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Volumn 2, Issue 1, 2014, Pages

Models of α-synuclein aggregation in Parkinson's disease

Author keywords

Animal models; Lewy body; Parkinson's disease; Rotenone; Smad3; synuclein

Indexed keywords

ALPHA SYNUCLEIN; DOPAMINE; GLUCOSYLCERAMIDASE; LRRK2 PROTEIN, HUMAN; PROTEIN AGGREGATE; PROTEIN SERINE THREONINE KINASE;

EID: 85043616983     PISSN: None     EISSN: 20515960     Source Type: Journal    
DOI: 10.1186/s40478-014-0176-9     Document Type: Article
Times cited : (93)

References (207)
  • 1
    • 84876058527 scopus 로고    scopus 로고
    • The history of Parkinson's disease: early clinical descriptions and neurological therapies
    • Goetz CG: The history of Parkinson's disease: early clinical descriptions and neurological therapies. Cold Spring Harb Perspect Med 2011, 1: a008862.
    • (2011) Cold Spring Harb Perspect Med , vol.1 , pp. a008862
    • Goetz, C.G.1
  • 2
    • 0006157767 scopus 로고
    • Paralysis agitans
    • Edited by: Lewandowsky M. Springer, City
    • Lewy FH: Paralysis agitans. In Pathologische anatomie. Edited by: Lewandowsky M. Springer, City; 1912:920-933.
    • (1912) Pathologische anatomie , pp. 920-933
    • Lewy, F.H.1
  • 3
    • 77950687692 scopus 로고    scopus 로고
    • Substantia nigra and Parkinson's disease: a brief history of their long and intimate relationship
    • Parent M, Parent A: Substantia nigra and Parkinson's disease: a brief history of their long and intimate relationship. Can J Neurol Sci 2010, 37: 313-319.
    • (2010) Can J Neurol Sci , vol.37 , pp. 313-319
    • Parent, M.1    Parent, A.2
  • 5
    • 34247631275 scopus 로고    scopus 로고
    • Multiple hit hypotheses for dopamine neuron loss in Parkinson's disease
    • Sulzer D: Multiple hit hypotheses for dopamine neuron loss in Parkinson's disease. Trends Neurosci 2007, 30: 244-250.
    • (2007) Trends Neurosci , vol.30 , pp. 244-250
    • Sulzer, D.1
  • 6
    • 64349083816 scopus 로고    scopus 로고
    • Non-motor symptoms of Parkinson's disease: dopaminergic pathophysiology and treatment
    • Chaudhuri KR, Schapira AH: Non-motor symptoms of Parkinson's disease: dopaminergic pathophysiology and treatment. Lancet Neurol 2009, 8: 464-474.
    • (2009) Lancet Neurol , vol.8 , pp. 464-474
    • Chaudhuri, K.R.1    Schapira, A.H.2
  • 7
    • 0036169364 scopus 로고    scopus 로고
    • The heterogeneity of idiopathic Parkinson's disease
    • Foltynie T, Brayne C, Barker RA: The heterogeneity of idiopathic Parkinson's disease. J Neurol 2002, 249: 138-145.
    • (2002) J Neurol , vol.249 , pp. 138-145
    • Foltynie, T.1    Brayne, C.2    Barker, R.A.3
  • 8
    • 0037337815 scopus 로고    scopus 로고
    • Neuronal loss is greater in the locus coeruleus than nucleus basalis and substantia nigra in Alzheimer and Parkinson diseases
    • Zarow C, Lyness SA, Mortimer JA, Chui HC: Neuronal loss is greater in the locus coeruleus than nucleus basalis and substantia nigra in Alzheimer and Parkinson diseases. Arch Neurol 2003, 60: 337-341.
    • (2003) Arch Neurol , vol.60 , pp. 337-341
    • Zarow, C.1    Lyness, S.A.2    Mortimer, J.A.3    Chui, H.C.4
  • 10
    • 53749089126 scopus 로고    scopus 로고
    • Loss of cholinergic neurons in the pedunculopontine nucleus in Parkinson's disease is related to disability of the patients
    • Rinne JO, Ma SY, Lee MS, Collan Y, Roytta M: Loss of cholinergic neurons in the pedunculopontine nucleus in Parkinson's disease is related to disability of the patients. Parkinsonism Relat Disord 2008, 14: 553-557.
    • (2008) Parkinsonism Relat Disord , vol.14 , pp. 553-557
    • Rinne, J.O.1    Ma, S.Y.2    Lee, M.S.3    Collan, Y.4    Roytta, M.5
  • 11
    • 34250897889 scopus 로고    scopus 로고
    • Hypocretin (orexin) cell loss in Parkinson's disease
    • Thannickal TC, Lai YY, Siegel JM: Hypocretin (orexin) cell loss in Parkinson's disease. Brain 2007, 130: 1586-1595.
    • (2007) Brain , vol.130 , pp. 1586-1595
    • Thannickal, T.C.1    Lai, Y.Y.2    Siegel, J.M.3
  • 13
    • 0029981526 scopus 로고    scopus 로고
    • Neuropathology of Parkinson's disease
    • Forno LS: Neuropathology of Parkinson's disease. J Neuropathol Exp Neurol 1996, 55: 259-272.
    • (1996) J Neuropathol Exp Neurol , vol.55 , pp. 259-272
    • Forno, L.S.1
  • 14
    • 0343527226 scopus 로고    scopus 로고
    • alpha-Synuclein immunoreactivity in dementia with Lewy bodies: morphological staging and comparison with ubiquitin immunostaining
    • Gomez-Tortosa E, Newell K, Irizarry MC, Sanders JL, Hyman BT: alpha-Synuclein immunoreactivity in dementia with Lewy bodies: morphological staging and comparison with ubiquitin immunostaining. Acta Neuropathol 2000, 99: 352-357.
    • (2000) Acta Neuropathol , vol.99 , pp. 352-357
    • Gomez-Tortosa, E.1    Newell, K.2    Irizarry, M.C.3    Sanders, J.L.4    Hyman, B.T.5
  • 15
    • 0141725659 scopus 로고    scopus 로고
    • Neuropathological spectrum of synucleinopathies
    • Jellinger KA: Neuropathological spectrum of synucleinopathies. Mov Disord 2003, 18(Suppl 6):S2-S12.
    • (2003) Mov Disord , vol.18 , pp. S2-S12
    • Jellinger, K.A.1
  • 16
    • 0036434291 scopus 로고    scopus 로고
    • Heterogeneity of nigral and cortical Lewy bodies differentiated by amplified triple-labeling for alpha-synuclein, ubiquitin, and thiazin red
    • Sakamoto M, Uchihara T, Hayashi M, Nakamura A, Kikuchi E, Mizutani T, Mizusawa H, Hirai S: Heterogeneity of nigral and cortical Lewy bodies differentiated by amplified triple-labeling for alpha-synuclein, ubiquitin, and thiazin red. Exp Neurol 2002, 177: 88-94.
    • (2002) Exp Neurol , vol.177 , pp. 88-94
    • Sakamoto, M.1    Uchihara, T.2    Hayashi, M.3    Nakamura, A.4    Kikuchi, E.5    Mizutani, T.6    Mizusawa, H.7    Hirai, S.8
  • 17
    • 83555166040 scopus 로고    scopus 로고
    • Pale neurites, premature alpha-synuclein aggregates with centripetal extension from axon collaterals
    • Kanazawa T, Adachi E, Orimo S, Nakamura A, Mizusawa H, Uchihara T: Pale neurites, premature alpha-synuclein aggregates with centripetal extension from axon collaterals. Brain Pathol 2012, 22: 67-78.
    • (2012) Brain Pathol , vol.22 , pp. 67-78
    • Kanazawa, T.1    Adachi, E.2    Orimo, S.3    Nakamura, A.4    Mizusawa, H.5    Uchihara, T.6
  • 18
    • 17644426350 scopus 로고    scopus 로고
    • Role of oxidative damage in protein aggregation associated with Parkinson's disease and related disorders
    • Norris EH, Giasson BI: Role of oxidative damage in protein aggregation associated with Parkinson's disease and related disorders. Antioxid Redox Signal 2005, 7: 672-684.
