CD40 and CD40 ligand (CD154) are coexpressed on microvessels in vivo in human cardiac allograft rejection

Transplantation

Volumn 64, Issue 12, 1997, Pages 1765-1774

  Reul, Ross M ^a   Fang, James C ^a   Denton, Mark D ^a   Geehan, Christopher ^a   Long, Catherine ^a   Mitchell, Richard N ^a   Ganz, Peter ^a   Briscoe, David M ^a,b  

^a BRIGHAM AND WOMEN S HOSPITAL   (United States)

^b BOSTON CHILDREN S HOSPITAL   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

CD40 ANTIGEN; CD40 LIGAND; LIGAND; UNCLASSIFIED DRUG;

CELL MEDIATED CYTOTOXICITY; CONFERENCE PAPER; ENDOTHELIUM CELL; GENE EXPRESSION; GRAFT REJECTION; HEART MUSCLE BIOPSY; HEART TRANSPLANTATION; HUMAN; HUMAN TISSUE; IMMUNOHISTOCHEMISTRY; MAJOR CLINICAL STUDY; MICROVASCULATURE; PRIORITY JOURNAL; REVERSE TRANSCRIPTION POLYMERASE CHAIN REACTION; T LYMPHOCYTE;

ANTIGENS, CD40; BIOPSY; CD40 LIGAND; CELLS, CULTURED; ENDOTHELIUM, VASCULAR; GENE EXPRESSION; GRAFT REJECTION; HEART TRANSPLANTATION; HUMANS; IMMUNOENZYME TECHNIQUES; MEMBRANE GLYCOPROTEINS; MICROCIRCULATION; RNA, MESSENGER;

EID: 0031463831     PISSN: 00411337     EISSN: None     Source Type: Journal    
DOI: 10.1097/00007890-199712270-00025     Document Type: Conference Paper

References (50)

