Familial Parkinson mutant α-synuclein causes dopamine neuron dysfunction in transgenic Caenorhabditis elegans

Journal of Biological Chemistry

Volumn 281, Issue 1, 2006, Pages 334-340

  Kuwahara, Tomoki ^a   Koyama, Akihiko ^a   Gengyo Ando, Keiko ^b   Masuda, Mayumi ^a   Kowa, Hisatomo ^a   Tsunoda, Makoto ^a   Mitani, Shohei ^b   Iwatsubo, Takeshi ^a  

^a UNIVERSITY OF TOKYO   (Japan)

^b TOKYO WOMEN'S MEDICAL UNIVERSITY   (Japan)

Author keywords

[No Author keywords available]

Indexed keywords

AMINES; CELLS; MUTAGENESIS; NEUROLOGY; PATHOLOGY;

CAENORHABDITIS ELEGANS (TG WORMS); LEWY BODIES; PARKINSON DISEASE; PATHOLOGICAL CASCADE;

DISEASES;

ALPHA SYNUCLEIN; DOPAMINE; ENHANCED GREEN FLUORESCENT PROTEIN; GREEN FLUORESCENT PROTEIN;

ANIMAL MODEL; ARTICLE; BRAIN NERVE CELL; CAENORHABDITIS ELEGANS; DENDRITIC CELL; LEWY BODY; LOCOMOTION; NONHUMAN; PARKINSON DISEASE; PHENOTYPE; PRIORITY JOURNAL; PROTEIN EXPRESSION; ANIMAL; DISEASE MODEL; DRUG EFFECT; FEEDING BEHAVIOR; GENETICS; HUMAN; IMMUNOHISTOCHEMISTRY; METABOLISM; NERVE CELL; PATHOPHYSIOLOGY; PHYSIOLOGY; TRANSGENIC ANIMAL;

ANIMALIA; CAENORHABDITIS ELEGANS;

ALPHA-SYNUCLEIN; ANIMALS; ANIMALS, GENETICALLY MODIFIED; CAENORHABDITIS ELEGANS; DISEASE MODELS, ANIMAL; DOPAMINE; FEEDING BEHAVIOR; GREEN FLUORESCENT PROTEINS; HUMANS; IMMUNOHISTOCHEMISTRY; NEURONS; PARKINSON DISEASE; PHENOTYPE;

EID: 33644849650     PISSN: 00219258     EISSN: 1083351X     Source Type: Journal    
DOI: 10.1074/jbc.M504860200     Document Type: Article

References (42)

