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Volumn 46, Issue 3, 2012, Pages 597-606

Animal models of the non-motor features of Parkinson's disease

Author keywords

Mice; Non human primates; Rats

Indexed keywords

1,2,3,6 TETRAHYDRO 1 METHYL 4 PHENYLPYRIDINE; ALCOHOL DEHYDROGENASE; ALCOHOL DEHYDROGENASE 4; DOPAMINE; LEVODOPA; NICOTINE; NICOTINIC AGENT; OXIDOPAMINE; PARAQUAT; PESTICIDE; ROTENONE; TRANSCRIPTION FACTOR PITX3; UNCLASSIFIED DRUG; VESICULAR MONOAMINE TRANSPORTER 2;

EID: 84859699540     PISSN: 09699961     EISSN: 1095953X     Source Type: Journal    
DOI: 10.1016/j.nbd.2011.12.040     Document Type: Review
Times cited : (134)

References (178)
  • 1
    • 27644439093 scopus 로고    scopus 로고
    • Excessive daytime sleepiness and subsequent development of Parkinson disease
    • Abbott R.D., et al. Excessive daytime sleepiness and subsequent development of Parkinson disease. Neurology 2005, 65:1442-1446.
    • (2005) Neurology , vol.65 , pp. 1442-1446
    • Abbott, R.D.1
  • 2
    • 34748826388 scopus 로고    scopus 로고
    • Bowel movement frequency in late-life and incidental Lewy bodies
    • Abbott R.D., et al. Bowel movement frequency in late-life and incidental Lewy bodies. Mov. Disord. 2007, 22:1581-1586.
    • (2007) Mov. Disord. , vol.22 , pp. 1581-1586
    • Abbott, R.D.1
  • 3
    • 0033405974 scopus 로고    scopus 로고
    • Nocturnal sleep structure and temperature slope in MPTP treated monkeys
    • Almirall H., et al. Nocturnal sleep structure and temperature slope in MPTP treated monkeys. J. Neural Transm. 1999, 106:1125-1134.
    • (1999) J. Neural Transm. , vol.106 , pp. 1125-1134
    • Almirall, H.1
  • 4
    • 34548230441 scopus 로고    scopus 로고
    • Loss of enteric dopaminergic neurons and associated changes in colon motility in an MPTP mouse model of Parkinson's disease
    • Anderson G., et al. Loss of enteric dopaminergic neurons and associated changes in colon motility in an MPTP mouse model of Parkinson's disease. Exp. Neurol. 2007, 207:4-12.
    • (2007) Exp. Neurol. , vol.207 , pp. 4-12
    • Anderson, G.1
  • 5
    • 49549100675 scopus 로고    scopus 로고
    • Impaired learning and memory in Pitx3 deficient aphakia mice: a genetic model for striatum-dependent cognitive symptoms in Parkinson's disease
    • Ardayfio P., et al. Impaired learning and memory in Pitx3 deficient aphakia mice: a genetic model for striatum-dependent cognitive symptoms in Parkinson's disease. Neurobiol. Dis. 2008, 31:406-412.
    • (2008) Neurobiol. Dis. , vol.31 , pp. 406-412
    • Ardayfio, P.1
  • 6
    • 77953895680 scopus 로고    scopus 로고
    • Association between sporadic Parkinson disease and interleukin-1 beta-511 gene polymorphisms in the Turkish population
    • Arman A., et al. Association between sporadic Parkinson disease and interleukin-1 beta-511 gene polymorphisms in the Turkish population. Eur. Cytokine Netw. 2010, 21:116-121.
    • (2010) Eur. Cytokine Netw. , vol.21 , pp. 116-121
    • Arman, A.1
  • 7
    • 69949103567 scopus 로고    scopus 로고
    • Sleep disorders in Parkinson's disease: the contribution of the MPTP non-human primate model
    • Barraud Q., et al. Sleep disorders in Parkinson's disease: the contribution of the MPTP non-human primate model. Exp. Neurol. 2009, 219:574-582.
    • (2009) Exp. Neurol. , vol.219 , pp. 574-582
    • Barraud, Q.1
  • 8
    • 79953306427 scopus 로고    scopus 로고
    • Nonmotor disturbances in Parkinson's disease
    • Bassetti C.L. Nonmotor disturbances in Parkinson's disease. Neurodegener. Dis. 2011, 8:95-108.
    • (2011) Neurodegener. Dis. , vol.8 , pp. 95-108
    • Bassetti, C.L.1
  • 9
    • 78650415859 scopus 로고    scopus 로고
    • Modeling Parkinson's disease genetics: altered function of the dopamine system in Adh4 knockout mice
    • Belin A.C., et al. Modeling Parkinson's disease genetics: altered function of the dopamine system in Adh4 knockout mice. Behav. Brain Res. 2011, 217:439-445.
    • (2011) Behav. Brain Res. , vol.217 , pp. 439-445
    • Belin, A.C.1
  • 10
    • 70449523364 scopus 로고    scopus 로고
    • PITX3 polymorphism is associated with early onset Parkinson's disease
