Wholegrain intake and risk of type 2 diabetes: Evidence from epidemiological and intervention studies

Nutrients

Volumn 10, Issue 9, 2018, Pages

  Della Pepa, Giuseppe ^a   Vetrani, Claudia ^a   Vitale, Marilena ^a   Riccardi, Gabriele ^a  

^a UNIVERSITY OF NAPLES FEDERICO II   (Italy)

Author keywords

Diabetes diet; Diabetes prevention; Plasma glucose; Plasma insulin; Type 2 diabetes mellitus; Wholegrain

Indexed keywords

CARBOHYDRATE; GASTROINTESTINAL HORMONE; GLUCOSE; HEMOGLOBIN A1C; HIGH DENSITY LIPOPROTEIN CHOLESTEROL; PEPTIDE YY; TRACE ELEMENT; TRIACYLGLYCEROL; BIOLOGICAL MARKER;

BODY MASS; BODY WEIGHT LOSS; CALORIC INTAKE; CALORIC RESTRICTION; CEREAL-BASED DIET; DIASTOLIC BLOOD PRESSURE; DIETARY FIBER; ENERGY METABOLISM; EXERCISE; FOOD INTAKE; GLUCOSE HOMEOSTASIS; GLUCOSE TOLERANCE; GLYCEMIC CONTROL; HOMEOSTASIS MODEL ASSESSMENT; HUMAN; INSULIN RESISTANCE; INSULIN SENSITIVITY; LIFESTYLE MODIFICATION; META ANALYSIS (TOPIC); METABOLIC SYNDROME X; NON INSULIN DEPENDENT DIABETES MELLITUS; OAT; OBESITY; OXIDATIVE STRESS; PHYSICAL ACTIVITY; PREVALENCE; RANDOMIZED CONTROLLED TRIAL (TOPIC); REFINED GRAIN; REVIEW; RISK ASSESSMENT; RISK FACTOR; SIGNAL TRANSDUCTION; WAIST CIRCUMFERENCE; WAIST HIP RATIO; WHOLE GRAIN; BLOOD; DIETARY REFERENCE INTAKE; GLUCOSE BLOOD LEVEL; HEALTHY DIET; INCIDENCE; METABOLISM; NUTRITIONAL VALUE; PROTECTION; RISK REDUCTION;

BIOMARKERS; BLOOD GLUCOSE; DIABETES MELLITUS, TYPE 2; HEALTHY DIET; HUMANS; INCIDENCE; NUTRITIVE VALUE; PROTECTIVE FACTORS; RECOMMENDED DIETARY ALLOWANCES; RISK ASSESSMENT; RISK FACTORS; RISK REDUCTION BEHAVIOR; WHOLE GRAINS;

EID: 85053545326     PISSN: None     EISSN: 20726643     Source Type: Journal    
DOI: 10.3390/nu10091288     Document Type: Review

References (99)

1. Ogurtsova, K.; da Rocha Fernandes, J.D.; Huang, Y.; Linnenkamp, U.; Guariguata, L.; Cho, N.H.; Cavan, D.; Shaw, J.E.; Makaroff, L.E. IDF Diabetes Atlas: Global estimates for the prevalence of diabetes for 2015 and 2040. Diabetes Res. Clin. Pract. 2017, 128, 40–50.
2. Bommer, C.; Heesemann, E.; Sagalova, V.; Manne-Goehler, J.; Atun, R.; Bärnighausen, T.; Vollmer, S. The global economic burden of diabetes in adults aged 20–79 years: A cost-of-illness study. Lancet Diabetes Endocrinol. 2017, 6, 423–430.
3. Skyler, J.S.; Bakris, G.L.; Bonifacio, E.; Darsow, T.; Eckel, R.H.; Groop, L.; Groop, P.H.; Handelsman, Y.; Insel, R.A.; Mathieu, C. et al. Differentiation of diabetes by pathophysiology, natural history, and prognosis. Diabetes 2017, 66, 241–255.
4. Barroso, T.A.; Braga Marins, L.; Alves, R.; Souza Gonçalves, A.C.; Barroso, S.G.; de Souza Rocha, G. Association of central obesity with the incidence of cardiovascular diseases and risk factors. Int. J. Cardiovasc. Sci. 2017, 30, 416–424
5. American Diabetes Association. Lifestyle Management: Standards of Medical Care in Diabetes. Diabetes Care 2018, 41, S51–S54.
