메뉴 건너뛰기




Volumn 47, Issue 3, 2015, Pages 226-232

Resveratrol improves insulin resistance, glucose and lipid metabolism in patients with non-alcoholic fatty liver disease: A randomized controlled trial

Author keywords

Insulin sensitivity; Metabolic syndrome; Nutrition

Indexed keywords

ADIPONECTIN; ALANINE AMINOTRANSFERASE; APOLIPOPROTEIN A1; APOLIPOPROTEIN B; ASPARTATE AMINOTRANSFERASE; C PEPTIDE; CHOLESTEROL; CREATININE; CYTOKERATIN 18; CYTOKINE; FIBROBLAST GROWTH FACTOR 21; GAMMA GLUTAMYLTRANSFERASE; HEMOGLOBIN; HIGH DENSITY LIPOPROTEIN CHOLESTEROL; INSULIN; LOW DENSITY LIPOPROTEIN CHOLESTEROL; PLACEBO; RESVERATROL; TUMOR NECROSIS FACTOR ALPHA; GLUCOSE BLOOD LEVEL; STILBENE DERIVATIVE;

EID: 84924079162     PISSN: 15908658     EISSN: 18783562     Source Type: Journal    
DOI: 10.1016/j.dld.2014.11.015     Document Type: Article
Times cited : (279)