    • Bergman O., et al. PITX3 polymorphism is associated with early onset Parkinson's disease. Neurobiol. Aging 2010, 31:114-117.
    • (2010) Neurobiol. Aging , vol.31 , pp. 114-117
    • Bergman, O.1
  • 11
    • 0033681149 scopus 로고    scopus 로고
    • Chronic systemic pesticide exposure reproduces features of Parkinson's disease
    • Betarbet R., et al. Chronic systemic pesticide exposure reproduces features of Parkinson's disease. Nat. Neurosci. 2000, 3:1301-1306.
    • (2000) Nat. Neurosci. , vol.3 , pp. 1301-1306
    • Betarbet, R.1
  • 12
    • 13444273340 scopus 로고    scopus 로고
    • Continuous dopaminergic stimulation reduces risk of motor complications in parkinsonian primates
    • Bibbiani F., et al. Continuous dopaminergic stimulation reduces risk of motor complications in parkinsonian primates. Exp. Neurol. 2005, 192:73-78.
    • (2005) Exp. Neurol. , vol.192 , pp. 73-78
    • Bibbiani, F.1
  • 13
    • 34948821535 scopus 로고    scopus 로고
    • Pathophysiology of REM sleep behaviour disorder and relevance to neurodegenerative disease
    • Boeve B.F., et al. Pathophysiology of REM sleep behaviour disorder and relevance to neurodegenerative disease. Brain 2007, 130:2770-2788.
    • (2007) Brain , vol.130 , pp. 2770-2788
    • Boeve, B.F.1
  • 14
    • 0037428241 scopus 로고    scopus 로고
    • Mutations in the DJ-1 gene associated with autosomal recessive early-onset parkinsonism
    • Bonifati V., et al. Mutations in the DJ-1 gene associated with autosomal recessive early-onset parkinsonism. Science 2003, 299:256-259.
    • (2003) Science , vol.299 , pp. 256-259
    • Bonifati, V.1
  • 15
    • 0037333666 scopus 로고    scopus 로고
    • Staging of brain pathology related to sporadic Parkinson's disease
    • Braak H., et al. Staging of brain pathology related to sporadic Parkinson's disease. Neurobiol. Aging 2003, 24:197-211.
    • (2003) Neurobiol. Aging , vol.24 , pp. 197-211
    • Braak, H.1
  • 16
    • 32544442518 scopus 로고    scopus 로고
    • Gastric alpha-synuclein immunoreactive inclusions in Meissner's and Auerbach's plexuses in cases staged for Parkinson's disease-related brain pathology
    • Braak H., et al. Gastric alpha-synuclein immunoreactive inclusions in Meissner's and Auerbach's plexuses in cases staged for Parkinson's disease-related brain pathology. Neurosci. Lett. 2006, 396:67-72.
    • (2006) Neurosci. Lett. , vol.396 , pp. 67-72
    • Braak, H.1
  • 17
    • 0015060694 scopus 로고
    • Depletion of brain noradrenaline and dopamine by 6-hydroxydopamine
    • Breese G.R., Traylor T.D. Depletion of brain noradrenaline and dopamine by 6-hydroxydopamine. Br. J. Pharmacol. 1971, 42:88-99.
    • (1971) Br. J. Pharmacol. , vol.42 , pp. 88-99
    • Breese, G.R.1    Traylor, T.D.2
  • 18
    • 79951526730 scopus 로고    scopus 로고
    • Deep brain stimulation for Parkinson disease: an expert consensus and review of key issues
    • Bronstein J.M., et al. Deep brain stimulation for Parkinson disease: an expert consensus and review of key issues. Arch. Neurol. 2011, 68:165.
    • (2011) Arch. Neurol. , vol.68 , pp. 165
    • Bronstein, J.M.1
  • 19
    • 32044453150 scopus 로고    scopus 로고
    • Pesticides and Parkinson's disease-is there a link?
    • Brown T.P., et al. Pesticides and Parkinson's disease-is there a link?. Environ. Health Perspect. 2006, 114:156-164.
    • (2006) Environ. Health Perspect. , vol.114 , pp. 156-164
    • Brown, T.P.1
  • 20
    • 64449085359 scopus 로고    scopus 로고
    • A highly reproducible rotenone model of Parkinson's disease
    • Cannon J.R., et al. A highly reproducible rotenone model of Parkinson's disease. Neurobiol. Dis. 2009, 34:279-290.
    • (2009) Neurobiol. Dis. , vol.34 , pp. 279-290
    • Cannon, J.R.1
  • 21
    • 0015448068 scopus 로고
    • Biochemical and pharmacological aspects of parkinsonism
    • Carlsson A. Biochemical and pharmacological aspects of parkinsonism. Acta Neurol. Scand. Suppl. 1972, 51:11-42.
    • (1972) Acta Neurol. Scand. Suppl. , vol.51 , pp. 11-42
    • Carlsson, A.1
  • 22
    • 0000428532 scopus 로고
    • 3,4-Dihydroxyphenylalanine and 5-hydroxytryptophan as reserpine antagonists