    • (2005) Antioxid Redox Signal , vol.7 , pp. 672-684
    • Norris, E.H.1    Giasson, B.I.2
  • 20
    • 0344808098 scopus 로고    scopus 로고
    • Immunoelectron-microscopic demonstration of NACP/alpha-synuclein-epitopes on the filamentous component of Lewy bodies in Parkinson's disease and in dementia with Lewy bodies
    • Arima K, Ueda K, Sunohara N, Hirai S, Izumiyama Y, Tonozuka-Uehara H, Kawai M: Immunoelectron-microscopic demonstration of NACP/alpha-synuclein-epitopes on the filamentous component of Lewy bodies in Parkinson's disease and in dementia with Lewy bodies. Brain Res 1998, 808: 93-100.
    • (1998) Brain Res , vol.808 , pp. 93-100
    • Arima, K.1    Ueda, K.2    Sunohara, N.3    Hirai, S.4    Izumiyama, Y.5    Tonozuka-Uehara, H.6    Kawai, M.7
  • 21
    • 0026563548 scopus 로고
    • Filaments of Lewy bodies contain insoluble cytoskeletal elements
    • Galloway PG, Mulvihill P, Perry G: Filaments of Lewy bodies contain insoluble cytoskeletal elements. Am J Pathol 1992, 140: 809-822.
    • (1992) Am J Pathol , vol.140 , pp. 809-822
    • Galloway, P.G.1    Mulvihill, P.2    Perry, G.3
  • 22
    • 44649167579 scopus 로고    scopus 로고
    • Three-layered structure shared between Lewy bodies and lewy neurites-three-dimensional reconstruction of triple-labeled sections
    • Kanazawa T, Uchihara T, Takahashi A, Nakamura A, Orimo S, Mizusawa H: Three-layered structure shared between Lewy bodies and lewy neurites-three-dimensional reconstruction of triple-labeled sections. Brain Pathol 2008, 18: 415-422.
    • (2008) Brain Pathol , vol.18 , pp. 415-422
    • Kanazawa, T.1    Uchihara, T.2    Takahashi, A.3    Nakamura, A.4    Orimo, S.5    Mizusawa, H.6
  • 24
    • 84878577036 scopus 로고    scopus 로고
    • alpha-Synuclein posttranslational modification and alternative splicing as a trigger for neurodegeneration
    • Beyer K, Ariza A: alpha-Synuclein posttranslational modification and alternative splicing as a trigger for neurodegeneration. Mol Neurobiol 2013, 47: 509-524.
    • (2013) Mol Neurobiol , vol.47 , pp. 509-524
    • Beyer, K.1    Ariza, A.2
  • 25
    • 77957283003 scopus 로고    scopus 로고
    • Leucine-rich repeat kinase 2 is associated with the endoplasmic reticulum in dopaminergic neurons and accumulates in the core of Lewy bodies in Parkinson disease
    • Vitte J, Traver S, Maues De Paula A, Lesage S, Rovelli G, Corti O, Duyckaerts C, Brice A: Leucine-rich repeat kinase 2 is associated with the endoplasmic reticulum in dopaminergic neurons and accumulates in the core of Lewy bodies in Parkinson disease. J Neuropathol Exp Neurol 2010, 69: 959-972.
    • (2010) J Neuropathol Exp Neurol , vol.69 , pp. 959-972
    • Vitte, J.1    Traver, S.2    Maues De Paula, A.3    Lesage, S.4    Rovelli, G.5    Corti, O.6    Duyckaerts, C.7    Brice, A.8
  • 26
    • 82055164435 scopus 로고    scopus 로고
    • Accumulation of histone deacetylase 6, an aggresome-related protein, is specific to Lewy bodies and glial cytoplasmic inclusions
    • Miki Y, Mori F, Tanji K, Kakita A, Takahashi H, Wakabayashi K: Accumulation of histone deacetylase 6, an aggresome-related protein, is specific to Lewy bodies and glial cytoplasmic inclusions. Neuropathology 2011, 31: 561-568.
    • (2011) Neuropathology , vol.31 , pp. 561-568
    • Miki, Y.1    Mori, F.2    Tanji, K.3    Kakita, A.4    Takahashi, H.5    Wakabayashi, K.6
  • 27
    • 84866491973 scopus 로고    scopus 로고
    • Endosomal sorting related protein CHMP2B is localized in Lewy bodies and glial cytoplasmic inclusions in alpha-synucleinopathy
    • Tanikawa S, Mori F, Tanji K, Kakita A, Takahashi H, Wakabayashi K: Endosomal sorting related protein CHMP2B is localized in Lewy bodies and glial cytoplasmic inclusions in alpha-synucleinopathy. Neurosci Lett 2012, 527: 16-21.
    • (2012) Neurosci Lett , vol.527 , pp. 16-21
    • Tanikawa, S.1    Mori, F.2    Tanji, K.3    Kakita, A.4    Takahashi, H.5    Wakabayashi, K.6
  • 30
    • 0346850964 scopus 로고    scopus 로고
    • Poor and protracted myelination as a contributory factor to neurodegenerative disorders
    • Braak H, Del Tredici K: Poor and protracted myelination as a contributory factor to neurodegenerative disorders. Neurobiol Aging 2004, 25: 19-23.
    • (2004) Neurobiol Aging , vol.25 , pp. 19-23
    • Braak, H.1    Del Tredici, K.2
  • 31
    • 70349123656 scopus 로고    scopus 로고
    • Neuroanatomy and pathology of sporadic Parkinson's disease
    • Springer, City
    • Braak H, del Tredici K: Neuroanatomy and pathology of sporadic Parkinson's disease. Springer, City; 2009.
    • (2009)
    • Braak, H.1    del Tredici, K.2
  • 33
    • 0034756740 scopus 로고    scopus 로고
    • Widespread occurrence of argyrophilic glial inclusions in Parkinson's disease
    • Hishikawa N, Hashizume Y, Yoshida M, Sobue G: Widespread occurrence of argyrophilic glial inclusions in Parkinson's disease. Neuropathol Appl Neurobiol 2001, 27: 362-372.
    • (2001) Neuropathol Appl Neurobiol , vol.27 , pp. 362-372
    • Hishikawa, N.1    Hashizume, Y.2    Yoshida, M.3    Sobue, G.4
  • 34
    • 34547727312 scopus 로고    scopus 로고
    • Development of alpha-synuclein immunoreactive astrocytes in the forebrain parallels stages of intraneuronal pathology in sporadic Parkinson's disease
    • Braak H, Sastre M, Del Tredici K: Development of alpha-synuclein immunoreactive astrocytes in the forebrain parallels stages of intraneuronal pathology in sporadic Parkinson's disease. Acta Neuropathol 2007, 114: 231-241.
    • (2007) Acta Neuropathol , vol.114 , pp. 231-241
    • Braak, H.1    Sastre, M.2    Del Tredici, K.3
  • 36
    • 57749095477 scopus 로고    scopus 로고
    • A critical evaluation of the Braak staging scheme for Parkinson's disease
    • Burke RE, Dauer WT, Vonsattel JP: A critical evaluation of the Braak staging scheme for Parkinson's disease. Ann Neurol 2008, 64: 485-491.
    • (2008) Ann Neurol , vol.64 , pp. 485-491
    • Burke, R.E.1    Dauer, W.T.2    Vonsattel, J.P.3
  • 37
    • 41149177434 scopus 로고    scopus 로고
    • The progression of pathology in longitudinally followed patients with Parkinson's disease
    • Halliday G, Hely M, Reid W, Morris J: The progression of pathology in longitudinally followed patients with Parkinson's disease. Acta Neuropathol 2008, 115: 409-415.