References (41)
  • 1
    • 0033038672 scopus 로고    scopus 로고
    • Non-alcoholic fatty liver disease: a spectrum of clinical and pathological severity
    • Matteoni C.A., Younossi Z.M., Gramilich T., et al. Non-alcoholic fatty liver disease: a spectrum of clinical and pathological severity. Gastroenterology 1999, 116:1413-1419.
    • (1999) Gastroenterology , vol.116 , pp. 1413-1419
    • Matteoni, C.A.1    Younossi, Z.M.2    Gramilich, T.3
  • 2
    • 84881232944 scopus 로고    scopus 로고
    • Cardiovascular and systemic risk in non-alcoholic fatty liver disease - atherosclerosis as a major player in the natural course of NAFLD
    • Lonardo A., Sookoian S., Chonchol M., et al. Cardiovascular and systemic risk in non-alcoholic fatty liver disease - atherosclerosis as a major player in the natural course of NAFLD. Current Pharmaceutical Design 2013, 19:5177-5192.
    • (2013) Current Pharmaceutical Design , vol.19 , pp. 5177-5192
    • Lonardo, A.1    Sookoian, S.2    Chonchol, M.3
  • 3
    • 77954239704 scopus 로고    scopus 로고
    • A meta-analysis of randomized trials for the treatment of non-alcoholic fatty liver disease
    • Musso G., Gambino R., Cassader M., et al. A meta-analysis of randomized trials for the treatment of non-alcoholic fatty liver disease. Hepatology 2010, 52:79-104.
    • (2010) Hepatology , vol.52 , pp. 79-104
    • Musso, G.1    Gambino, R.2    Cassader, M.3
  • 4
    • 84884419004 scopus 로고    scopus 로고
    • From NAFLD in clinical practice to answers from guidelines
    • Nascimbeni F., Pais R., Bellentani S., et al. From NAFLD in clinical practice to answers from guidelines. Journal of Hepatology 2013, 59:859-871.
    • (2013) Journal of Hepatology , vol.59 , pp. 859-871
    • Nascimbeni, F.1    Pais, R.2    Bellentani, S.3
  • 5
    • 84894234723 scopus 로고    scopus 로고
    • Risk of cardiovascular, cardiac and arrhythmic complications in patients with non-alcoholic fatty liver disease
    • Ballestri S., Lonardo A., Bonapace S., et al. Risk of cardiovascular, cardiac and arrhythmic complications in patients with non-alcoholic fatty liver disease. World Journal of Gastroenterology: WJG 2014, 20:1724-1745.
    • (2014) World Journal of Gastroenterology: WJG , vol.20 , pp. 1724-1745
    • Ballestri, S.1    Lonardo, A.2    Bonapace, S.3
  • 6
    • 84888063646 scopus 로고    scopus 로고
    • The role of medications for the management of patients with NAFLD
    • Mazzella N., Ricciardi L.M., Mazzotti A., et al. The role of medications for the management of patients with NAFLD. Clinics in Liver Disease 2014, 18:73-89.
    • (2014) Clinics in Liver Disease , vol.18 , pp. 73-89
    • Mazzella, N.1    Ricciardi, L.M.2    Mazzotti, A.3
  • 7
    • 78549288940 scopus 로고    scopus 로고
    • Repeat dose study of the cancer chemopreventive agent resveratrol in healthy volunteers: safety, pharmacokinetics, and effect on the insulin-like growth factor axis
    • Brown V.A., Patel K.R., Viskaduraki M., et al. Repeat dose study of the cancer chemopreventive agent resveratrol in healthy volunteers: safety, pharmacokinetics, and effect on the insulin-like growth factor axis. Cancer Research 2010, 70:9003-9011.
    • (2010) Cancer Research , vol.70 , pp. 9003-9011
    • Brown, V.A.1    Patel, K.R.2    Viskaduraki, M.3
  • 8
    • 78649436142 scopus 로고    scopus 로고
    • Dose-dependency of resveratrol in providing health benefits
    • Mukherjee S., Dudley J.I., Das D.K. Dose-dependency of resveratrol in providing health benefits. Dose-Response 2010, 8:478-500.
    • (2010) Dose-Response , vol.8 , pp. 478-500
    • Mukherjee, S.1    Dudley, J.I.2    Das, D.K.3
  • 9
    • 84855974972 scopus 로고    scopus 로고
    • Resveratrol attenuates steatosis in obese Zucker rats by decreasing fatty acid availability and reducing oxidative stress
    • Gomez-Zorita S., Fernandez-Quintela A., Macarulla M.T., et al. Resveratrol attenuates steatosis in obese Zucker rats by decreasing fatty acid availability and reducing oxidative stress. British Journal of Nutrition 2012, 107:202-210.
    • (2012) British Journal of Nutrition , vol.107 , pp. 202-210
    • Gomez-Zorita, S.1    Fernandez-Quintela, A.2    Macarulla, M.T.3
  • 10
    • 44849131936 scopus 로고    scopus 로고
    • Resveratrol improves non-alcoholic fatty liver disease by activating AMP-activated protein kinase
    • Shang J., Chen L.L., Xiao F.X., et al. Resveratrol improves non-alcoholic fatty liver disease by activating AMP-activated protein kinase. Acta Pharmacologica Sinica 2008, 29:698-706.
    • (2008) Acta Pharmacologica Sinica , vol.29 , pp. 698-706
    • Shang, J.1    Chen, L.L.2    Xiao, F.X.3