6. Mozaffarrian, D. Dietary and policy priorities for cardiovascular disease, diabetes, and obesity—A comprehensive review. Circulation 2016, 2, 187–225.
7. Schwingshackl, L.; Hoffmann, G.; Lampousi, A.M.; Knüppel, S.; Iqbal, K.; Schwedhelm, C.; Bechthold, A.; Schlesinger, S.; Boeing, H. Food groups and risk of type 2 diabetes mellitus: A systematic review and meta-analysis of prospective studies. Eur. J. Epidemiol. 2017, 32, 363–375.
8. Salas-Salvadó, J.; Bulló, M.; Estruch, R.; Ros, E.; Covas, M.I.; Ibarrola-Jurado, N.; Corella, D.; Arós, F.; Gómez-Gracia, E.; Ruiz-Gutiérrez, V. et al. Prevention of diabetes with Mediterranean diets: A subgroup analysis of a randomized trial. Ann. Intern. Med. 2014, 160, 1–10.
9. Seal, C.J.; Brownlee, I.A. Whole-grain foods and chronic disease: Evidence from epidemiological and intervention studies. Proc. Nutr. Soc. 2015, 74, 313–319.
10. American Association of Cereal Chemists International. Whole Grain Definition. Available online: http://www.aaccnet.org/initiatives/definitions/Pages/WholeGrain.aspx (accessed on 24 August 2018).
11. Ross, A.B.; van der Kamp, J.W.; King, R.; Lê, K.A.; Mejborn, H.; Seal, K.J.; Thielecke, F. Perspective: A definition for whole-grain food products—Recommendations from the healthgrain forum. Adv. Nutr. 2017, 8, 525–531.
12. van der Kamp, J.W.; Poutanen, K.; Seal, C.J.; Richardson, D.P. The HEALTHGRAIN definition of “whole grain”. Food Nutr. Res. 2014, 58, 22100.
13. Composition of Foods Raw, Processed, Prepared USDA National Nutrient Database for Standard Reference, Release 20. Available online: https://ndb.nal.usda.gov/ndb (accessed on 24 August 2018).
14. Belobrajdic, D.P.; Bird, A.R. The potential role of phytochemicals in wholegrain cereals for the prevention of type-2 diabetes. Nutr. J. 2013, 12, 62.
15. Rouf Shah, T.; Prasad, K.; Kumar, P. Maize—A potential source of human nutrition and health: A review. Cogent Food Agric. 2016, 2, 1166995.
16. Mattila, P.; Pihlava, J.M.; Hellström, J. Contents of phenolic acids, alkyl- and alkenylresorcinols, and avenanthramides in commercial grain products. J. Agric. Food Chem. 2005, 53, 8290–8295.
17. Ferruzzi, M.G.; Jonnalagadda, S.S.; Liu, S.; Marquart, L.; McKeown, N.; Reicks, M.; Riccardi, G.; Seal, C.; Slavin, J.; Thielecke, F. et al. Developing a standard definition of whole-grain foods for dietary recommendations: Summary report of a multidisciplinary expert roundtable discussion. Adv. Nutr. 2014, 5, 164–176.
18. Slavin, J. Why wholegrains are protective: Biological mechanisms. Proc. Nutr. Soc. 2003, 62, 129–134.
19. Develaraja, S.; Reddy, A.; Yadav, M.; Jain, S.; Yadav, H. Whole grains in amelioration of metabolic derangements. J. Nutr. Health Food Sci. 2016, 4, 1–11.
20. Priebe, M.G.; van Binsbergen, J.J.; de Vos, R.; Vonk, R.J. Whole grain foods for the prevention of type 2 diabetes mellitus. Cochrane Database Syst. Rev. 2008, 23, CD006061.
21. Ye, E.Q.; Chacko, S.A.; Chou, E.L.; Kugizaki, M.; Liu, S. Greater whole-grain intake is associated with lower risk of type 2 diabetes, cardiovascular disease, and weight gain. J. Nutr. 2012, 142, 1304–1313.