    • (2008) Acta Neuropathol , vol.115 , pp. 409-415
    • Halliday, G.1    Hely, M.2    Reid, W.3    Morris, J.4
  • 40
    • 33645116252 scopus 로고    scopus 로고
    • Genetics of Parkinson disease: paradigm shifts and future prospects
    • Farrer MJ: Genetics of Parkinson disease: paradigm shifts and future prospects. Nat Rev Genet 2006, 7: 306-318.
    • (2006) Nat Rev Genet , vol.7 , pp. 306-318
    • Farrer, M.J.1
  • 41
    • 42549125512 scopus 로고    scopus 로고
    • Review: Familial Parkinson's disease-genetics, clinical phenotype and neuropathology in relation to the common sporadic form of the disease
    • Schiesling C, Kieper N, Seidel K, Kruger R: Review: Familial Parkinson's disease-genetics, clinical phenotype and neuropathology in relation to the common sporadic form of the disease. Neuropathol Appl Neurobiol 2008, 34: 255-271.
    • (2008) Neuropathol Appl Neurobiol , vol.34 , pp. 255-271
    • Schiesling, C.1    Kieper, N.2    Seidel, K.3    Kruger, R.4
  • 42
    • 80054787664 scopus 로고    scopus 로고
    • What genetics tells us about the causes and mechanisms of Parkinson's disease
    • Corti O, Lesage S, Brice A: What genetics tells us about the causes and mechanisms of Parkinson's disease. Physiol Rev 2011, 91: 1161-1218.
    • (2011) Physiol Rev , vol.91 , pp. 1161-1218
    • Corti, O.1    Lesage, S.2    Brice, A.3
  • 54
    • 12744258045 scopus 로고    scopus 로고
    • Australian data and meta-analysis lend support for alpha-synuclein (NACP-Rep1) as a risk factor for Parkinson's disease
    • Mellick GD, Maraganore DM, Silburn PA: Australian data and meta-analysis lend support for alpha-synuclein (NACP-Rep1) as a risk factor for Parkinson's disease. Neurosci Lett 2005, 375: 112-116.
    • (2005) Neurosci Lett , vol.375 , pp. 112-116
    • Mellick, G.D.1    Maraganore, D.M.2    Silburn, P.A.3
  • 57
    • 84884250340 scopus 로고    scopus 로고
    • The function of alpha-synuclein
    • Bendor JT, Logan TP, Edwards RH: The function of alpha-synuclein. Neuron 2013, 79: 1044-1066.
    • (2013) Neuron , vol.79 , pp. 1044-1066
    • Bendor, J.T.1    Logan, T.P.2    Edwards, R.H.3
  • 58
    • 84873311048 scopus 로고    scopus 로고
    • Mapping the subcellular distribution of alpha-synuclein in neurons using genetically encoded probes for correlated light and electron microscopy: implications for Parkinson's disease pathogenesis
    • Boassa D, Berlanga ML, Yang MA, Terada M, Hu J, Bushong EA, Hwang M, Masliah E, George JM, Ellisman MH: Mapping the subcellular distribution of alpha-synuclein in neurons using genetically encoded probes for correlated light and electron microscopy: implications for Parkinson's disease pathogenesis. J Neurosci 2013, 33: 2605-2615.
    • (2013) J Neurosci , vol.33 , pp. 2605-2615
    • Boassa, D.1    Berlanga, M.L.2    Yang, M.A.3    Terada, M.4    Hu, J.5    Bushong, E.A.6    Hwang, M.7    Masliah, E.8    George, J.M.9    Ellisman, M.H.10
  • 59
    • 79960260042 scopus 로고    scopus 로고
    • Familial Parkinson disease mutations influence alpha-synuclein assembly
    • Ono K, Ikeda T, Takasaki J, Yamada M: Familial Parkinson disease mutations influence alpha-synuclein assembly. Neurobiol Dis 2011, 43: 715-724.
    • (2011) Neurobiol Dis , vol.43 , pp. 715-724
    • Ono, K.1    Ikeda, T.2    Takasaki, J.3    Yamada, M.4
  • 60
    • 0035097503 scopus 로고    scopus 로고
    • Clinical and pathological features of a Parkinsonian syndrome in a family with an Ala53Thr alpha-synuclein mutation
    • Spira PJ, Sharpe DM, Halliday G, Cavanagh J, Nicholson GA: Clinical and pathological features of a Parkinsonian syndrome in a family with an Ala53Thr alpha-synuclein mutation. Ann Neurol 2001, 49: 313-319.
    • (2001) Ann Neurol , vol.49 , pp. 313-319
    • Spira, P.J.1    Sharpe, D.M.2    Halliday, G.3    Cavanagh, J.4    Nicholson, G.A.5
  • 62
    • 0037118259 scopus 로고    scopus 로고
    • Neuronal alpha-synucleinopathy with severe movement disorder in mice expressing A53T human alpha-synuclein
    • Giasson BI, Duda JE, Quinn SM, Zhang B, Trojanowski JQ, Lee VM: Neuronal alpha-synucleinopathy with severe movement disorder in mice expressing A53T human alpha-synuclein. Neuron 2002, 34: 521-533.
    • (2002) Neuron , vol.34 , pp. 521-533
    • Giasson, B.I.1    Duda, J.E.2    Quinn, S.M.3    Zhang, B.4    Trojanowski, J.Q.5    Lee, V.M.6
  • 64
    • 0034069848 scopus 로고    scopus 로고
    • Distinctive neuropathology revealed by alpha-synuclein antibodies in hereditary parkinsonism and dementia linked to chromosome 4p
    • Gwinn-Hardy K, Mehta ND, Farrer M, Maraganore D, Muenter M, Yen SH, Hardy J, Dickson DW: Distinctive neuropathology revealed by alpha-synuclein antibodies in hereditary parkinsonism and dementia linked to chromosome 4p. Acta Neuropathol 2000, 99: 663-672.
    • (2000) Acta Neuropathol , vol.99 , pp. 663-672
    • Gwinn-Hardy, K.1    Mehta, N.D.2    Farrer, M.3    Maraganore, D.4    Muenter, M.5    Yen, S.H.6    Hardy, J.7    Dickson, D.W.8
  • 68
    • 42049122637 scopus 로고    scopus 로고
    • Comprehensive analysis of LRRK2 in publicly available Parkinson's disease cases and neurologically normal controls
    • Paisan-Ruiz C, Nath P, Washecka N, Gibbs JR, Singleton AB: Comprehensive analysis of LRRK2 in publicly available Parkinson's disease cases and neurologically normal controls. Hum Mutat 2008, 29: 485-490.
    • (2008) Hum Mutat , vol.29 , pp. 485-490
    • Paisan-Ruiz, C.1    Nath, P.2    Washecka, N.3    Gibbs, J.R.4    Singleton, A.B.5
  • 69
    • 77954622198 scopus 로고    scopus 로고
    • Genetics of Parkinson disease and essential tremor
    • Wider C, Ross OA, Wszolek ZK: Genetics of Parkinson disease and essential tremor. Curr Opin Neurol 2010, 23: 388-393.
    • (2010) Curr Opin Neurol , vol.23 , pp. 388-393
    • Wider, C.1    Ross, O.A.2    Wszolek, Z.K.3
  • 70
    • 67749118059 scopus 로고    scopus 로고
    • LRRK2 gene variation and its contribution to Parkinson disease
    • Paisan-Ruiz C: LRRK2 gene variation and its contribution to Parkinson disease. Hum Mutat 2009, 30: 1153-1160.
    • (2009) Hum Mutat , vol.30 , pp. 1153-1160
    • Paisan-Ruiz, C.1
  • 74
    • 84861595545 scopus 로고    scopus 로고
    • Disrupted autophagy leads to dopaminergic axon and dendrite degeneration and promotes presynaptic accumulation of alpha-synuclein and LRRK2 in the brain
    • Friedman LG, Lachenmayer ML, Wang J, He L, Poulose SM, Komatsu M, Holstein GR, Yue Z: Disrupted autophagy leads to dopaminergic axon and dendrite degeneration and promotes presynaptic accumulation of alpha-synuclein and LRRK2 in the brain. J Neurosci 2012, 32: 7585-7593.
