The induction of a protective response in Leishmania major-infected BALB/c mice with anti-CD40 mAb

European Journal of Immunology

Volumn 28, Issue 2, 1998, Pages 525-531

  Ferlin, Walter G ^a   Von Der Weid, Thierry ^a   Cottrez, Françoise ^a   Ferrick, David A ^b   Coffman, Robert L ^a   Howard, Maureen C ^a,c  

^a MERCK RESEARCH LABORATORIES   (United States)

^b UNIVERSITY OF CALIFORNIA   (United States)

^c GLAXOSMITHKLINE   (United States)

Author keywords

CD40; Cytokine; Leishmania major; Th1; Th2

Indexed keywords

CD40 ANTIGEN; GAMMA INTERFERON; GLYCOPROTEIN GP 39; INTERLEUKIN 12; MONOCLONAL ANTIBODY;

ANIMAL CELL; ANIMAL EXPERIMENT; ARTICLE; FEMALE; LEISHMANIA MAJOR; LEISHMANIASIS; LYMPH NODE; MOUSE; NONHUMAN; PARASITE IMMUNITY; PRIORITY JOURNAL;

ANIMALS; ANTIBODIES, MONOCLONAL; ANTIGENS, CD40; CYTOKINES; FEMALE; IMMUNITY, NATURAL; LEISHMANIA MAJOR; LEISHMANIASIS, CUTANEOUS; MICE; MICE, INBRED BALB C; MICE, INBRED C57BL; MICE, KNOCKOUT; T-LYMPHOCYTES; TH1 CELLS;

EID: 0031888939     PISSN: 00142980     EISSN: None     Source Type: Journal    
DOI: 10.1002/(SICI)1521-4141(199802)28:02<525::AID-IMMU525>3.0.CO;2-M     Document Type: Article

References (35)