  • 11
    • 84874586560 scopus 로고    scopus 로고
    • Creation of resveratrol-enriched rice for the treatment of metabolic syndrome and related diseases
    • Baek S.H., Shin W.C., Ryu H.S., et al. Creation of resveratrol-enriched rice for the treatment of metabolic syndrome and related diseases. PLOS ONE 2013, 8:1-10.
    • (2013) PLOS ONE , vol.8 , pp. 1-10
    • Baek, S.H.1    Shin, W.C.2    Ryu, H.S.3
  • 12
  • 13
    • 79551601710 scopus 로고    scopus 로고
    • Resveratrol improves oxidative stress and protects against diabetic nephropathy through normalization of Mn-SOD dysfunction in AMPK/SIRT1-independent pathway
    • Kitada M., Kume S., Imaizumi N., et al. Resveratrol improves oxidative stress and protects against diabetic nephropathy through normalization of Mn-SOD dysfunction in AMPK/SIRT1-independent pathway. Diabetes 2011, 60:634-643.
    • (2011) Diabetes , vol.60 , pp. 634-643
    • Kitada, M.1    Kume, S.2    Imaizumi, N.3
  • 14
    • 84902211288 scopus 로고    scopus 로고
    • Calorie restriction-induced changes in the secretome of human adipocytes, comparison with resveratrol-induced secretome effects
    • Renes J., Rosenow A., Roumans N., et al. Calorie restriction-induced changes in the secretome of human adipocytes, comparison with resveratrol-induced secretome effects. Biochimica et Biophysica Acta 2014, 1844:1511-1522.
    • (2014) Biochimica et Biophysica Acta , vol.1844 , pp. 1511-1522
    • Renes, J.1    Rosenow, A.2    Roumans, N.3
  • 15
    • 80455143206 scopus 로고    scopus 로고
    • Calorie restriction-like effects of 30 days of resveratrol supplementation on energy metabolism and metabolic profile in obese humans
    • Timmers S., Konings E., Bilet L., et al. Calorie restriction-like effects of 30 days of resveratrol supplementation on energy metabolism and metabolic profile in obese humans. Cell Metabolism 2011, 14:612-622.
    • (2011) Cell Metabolism , vol.14 , pp. 612-622
    • Timmers, S.1    Konings, E.2    Bilet, L.3
  • 16
    • 80052910300 scopus 로고    scopus 로고
    • Resveratrol improves insulin sensitivity, reduces oxidative stress and activates the Akt pathway in type 2 diabetic patients
    • Brasnyo P., Molnar G.A., Mohas M., et al. Resveratrol improves insulin sensitivity, reduces oxidative stress and activates the Akt pathway in type 2 diabetic patients. British Journal of Nutrition 2011, 106:383-389.
    • (2011) British Journal of Nutrition , vol.106 , pp. 383-389
    • Brasnyo, P.1    Molnar, G.A.2    Mohas, M.3
  • 17
    • 84901659368 scopus 로고    scopus 로고
    • Effect of resveratrol on glucose control and insulin sensitivity: a meta-analysis of 11 randomized controlled trials
    • Liu K., Zhou R., Wang B., et al. Effect of resveratrol on glucose control and insulin sensitivity: a meta-analysis of 11 randomized controlled trials. American Journal of Clinical Nutrition 2014.
    • (2014) American Journal of Clinical Nutrition
    • Liu, K.1    Zhou, R.2    Wang, B.3
  • 18
    • 79955611314 scopus 로고    scopus 로고
    • Resveratrol exerts anti-obesity effects via mechanisms involving down-regulation of adipogenic and inflammatory processes in mice
    • Kim S., Jin Y., Choi Y., et al. Resveratrol exerts anti-obesity effects via mechanisms involving down-regulation of adipogenic and inflammatory processes in mice. Biochemical Pharmacology 2011, 81:1343-1351.
    • (2011) Biochemical Pharmacology , vol.81 , pp. 1343-1351
    • Kim, S.1    Jin, Y.2    Choi, Y.3
  • 19
    • 84871445402 scopus 로고    scopus 로고
    • Resveratrol supplementation does not improve metabolic function in nonobese women with normal glucose tolerance
    • Yoshino J., Conte C., Fontana L., et al. Resveratrol supplementation does not improve metabolic function in nonobese women with normal glucose tolerance. Cell Metabolism 2012, 16:658-664.
    • (2012) Cell Metabolism , vol.16 , pp. 658-664
    • Yoshino, J.1    Conte, C.2    Fontana, L.3
  • 20
    • 84875431034 scopus 로고    scopus 로고
    • High-dose resveratrol supplementation in obese men: an investigator-initiated, randomized, placebo-controlled clinical trial of substrate metabolism, insulin sensitivity, and body composition
    • Poulsen M.M., Vestergaard P.F., Clasen B.F., et al. High-dose resveratrol supplementation in obese men: an investigator-initiated, randomized, placebo-controlled clinical trial of substrate metabolism, insulin sensitivity, and body composition. Diabetes 2013, 62:1186-1195.
    • (2013) Diabetes , vol.62 , pp. 1186-1195
    • Poulsen, M.M.1    Vestergaard, P.F.2    Clasen, B.F.3
  • 22
    • 40449086665 scopus 로고    scopus 로고