22. Aune, D.; Norat, T.; Romundstad, P.; Vatten, L.J. Whole grain and refined grain consumption and the risk of type 2 diabetes: A systematic review and dose-response meta-analysis of cohort studies. Eur. J. Epidemiol. 2013, 28, 845–858.
23. Sun, T.; Rong, Y.; Hu, X.; Zhu, Y.; Huang, H.; Chen, L.; Li, P.; Li, S.; Yang, W.; Cheng, J. et al. Plasma alkylresorcinol metabolite, a biomarker of whole-grain wheat and rye intake, and risk of type 2 diabetes and impaired glucose regulation in a Chinese population. Diabetes Care 2018, 41, 440–445.
24. Savolainen, O.; Lind, M.V.; Bergström, G.; Fagerberg, B.; Sandberg, A.S.; Ross, A. Biomarkers of food intake and nutrient status are associated with glucose tolerance status and development of type 2 diabetes in older Swedish women. Am. J. Clin. Nutr. 2017, 106, 1302–1310.
25. Biskup, I.; Kyrø, C.; Marklund, M.; Olsen, A.; van Dam, R.M.; Tjønneland, A.; Overvad, K.; Lindahl, B.; Johansson, I.; Landberg, R. Plasma alkylresorcinols, biomarkers of whole-grain wheat and rye intake, and risk of type 2 diabetes in Scandinavian men and women. Am. J. Clin. Nutr. 2016, 104, 88–96.
26. Micha, R.; Khatibzadeh, S.; Shi, P.; Andrews, K.G.; Engell, R.E.; Mozaffarian, D.; Global Burden of Diseases Nutrition and Chronic Diseases Expert Group (NutriCoDE). Global, regional and national consumption of major food groups in 1990 and 2010: A systematic analysis including 266 country-specific nutrition surveys worldwide. BMJ Open 2015, 5, e008705.
27. Johnsen, N.F.; Frederiksen, K.; Christensen, J.; Skeie, G.; Lund, E.; Landberg, R.; Johansson, I.; Nilsson, L.M.; Halkjær, J.; Olsen, A. et al. Whole-grain products and whole-grain types are associated with lower all-cause and cause-specific mortality in the Scandinavian HELGA cohort. Br. J. Nutr. 2015, 114, 608–623.
28. Jacobs, D.R., Jr.; Meyer, K.A.; Kushi, L.H.; Folsom, A.R. Is whole grain intake associated with reduced total and cause-specific death rates in older women? The Iowa Women’s Health Study. Am. J. Public Health 1999, 89, 322–329.
29. Muhihi, A.; Gimbi, D.; Njelekela, M.; Shemaghembe, E.; Mwambene, K.; Chiwanga, F.; Malik, V.S.; Wedick, N.M.; Spiegelman, D.; Hu, F.B. et al. Consumption and acceptability of whole grain staples for lowering markers of diabetes risk among overweight and obese Tanzanian adults. Glob. Health 2013, 9, 26.
30. Zhang, G.; Pan, A.; Zong, G.; Yu, Z.; Wu, H.; Chen, X.; Tang, L.; Feng, Y.; Zhou, H.; Chen, X. et al. Substituting white rice with brown rice for 16 weeks does not substantially affect metabolic risk factors in middle-aged Chinese men and women with diabetes or a high risk for diabetes. J. Nutr. 2011, 141, 1685–1690.
31. Meyer, K.A.; Kushi, L.H.; Jacobs, D.R., Jr.; Slavin, J.; Sellers, T.A.; Folsom, A.R. Carbohydrates, dietary fiber, and incident type 2 diabetes in older women. Am. J. Clin. Nutr. 2000, 71, 921–930.
32. Liu, S.; Manson, J.E.; Stampfer, M.J.; Hu, F.B.; Giovannucci, E.; Colditz, G.A.; Hennekens, C.H.; Willett, W.C. A prospective study of whole-grain intake and risk of type 2 diabetes mellitus in US women. Am. J. Public Health 2000, 90, 1409–1415.
33. Fung, T.T.; Hu, F.B.; Pereira, M.A.; Liu, S.; Stampfer, M.J.; Colditz, G.A.; Willett, W.C. Whole-grain intake and the risk of type 2 diabetes: A prospective study in men. Am. J. Clin. Nutr. 2002, 76, 535–540.