    • (2012) J Neurosci , vol.32 , pp. 7585-7593
    • Friedman, L.G.1    Lachenmayer, M.L.2    Wang, J.3    He, L.4    Poulose, S.M.5    Komatsu, M.6    Holstein, G.R.7    Yue, Z.8
  • 75
    • 84879573207 scopus 로고    scopus 로고
    • Divergent alpha-synuclein solubility and aggregation properties in G2019S LRRK2 Parkinson's disease brains with Lewy Body pathology compared to idiopathic cases
    • Mamais A, Raja M, Manzoni C, Dihanich S, Lees A, Moore D, Lewis PA, Bandopadhyay R: Divergent alpha-synuclein solubility and aggregation properties in G2019S LRRK2 Parkinson's disease brains with Lewy Body pathology compared to idiopathic cases. Neurobiol Dis 2013, 58: 183-190.
    • (2013) Neurobiol Dis , vol.58 , pp. 183-190
    • Mamais, A.1    Raja, M.2    Manzoni, C.3    Dihanich, S.4    Lees, A.5    Moore, D.6    Lewis, P.A.7    Bandopadhyay, R.8
  • 78
    • 84891300736 scopus 로고    scopus 로고
    • Ubiquitination increases parkin activity to promote autophagic alpha-synuclein clearance
    • Lonskaya I, Desforges NM, Hebron ML, Moussa CE: Ubiquitination increases parkin activity to promote autophagic alpha-synuclein clearance. PLoS One 2013, 8: e83914.
    • (2013) PLoS One , vol.8
    • Lonskaya, I.1    Desforges, N.M.2    Hebron, M.L.3    Moussa, C.E.4
  • 79
  • 82
    • 80052028927 scopus 로고    scopus 로고
    • Exploring the link between glucocerebrosidase mutations and parkinsonism
    • Westbroek W, Gustafson AM, Sidransky E: Exploring the link between glucocerebrosidase mutations and parkinsonism. Trends Mol Med 2011, 17: 485-493.
    • (2011) Trends Mol Med , vol.17 , pp. 485-493
    • Westbroek, W.1    Gustafson, A.M.2    Sidransky, E.3
  • 85
    • 84966281067 scopus 로고    scopus 로고
    • How many ways an mouse behavioral experiments go wrong? Confounding variables in mouse models of neurodegenerative diseases and how to control them
    • Edited by: Brockmann HJ. Academic Press, Burlington
    • Schellinck HM, Cyr DP, Brown RE: How many ways an mouse behavioral experiments go wrong? Confounding variables in mouse models of neurodegenerative diseases and how to control them. In Advances in the Study of Behavior. Edited by: Brockmann HJ. Academic Press, Burlington; 2010:255-366.
    • (2010) Advances in the Study of Behavior , pp. 255-366
    • Schellinck, H.M.1    Cyr, D.P.2    Brown, R.E.3
  • 87
    • 0036328118 scopus 로고    scopus 로고
    • The validity of animal models of predisposition to depression
    • Willner P, Mitchell PJ: The validity of animal models of predisposition to depression. Behav Pharmacol 2002, 13: 169-188.
    • (2002) Behav Pharmacol , vol.13 , pp. 169-188
    • Willner, P.1    Mitchell, P.J.2
  • 88
    • 80052533576 scopus 로고    scopus 로고
    • Animal models of Parkinson's disease: a source of novel treatments and clues to the cause of the disease
    • Duty S, Jenner P: Animal models of Parkinson's disease: a source of novel treatments and clues to the cause of the disease. Br J Pharmacol 2011, 164: 1357-1391.
    • (2011) Br J Pharmacol , vol.164 , pp. 1357-1391
    • Duty, S.1    Jenner, P.2
  • 89
    • 46649111324 scopus 로고    scopus 로고
    • Animal models of Parkinson's disease and L-dopa induced dyskinesia: how close are we to the clinic?
    • Lane E, Dunnett S: Animal models of Parkinson's disease and L-dopa induced dyskinesia: how close are we to the clinic? Psychopharmacology (Berl) 2008, 199: 303-312.
    • (2008) Psychopharmacology (Berl) , vol.199 , pp. 303-312
    • Lane, E.1    Dunnett, S.2
  • 90
    • 34248524675 scopus 로고    scopus 로고
    • Why hasn't neuroprotection worked in Parkinson's disease?
    • Kieburtz K, Ravina B: Why hasn't neuroprotection worked in Parkinson's disease? Nat Clin Pract Neurol 2007, 3: 240-241.
    • (2007) Nat Clin Pract Neurol , vol.3 , pp. 240-241
    • Kieburtz, K.1    Ravina, B.2
  • 91
    • 84922266926 scopus 로고    scopus 로고
    • Augmentation of phenotype in a transgenic Parkinson mouse heterozygous for a Gaucher mutation
    • Fishbein I, Kuo YM, Giasson BI, Nussbaum RL: Augmentation of phenotype in a transgenic Parkinson mouse heterozygous for a Gaucher mutation. Brain 2014, 137: 3235-3247.
    • (2014) Brain , vol.137 , pp. 3235-3247
    • Fishbein, I.1    Kuo, Y.M.2    Giasson, B.I.3    Nussbaum, R.L.4
  • 94
    • 0037269421 scopus 로고    scopus 로고
    • The contribution of the MPTP-treated primate model to the development of new treatment strategies for Parkinson's disease
    • Jenner P: The contribution of the MPTP-treated primate model to the development of new treatment strategies for Parkinson's disease. Parkinsonism Relat Disord 2003, 9: 131-137.
    • (2003) Parkinsonism Relat Disord , vol.9 , pp. 131-137
    • Jenner, P.1
  • 95
    • 58349099832 scopus 로고    scopus 로고
    • Functional models of Parkinson's disease: a valuable tool in the development of novel therapies
    • Jenner P: Functional models of Parkinson's disease: a valuable tool in the development of novel therapies. Ann Neurol 2008, 64(Suppl 2):S16-S29.
    • (2008) Ann Neurol , vol.64 , pp. S16-S29
    • Jenner, P.1
  • 97
    • 84859699540 scopus 로고    scopus 로고
    • Animal models of the non-motor features of Parkinson's disease
    • McDowell K, Chesselet MF: Animal models of the non-motor features of Parkinson's disease. Neurobiol Dis 2012, 46: 597-606.
    • (2012) Neurobiol Dis , vol.46 , pp. 597-606
    • McDowell, K.1    Chesselet, M.F.2
  • 99
    • 0023932211 scopus 로고
    • Neurotoxic effects of 1-methyl-4-phenyl-1,2,3,6-tetrahydropyridine (MPTP) and methamphetamine in several strains of mice
    • Sonsalla PK, Heikkila RE: Neurotoxic effects of 1-methyl-4-phenyl-1,2,3,6-tetrahydropyridine (MPTP) and methamphetamine in several strains of mice. Prog Neuropsychopharmacol Biol Psychiatry 1988, 12: 345-354.
    • (1988) Prog Neuropsychopharmacol Biol Psychiatry , vol.12 , pp. 345-354
    • Sonsalla, P.K.1    Heikkila, R.E.2
  • 100
    • 0037159608 scopus 로고    scopus 로고
    • Lysosomal malfunction accompanies alpha-synuclein aggregation in a progressive mouse model of Parkinson's disease
    • Meredith GE, Totterdell S, Petroske E, Santa Cruz K, Callison RC Jr, Lau YS: Lysosomal malfunction accompanies alpha-synuclein aggregation in a progressive mouse model of Parkinson's disease. Brain Res 2002, 956: 156-165.