    • Dose translation from animal to human studies revisited
    • Reagan-Shaw S., Nihal M., Ahmad N. Dose translation from animal to human studies revisited. FASEB Journal 2008, 22:659-661.
    • (2008) FASEB Journal , vol.22 , pp. 659-661
    • Reagan-Shaw, S.1    Nihal, M.2    Ahmad, N.3
  • 23
    • 84897584579 scopus 로고    scopus 로고
    • The role of lifestyle change in the prevention and treatment of NAFLD
    • Centis E., Marzocchi R., Suppini A., et al. The role of lifestyle change in the prevention and treatment of NAFLD. Current Pharmaceutical Design 2013, 19:5270-5279.
    • (2013) Current Pharmaceutical Design , vol.19 , pp. 5270-5279
    • Centis, E.1    Marzocchi, R.2    Suppini, A.3
  • 24
    • 84884563517 scopus 로고    scopus 로고
    • Ultrasound evaluation and correlates of fatty liver disease: a population study in a Mediterranean area
    • Chiloiro M., Caruso M.G., Cisternino A.M., et al. Ultrasound evaluation and correlates of fatty liver disease: a population study in a Mediterranean area. Metabolic Syndrome and Related Disorders 2013, 11:349-358.
    • (2013) Metabolic Syndrome and Related Disorders , vol.11 , pp. 349-358
    • Chiloiro, M.1    Caruso, M.G.2    Cisternino, A.M.3
  • 25
    • 84867574518 scopus 로고    scopus 로고
    • Regular coffee but not espresso drinking is protective against fibrosis in a cohort mainly composed of morbidly obese European women with NAFLD undergoing bariatric surgery
    • Anty R., Marjoux S., Iannelli A., et al. Regular coffee but not espresso drinking is protective against fibrosis in a cohort mainly composed of morbidly obese European women with NAFLD undergoing bariatric surgery. Journal of Hepatology 2012, 57:1090-1096.
    • (2012) Journal of Hepatology , vol.57 , pp. 1090-1096
    • Anty, R.1    Marjoux, S.2    Iannelli, A.3
  • 26
    • 33644547706 scopus 로고    scopus 로고
    • Non-alcoholic fatty liver disease: from steatosis to cirrhosis
    • Farrell G.C., Larter C.Z. Non-alcoholic fatty liver disease: from steatosis to cirrhosis. Hepatology 2006, 43:S99-S112.
    • (2006) Hepatology , vol.43 , pp. S99-S112
    • Farrell, G.C.1    Larter, C.Z.2
  • 27
    • 84883556330 scopus 로고    scopus 로고
    • Short-term multidisciplinary non-pharmacological intervention is effective in reducing liver fat content assessed non-invasively in patients with non-alcoholic fatty liver disease (NAFLD)
    • Scaglioni F., Marino M., Ciccia S., et al. Short-term multidisciplinary non-pharmacological intervention is effective in reducing liver fat content assessed non-invasively in patients with non-alcoholic fatty liver disease (NAFLD). Clinics and Research in Hepatology and Gastroenterology 2013, 37:353-358.
    • (2013) Clinics and Research in Hepatology and Gastroenterology , vol.37 , pp. 353-358
    • Scaglioni, F.1    Marino, M.2    Ciccia, S.3
  • 29
    • 34247604581 scopus 로고    scopus 로고
    • TNF-alpha induces hepatic steatosis in mice by enhancing gene expression of sterol regulatory element binding protein-1c (SREBP-1c)
    • Endo M., Masaki T., Seike M., et al. TNF-alpha induces hepatic steatosis in mice by enhancing gene expression of sterol regulatory element binding protein-1c (SREBP-1c). Experimental Biology and Medicine 2007, 232:614-621.
    • (2007) Experimental Biology and Medicine , vol.232 , pp. 614-621
    • Endo, M.1    Masaki, T.2    Seike, M.3
  • 30
    • 40749092464 scopus 로고    scopus 로고
    • Influence of insulin resistance and adipokines in the grade of steatosis of non-alcoholic fatty liver disease
    • Aller R., Luis D.A., Fernandez L., et al. Influence of insulin resistance and adipokines in the grade of steatosis of non-alcoholic fatty liver disease. Digestive Diseases and Sciences 2008, 53:1088-1092.
    • (2008) Digestive Diseases and Sciences , vol.53 , pp. 1088-1092
    • Aller, R.1    Luis, D.A.2    Fernandez, L.3
  • 31
    • 0842269790 scopus 로고    scopus 로고
    • Adiponectin, an adipocyte-derived protein, predicts future insulin resistance: two-year follow-up study in Japanese population
    • Yamamoto Y., Hirose H., Saito I., et al. Adiponectin, an adipocyte-derived protein, predicts future insulin resistance: two-year follow-up study in Japanese population. Journal of Clinical Endocrinology and Metabolism 2004, 89:87-90.
    • (2004) Journal of Clinical Endocrinology and Metabolism , vol.89 , pp. 87-90
    • Yamamoto, Y.1    Hirose, H.2    Saito, I.3
  • 32
    • 79955634116 scopus 로고    scopus 로고
    • Resveratrol protects diabetic kidney by attenuating hyperglycemia-mediated oxidative stress and renal inflammatory cytokines via Nrf2-Keap1 signaling