34. Liu, S.; Willett, W.C.; Manson, J.E.; Hu, F.B.; Rosner, B.; Colditz, G. Relation between changes in intakes of dietary fiber and grain products and changes in weight and development of obesity among middle-aged women. Am. J. Clin. Nutr. 2003, 78, 920–927.
35. McKeown, N.M.; Yoshida, M.; Shea, M.K.; Jacques, P.F.; Lichtenstein, A.H.; Rogers, G.; Booth, S.L.; Saltzman, E. Whole-grain intake and cereal fiber are associated with lower abdominal adiposity in older adults. J. Nutr. 2009, 139, 1950–1955.
36. Koh-Banerjee, P.; Franz, M.; Sampson, L.; Liu, S.; Jacobs, D.R., Jr.; Spiegelman, D.; Willett, W.; Rimm, E. Changes in whole-grain, bran, and cereal fiber consumption in relation to 8-year weight gain among men. Am. J. Clin. Nutr. 2004, 80, 1237–1245.
37. Giacco, R.; Della Pepa, G.; Luongo, D.; Riccardi, G. Whole grain intake in relation to body weight: From epidemiological evidence to clinical trials. Nutr. Metab. Cardiovasc. Dis. 2011, 21, 901–908.
38. Pol, K.; Christensen, R.; Bartels, E.M.; Raben, A.; Tetens, I.; Kristensen, M. Whole grain and body weight changes in apparently healthy adults: A systematic review and meta-analysis of randomized controlled studies. Am. J. Clin. Nutr. 2013, 98, 872–884.
39. Kirwan, J.P.; Malin, S.K.; Scelsi, A.R.; Kullman, E.L.; Navaneethan, S.D.; Pagadala, M.R.; Haus, J.M.; Filion, J.; Godin, J.P.; Kochhar, S. et al. A whole-grain diet reduces cardiovascular risk factors in overweight and obese adults: A randomized controlled trial. J. Nutr. 2016, 146, 2244–2251.
40. Suhr, J.; Vuholm, S.; Iversen, K.N.; Landberg, R.; Kristensen, M. Wholegrain rye, but not wholegrain wheat, lowers body weight and fat mass compared with refined wheat: A 6-week randomized study. Eur. J. Clin. Nutr. 2017, 71, 959–967.
41. Li, X.; Cai, X.; Ma, X.; Jing, L.; Gu, J.; Bao, L.; Jun, Li.; Xu, M.; Zhang, Z.; Li, Y. Short- and Long-Term Effects of wholegrain oat intake on weight management and glucolipid metabolism in overweight type-2 diabetics: A randomized control trial. Nutrients 2016, 8, 549.
42. Karl, J.P.; Meydani, M.; Barnett, J.B.; Vanegas, S.M.; Goldin, B.; Kane, A.; Rasmussen, H.; Saltzman, E.; Vangay, P.; Knights, D. et al. Substituting whole grains for refined grains in a 6-week randomized trial favorably affects energy-balance metrics in healthy men and postmenopausal women. Am. J. Clin. Nutr. 2017, 105, 589–599.
43. Grundy, S.M.; Becker, D.; Clark, L.T.; Cooper, R.S.; Denke, M.A.; Howard, J.; Hunninghake, D.B.; Illingworth, D.R.; Luepker, R.V.; McBride, P. et al. Detection, evaluation, and treatment of high blood cholesterol in adults (Adult Treatment Panel III) final report. Circulation 2002, 106, 3143–3421.
44. Steffen, L.M.; Jacobs, D.R., Jr.; Murtaugh, M.A.; Moran, A.; Steinberger, J.; Hong, C.P.; Sinaiko, A.R. Whole grain intake is associated with lower body mass and greater insulin sensitivity among adolescents. Am. J. Epidemiol. 2003, 158, 243–250.
45. McKeown, N.M.; Meigs, J.B.; Liu, S.; Wilson, P.W.; Jacques, P.F. Whole-grain intake is favorably associated with metabolic risk factors for type 2 diabetes and cardiovascular disease in the Framingham offspring study. Am. J. Clin. Nutr. 2002, 76, 390–398.
