Markers of cardiovascular risk are not changed by increased whole-grain intake: The WHOLEheart study, a randomised, controlled dietary intervention

British Journal of Nutrition

Volumn 104, Issue 1, 2010, Pages 125-134

  Brownlee, Iain A ^a   Moore, Carmel ^b   Chatfield, Mark ^b   Richardson, David P ^c   Ashby, Peter ^d   Kuznesof, Sharron A ^a   Jebb, Susan A ^b   Seal, Chris J ^a  

^a NEWCASTLE UNIVERSITY   (United Kingdom)

^b MRC HUMAN NUTRITION RESEARCH   (United Kingdom)

^c DPR Nutrition Limited   (United Kingdom)

^d Cereal Partners Worldwide   (United Kingdom)

Author keywords

CVD risk; Dietary intervention; LDL cholesterol; Wholegrain foods

Indexed keywords

GLUCOSE; INSULIN; LIPID; BIOLOGICAL MARKER;

ADULT; AGED; ARTICLE; BODY FAT; BODY MASS; CARDIOVASCULAR RISK; CLINICAL TRIAL; CONTROLLED CLINICAL TRIAL; CONTROLLED STUDY; DIET RESTRICTION; DIETARY INTAKE; DISEASE MARKER; FEMALE; FOOD INTAKE; GLUCOSE BLOOD LEVEL; GRAIN; HEMOSTASIS; HUMAN; HUMAN EXPERIMENT; INFLAMMATION; INSULIN BLOOD LEVEL; INSULIN SENSITIVITY; INTERVENTION STUDY; LIFESTYLE MODIFICATION; LIPID BLOOD LEVEL; MALE; NORMAL HUMAN; PARALLEL DESIGN; PUBLIC HEALTH; RANDOMIZED CONTROLLED TRIAL; WAIST CIRCUMFERENCE; ADIPOSE TISSUE; ADOLESCENT; BLOOD; BLOOD CLOTTING; CARDIOVASCULAR DISEASE; CEREAL; DIET; FEEDING BEHAVIOR; FOOD HANDLING; MIDDLE AGED; PHYSIOLOGY; RISK FACTOR; STATISTICAL MODEL; TIME; VASCULAR ENDOTHELIUM;

ADIPOSE TISSUE; ADOLESCENT; ADULT; AGED; BIOLOGICAL MARKERS; BLOOD COAGULATION; BLOOD GLUCOSE; BODY MASS INDEX; CARDIOVASCULAR DISEASES; CEREALS; DIET; ENDOTHELIUM, VASCULAR; FEMALE; FOOD HABITS; FOOD HANDLING; HUMANS; INFLAMMATION; INSULIN; LIPIDS; MALE; MIDDLE AGED; MODELS, STATISTICAL; RISK FACTORS; TIME FACTORS; WAIST CIRCUMFERENCE; YOUNG ADULT;

EID: 77954687438     PISSN: 00071145     EISSN: 14752662     Source Type: Journal    
DOI: 10.1017/S0007114510000644     Document Type: Article

References (45)

