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41
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High level IL-12 production by murine dendritic cells: Upregulation via MHC class II and CD40 molecules and downregulation by IL-4 and IL-10
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43
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of special interest. This paper suggests that one of CD40L's major functions in the development of T cell responses is to upregulate B7 expression on APCs during the genesis of immune response
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Grewal IS, Foellmer HG, Grewal KD, Xu J, Hardardottir F, Baron JL, Janeway CA Jr, aiFlavell RA. Requirement for CD40 ligand in costimulation induction, T cell activation, and experimental allergic encephalomyelitis. of special interest Science. 273:1996;1864-1867 This paper suggests that one of CD40L's major functions in the development of T cell responses is to upregulate B7 expression on APCs during the genesis of immune response.
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Grewal, I.S.1
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Janeway C.A., Jr.7
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44
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CD40-CD40L interactions play a critical role during allograft rejection
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of special interest. This report indicates that the blockade of CD40L can profoundly impair graft rejection responses. The demonstration that early intragraft expression of B7 and T cell cytokine transcripts occurs in the present of such a blockade suggests that this blockade interrupts processes downstream of the initial T cell activation events
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Larsen CP, Alexander DZ, Hollenbaugh D, Elwood ET, Ritchie SC, Aruffo A, Hendrix R, Pearson TC. CD40-CD40L interactions play a critical role during allograft rejection. of special interest Transplantation. 61:1996;4-9 This report indicates that the blockade of CD40L can profoundly impair graft rejection responses. The demonstration that early intragraft expression of B7 and T cell cytokine transcripts occurs in the present of such a blockade suggests that this blockade interrupts processes downstream of the initial T cell activation events.
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Larsen, C.P.1
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Pearson, T.C.8
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45
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Long-term acceptance of skin and cardiac allografts after blocking CD40 and CD28 pathways
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of special interest. The inhibition of skin graft rejection by single and combined CD40 and CD28 blockades, as reported in this paper, suggests that, although interrelated, CD40 and CD28 have distinct functions in the development of rejection
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Larsen CP, Elwood ET, Alexander DZ, Ritchie SC, Hendrix R, Tucker-Burden C, Cho HR, Aruffo A, Hollenbaugh D, Linsley PS, et al. Long-term acceptance of skin and cardiac allografts after blocking CD40 and CD28 pathways. of special interest Nature. 381:1996;434-438 The inhibition of skin graft rejection by single and combined CD40 and CD28 blockades, as reported in this paper, suggests that, although interrelated, CD40 and CD28 have distinct functions in the development of rejection.
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Nature
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Larsen, C.P.1
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Tucker-Burden, C.6
Cho, H.R.7
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Hollenbaugh, D.9
Linsley, P.S.10
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46
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Regulation of immunostimulatory function and costimulatory molecule (B7-1 and B7-2) expression on murine dendritic cells
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Larsen CP, Ritchie SC, Hendrix R, Linsley PS, Hathcock KS, Hodes RJ, Lowry RP, Pearson TC. Regulation of immunostimulatory function and costimulatory molecule (B7-1 and B7-2) expression on murine dendritic cells. J Immunol. 152:1994;5208-5219.
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Larsen, C.P.1
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Hodes, R.J.6
Lowry, R.P.7
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47
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48
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49
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50
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51
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++ T lymphocytes generates a costimulatory signal that up-regulates IL-4 synthesis
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+ T cells enhances IL-4 synthesis, provides the most direct evidence that CD40L may serve as a receptor which transduces a costimulatory signal to the T cell
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+ T cells enhances IL-4 synthesis, provides the most direct evidence that CD40L may serve as a receptor which transduces a costimulatory signal to the T cell.
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Antibody to the ligand of CD40, CD40L, blocks the occurrence of the acute and chronic forms of graft-vs-host disease
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Durie FH, Aruffo A, Ledbetter J, Crassi KM, Green WR, Fast LD, Noelle RJ. Antibody to the ligand of CD40, CD40L, blocks the occurrence of the acute and chronic forms of graft-vs-host disease. J Clin Invest. 94:1994;1333-1338.
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61
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Costimulation blockade prevents rejection following primate renal allotransplanation
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of special interest. This study is the first to show that blockade of the CD40L - CD40 pathway can markedly prolong allograft survival in a pre-clinical large animal model, the rhesus monkey
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Kirk AD, Harlan DM, Armstrong NN, Davis TA, Dong Y, Gray GS, Hong X, Thomas D, Fechner JH, Knechtle SJ. Costimulation blockade prevents rejection following primate renal allotransplanation. of special interest Proc Natl Acad Sci USA. 94:1997;8780-8794 This study is the first to show that blockade of the CD40L - CD40 pathway can markedly prolong allograft survival in a pre-clinical large animal model, the rhesus monkey.
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Kirk, A.D.1
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62
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CD40 ligand-dependent T cell activation: Requirement of B7-CD28 signaling through CD40
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of special interest. This report examines the interaction of the CD40L - CD40 and B7 - CD28 pathways in the cellular and humoral immune responses to hepatocytes transduced by adenoviral vectors in a murine model. The data indicate that the CD40L dependent activation of T cells occurs through signaling of CD40 on the APC which enhances the B7 co-stimulatory pathway
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Yang Y, Wilson JM. CD40 ligand-dependent T cell activation: requirement of B7-CD28 signaling through CD40. of special interest Science. 273:1996;1862-1864 This report examines the interaction of the CD40L - CD40 and B7 - CD28 pathways in the cellular and humoral immune responses to hepatocytes transduced by adenoviral vectors in a murine model. The data indicate that the CD40L dependent activation of T cells occurs through signaling of CD40 on the APC which enhances the B7 co-stimulatory pathway.
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Yang, Y.1
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63
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Costimulatory function and expression of CD40 ligand, CD80, and CD86 in vascularized murine cardiac allograft rejection
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of special interest. These authors demonstrate that the combination of anti-CD40L mAb with an infusion of donor antigens in the form of splenocytes induces long-term survival of mouse cardiac allografts. Analysis of this model indicates that the CD40 pathway can directly co-stimulate T cells, independently of its effect on the B7 - CD28 pathway
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Hancock WW, Sayegh MH, Zheng XG, Peach R, Linsley PS, Turka LA. Costimulatory function and expression of CD40 ligand, CD80, and CD86 in vascularized murine cardiac allograft rejection. of special interest Proc Natl Acad Sci USA. 93:1996;13967-13972 These authors demonstrate that the combination of anti-CD40L mAb with an infusion of donor antigens in the form of splenocytes induces long-term survival of mouse cardiac allografts. Analysis of this model indicates that the CD40 pathway can directly co-stimulate T cells, independently of its effect on the B7 - CD28 pathway.
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Hancock, W.W.1
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64
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Regulation of immunostimulatory function and costimulatory molecule (B7-1 and B7-2) expression on murine dendritic cells
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Larsen CP, Ritchie SC, Hendrix R, Linsley PS, Hathcock KS, Hodes RJ, Lowry RP, Pearson TC. Regulation of immunostimulatory function and costimulatory molecule (B7-1 and B7-2) expression on murine dendritic cells. J Immunol. 152:1994;5208-5219.
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