46. Esmaillzadeh, A.; Mirmiran, P.; Azizi, F. Whole-grain consumption and the metabolic syndrome: A favorable association in Tehranian adults. Eur. J. Clin. Nutr. 2005, 59, 353–362.
47. Sahyoun, N.R.; Jacques, P.F.; Zhang, X.L.; Juan, W.; McKeown, N.M. Whole grain intake is inversely associated with the metabolic syndrome and mortality in older adults. Am. J. Clin. Nutr. 2006, 83, 124–131.
48. Liese, A.D.; Roach, A.K.; Sparks, K.C.; Marquart, L.; D’Agostino, R.B., Jr.; Mayer-Davis, E.J. Whole-grain intake and insulin sensitivity: The insulin resistance atherosclerosis study. Am. J. Clin. Nutr. 2003, 78, 965–971.
49. Damsgaard, C.T.; Biltoft-Jensen, A.; Tetens, I.; Michaelsen, K.F.; Lind, M.V.; Astrup, A.; Landberg, R. Whole-grain intake, reflected by dietary records and biomarkers, is inversely associated with circulating insulin and other cardiometabolic markers in 8- to 11-year-old children. J. Nutr. 2017, 147, 816–824.
50. Pereira, M.A.; Jacobs, D.R., Jr.; Pins, J.J.; Raatz, S.K.; Gross, M.D.; Slavin, J.L.; Seaquist, E.R. Effect of whole grains on insulin sensitivity in overweight hyperinsulinemic adults. Am. J. Clin. Nutr. 2002, 75, 848–855.
51. Juntunen, K.S.; Laaksonen, D.E.; Poutanen, K.S.; Niskanen, L.K.; Mykkänen, H.M. High fiber rye bread and insulin secretion and sensitivity in healthy postmenopausal women. Am. J. Clin. Nutr. 2003, 77, 385–391.
52. McIntosh, G.H.; Noakes, M.; Royle, P.J.; Foster, P.R. Whole grain rye and wheat foods and markers of bowel health in overweight middle aged men. Am. J. Clin. Nutr. 2003, 77, 967–974.
53. Andersson, A.; Tengblad, S.; Karlström, B.; Kamal Eldin, A.; Landberg, R.; Basu, S.; Aman, P.; Vessby, B. Whole grain foods do not affect insulin sensitivity or markers of lipid peroxidation and inflammation in healthy, moderately overweight subjects. J. Nutr. 2007, 137, 1401–1407.
54. Katcher, H.I.; Legro, R.S.; Kunselman, A.R.; Gillies, P.J.; Demers, L.M.; Bagshaw, D.M.; Kris-Etherton, P.M. The effects of a whole grain enriched hypocaloric diet on cardiovascular disease risk factors in men and women with metabolic syndrome. Am. J. Clin. Nutr. 2008, 87, 79–90.
55. Giacco, R.; Clemente, G.; Cipriano, D.; Luongo, D.; Viscovo, D.; Patti, L.; Di Marino, L.; Giacco, A.; Naviglio, D.; Bianchi, M.A. et al. Effects of the regular consumption of wholemeal wheat foods on cardiovascular risk factors in healthy people. Nutr. Metab. Cardiovasc. Dis. 2010, 20, 186–194.
56. Brownlee, I.A.; Moore, C.; Chatfield, M.; Richardson, D.P.; Ashby, P.; Kuznesof, S.A.; Jebb, S.A.; Seal, C.J. Markers of cardiovascular risk are not changed by increased whole grain intake: The WHOLEheart study, a randomised, controlled dietary intervention. Br. J. Nutr. 2010, 104, 125–134.
57. Giacco, R.; Lappi, J.; Costabile, G.; Kolehmainen, M.; Schwab, U.; Landberg, R.; Uusitupa, M.; Poutanen, K.; Pacini, G.; Rivellese, A.A. et al. Effects of rye and whole wheat versus refined cereal foods on metabolic risk factors: A randomised controlled two-centre intervention study. Clin. Nutr. 2013, 32, 941–949.
58. Malin, S.K.; Kullman, E.L.; Scelsi, A.R.; Haus, J.M.; Filion, J.; Pagadala, M.R.; Godin, J.P.; Kochhar, S.; Ross, A.B.; Kirwan, J.P. A whole-grain diet reduces peripheral insulin resistance and improves glucose kinetics in obese adults: A randomized-controlled trial. Metabolism 2018, 82, 111–117.
