40. Rothe, M., Sarma, V., Dixit, V. M. and Goeddel, D. V., TRAF2-mediated activation of NF-NB by TNF receptor 2 and CD40. Science 1995. 269: 1424-1427.
41. Ishida, T., Tojo, T., Aoki, T., Kobayashi, N., Ohishi, T., Watanabe, T., Yamamoto, T. and Inoue, J., TRAF5, a novel tumor necrosis factor receptor-associated factor family protein, mediates CD40 signaling. Proc. Natl. Acad. Sci. USA 1996. 93: 9437-9442.
42. Ishida, T., Mizushima, S., Azuma, S., Kobayashi, N., Tojo, T., Suzuki, K., Aizawa, S., Watanabe, T., Mosialos, G., Kieff, E., Yamamoto, T. and Inoue, J., Identification of TRAF6, a novel tumor necrosis factor receptor-associated factor protein that mediates signaling from an amino-terminal domain of the CD40 cytoplasmic region. J. Biol. Chem. 1996. 271: 28745-28748.
43. Nakano, H., Oshima, H., Chung, W., Williams-Abbott, L., Ware, C. F., Yagita, H. and Okumura, K., TRAF5, an activator of NF-NB and putative signal transducer for the lymphotoxin-β receptor. J. Biol. Chem. 1996. 271: 14661-14664.
44. Francis, D. A., Karras, J. G., Ke, X. Y., Sen, R. and Rothstein, T. L., Induction of the transcription factors NF-NB, AP-1 and NF-AT during B cell stimulation through the CD40 receptor. Int. Immunol. 1995. 7: 151-161.
45. Miyamoto, S., Schmitt, M. J. and Verma, I. M., Qualitative changes in the subunit composition of NB-binding complexes during murine B-cell differentiation. Proc. Natl. Acad. Sci. USA 1994. 91: 5056-5060.
46. Utsunomiya, Y., Kosaka, H. and Kanagawa, O., Differential reactivity of Vβ9 T cells to minor lymphocyte stimulating antigen in vitro and in vivo. Eur. J. Immunol. 1991. 21: 1007-1011.
47. L, Cdk4, and Cdk6. Implication of their cooperation in selective B cell growth. J. Immunol. 1995. 155: 5527-5535.
48. Yoshimoto, T., Nagase, H., Nakano, H., Matsuzawa, A. and Nariuchi, H., A Vβ8.2-specific superantigen from exogenous mouse mammary tumor virus carried by FM mice. Eur. J. Immunol. 1994. 24: 1612-1619.
49. Goodman, R. E., Nestle, F., Naidu, Y. M., Green, J. M., Thompson, C. B., Nickoloff, B. J. and Turka, L. A., Keratinocyte-derived T cell costimulation induces preferential production of IL-2 and IL-4 but not IFN-γ. J. Immunol. 1994. 152: 5189-5198.
50. Yoshimoto, T., Yoshimoto, E. and Meruelo, D., Enhanced gene expression of murine ecotropic retroviral receptor and its human homologue. J. Virol. 1992. 66: 4377-4381.
51. Adrews, N. C. and Faller, D. V., A rapid micropreparation technique for extraction of DNA-binding proteins from limiting numbers of mammalian cells. Nucleic Acids Res. 1991. 19: 2499.
52. Luckow, B. and Schutz, G., CAT constructions with multiple unique restriction sites for the functional analysis of eukaryotic promoters and regulatory elements. Nucleic Acid Res. 1987. 15: 5490.