1. Anderson JW (2003) Whole grains protect against atherosclerotic cardiovascular disease. Proc Nutr Soc 62, 135-142.
2. Jacobs DR, Meyer KA, Kushi LH, et al. (1998) Whole-grain intake may reduce the risk of ischemic heart disease death in postmenopausal women: the Iowa Women's Health Study. Am J Clin Nutr 68, 248-257.
3. Liu SM, Stampfer MJ, Hu FB, et al. (1999) Whole-grain consumption and risk of coronary heart disease: results from the Nurses' Health Study. Am J Clin Nutr 70, 412-419.
4. Liu SM, Manson JE, Stampfer MJ, et al. (2000) Whole grain consumption and risk of ischemic stroke in women-a prospective study. JAMA 284, 1534-1540.
5. McKeown NM, Jacques P & Mayer J (2001) Whole grain intake and risk of ischemic stroke in women. Nutr Rev 59, 149-152.
6. Ajani UA, Ford ES & Mokdad AH (2004) Dietary fiber and C-reactive protein: findings from National Health and Nutrition Examination Survey Data. J Nutr 134, 1181-1185.
7. Pereira MA, Jacobs DR, Kushi LH, et al. (1998) Whole grain consumption, body weight, fat distribution, and insulin in a bi-racial cohort of young adults: The CARDIA Study. Circulation 97, 18.
8. McKeown NM, Meigs JB, Liu SM, et al. (2002) Whole-grain intake is favorably associated with metabolic risk factors for type 2 diabetes and cardiovascular disease in the Framingham Offspring Study. Am J Clin Nutr 76, 390-398.
9. Food and Drink Administration (2005) Health Claim Notification for Whole Grain Foods with Moderate Fat Content. http://www.cfsan.fda.gov/,dms/flgrain2. html
10. Food Standards Agency (2005) Eat well, be well. Helping you make healthier choices. http://www.eatwell.gov.uk/
11. Swedish Nutrition Foundation (2003) New Generic Health Claim. http://www.snf.ideon.se/snf/en/rh/Wholegrain.htm
12. Truswell AS (2002) Cereal grains and coronary heart disease. Eur J Clin Nutr 56, 1-14.
13. Pereira MA, Jacobs DR, Pins JJ, et al. (2002) Effect of whole grains on insulin sensitivity in overweight hyperinsulinemic adults. Am J Clin Nutr 75, 848-855.
14. Andersson A, Tengblad S, Karlstrom B, et al. (2007) Whole-grain foods do not affect insulin sensitivity or markers of lipid peroxidation and inflammation in healthy, moderately overweight subjects. J Nutr 137, 1401-1407.
15. Behall KM, Scholfield DJ & Hallfrisch J (2006) Whole-grain diets reduce blood pressure in mildly hypercholesterolemic men and women. J Am Diet Assoc 106, 1445-1449.
16. Katcher HI, Legro RS, Kunselman AR, et al. (2008) The effects of a whole grain-enriched hypocaloric diet on cardiovascular disease risk factors in men and women with metabolic syndrome. Am J Clin Nutr 87, 79-90.
17. Kelly SAM, Summerbell CD & Brynes A, et al. (2007) Wholegrain cereals for coronary heart disease. The Cochrane Database of Systematic Reviews 2007, issue 2, CD005051. http://www.mrw.interscience.wiley.com/cochrane/clsysrev/ articles/ CD005051/frame.html
18. Life Sciences Research Office(2008) Whole Grain Intake and Cardiovascular Disease and Whole Grain Intake and Diabetes: A Review. Bethesda, MD: Life Sciences Research Office.
19. Lang R, Thane CW, Bolton-Smith C, et al. (2003) Consumption of whole-grain foods by British adults: findings from further analysis of two national dietary surveys. Public Health Nutr 6, 479-484.
20. Zanchetti A (2003) 2003 European Society of Hypertension-European Society of Cardiology guidelines for the management of arterial hypertension. J Hypertens 21, 1011-1053.
21. Thane CW, Jones AR, Stephen AM, et al. (2007) Comparative whole-grain intake of British adults in 1986-7 and 2000-1. Br J Nutr 97, 987-992.
22. Jebb SA, Cole TJ, Doman D, et al. (2000) Evaluation of the novel Tanita body-fat analyser to measure body composition by comparison with a four-compartment model. Br J Nutr 83, 115-122.
23. Brady LM, Gower BA, Lovegrove SS, et al. (2004) Revised QUICKI provides a strong surrogate estimate of insulin sensitivity when compared with the minimal model. Int J Obes 28, 222-227.