59. He, L.X.; Zhao, J.; Huang, Y.S.; Li, Y. The difference between oats and beta-glucan extract intake in the management of HbA1c, fasting glucose and insulin sensitivity: A meta-analysis of randomized controlled trials. Food Funct. 2016, 7, 1413–1428.
60. Marventano, S.; Vetrani, C.; Vitale, M.; Godos, J.; Riccardi, G.; Grosso, G. Whole grain intake and glycaemic control in healthy subjects: A systematic review and meta-analysis of randomized controlled trials. Nutrients 2017, 19, 769.
61. Giacco, R.; Costabile, G.; Della Pepa, G.; Anniballi, G.; Griffo, E.; Mangione, A.; Cipriano, P.; Viscovo, D.; Clemente, G.; Landberg, R. et al. A whole-grain cereal-based diet lowers postprandial plasma insulin and triglyceride levels in individuals with metabolic syndrome. Nutr. Metab. Cardiovasc. Dis. 2014, 24, 837–844.
62. Magnusdottir, O.K.; Landberg, R.; Gunnarsdottir, I.; Cloetens, L.; Akesson, B.; Landin-Olsson, M.; Rosqvist, F.; Iggman, D.; Schwab, U.; Herzig, K.H. et al. Plasma alkylresorcinols C17:0/C21:0 ratio, a biomarker of relative whole-grain rye intake, is associated to insulin sensitivity: A randomized study. Eur. J. Clin. Nutr. 2014, 68, 453–458.
63. Bao, L.; Cai, X.; Xu, M.; Li, Y. Effect of oat intake on glycaemic control and insulin sensitivity: A meta-analysis of randomised controlled trials. Br. J. Nutr. 2014, 112, 457–466.
64. Wirström, T.; Hilding, A.; Gu, H.F.; Östenson, C.G.; Björklund, A. Consumption of whole grain reduces risk of deteriorating glucose tolerance, including progression to prediabetes. Am. J. Clin. Nutr. 2013, 97, 179–187.
65. Lappi, J.; Salojärvi, J.; Kolehmainen, M.; Mykkänen, H.; Poutanen, K.; de Vos, W.M.; Salonen, A. Intake of whole-grain and fiber-rich rye bread versus refined wheat bread does not differentiate intestinal microbiota composition. J. Nutr. 2013, 143, 648–655.
66. European Food Safety Authority. Scientific opinion on the substantiation of health claims related to beta glucans and maintenance or achievement of normal blood glucose concentrations (ID 756, 802, 2935) pursuant to Article 13(1) of Regulation (EC) No 1924/2006. EFSA J. 2010, 8, 1482.
67. Kdnudsen, K.E. Fiber and nonstarch polysaccharide content and variation in common crops used in broiler diets. Poult. Sci. 2014, 9, 2380–2393.
68. Jenkins, D.; Kendall, C.W.; Augustin, L.S.; Martini, M.C.; Axelsen, M.; Faulkner, D.; Vidgen, E.; Parker, T.; Lau, H.; Connelly, P.W. et al. Effect of wheat bran on glycemic control and risk factors for cardiovascular disease in type 2 diabetes. Diabetes Care 2002, 25, 1522–1528.
69. Silva, F.M.; Kramer, C.K.; de Almeida, J.C.; Steemburgo, T.; Gross, J.L.; Azevedo, M.J. Fiber intake and glycemic control in patients with type 2 diabetes mellitus: A systematic review with meta-analysis of randomized controlled trials. Nutr. Rev. 2013, 71, 790–801.
70. Hou, Q.; Li, Y.; Li, L.; Cheng, G.; Sun, X.; Li, S.; Tian, H. The metabolic effects of oats intake in patients with type 2 diabetes: A systematic review and meta-analysis. Nutrients 2015, 7, 10369–10387.
71. Shen, X.L.; Zhao, T.; Zhou, Y.; Shi, X.; Zou, Y.; Zhao, G. Effect of oat β-glucan intake on glycaemic control and insulin sensitivity of diabetic patients: A meta-analysis of randomized controlled trials. Nutrients 2016, 8, 39.