    • (2002) Brain Res , vol.956 , pp. 156-165
    • Meredith, G.E.1    Totterdell, S.2    Petroske, E.3    Santa Cruz, K.4    Callison, R.C.5    Lau, Y.S.6
  • 104
    • 65549105080 scopus 로고    scopus 로고
    • Differences between subacute and chronic MPTP mice models: investigation of dopaminergic neuronal degeneration and alpha-synuclein inclusions
    • Gibrat C, Saint-Pierre M, Bousquet M, Levesque D, Rouillard C, Cicchetti F: Differences between subacute and chronic MPTP mice models: investigation of dopaminergic neuronal degeneration and alpha-synuclein inclusions. J Neurochem 2009, 109: 1469-1482.
    • (2009) J Neurochem , vol.109 , pp. 1469-1482
    • Gibrat, C.1    Saint-Pierre, M.2    Bousquet, M.3    Levesque, D.4    Rouillard, C.5    Cicchetti, F.6
  • 107
    • 33745143950 scopus 로고    scopus 로고
    • Inhibitory effects of pesticides on proteasome activity: implication in Parkinson's disease
    • Wang XF, Li S, Chou AP, Bronstein JM: Inhibitory effects of pesticides on proteasome activity: implication in Parkinson's disease. Neurobiol Dis 2006, 23: 198-205.
    • (2006) Neurobiol Dis , vol.23 , pp. 198-205
    • Wang, X.F.1    Li, S.2    Chou, A.P.3    Bronstein, J.M.4
  • 109
    • 0037229425 scopus 로고    scopus 로고
    • Subcutaneous rotenone exposure causes highly selective dopaminergic degeneration and alpha-synuclein aggregation
    • Sherer TB, Kim JH, Betarbet R, Greenamyre JT: Subcutaneous rotenone exposure causes highly selective dopaminergic degeneration and alpha-synuclein aggregation. Exp Neurol 2003, 179: 9-16.
    • (2003) Exp Neurol , vol.179 , pp. 9-16
    • Sherer, T.B.1    Kim, J.H.2    Betarbet, R.3    Greenamyre, J.T.4
  • 110
    • 84877118559 scopus 로고    scopus 로고
    • Neonatal exposure to lipopolysaccharide enhances accumulation of alpha-synuclein aggregation and dopamine transporter protein expression in the substantia nigra in responses to rotenone challenge in later life
    • Tien LT, Kaizaki A, Pang Y, Cai Z, Bhatt AJ, Fan LW: Neonatal exposure to lipopolysaccharide enhances accumulation of alpha-synuclein aggregation and dopamine transporter protein expression in the substantia nigra in responses to rotenone challenge in later life. Toxicology 2013, 308: 96-103.
    • (2013) Toxicology , vol.308 , pp. 96-103
    • Tien, L.T.1    Kaizaki, A.2    Pang, Y.3    Cai, Z.4    Bhatt, A.J.5    Fan, L.W.6
  • 111
    • 85019505446 scopus 로고    scopus 로고
    • Biophysical Characterization of alpha-Synuclein and Rotenone Interaction
    • Silva BA, Einarsdottir O, Fink AL, Uversky VN: Biophysical Characterization of alpha-Synuclein and Rotenone Interaction. Biomolecules 2013, 3: 703-732.
    • (2013) Biomolecules , vol.3 , pp. 703-732
    • Silva, B.A.1    Einarsdottir, O.2    Fink, A.L.3    Uversky, V.N.4
  • 112
    • 0035816404 scopus 로고    scopus 로고
    • Pesticides directly accelerate the rate of alpha-synuclein fibril formation: a possible factor in Parkinson's disease
    • Uversky VN, Li J, Fink AL: Pesticides directly accelerate the rate of alpha-synuclein fibril formation: a possible factor in Parkinson's disease. FEBS Lett 2001, 500: 105-108.
    • (2001) FEBS Lett , vol.500 , pp. 105-108
    • Uversky, V.N.1    Li, J.2    Fink, A.L.3
  • 113
    • 69749124032 scopus 로고    scopus 로고
    • Chronic rotenone exposure reproduces Parkinson's disease gastrointestinal neuropathology
    • Drolet RE, Cannon JR, Montero L, Greenamyre JT: Chronic rotenone exposure reproduces Parkinson's disease gastrointestinal neuropathology. Neurobiol Dis 2009, 36: 96-102.
    • (2009) Neurobiol Dis , vol.36 , pp. 96-102
    • Drolet, R.E.1    Cannon, J.R.2    Montero, L.3    Greenamyre, J.T.4
  • 114
    • 79953709369 scopus 로고    scopus 로고
    • Characterisation of a novel model of Parkinson's disease by intra-striatal infusion of the pesticide rotenone
    • Mulcahy P, Walsh S, Paucard A, Rea K, Dowd E: Characterisation of a novel model of Parkinson's disease by intra-striatal infusion of the pesticide rotenone. Neuroscience 2011, 181: 234-242.
    • (2011) Neuroscience , vol.181 , pp. 234-242
    • Mulcahy, P.1    Walsh, S.2    Paucard, A.3    Rea, K.4    Dowd, E.5
  • 115
    • 69549084529 scopus 로고    scopus 로고
    • Environmental toxins and Parkinson's disease: what have we learned from pesticide-induced animal models?
    • Cicchetti F, Drouin-Ouellet J, Gross RE: Environmental toxins and Parkinson's disease: what have we learned from pesticide-induced animal models? Trends Pharmacol Sci 2009, 30: 475-483.
    • (2009) Trends Pharmacol Sci , vol.30 , pp. 475-483
    • Cicchetti, F.1    Drouin-Ouellet, J.2    Gross, R.E.3
  • 117
    • 37649004547 scopus 로고    scopus 로고
    • Cell systems and the toxic mechanism(s) of alpha-synuclein
    • Cookson MR, van der Brug M: Cell systems and the toxic mechanism(s) of alpha-synuclein. Exp Neurol 2008, 209: 5-11.
    • (2008) Exp Neurol , vol.209 , pp. 5-11
    • Cookson, M.R.1    van der Brug, M.2
  • 118
    • 3042794162 scopus 로고    scopus 로고
    • Systemic exposure to proteasome inhibitors causes a progressive model of Parkinson's disease
    • McNaught KS, Perl DP, Brownell AL, Olanow CW: Systemic exposure to proteasome inhibitors causes a progressive model of Parkinson's disease. Ann Neurol 2004, 56: 149-162.
    • (2004) Ann Neurol , vol.56 , pp. 149-162
    • McNaught, K.S.1    Perl, D.P.2    Brownell, A.L.3    Olanow, C.W.4
  • 120
    • 84873844495 scopus 로고    scopus 로고
    • Pale body-like inclusion formation and neurodegeneration following depletion of 26S proteasomes in mouse brain neurones are independent of alpha-synuclein
    • Paine SM, Anderson G, Bedford K, Lawler K, Mayer RJ, Lowe J, Bedford L: Pale body-like inclusion formation and neurodegeneration following depletion of 26S proteasomes in mouse brain neurones are independent of alpha-synuclein. PLoS One 2013, 8: e54711.
    • (2013) PLoS One , vol.8
    • Paine, S.M.1    Anderson, G.2    Bedford, K.3    Lawler, K.4    Mayer, R.J.5    Lowe, J.6    Bedford, L.7
  • 121
    • 68649108355 scopus 로고    scopus 로고
    • Mitochondrial dysfunction in the limelight of Parkinson's disease pathogenesis
    • Banerjee R, Starkov AA, Beal MF, Thomas B: Mitochondrial dysfunction in the limelight of Parkinson's disease pathogenesis. Biochim Biophys Acta 2009, 1792: 651-663.
    • (2009) Biochim Biophys Acta , vol.1792 , pp. 651-663
    • Banerjee, R.1    Starkov, A.A.2    Beal, M.F.3    Thomas, B.4
  • 123
    • 77957239234 scopus 로고    scopus 로고
    • Neurotoxic in vivo models of Parkinson's disease recent advances
    • Cannon JR, Greenamyre JT: Neurotoxic in vivo models of Parkinson's disease recent advances. Prog Brain Res 2010, 184: 17-33.