1. Clark EA, Ledbetter JA. Activation of human B cells mediated through two distinct cell surface differentiation antigens, Bp35 and Bp50. Proc Natl Acad Sci USA 1986; 83: 4494.
2. Armitage RJ, Tough TW, Macduff BM, et al. CD40 ligand is a T cell growth factor. Eur J Immunol 1993; 23: 2326.
3. Alderson MR, Armitage RJ, Tough TW, Strockbine L, Fanslow WC, Spriggs MK. CD40 expression by human monocytes: regulation by cytokines and activation of monocytes by the ligand for CD40. J Exp Med 1993; 178: 669.
4. Schriever F, Freedman AS, Freeman G, et al. Isolated human follicular dendritic cells display a unique antigenic phenotype. J Exp Med 1989; 169: 2043.
5. Galy AH, Spits H. CD40 is functionally expressed on human thymic epithelial cells. J Immunol 1992; 149: 779.
6. Young LS, Dawson CW, Brown KW, Rickinson AB. Identification of a human epithelial cell surface protein sharing an epitope with the C3d/Epstein-Barr virus receptor molecule of B lymphocytes. Int J Cancer 1989; 43: 786.
7. Peguet-Navarro J, Dalbiez-Gauthier C, Moulon C, et al. CD40 ligation of human keratinocytes inhibits their proliferation and induces their differentiation. J Immunol 1997; 158: 144.
8. Yellin MJ, Winikoff S, Fortune SM, et al. Ligation of CD40 on fibroblasts induces CD54 (ICAM-1) and CD106 (VCAM-1) upregulation, IL-6 production and proliferation. J Leukoc Biol 1995; 58: 209.
9. Hollenbaugh D, Mischel-Petty N, Edwards CP, et al. Expression of functional CD40 by vascular endothelial cells. J Exp Med 1995; 182: 33.
10. Karmann K, Hughes CCW, Schechner J, Fanslow WC, Pober JS. CD40 on human endothelial cells: inducibility by cytokines and functional regulation of adhesion molecule expression. Proc Natl Acad Sci USA 1995; 92: 4342.
11. Yellin MJ, Brett J, Baum D, et al. Functional interactions of T cells with endothelial cells: the role of CD40L-CD40-mediated signals. J Exp Med 1995; 182: 1857.
12. Hollenbaugh D, Grosmaire LS, Kullas CD, et al. The human T cell antigen gp39, a member of the TNF gene family is a ligand for the CD40 receptor: expression of a soluble form of gp39 with B cell co-stimulatory activity. EMBO J 1992; 11: 4313.
13. Noelle RJ, Roy M, Shepherd DM, Stamenkovic I, Ledbetter JA, Aruffo A. A 39-kDa protein on activated helper T cells binds CD40 and transduces the signal for cognate activation of B cells. Proc Natl Acad Sci USA 1992; 89: 6550.
14. Graf D, Korthauer U, Mages HW, Senger G, Kroczek RA. Cloning of TRAP, a ligand for CD40 on human T cells. Eur J Immunol 1992; 22: 3191.
15. Roy M, Waldschmidt T, Aruffo A, Ledbetter JA, Noelle RJ. The regulation of the expression of gp39, the CD40 ligand, on normal and cloned CD4+ T cells. J Immunol 1993; 151: 2497.
16. Grewell IS, Flavell RA. A central role of CD40 ligand in the regulation of CD4+ T-cell responses. Immunol Today 1996; 17: 410.
17. Klaus SJ, Pinchuk GV, Ochs HD, et al. Costimulation through CD28 enhances T cell-dependent B cell activation via CD40-CD40L interaction. J Immunol 1994; 152: 5643.
18. Spriggs MK, Armitage RJ, Strockbine L, et al. Recombinant human CD40 ligand stimulates B cell proliferation and immunoglobulin IgE secretion. J Exp Med 1992; 176: 1543.
19. Urashima M, Chauhan D, Hatziyanni M, et al. CD40 ligand triggers interleukin-6 mediated B cell differentiation. Leukemia Res 1996; 20: 507.
20. Wang H, Grand RJ, Milner AE, Armitage RJ, Gordon J, Gregory CD. Repression of apoptosis in human B-lymphoma cells by CD40-ligand and Bcl-2 relationship to the cell cycle and role of the retinoblastoma protein. Oncogene 1996; 13: 373.
21. Armitage RJ, Macduff BM, Spriggs MK, Fanslow WC. Human B cell proliferation and Ig secretion induced by recombinant CD40 ligand are modulated by soluble cytokines. J Immunol 1993; 150: 3671.
22. Nonoyama S, Hollenbaugh D, Aruffo A, Ledbetter JA, Ochs HD. B cell activation via CD40 is required for specific antibody production by antigen-stimulated human B cells. J Exp Med 1993; 178: 1097.
23. Korthauer U, Graf D, Mages HW, et al. Defective expression of T cell CD40 ligand causes X-linked immunodeficiency with hyper-IgM. Nature 1993; 361: 539.
24. Renshaw BR, Fanslow WC III, Armitage RJ, et al. Humoral immune responses in CD40 ligand-deficient mice. J Exp Med 1994; 180: 1889.
25. Xu J, Foy TM, Laman JD, et al. Mice deficient for the CD40 ligand. Immunity 1994; 1: 423.