72. Fardet, A. New hypotheses for the health-protective mechanisms of whole-grain cereals: What is beyond fibre? Nutr. Res. Rev. 2010, 23, 65–134.
73. Karimi, G.; Azadbakht, L.; Haghighatdoost, F.; Esmaillzadeh, A. Low energy density diet, weight loss maintenance, and risk of cardiovascular disease following a recent weight reduction program: A randomized control trial. J. Res. Med. Sci. 2016, 21, 32.
74. Wanders, A.J.; Van de Borne, J.J.; de Graaf, C.; Hulshof, T.; Jonathan, M.C.; Kristensen, M.; Mars, M.; Schols, H.A.; Feskens, E.J. Effects of dietary fibre on subjective appetite, energy intake and body weight: A systematic review of randomized controlled trials. Obes. Rev. 2011, 12, 724–739.
75. Westerterp-Plantenga, M.S. Effects of energy density of daily food intake on long-term energy intake. Physiol. Behav. 2004, 81, 765–771.
76. McRorie, J.W. Evidence-based approach to fiber supplements and clinically meaningful health benefits, What to look for and how to recommend an effective fiber therapy. Nutr. Today 2015, 50, 82–89.
77. Sanchez, D.; Miguel, M.; Aleixandre, A. Dietary fiber, gut peptides, and adipocytokines. J. Med. Food 2012, 15, 223–230.
78. Bodnaruc, A.M.; Prud’homme, D.; Blanchet, R.; Giroux, I. Nutritional modulation of endogenous glucagon-like peptide-1 secretion: A review. Nutr. Metab. 2016, 13, 92.
79. Costabile, G.; Griffo, E.; Cipriano, P.; Vetrani, C.; Vitale, M.; Mamone, G.; Rivellese, A.A.; Riccardi, G.; Giacco, R. Subjective satiety and plasma PYY concentration after wholemeal pasta. Appetite 2018, 125, 172–181.
80. Nilsson, A.C.; Johansson-Boll, E.V.; Björck, I.M. Increased gut hormones and insulin sensitivity index following a 3-d intervention with a barley kernel-based product: A randomised cross-over study in healthy middle-aged subjects. Br. J. Nutr. 2015, 114, 899–907.
81. Bozzetto, L.; Costabile, G.; Della Pepa, G.; Ciciola, P.; Vetrani, C.; Vitale, M.; Rivellese, A.A.; Annuzzi, G. Dietary fibre as a unifying remedy for the whole spectrum of obesity-associated cardiovascular risk. Nutrients 2018, 10, 943.
82. Hartvigsen, M.L.; Gregersen, S.; Lærke, H.N.; Holst, J.J.; Bach Knudsen, K.E.; Hermansen, K. Effects of concentrated arabinoxylan and β-glucan compared with refined wheat and whole grain rye on glucose and appetite in subjects with the metabolic syndrome: A randomized study. Eur. J. Clin. Nutr. 2014, 1, 84–90.
83. Hartvigsen, M.L.; Lærke, H.N.; Overgaard, A.; Holst, J.J.; Bach Knudsen, K.E.; Hermansen, K. Postprandial effects of test meals including concentrated arabinoxylan and whole grain rye in subjects with the metabolic syndrome: A randomised study. Eur. J. Clin. Nutr. 2014, 5, 567–574.
84. Canfora, E.E.; Jocken, J.W.; Blaak, E.E. Short-chain fatty acids in control of body weight and insulin sensitivity. Nat. Rev. Endocrinol. 2015, 11, 577–591.
85. Vetrani, C.; Costabile, G.; Luongo, D.; Naviglio, D.; Rivellese, A.A.; Riccardi, G.; Giacco, R. Effects of whole-grain cereal foods on plasma short chain fatty acid concentrations in individuals with the metabolic syndrome. Nutrition 2016, 32, 217–221.
86. Vitaglione, P.; Mennella, I.; Ferracane, R.; Rivellese, A.A.; Giacco, R.; Ercolini, D.; Gibbons, S.M.; La Storia, A.; Gilbert, J.A.; Jonnalagadda, S. et al. Whole-grain wheat consumption reduces inflammation in a randomized controlled trial on overweight and obese subjects with unhealthy dietary and lifestyle behaviors: Role of polyphenols bound to cereal dietary fiber. Am. J. Clin. Nutr. 2015, 101, 251–261.