1. Heinzel, F. P., Sadick, M. D., Holaday, B. J., Coffman, R. L. and Locksley, R. M., Reciprocal expression of interferon gamma or interleukin 4 during the resolution or progression of murine leishmaniasis. Evidence for expansion of distinct helper T cell subsets. J. Exp. Med. 1989. 169: 59-72.
2. + T-cell subsets in the regulation of parasite immunity and disease. Immunol. Rev. 1989. 112: 161-182.
3. Reiner, S. L. and Locksley, R. M., The regulation of immunity to Leishmania major. Annu. Rev. Immunol. 1995. 13: 151-177.
4. Carrera, L., Gazzinelli, R. T., Badolato, R., Hieny, S., Müller, W., Kühn, R. and Sacks, D. L., Leishmania promastigotes selectively inhibit interleukin 12 induction in bone marrow-derived macrophages from susceptible and resistant mice. J. Exp. Med. 1996. 183: 515-526.
5. + T cells during initiation of infection. J. Exp. Med. 1994. 179: 447-456.
6. Biron, C. A. and Gazzinelli, R. T., Effects of IL-12 on immune responses to microbial infections: a key mediator in regulating disease outcome. Curr. Opin. Immunol. 1995. 7: 485-496.
7. + T cells through IL-12 produced by Listeria-induced macrophages. Science 1993. 260: 547-549.
8. + T cells from alpha beta TCR transgenic mice: IL-12 substitution for macrophages to stimulate IFN-gamma production is IFN-gamma-dependent. Int. Immunol. 1993. 5: 1119-1128.
9. Scharton, K. T., Afonso, L. C., Wysocka, M., Trinchieri, G. and Scott, P., IL-12 is required for natural killer cell activation and subsequent T helper 1 cell development in experimental leishmaniasis. J. Immunol. 1995. 154: 5320-5330.
10. Gazzinelli, R. T., Hieny, S., Wynn, T. A., Wolf, S. and Sher, A., Interleukin 12 is required for the T-lymphocyte-independent induction of interferon gamma by an intracellular parasite and induces resistance in T-cell-deficient hosts. Proc. Natl. Acad. Sci. USA 1993. 90: 6115-6119.
11. Bogdan, C., Gessner, A. and Röllinghoff, M., Cytokines in leishmaniasis: a complex network of stimulatory and inhibitory interactions. Immunobiology 1993. 189: 356-396.
12. Liew, F. Y. and O'Donnell, C. A., Immunology of leishmaniasis. Adv. Parasitol. 1993. 32: 161-259.
13. Green, S. J., Nacy, C. A. and Meltzer, M. S., Cytokine-induced synthesis of nitrogen oxides in macrophages: a protective host response to Leishmania and other intracellular pathogens. J. Leukoc. Biol. 1991. 50: 93-103.
14. + T cell subsets and induces early resistance to Leishmania major in mice. J. Exp. Med. 1993. 178: 567-577.
15. Soong, L., Xu, J. C., Grewal, I. S., Kima, P., Sun, J., Longley, B. J., Ruddle, N. H., McMahon, P. D. and Flavell, R. A., Disruption of CD40-CD40 ligand interactions results in an enhanced susceptibility to Leishmania amazonesis infection. Immunity 1996. 4: 263-273.
16. Campbell, K. A., Ovendale, P. J., Kennedy, M. K., Fanslow, W. C., Reed, S. G. and Maliszewsky, C. R., CD40 ligand is required for protective cell-mediated immunity to Leishmania major. Immunity 1996. 4: 283-289.
17. Kamanaka, M., Yu, P., Yasui, T., Yoshida, K., Kawabe, T., Horii, T., Kishimoto, T. and Kikutani, H., Protective role of CD40 in Leishmania major infection at two distinct phases of cell-mediated immunity. Immunity 1996. 4: 275-281.
18. Shu, U., Kiniwa, M., Wu, C. Y., Maliszewski, C., Vezzio, N., Hakimi, J., Gately, M. and Delespesse, G., Activated T cells induce interleukin-12 production by monocytes via CD40-CD40 ligand interaction. Eur. J. Immunol. 1995. 25: 1125-1128.
19. Stout, R. D., Suttles, J., Xu, J., Grewal, I. S. and Flavell, R. A., Impaired T cell-mediated macrophage activation in CD40 ligand-deficient mice. J. Immunol. 1996. 156: 8-11.
20. Tian, L., Noelle, R. J. and Lawrence, D. A., Activated T cells enhance nitric oxide production by murine splenic macrophages through gp39 and LFA-1. Eur. J. Immunol. 1995. 25: 306-309.
21. Stenger, S., Thuring, H., Röllinghoff, M. and Bogdan, C., Tissue expression of inducible nitric oxide synthase is closely associated with resistance to Leishmania major. J. Exp. Med. 1994. 180: 783-793.
22. Iseki, M., Anzo, M., Yamashita, N. and Matsuo, N., Hyper-lgM immunodeficiency with disseminated cryptococcosis. Acta. Paediatr. 1994. 83: 780-782.
23. Tabone, M. D., Leverger, G., Landman, J., Aznar, C., Boccon, G. L. and Lasfargues, G., Disseminated lymphonodular cryptococcosis in a child with X-linked hyper-lgM immunodeficiency. Pediatr. Infect. Dis. J. 1994. 13: 77-79.
24. Grewal, I. S., Xu, J. and Flavell, R. A., Impairment of antigen-specific T-cell priming in mice lacking CD40 ligand. Nature 1995. 378: 617-620.
25. Heath, A. W., Wu, W. W. and Howard, M. C., Monoclonal antibodies to murine CD40 define two distinct functional epitopes. Eur. J. Immunol. 1994. 24: 1828-1834.
26. Mombaerts, P., Mizoguchi, E., Ljunggren, H. G., Iacomini, J., Ishikawa, H., Wang, L., Grusby, M. J., Glimcher, L. H., Winn, H. J., Bhan, A. K. and Tonegawa, S., Peripheral lymphoid development and function in TCR mutant mice. Int. Immunol. 1994. 6: 1061-1070.
27. - T cell population. J. Immunol. 1996. 157: 4421-4427.
28. Koo, G. C. and Peppard, J. R., Establishment of monoclonal anti-Nk-1.1 antibody. Hybridoma 1984. 3: 301-303.
29. Stout, R. D. and Suttles, J., The many roles of CD40 in cell-mediated inflammatory responses. Immunol. Today. 1996. 17: 487-492.
30. Wysocka, M., Kubin, M., Vieira, L. Q., Ozmen, L., Garotta, G., Scott, P. and Trinchieri, G., Interleukin-12 is required for interferon-gamma production and lethality in lipopolysaccharide-induced shock in mice. Eur. J. Immunol. 1995. 25: 672-676.
31. Abrams, J. S., Roncarolo, M. G., Yssel, H., Andersson, U., Gleich, G. J. and Silver, J. E., Strategies of anti-cytokine monoclonal antibody development: immunoassay of IL-10 and IL-5 in clinical samples. Immunol: Rev. 1992. 127: 5-24.
32. + T cells induce or protect from chronic intestinal inflammation in C.B-17 seid mice. Int. Immunol. 1993. 5: 1461-1471.
33. Cherwinski, H. M., Schumacher, J. H., Brown, K. D. and Mosmann, T. R., Two types of mouse helper T cell clone. III. Further differences in lymphokine synthesis between Th1 and Th2 clones revealed by RNA hybridization, functionally monospecific bioassays, and monoclonal antibodies. J. Exp. Med. 1987. 166: 1229-1244.
34. Ferrick, D. A., Schrenzel, M. D., Mulvania, T., Hsieh, B., Ferlin, W. G. and Lepper, H., Differential production of interferon-gamma and interleukin-4 in response to Th1- and Th2-stimulating pathogens by gamma delta T cells in vivo. Nature 1995. 373: 255-257.
35. Openshaw, P., Murphy, E. E., Hosken, N. A., Maino, V., Davis, K., Murphy, K. and O'Garra, A., Heterogeneity of intracellular cytokine synthesis at the single-cell level in polarized T helper 1 and T helper 2 populations. J. Exp. Med. 1995. 182: 1357-1367.