1. Dawson, T. M., and Dawson, V. L. (2003) Science 302, 819-822
2. Trojanowski, J. Q., and Lee, V. M. (2003) Ann. N. Y. Acad. Sci. 991, 107-110
3. Polymeropoulos, M. H., Lavedan, C., Leroy, E., Ide, S. E., Dehejia, A., Dutra, A., Pike, B., Root, H., Rubenstein, J., Boyer, R., Stenroos, E. S., Chandrasekharappa, S., Athanassiadou, A., Papapetropoulos, T., Johnson, W. G., Lazzarini, A. M., Duvoisin, R. C., Di Iorio, G., Golbe, L. I., and Nussbaum, R. L. (1997) Science 276, 2045-2047
4. Krüger, R. Kuhn, W., Muller, T., Woitalla, D., Graeber, M., Kosel, S., Przuntek, H., Epplen, J. T., Schols, L., and Riess, O. (1998) Nat. Genet. 18, 106-108
5. Zarranz, J. J., Alegre, J., Gomez-Esteban, J. C., Lezcano, E., Ros, R., Ampuero, I., Vidal, L., Hoenicka, J., Rodriguez, O., Atares, B., Llorens, V., Gomez Tortosa, E., del Ser, T., Munoz, D. G., and de Yebenes, J. G. (2004) Ann. Neurol. 55, 164-173
6. Singleton, A. B., Farrer, M., Johnson, J., Singleton, A., Hague, S., Kachergus, J., Hulihan, M., Peuralinna, T., Dutra, A., Nussbaum, R., Lincoln, S., Crawley, A., Hanson, M., Maraganore, D., Adler, C., Cookson, M. R., Muenter, M., Baptista, M., Miller, D., Blancato, J., Hardy, J., and Gwinn-Hardy, K. (2003) Science 302, 841
7. Chartier-Harlin, M. C., Kachergus, J., Roumier, C., Mouroux, V., Douay, X., Lincoln, S., Levecque, C., Larvor, L., Andrieux, J., Hulihan, M., Waucquier, N., Defebvre, L., Amouyel, P., Farrer, M., and Destee, A. (2004) Lancet 364, 1167-1169
8. Ibáñez, P., Bonnet, A. M., Debarges, B., Lohmann, E., Tison, F., Pollak, P., Agid, Y., Durr, A., Brice, A. (2004) Lancet 364, 1169-1171
9. Spillantini, M. G., Schmidt, M. L., Lee, V. M.-Y., Trojanowski, J. Q., Jakes, R., and Goedert, M. (1997) Nature 388, 839-840
10. Baba, M., Nakajo, S., Tu, P. H., Tomita, T., Nakaya, K., Lee, V. M., Trojanowski, J. Q., and Iwatsubo, T. (1998) Am. J. Pathol. 152, 879-884
11. Conway, K. A., Lee, S. J., Rochet, J. C., Ding, T. T., Williamson, R. E., and Lansbury, P. T., Jr. (2000) Proc. Natl. Acad. Sci. U. S. A. 97, 571-576
12. Li, J., Uversky, V. N., and Fink, A. L. (2001) Biochemistry 40, 11604-11613
13. Choi, W., Zibaee, S., Jakes, R., Serpell, L. C., Davletov, B., Crowther, R. A., and Goedert, M. (2004) FEBS Lett. 576, 363-368
14. Greenbaum, E. A., Graves, C. L., Mishizen-Eberz, A. J., Lupoli, M. A., Lynch, D. R., Englander, S. W., Axelsen, P. H., and Giasson, B. I. (2005) J. Biol. Chem. 280, 7800-7807
15. Masliah, E., Rockenstein, E., Veinbergs, I., Mallory, M., Hashimoto, M., Takeda, A., Sagara, Y., Sisk, A., and Mucke, L. (2000) Science 287, 1265-1269
16. Kahle, P. J., Neumann, M., Ozmen, L., Muller, V., Jacobsen, H., Schindzielorz, A., Okochi, M., Leimer, U., van Der Putten, H., Probst, A., Kremmer, E., Kretzschmar, H. A., and Haass, C. (2000) J. Neurosci. 20, 6365-6373
17. Matsuoka, Y., Vila, M., Lincoln, S., McCormack, A., Picciano, M., LaFrancois, J., Yu, X., Dickson, D., Langston, W. J., McGowan, E., Farrer, M., Hardy, J., Duff, K., Przedborski, S., and Di Monte, D. A. (2001) Neurobiol. Dis. 8, 535-539
18. Giasson, B. I., Duda, J. E., Quinn, S. M., Zhang, B., Trojanowski, J. Q., and Lee, V. M. (2002) Neuron 34, 521-533
19. Lee, M. K., Stirling, W., Xu, Y., Xu, X., Qui, D., Mandir, A. S., Dawson, T. M., Copeland, N. G., Jenkins, N. A., and Price, D. L. (2002) Proc. Natl. Acad. Sci. U. S. A. 99, 8968-8973
20. Gomez-Isla, T., Irizarry, M. C., Mariash, A., Cheung, B., Soto, O., Schrump, S., Sondel, J., Kotilinek, L., Day, J., Schwarzschild, M. A., Cha, J. H., Newell, K., Miller, D. W., Ueda, K., Young, A. B., Hyman, B. T., and Ashe, K. H. (2003) Neurobiol. Aging 24, 245-258
21. Feany, M. B., and Bender, W. W. (2000) Nature 404, 394-398
22. Auluck, P. K., and Bonini, N. M. (2002) Nat. Med. 8, 1185-1186
23. Lakso, M., Vartiainen, S., Moilanen, A. M., Sirvio, J., Thomas, J. H., Nass, R., Blakely, R. D., and Wong, G. (2003) J. Neurochem. 86, 165-172
24. Outeiro, T. F., and Lindquist, S. (2003) Science 302, 1772-1775
25. Sawin, E. R., Ranganathan, R., and Horvitz, H. R. (2000) Neuron 26, 619-631
26. Nass, R., Hall, D. H., Miller, D. M., III, and Blakely, R. D. (2002) Proc. Natl. Acad. Sci. U. S. A. 99, 3264-3269
27. Brenner, S. (1974) Genetics 77, 71-94
28. Sulston, J., Dew, M., and Brenner, S. (1975) J Comp Neurol. 163, 215-226
29. Mitani, S. (1995) Dev. Growth Differ. 37, 551-557
30. Fujiwara, H., Hasegawa, M., Dohmae, N., Kawashima, A., Masliah, E., Goldberg, M. S., Shen, J., Takio, K., and Iwatsubo, T. (2002) Nat. Cell Biol. 4, 160-164
31. Kowa, H., Sakakura, T., Matsuura, Y., Wakabayashi, T., Mann, D. M. A., Duff, K., Tsuji, S., Hashimoto, T., and Iwatsubo, T. (2004) Am. J. Pathol. 165, 273-281
32. Tsunoda, M., Takezawa, K., Santa, T., and Imai, K. (1999) Anal. Biochem. 269, 386-392
33. Kahle, P. J., Neumann, M., Ozmen, L., Muller, V., Jacobsen, H., Spooren, W., Fuss, B., Mallon, B., Macklin, W. B., Fujiwara, H., Hasegawa, M., Iwatsubo, T., Kretzschmar, H. A., and Haass, C. (2002) EMBO Rep. 3, 583-588
34. Neumann, M., Kahle, P. J., Giasson, B. I., Ozmen, L., Borroni, E., Spooren, W., Muller, V., Odoy, S., Fujiwara, H., Hasegawa, M., Iwatsubo, T., Trojanowski, J. Q., Kretzschmar, H. A., and Haass, C. (2002) J. Clin. Investig. 110, 1429-1439
35. Auluck, P. K., Chan, H. Y., Trojanowski, J. Q., Lee, V. M., and Bonini, N. M. (2002) Science 295, 865-868
36. Auluck, P. K., Meulener, M. C., and Bonini, N. M. (2005) J. Biol. Chem. 280, 2873-2878
37. Perez, R. G., Waymire, J. C., Lin, E., Liu, J. J., Guo, F., and Zigmond, M. J. (2002) J Neurosci. 22, 3090-3099
38. Conway, K. A., Rochet, J. C., Bieganski, R. M., and Lansbury, P. T., Jr. (2001) Science 294, 1346-1349
39. Chen, L., and Feany, M. B. (2005) Nat. Neurosci. 8, 657-663
40. Smith, W. W., Margolis, R. L., Li, X., Troncoso, J. C., Lee, M. K., Dawson, V. L., Dawson, T. M., Iwatsubo, T., and Ross, C. A. (2005) J. Neurosci. 25, 5544-5552
41. Svendsen, P.C., and McGhee, J. D. (1995) Development (Camb.) 121, 1253-1262
42. Mello, C. C., Kramer, J. M., Stinchcomb, D., and Ambros, V. (1991) EMBO J. 10, 3959-3970