87. De Angelis, M.; Montemurno, E.; Vannini, L.; Cosola, C.; Cavallo, N.; Gozzi, G.; Maranzano, V.; Di Cagno, R.; Gobbetti, M.; Gesualdo, L. Effect of whole-grain barley on the human fecal microbiota and metabolome. Appl. Environ. Microbiol. 2015, 81, 7945–7956.
88. Adom, K.K.; Sorrells, M.E.; Liu, R.H. Phytochemicals and antioxidant activity of milled fractions of different wheat varieties. J. Agric. Food Chem. 2005, 53, 2297–2306.
89. Singh, A.; Sharma, S. Bioactive components and functional properties of biologically activated cereal grains: A bibliographic review. Crit. Rev. Food Sci. Nutr. 2017, 14, 3051–3071.
90. Chen, S.; Zhao, X.; Ran, L.; Wan, J.; Wang, X.; Qin, J.; Shu, F.; Gao, Y.; Yuan, L.; Zhang, Q. et al. Resveratrol improves insulin resistance, glucose and lipid metabolism in patients with non-alcoholic fatty liver disease: A randomized controlled trial. Dig. Liver Dis. 2015, 47, 226–232.
91. Bozzetto, L.; Annuzzi, G.; Pacini, G.; Costabile, G.; Vetrani, V.; Vitale, M.; Griffo, G.; Giacco, A.; De Natale, C.; Cocozza, S. et al. Polyphenol-rich diets improve glucose metabolism in people at high cardiometabolic risk: A controlled randomized intervention trial. Diabetologia 2015, 58, 1551–1560.
92. Via, M. The malnutrition of obesity: Micronutrient deficiencies that promote diabetes. ISRN Endocrinol. 2012, 2012, 103472.
93. Garcia-Bailo, B.; El-Sohemy, A.; Haddad, P.S.; Arora, P.; BenZaied, F.; Karmali, M.; Badawi, A. Vitamins D, C, and E in the prevention of type 2 diabetes mellitus: Modulation of inflammation and oxidative stress. Biologics 2011, 5, 7–19.
94. Costabile, G.; Della Pepa, G.; Bozzetto, L.; Annuzzi, G.; Vetrani, C.; Giacco, R.; Della Corte, G.; Conte, F.S.; Di Marino, L.; Rivellese, A.A. Urine 8-isoprostane in relation to adiposity and insulin resistance in individuals at high cardiometabolic risk. Metab. Syndr. Relat. Disord. 2015, 13, 187–191.
95. Bozzetto, L.; Annuzzi, G.; Ragucci, M.; Di Donato, O.; Della Pepa, G.; Della Corte, G.; Griffo, E.; Anniballi, G.; Giacco, A.; Mancini, M. et al. Insulin resistance, postprandial GLP-1 and adaptive immunity are the main predictors of NAFLD in a homogeneous population at high cardiovascular risk. Nutr. Metab. Cardiovasc. Dis. 2016, 26, 623–629.
96. Barbagallo, M.; Dominguez, L.J. Magnesium and type 2 diabetes. World J. Diabetes 2015, 6, 1152–1157.
97. Heer, M.; Egert, S. Nutrients other than carbohydrates: Their effects on glucose homeostasis in humans. Diabetes Metab. Res. Rev. 2015, 31, 14–35.
98. O’Neil, C.E.; Nicklas, T.A.; Zanovec, M.; Cho, S. Whole grain consumption is associated with diet quality and nutrient intake in adults: The national health and nutrition examination survey, 1999–2004. J. Am. Diet. Assoc. 2010, 110, 1461–1468.
99. Authors/Task Force Members; Rydén, L.; Grant, P.J.; Anker, S.D.; Berne, C.; Cosentino, F.; Danchin, N.; Deaton, C.; Escaned, J.; Hammes, H.P. et al. ESC guidelines on diabetes, pre-diabetes, and cardiovascular diseases developed in collaboration with the EASD: The task force on diabetes, pre-diabetes, and cardiovascular diseases of the European Society of Cardiology (ESC) and developed in collaboration with the European Association for the Study of Diabetes (EASD). Eur. Heart. J. 2013, 39, 3035–3087.