26. Kawabe T, Naka T, Yoshida K, et al. The immune responses in CD40-deficient mice: impaired immunoglobulin class switching and germinal center formation. Immunity 1994; 1: 167.
27. Fanslow WC, Clifford KN, Seaman M, Alderson MR, Spriggs MK, Armitage RJ. Recombinant CD40 ligand exerts potent biologic effects on T cells. J Immunol 1994; 152: 4262.
28. Blazar BR, Taylor PA, Panoskaltsis-Mortari A, et al. Blockade of CD40 ligand-CD40 interaction impairs CD4+ T cell mediated alloreactivity by inhibiting mature donor T cell expansion and function after bone marrow transplantation. J Immunol 1997; 158: 29.
29. Durie FH, Aruffo A, Ledbetter JA, et al. Antibody to the ligand of CD40, gp39, blocks the occurrence of acute and chronic forms of graft vs host disease. J Clin Invest 1994; 94: 1333.
30. Larsen CP, Alexander DZ, Hollenbaugh D, et al. CD40-gp39 interactions play a critical role during allograft rejection. Transplantation 1996; 61: 4.
31. Larsen CP, Elwood ET, Alexander DZ, et al. Long-term acceptance of skin and cardiac allografts after blocking CD40 and CD28 pathways. Nature 1996; 381: 434.
32. van Essen D, Kikutani H, Gray D. CD40 ligand-transduced co-stimulation of T cells in the development of helper function. Nature 1995; 378: 620.
33. Roy M, Aruffo A, Ledbetter JA, Linsley PS, Kehry M, Noelle R. Studies on the interdependence of gp39 and B7 expression and function during antigen-specific immune responses. Eur J Immunol 1995; 25: 596.
34. Pober JS, Orosz CG, Rose ML, Savage COS. Can graft endothelial cells initiate a host anti-graft immune response? Transplantation 1996; 61: 343.
35. Briscoe DM, Ganz P, Alexander SI, et al. The problem of chronic rejection: influence of leukocyte-endothelial interactions. Kidney Int Suppl 1997; 58: S22.
36. Briscoe DM, Yeung AC, Schoen FJ, et al. Predictive value of inducible endothelial cell adhesion molecule expression for acute rejection of human cardiac allografts. Transplantation 1995; 59: 204.
37. Billingham ME, Cary NR, Hammond ME, et al. A working formulation for the standardization of nomenclature in the diagnosis of heart and lung rejection: heart rejection study group. J Heart Transplant 1990; 9: 587.
38. Rothlein R, Dustin ML, Marlin SD, Springer TA. A human intercellular adhesion molecule (ICAM-1) distinct from LFA-1. J Immunol 1986; 137: 1270.
39. Gimbrone MA Jr. Culture of human vascular endothelium. Prog Hemost Thromb 1976; 3: 1.
40. Ausubel F, Brent R, Kingston RE, et al. Short protocols in molecular biology. New York: John Wiley & Sons, 1995.
41. Shevach EM. Immunofluorescence and cell sorting. In: Coligan JE, Kruisbeek AM, Margulies DH, Shevach EM, Strober W, eds. Current protocols in immunology. New York: John Wiley & Sons, 1994: 5.0.1
42. Briscoe DM, Cotran RS. Role of leukocyte-endothelial cell adhesion molecules in renal inflammation: in vitro and in vivo studies. Kidney Int Suppl 1993; 42: S27.
43. Damle NK, Klussman K, Linsley PS, Aruffo A. Differential costimulatory effects of adhesion molecules B7, ICAM-1, LFA-3, and VCAM-1 on resting and antigen-primed CD4+ T lymphocytes. J Immunol 1992; 148: 1985.
44. Jenkins MK. The ups and downs of T cell costimulation. Immunity 1994; 1: 443.
45. Pinchuk LM, Klaus SJ, Magelletti DM, Pinchuk GV, Norsen JP, Clark EA. Functional CD40 ligand expressed by human blood dendritic cells is upregulated by CD40 ligation. J Immunol 1996; 157: 4363.
46. Grammer AC, Bergman MC, Miura Y, Fujita K, Davis LS, Lipsky PE. The CD40 ligand expressed by human B cells costimulates B cell responses. J Immunol 1995; 154: 4996.
47. Graf D, Muller S, Korthauer U, Van Kooten C, Weise C, Kroczek RA. A soluble form of TRAP (CD40 ligand) is rapidly released after T cell activation. Eur J Immunol 1995; 25: 1749.
48. Mach F, Schonbeck U, Sukhova GK, et al. Functional CD40 ligand is expressed on human vascular endothelial cells, smooth muscle cells and macrophages: implications of CD40-CD40 ligand signaling in atherosclerosis. Proc Natl Acad Sci USA 1997; 94: 1931.
49. Rice EG, Munro JM, Bevilacqua MP. Inducible cell adhesion molecule-110 (INCAM-110) is an endothelial receptor for lymphocytes. J Exp Med 1990; 171: 1369.
50. Yago T, Tsukuda M, Tajima H, Nishi T, Kurata-Miura K, Ohkubo J. Analysis and initial attachment of B cells to endothelial cell under flow conditions. J Immunol 1997; 158: 707.