24. Cicero AFG, Nascetti S, Lopez-Sabater MC, et al. (2008) Changes in LDL fatty acid composition as a response to olive oil treatment are inversely related to lipid oxidative damage: The EUROLIVE study. J Am Coll Nutr 27, 314-320.
25. Madsen MB, Jensen AM & Schmidt EB (2007) The effect of a combination of plant sterol-enriched foods in mildly hyper-cholesterolemic subjects. Clin Nutr 26, 792-798.
26. Jenkins DJA, Kendall CWC, Marchie A, et al. (2005) Direct comparison of a dietary portfolio of cholesterol-lowering foods with a statin in hypercholesterolemic participants. Am J Clin Nutr 81, 380-387.
27. American Association of Cereal Chemists (2005) AACC Definition/Reports: AACC International defines whole grain. http://www.aaccnet.org/definitions/ wholegrain.asp
28. Foster-Powell K, Holt SHA & Brand-Miller JC (2002) International table of glycemic index and glycemic load values: 2002. Am J Clin Nutr 76, 5-56.
29. Jenkins DJA, Wesson V, Wolever TMS, et al. (1988) Wholemeal versus wholegrain breads-proportion of whole or cracked grain and the glycemic response. BMJ 297, 958-960.
30. Wesenberg JC, Carter K, Kadatz D, et al. (2000) Evaluation of Dade-Behring, Sigma and Randox homogeneous HDL cholesterol assays on the Dade-Behring Dimension RxL. Clin Chem 46, A94-A94.
31. Nandeesha H, Koner BC, Dorairajan LN, et al. (2006) Hyper-insulinemia and dyslipidemia in non-diabetic benign prostatic hyperplasia. Clin Chim Acta 370, 89-93.
32. w clinical chemistry system. Clin Chem 47, A57-A57.
33. Shimizu S, Tani Y, Yamada H, et al. (1980) Enzymatic determination of serum-free fatty-acids-a colorimetric method. Anal Biochem 107, 193-198.
34. Savoca R, Jaworek B & Huber AR (2006) New 'plasma referenced' POCT glucose monitoring systems-are they suitable for glucose monitoring and diagnosis of diabetes? Clin Chim Acta 372, 199-201.
35. Andersen L, Dinesen B, Jorgensen PN, et al. (1993) Enzyme-immunoassay for intact human insulin in serum or plasma. Clin Chem 39, 578-582.
36. Katz A, Nambi SS, Mather K, et al. (2000) Quantitative insulin sensitivity check index: a simple, accurate method for assessing insulin sensitivity in humans. J Clin Endocrinol Metab 85, 2402-2410.
37. Rabasa-Lhoret R, Bastard JP, Jan V, et al. (2003) Modified quantitative insulin sensitivity check index is better correlated to hyperinsulinemic glucose clamp than other fasting-based index of insulin sensitivity in different insulin-resistant states. J Clin Endocrinol Metab 88, 4917-4923.
38. Register TC, Burdon KP, Lenchik L, et al. (2004) Variability of serum soluble intercellular adhesion molecule-1 measurements attributable to a common polymorphism. Clin Chem 50, 2185-2187.
39. Garton KJ, Gough PJ, Philalay J, et al. (2003) Stimulated shedding of vascular cell adhesion molecule 1 (VCAM-1) is mediated by tumor necrosis factor-a-converting enzyme (ADAM 17). J Biol Chem 278, 37459-37464.
40. Ruchaud-Sparagano MH, Drost EM, Donnelly SC, et al. (1998) Potential pro-inflammatory effects of soluble E-selectin upon neutrophil function. Eur J Immunol 28, 80-89.
41. Webber D, Radcliffe CM, Royle L, et al. (2006) Sialylation of urinary prothrombin fragment 1 is implicated as a contributory factor in the risk of calcium oxalate kidney stone formation. FEBS J 273, 3024-3037.
42. Roberts WL, Moulton L, Law TC, et al. (2001) Evaluation of nine automated high-sensitivity C-reactive protein methods: implications for clinical and epidemiological applications. Part 2. Clin Chem 47, 418-425.
43. Wehlin L, Vedin J, Vaage J, et al. (2004) Activation of complement and leukocyte receptors during on-and off pump coronary artery bypass surgery. Eur J Cardiothorac Surg 25, 35-42.
44. Al-Barjas HS, Ariens R, Grant P, et al. (2006) Raised plasma fibrinogen concentration in patients with abdominal aortic aneurysm. Angiology 57, 607-614.
45. Pannekoek H, Veerman H, Lambers H, et al. (1986) Endothelial plasminogen-activator inhibitor (PAI)-a new member of the serpin gene family. EMBO J 5, 2539-2544.