    • (2010) Prog Brain Res , vol.184 , pp. 17-33
    • Cannon, J.R.1    Greenamyre, J.T.2
  • 125
    • 77953666105 scopus 로고    scopus 로고
    • Genetic animal models of Parkinson's disease
    • Dawson TM, Ko HS, Dawson VL: Genetic animal models of Parkinson's disease. Neuron 2010, 66: 646-661.
    • (2010) Neuron , vol.66 , pp. 646-661
    • Dawson, T.M.1    Ko, H.S.2    Dawson, V.L.3
  • 127
    • 37549030985 scopus 로고    scopus 로고
    • In vivo alpha-synuclein overexpression in rodents: a useful model of Parkinson's disease?
    • Chesselet MF: In vivo alpha-synuclein overexpression in rodents: a useful model of Parkinson's disease? Exp Neurol 2008, 209: 22-27.
    • (2008) Exp Neurol , vol.209 , pp. 22-27
    • Chesselet, M.F.1
  • 129
    • 81255210997 scopus 로고    scopus 로고
    • Modelling of Parkinson's disease in mice
    • Chesselet MF, Richter F: Modelling of Parkinson's disease in mice. Lancet Neurol 2011, 10: 1108-1118.
    • (2011) Lancet Neurol , vol.10 , pp. 1108-1118
    • Chesselet, M.F.1    Richter, F.2
  • 134
    • 77953090478 scopus 로고    scopus 로고
    • Loss of leucine-rich repeat kinase 2 causes impairment of protein degradation pathways, accumulation of alpha-synuclein, and apoptotic cell death in aged mice
    • Tong Y, Yamaguchi H, Giaime E, Boyle S, Kopan R, Kelleher RJ 3rd, Shen J: Loss of leucine-rich repeat kinase 2 causes impairment of protein degradation pathways, accumulation of alpha-synuclein, and apoptotic cell death in aged mice. Proc Natl Acad Sci U S A 2010, 107: 9879-9884.
    • (2010) Proc Natl Acad Sci U S A , vol.107 , pp. 9879-9884
    • Tong, Y.1    Yamaguchi, H.2    Giaime, E.3    Boyle, S.4    Kopan, R.5    Kelleher, R.J.6    Shen, J.7
  • 139
    • 39849109338 scopus 로고    scopus 로고
    • Autophagy fights disease through cellular self-digestion
    • Mizushima N, Levine B, Cuervo AM, Klionsky DJ: Autophagy fights disease through cellular self-digestion. Nature 2008, 451: 1069-1075.
    • (2008) Nature , vol.451 , pp. 1069-1075
    • Mizushima, N.1    Levine, B.2    Cuervo, A.M.3    Klionsky, D.J.4
  • 140
    • 68149123529 scopus 로고    scopus 로고
    • Alterations in lysosomal and proteasomal markers in Parkinson's disease: relationship to alpha-synuclein inclusions
    • Chu Y, Dodiya H, Aebischer P, Olanow CW, Kordower JH: Alterations in lysosomal and proteasomal markers in Parkinson's disease: relationship to alpha-synuclein inclusions. Neurobiol Dis 2009, 35: 385-398.
    • (2009) Neurobiol Dis , vol.35 , pp. 385-398
    • Chu, Y.1    Dodiya, H.2    Aebischer, P.3    Olanow, C.W.4    Kordower, J.H.5
  • 142
    • 4344659685 scopus 로고    scopus 로고
    • Impaired degradation of mutant alpha-synuclein by chaperone-mediated autophagy
    • Cuervo AM, Stefanis L, Fredenburg R, Lansbury PT, Sulzer D: Impaired degradation of mutant alpha-synuclein by chaperone-mediated autophagy. Science 2004, 305: 1292-1295.
    • (2004) Science , vol.305 , pp. 1292-1295
    • Cuervo, A.M.1    Stefanis, L.2    Fredenburg, R.3    Lansbury, P.T.4    Sulzer, D.5
  • 145
    • 84870687953 scopus 로고    scopus 로고
    • alpha-Synuclein-induced down-regulation of Nurr1 disrupts GDNF signaling in nigral dopamine neurons
    • Decressac M, Kadkhodaei B, Mattsson B, Laguna A, Perlmann T, Bjorklund A: alpha-Synuclein-induced down-regulation of Nurr1 disrupts GDNF signaling in nigral dopamine neurons. Sci Transl Med 2012, 4: 163ra156.
    • (2012) Sci Transl Med , vol.4 , pp. 156-163
    • Decressac, M.1    Kadkhodaei, B.2    Mattsson, B.3    Laguna, A.4    Perlmann, T.5    Bjorklund, A.6
  • 147
    • 5144225578 scopus 로고    scopus 로고
    • Lentiviral nigral delivery of GDNF does not prevent neurodegeneration in a genetic rat model of Parkinson's disease
    • Lo Bianco C, Deglon N, Pralong W, Aebischer P: Lentiviral nigral delivery of GDNF does not prevent neurodegeneration in a genetic rat model of Parkinson's disease. Neurobiol Dis 2004, 17: 283-289.
    • (2004) Neurobiol Dis , vol.17 , pp. 283-289
    • Lo Bianco, C.1    Deglon, N.2    Pralong, W.3    Aebischer, P.4
  • 148
    • 0028980156 scopus 로고
    • Transforming growth factor-beta-1 levels are elevated in the striatum and in ventricular cerebrospinal fluid in Parkinson's disease
    • Mogi M, Harada M, Kondo T, Narabayashi H, Riederer P, Nagatsu T: Transforming growth factor-beta-1 levels are elevated in the striatum and in ventricular cerebrospinal fluid in Parkinson's disease. Neurosci Lett 1995, 193: 129-132.
    • (1995) Neurosci Lett , vol.193 , pp. 129-132
    • Mogi, M.1    Harada, M.2    Kondo, T.3    Narabayashi, H.4    Riederer, P.5    Nagatsu, T.6
  • 149
    • 0030471162 scopus 로고    scopus 로고
    • TGF beta 1 and TGF beta 2 concentrations are elevated in Parkinson's disease in ventricular cerebrospinal fluid
    • Vawter MP, Dillon-Carter O, Tourtellotte WW, Carvey P, Freed WJ: TGF beta 1 and TGF beta 2 concentrations are elevated in Parkinson's disease in ventricular cerebrospinal fluid. Exp Neurol 1996, 142: 313-322.
    • (1996) Exp Neurol , vol.142 , pp. 313-322
    • Vawter, M.P.1    Dillon-Carter, O.2    Tourtellotte, W.W.3    Carvey, P.4    Freed, W.J.5
  • 150
    • 0041659303 scopus 로고    scopus 로고
    • Transforming growth factor beta 1 overexpression in the nigrostriatal system increases the dopaminergic deficit of MPTP mice
    • Sánchez-Capelo A, Colin P, Guibert B, Biguet NF, Mallet J: Transforming growth factor beta 1 overexpression in the nigrostriatal system increases the dopaminergic deficit of MPTP mice. Mol Cell Neurosci 2003, 23: 614-625.
    • (2003) Mol Cell Neurosci , vol.23 , pp. 614-625
    • Sánchez-Capelo, A.1    Colin, P.2    Guibert, B.3    Biguet, N.F.4    Mallet, J.5
  • 151
    • 0033551593 scopus 로고    scopus 로고
    • Adenovirus-mediated over-expression of TGF beta 1 in the striatum decreases dopaminergic cell survival in embryonic nigral grafts
    • Sánchez-Capelo A, Corti O, Mallet J: Adenovirus-mediated over-expression of TGF beta 1 in the striatum decreases dopaminergic cell survival in embryonic nigral grafts. Neuroreport 1999, 10: 2169-2173.