    • Palsamy P., Subramanian S. Resveratrol protects diabetic kidney by attenuating hyperglycemia-mediated oxidative stress and renal inflammatory cytokines via Nrf2-Keap1 signaling. Biochimica et Biophysica Acta - Molecular Basis of Disease 2011, 1812:719-731.
    • (2011) Biochimica et Biophysica Acta - Molecular Basis of Disease , vol.1812 , pp. 719-731
    • Palsamy, P.1    Subramanian, S.2
  • 33
    • 33745904468 scopus 로고    scopus 로고
    • In vivo assessment of liver cell apoptosis as a novel biomarker of disease severity in non-alcoholic fatty liver disease
    • Wieckowska A., Zein N.N., Yerian L.M., et al. In vivo assessment of liver cell apoptosis as a novel biomarker of disease severity in non-alcoholic fatty liver disease. Hepatology 2006, 44:27-33.
    • (2006) Hepatology , vol.44 , pp. 27-33
    • Wieckowska, A.1    Zein, N.N.2    Yerian, L.M.3
  • 34
    • 42949086433 scopus 로고    scopus 로고
    • Cellular and molecular mechanisms of liver injury
    • Malhi H., Gores G.J. Cellular and molecular mechanisms of liver injury. Gastroenterology 2008, 134:1641-1654.
    • (2008) Gastroenterology , vol.134 , pp. 1641-1654
    • Malhi, H.1    Gores, G.J.2
  • 35
    • 70350046669 scopus 로고    scopus 로고
    • Cytokeratin-18 fragment levels as noninvasive biomarkers for non-alcoholic steatohepatitis: a multicenter validation study
    • Feldstein A.E., Wieckowska A., Lopez A.R., et al. Cytokeratin-18 fragment levels as noninvasive biomarkers for non-alcoholic steatohepatitis: a multicenter validation study. Hepatology 2009, 50:1072-1078.
    • (2009) Hepatology , vol.50 , pp. 1072-1078
    • Feldstein, A.E.1    Wieckowska, A.2    Lopez, A.R.3
  • 36
    • 0034697846 scopus 로고    scopus 로고
    • Identification of a novel FGF,FGF-21, preferentially expressed in the liver
    • Nishimura T., Nakatake Y., Konishi M., et al. Identification of a novel FGF,FGF-21, preferentially expressed in the liver. Biochimica et Biophysica Acta 2000, 1492:203-206.
    • (2000) Biochimica et Biophysica Acta , vol.1492 , pp. 203-206
    • Nishimura, T.1    Nakatake, Y.2    Konishi, M.3
  • 37
    • 66549097241 scopus 로고    scopus 로고
    • Fibroblast growth factor 21: a novel metabolic regulator with potential therapeutic properties in obesity/type 2 diabetes mellitus
    • Dostálová I., Haluzíková D., Haluzík M. Fibroblast growth factor 21: a novel metabolic regulator with potential therapeutic properties in obesity/type 2 diabetes mellitus. Physiological Research 2009, 58:1-7.
    • (2009) Physiological Research , vol.58 , pp. 1-7
    • Dostálová, I.1    Haluzíková, D.2    Haluzík, M.3
  • 38
    • 84855473367 scopus 로고    scopus 로고
    • High plasma level of fibroblast growth factor 21 is an independent predictor of type 2 diabetes a 5.4-year population-based prospective study in Chinese subjects
    • Chen C., Cheung B.M.Y., Tso A.W.K., et al. High plasma level of fibroblast growth factor 21 is an independent predictor of type 2 diabetes a 5.4-year population-based prospective study in Chinese subjects. Diabetes Care 2011, 34:2113-2115.
    • (2011) Diabetes Care , vol.34 , pp. 2113-2115
    • Chen, C.1    Cheung, B.M.Y.2    Tso, A.W.K.3
  • 39
    • 77955474305 scopus 로고    scopus 로고
    • Increased fibroblast growth factor 21 in obesity and non-alcoholic fatty liver disease
    • Dushay J., Chui P.C., Gopalakrishnan G.S., et al. Increased fibroblast growth factor 21 in obesity and non-alcoholic fatty liver disease. Gastroenterology 2010, 139:456-463.
    • (2010) Gastroenterology , vol.139 , pp. 456-463
    • Dushay, J.1    Chui, P.C.2    Gopalakrishnan, G.S.3
  • 40
    • 0030047836 scopus 로고    scopus 로고
    • Sonographic diagnosis of fatty liver using a histogram technique that compares liver and renal cortical echo amplitudes
    • Osawa H., Mori Y. Sonographic diagnosis of fatty liver using a histogram technique that compares liver and renal cortical echo amplitudes. Journal of Clinical Ultrasound: JCU 1996, 24:25-29.
    • (1996) Journal of Clinical Ultrasound: JCU , vol.24 , pp. 25-29
    • Osawa, H.1    Mori, Y.2
  • 41
    • 80052012241 scopus 로고    scopus 로고
    • Diagnostic accuracy and reliability of ultrasonography for the detection of fatty liver: a meta-analysis
    • Hernaez R., Lazo M., Bonekamp S., et al. Diagnostic accuracy and reliability of ultrasonography for the detection of fatty liver: a meta-analysis. Hepatology 2011, 54:1082-1090.
    • (2011) Hepatology , vol.54 , pp. 1082-1090
    • Hernaez, R.1    Lazo, M.2    Bonekamp, S.3


* 이 정보는 Elsevier사의 SCOPUS DB에서 KISTI가 분석하여 추출한 것입니다.