    • (1999) Neuroreport , vol.10 , pp. 2169-2173
    • Sánchez-Capelo, A.1    Corti, O.2    Mallet, J.3
  • 154
    • 84880383782 scopus 로고    scopus 로고
    • New experimental and clinical links between the hippocampus and the dopaminergic system in Parkinson's disease
    • Calabresi P, Castrioto A, Di Filippo M, Picconi B: New experimental and clinical links between the hippocampus and the dopaminergic system in Parkinson's disease. Lancet Neurol 2013, 12: 811-821.
    • (2013) Lancet Neurol , vol.12 , pp. 811-821
    • Calabresi, P.1    Castrioto, A.2    Di Filippo, M.3    Picconi, B.4
  • 157
  • 158
    • 0034704752 scopus 로고    scopus 로고
    • A Drosophila model of Parkinson's disease
    • Feany MB, Bender WW: A Drosophila model of Parkinson's disease. Nature 2000, 404: 394-398.
    • (2000) Nature , vol.404 , pp. 394-398
    • Feany, M.B.1    Bender, W.W.2
  • 159
    • 79251551356 scopus 로고    scopus 로고
    • alpha-Synuclein Transgenic Drosophila As a Model of Parkinson's Disease and Related Synucleinopathies
    • Mizuno H, Fujikake N, Wada K, Nagai Y: alpha-Synuclein Transgenic Drosophila As a Model of Parkinson's Disease and Related Synucleinopathies. Parkinsons Dis 2010, 2011: 212706.
    • (2010) Parkinsons Dis , vol.2011 , pp. 212706
    • Mizuno, H.1    Fujikake, N.2    Wada, K.3    Nagai, Y.4
  • 160
    • 33644849650 scopus 로고    scopus 로고
    • Familial Parkinson mutant alpha-synuclein causes dopamine neuron dysfunction in transgenic Caenorhabditis elegans
    • Kuwahara T, Koyama A, Gengyo-Ando K, Masuda M, Kowa H, Tsunoda M, Mitani S, Iwatsubo T: Familial Parkinson mutant alpha-synuclein causes dopamine neuron dysfunction in transgenic Caenorhabditis elegans. J Biol Chem 2006, 281: 334-340.
    • (2006) J Biol Chem , vol.281 , pp. 334-340
    • Kuwahara, T.1    Koyama, A.2    Gengyo-Ando, K.3    Masuda, M.4    Kowa, H.5    Tsunoda, M.6    Mitani, S.7    Iwatsubo, T.8
  • 164
    • 24344470188 scopus 로고    scopus 로고
    • Alpha-synuclein activation of protein phosphatase 2A reduces tyrosine hydroxylase phosphorylation in dopaminergic cells
    • Peng X, Tehranian R, Dietrich P, Stefanis L, Perez RG: Alpha-synuclein activation of protein phosphatase 2A reduces tyrosine hydroxylase phosphorylation in dopaminergic cells. J Cell Sci 2005, 118: 3523-3530.
    • (2005) J Cell Sci , vol.118 , pp. 3523-3530
    • Peng, X.1    Tehranian, R.2    Dietrich, P.3    Stefanis, L.4    Perez, R.G.5
  • 165
    • 33750461646 scopus 로고    scopus 로고
    • Alpha-synuclein inhibits aromatic amino acid decarboxylase activity in dopaminergic cells
    • Tehranian R, Montoya SE, Van Laar AD, Hastings TG, Perez RG: Alpha-synuclein inhibits aromatic amino acid decarboxylase activity in dopaminergic cells. J Neurochem 2006, 99: 1188-1196.
    • (2006) J Neurochem , vol.99 , pp. 1188-1196
    • Tehranian, R.1    Montoya, S.E.2    Van Laar, A.D.3    Hastings, T.G.4    Perez, R.G.5
  • 166
    • 84862303338 scopus 로고    scopus 로고
    • Dysregulated dopamine storage increases the vulnerability to alpha-synuclein in nigral neurons
    • Ulusoy A, Bjorklund T, Buck K, Kirik D: Dysregulated dopamine storage increases the vulnerability to alpha-synuclein in nigral neurons. Neurobiol Dis 2012, 47: 367-377.
    • (2012) Neurobiol Dis , vol.47 , pp. 367-377
    • Ulusoy, A.1    Bjorklund, T.2    Buck, K.3    Kirik, D.4
  • 169
    • 13844313915 scopus 로고    scopus 로고
    • Parkin-deficient mice are not a robust model of parkinsonism
    • Perez FA, Palmiter RD: Parkin-deficient mice are not a robust model of parkinsonism. Proc Natl Acad Sci USA 2005, 102: 2174-2179.
    • (2005) Proc Natl Acad Sci USA , vol.102 , pp. 2174-2179
    • Perez, F.A.1    Palmiter, R.D.2
  • 174
    • 33847773421 scopus 로고    scopus 로고
    • Prime time for alpha-synuclein
    • Gitler AD, Shorter J: Prime time for alpha-synuclein. J Neurosci 2007, 27: 2433-2434.
    • (2007) J Neurosci , vol.27 , pp. 2433-2434
    • Gitler, A.D.1    Shorter, J.2
  • 178
    • 43249114934 scopus 로고    scopus 로고
    • Lewy body-like pathology in long-term embryonic nigral transplants in Parkinson's disease
    • Kordower JH, Chu Y, Hauser RA, Freeman TB, Olanow CW: Lewy body-like pathology in long-term embryonic nigral transplants in Parkinson's disease. Nat Med 2008, 14: 504-506.
    • (2008) Nat Med , vol.14 , pp. 504-506
    • Kordower, J.H.1    Chu, Y.2    Hauser, R.A.3    Freeman, T.B.4    Olanow, C.W.5
  • 179
    • 84869109864 scopus 로고    scopus 로고
    • Pathological alpha-synuclein transmission initiates Parkinson-like neurodegeneration in nontransgenic mice
    • Luk KC, Kehm V, Carroll J, Zhang B, O'Brien P, Trojanowski JQ, Lee VM: Pathological alpha-synuclein transmission initiates Parkinson-like neurodegeneration in nontransgenic mice. Science 2012, 338: 949-953.
    • (2012) Science , vol.338 , pp. 949-953
    • Luk, K.C.1    Kehm, V.2    Carroll, J.3    Zhang, B.4    O'Brien, P.5    Trojanowski, J.Q.6    Lee, V.M.7
  • 183
    • 84893858665 scopus 로고    scopus 로고
    • Extracellular alpha-synuclein-a novel and crucial factor in Lewy body diseases
    • Lee HJ, Bae EJ, Lee SJ: Extracellular alpha-synuclein-a novel and crucial factor in Lewy body diseases. Nat Rev Neurol 2014, 10: 92-98.
    • (2014) Nat Rev Neurol , vol.10 , pp. 92-98
    • Lee, H.J.1    Bae, E.J.2    Lee, S.J.3
  • 185
    • 84924437783 scopus 로고    scopus 로고
    • Biophysical characterization of alpha-synuclein and its controversial structure
    • Alderson TR, Markley JL: Biophysical characterization of alpha-synuclein and its controversial structure. Intrinsically Disord Proteins 2013, 1: 18-39.
    • (2013) Intrinsically Disord Proteins , vol.1 , pp. 18-39
    • Alderson, T.R.1    Markley, J.L.2
  • 186
    • 84878582896 scopus 로고    scopus 로고
    • The remarkable conformational plasticity of alpha-synuclein: blessing or curse?
    • Deleersnijder A, Gerard M, Debyser Z, Baekelandt V: The remarkable conformational plasticity of alpha-synuclein: blessing or curse? Trends Mol Med 2013, 19: 368-377.
    • (2013) Trends Mol Med , vol.19 , pp. 368-377
    • Deleersnijder, A.1    Gerard, M.2    Debyser, Z.3    Baekelandt, V.4
  • 187
    • 80052398365 scopus 로고    scopus 로고
    • alpha-Synuclein occurs physiologically as a helically folded tetramer that resists aggregation
    • Bartels T, Choi JG, Selkoe DJ: alpha-Synuclein occurs physiologically as a helically folded tetramer that resists aggregation. Nature 2011, 477: 107-110.
    • (2011) Nature , vol.477 , pp. 107-110
    • Bartels, T.1    Choi, J.G.2    Selkoe, D.J.3
  • 189
    • 34548313729 scopus 로고    scopus 로고
    • Mechanistic aspects of Parkinson's disease: alpha-synuclein and the biomembrane
    • Beyer K: Mechanistic aspects of Parkinson's disease: alpha-synuclein and the biomembrane. Cell Biochem Biophys 2007, 47: 285-299.
    • (2007) Cell Biochem Biophys , vol.47 , pp. 285-299
    • Beyer, K.1
  • 190
    • 0033538541 scopus 로고    scopus 로고
    • alpha-synuclein fibrillogenesis is nucleation-dependent. Implications for the pathogenesis of Parkinson's disease
    • Wood SJ, Wypych J, Steavenson S, Louis JC, Citron M, Biere AL: alpha-synuclein fibrillogenesis is nucleation-dependent. Implications for the pathogenesis of Parkinson's disease. J Biol Chem 1999, 274: 19509-19512.
    • (1999) J Biol Chem , vol.274 , pp. 19509-19512
    • Wood, S.J.1    Wypych, J.2    Steavenson, S.3    Louis, J.C.4    Citron, M.5    Biere, A.L.6
  • 191
    • 0034681163 scopus 로고    scopus 로고
    • Acceleration of oligomerization, not fibrillization, is a shared property of both alpha-synuclein mutations linked to early-onset Parkinson's disease: implications for pathogenesis and therapy
    • Conway KA, Lee SJ, Rochet JC, Ding TT, Williamson RE, Lansbury PT Jr: Acceleration of oligomerization, not fibrillization, is a shared property of both alpha-synuclein mutations linked to early-onset Parkinson's disease: implications for pathogenesis and therapy. Proc Natl Acad Sci U S A 2000, 97: 571-576.
    • (2000) Proc Natl Acad Sci U S A , vol.97 , pp. 571-576
    • Conway, K.A.1    Lee, S.J.2    Rochet, J.C.3    Ding, T.T.4    Williamson, R.E.5    Lansbury, P.T.6
  • 192
    • 0034712918 scopus 로고    scopus 로고
    • Fiber diffraction of synthetic alpha-synuclein filaments shows amyloid-like cross-beta conformation
    • Serpell LC, Berriman J, Jakes R, Goedert M, Crowther RA: Fiber diffraction of synthetic alpha-synuclein filaments shows amyloid-like cross-beta conformation. Proc Natl Acad Sci U S A 2000, 97: 4897-4902.
    • (2000) Proc Natl Acad Sci U S A , vol.97 , pp. 4897-4902
    • Serpell, L.C.1    Berriman, J.2    Jakes, R.3    Goedert, M.4    Crowther, R.A.5
  • 193
    • 0035815664 scopus 로고    scopus 로고
    • Evidence for a partially folded intermediate in alpha-synuclein fibril formation
    • Uversky VN, Li J, Fink AL: Evidence for a partially folded intermediate in alpha-synuclein fibril formation. J Biol Chem 2001, 276: 10737-10744.
    • (2001) J Biol Chem , vol.276 , pp. 10737-10744
    • Uversky, V.N.1    Li, J.2    Fink, A.L.3
  • 196
    • 84876891740 scopus 로고    scopus 로고
    • alpha-Synuclein oligomers: an amyloid pore? Insights into mechanisms of alpha-synuclein oligomer-lipid interactions
    • Stockl MT, Zijlstra N, Subramaniam V: alpha-Synuclein oligomers: an amyloid pore? Insights into mechanisms of alpha-synuclein oligomer-lipid interactions. Mol Neurobiol 2013, 47: 613-621.
    • (2013) Mol Neurobiol , vol.47 , pp. 613-621
    • Stockl, M.T.1    Zijlstra, N.2    Subramaniam, V.3
  • 197
    • 73549085595 scopus 로고    scopus 로고
    • Increased expression of alpha-synuclein reduces neurotransmitter release by inhibiting synaptic vesicle reclustering after endocytosis
    • Nemani VM, Lu W, Berge V, Nakamura K, Onoa B, Lee MK, Chaudhry FA, Nicoll RA, Edwards RH: Increased expression of alpha-synuclein reduces neurotransmitter release by inhibiting synaptic vesicle reclustering after endocytosis. Neuron 2010, 65: 66-79.
    • (2010) Neuron , vol.65 , pp. 66-79
    • Nemani, V.M.1    Lu, W.2    Berge, V.3    Nakamura, K.4    Onoa, B.5    Lee, M.K.6    Chaudhry, F.A.7    Nicoll, R.A.8    Edwards, R.H.9
  • 198
    • 0035834360 scopus 로고    scopus 로고
    • Kinetic stabilization of the alpha-synuclein protofibril by a dopamine-alpha-synuclein adduct
    • Conway KA, Rochet JC, Bieganski RM, Lansbury PT Jr: Kinetic stabilization of the alpha-synuclein protofibril by a dopamine-alpha-synuclein adduct. Science 2001, 294: 1346-1349.
    • (2001) Science , vol.294 , pp. 1346-1349
    • Conway, K.A.1    Rochet, J.C.2    Bieganski, R.M.3    Lansbury, P.T.4
  • 199
    • 4344650564 scopus 로고    scopus 로고
    • Dopamine and L-dopa disaggregate amyloid fibrils: implications for Parkinson's and Alzheimer's disease
    • Li J, Zhu M, Manning-Bog AB, Di Monte DA, Fink AL: Dopamine and L-dopa disaggregate amyloid fibrils: implications for Parkinson's and Alzheimer's disease. FASEB J 2004, 18: 962-964.
    • (2004) FASEB J , vol.18 , pp. 962-964
    • Li, J.1    Zhu, M.2    Manning-Bog, A.B.3    Di Monte, D.A.4    Fink, A.L.5
  • 200
    • 20444401187 scopus 로고    scopus 로고
    • Reversible inhibition of alpha-synuclein fibrillization by dopaminochrome-mediated conformational alterations
    • Norris EH, Giasson BI, Hodara R, Xu S, Trojanowski JQ, Ischiropoulos H, Lee VM: Reversible inhibition of alpha-synuclein fibrillization by dopaminochrome-mediated conformational alterations. J Biol Chem 2005, 280: 21212-21219.
    • (2005) J Biol Chem , vol.280 , pp. 21212-21219
    • Norris, E.H.1    Giasson, B.I.2    Hodara, R.3    Xu, S.4    Trojanowski, J.Q.5    Ischiropoulos, H.6    Lee, V.M.7
  • 201
    • 0035949542 scopus 로고    scopus 로고
    • Effect of familial Parkinson's disease point mutations A30P and A53T on the structural properties, aggregation, and fibrillation of human alpha-synuclein
    • Li J, Uversky VN, Fink AL: Effect of familial Parkinson's disease point mutations A30P and A53T on the structural properties, aggregation, and fibrillation of human alpha-synuclein. Biochemistry 2001, 40: 11604-11613.
    • (2001) Biochemistry , vol.40 , pp. 11604-11613
    • Li, J.1    Uversky, V.N.2    Fink, A.L.3
  • 204
    • 77955366745 scopus 로고    scopus 로고
    • Role of phost-translational modifications in modulating the structure, function and toxicity of a-synuclein: implications for Parkinson's disease pathogenesis and therapies
    • Edited by: Björklund A, Cenci MA. Academic Press, City
    • Oueslati A, Fournier M, Lashuel HA: Role of phost-translational modifications in modulating the structure, function and toxicity of a-synuclein: implications for Parkinson's disease pathogenesis and therapies. In Progress in Brain Research. Edited by: Björklund A, Cenci MA. Academic Press, City; 2010:115-145.
    • (2010) Progress in Brain Research , pp. 115-145
    • Oueslati, A.1    Fournier, M.2    Lashuel, H.A.3


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