    • Carlsson A., et al. 3,4-Dihydroxyphenylalanine and 5-hydroxytryptophan as reserpine antagonists. Nature 1957, 180:1200.
    • (1957) Nature , vol.180 , pp. 1200
    • Carlsson, A.1
  • 23
    • 34547467082 scopus 로고    scopus 로고
    • Reduced vesicular storage of dopamine causes progressive nigrostriatal neurodegeneration
    • Caudle W.M., et al. Reduced vesicular storage of dopamine causes progressive nigrostriatal neurodegeneration. J. Neurosci. 2007, 27:8138-8148.
    • (2007) J. Neurosci. , vol.27 , pp. 8138-8148
    • Caudle, W.M.1
  • 24
    • 39549094242 scopus 로고    scopus 로고
    • Progressive behavioral deficits in DJ-1-deficient mice are associated with normal nigrostriatal function
    • Chandran J.S., et al. Progressive behavioral deficits in DJ-1-deficient mice are associated with normal nigrostriatal function. Neurobiol. Dis. 2008, 29:505-514.
    • (2008) Neurobiol. Dis. , vol.29 , pp. 505-514
    • Chandran, J.S.1
  • 26
    • 58849098133 scopus 로고    scopus 로고
    • Neurochemical plasticity in the enteric nervous system of a primate animal model of experimental Parkinsonism
    • Chaumette T., et al. Neurochemical plasticity in the enteric nervous system of a primate animal model of experimental Parkinsonism. Neurogastroenterol. Motil. 2009, 21:215-222.
    • (2009) Neurogastroenterol. Motil. , vol.21 , pp. 215-222
    • Chaumette, T.1
  • 27
    • 0030271126 scopus 로고    scopus 로고
    • Basal ganglia and movement disorders: an update
    • Chesselet M.F., Delfs J.M. Basal ganglia and movement disorders: an update. Trends Neurosci. 1996, 19:417-422.
    • (1996) Trends Neurosci. , vol.19 , pp. 417-422
    • Chesselet, M.F.1    Delfs, J.M.2
  • 28
    • 44449159481 scopus 로고    scopus 로고
    • Nociceptive behavioral responses to chemical, thermal and mechanical stimulation after unilateral, intrastriatal administration of 6-hydroxydopamine
    • Chudler E.H., Lu Y. Nociceptive behavioral responses to chemical, thermal and mechanical stimulation after unilateral, intrastriatal administration of 6-hydroxydopamine. Brain Res. 2008, 1213:41-47.
    • (2008) Brain Res. , vol.1213 , pp. 41-47
    • Chudler, E.H.1    Lu, Y.2
  • 29
    • 0035191059 scopus 로고    scopus 로고
    • Enhanced or impaired cognitive function in Parkinson's disease as a function of dopaminergic medication and task demands
    • Cools R., et al. Enhanced or impaired cognitive function in Parkinson's disease as a function of dopaminergic medication and task demands. Cereb. Cortex 2001, 11:1136-1143.
    • (2001) Cereb. Cortex , vol.11 , pp. 1136-1143
    • Cools, R.1
  • 30
    • 33845696933 scopus 로고    scopus 로고
    • L-DOPA disrupts activity in the nucleus accumbens during reversal learning in Parkinson's disease
    • Cools R., et al. L-DOPA disrupts activity in the nucleus accumbens during reversal learning in Parkinson's disease. Neuropsychopharmacology 2007, 32:180-189.
    • (2007) Neuropsychopharmacology , vol.32 , pp. 180-189
    • Cools, R.1
  • 31
    • 0034980098 scopus 로고    scopus 로고
    • Memory disruption in rats with nigral lesions induced by MPTP: a model for early Parkinson's disease amnesia
    • Da Cunha C., et al. Memory disruption in rats with nigral lesions induced by MPTP: a model for early Parkinson's disease amnesia. Behav. Brain Res. 2001, 124:9-18.
    • (2001) Behav. Brain Res. , vol.124 , pp. 9-18
    • Da Cunha, C.1
  • 32
    • 4544368233 scopus 로고    scopus 로고
    • Attention and executive function deficits in chronic low-dose MPTP-treated non-human primates
    • Decamp E., Schneider J.S. Attention and executive function deficits in chronic low-dose MPTP-treated non-human primates. Eur. J. Neurosci. 2004, 20:1371-1378.
    • (2004) Eur. J. Neurosci. , vol.20 , pp. 1371-1378
    • Decamp, E.1    Schneider, J.S.2
  • 33
    • 61849171662 scopus 로고    scopus 로고
    • Interaction between nicotinic and dopaminergic therapies on cognition in a chronic Parkinson model
    • Decamp E., Schneider J.S. Interaction between nicotinic and dopaminergic therapies on cognition in a chronic Parkinson model. Brain Res. 2009, 1262:109-114.
    • (2009) Brain Res. , vol.1262 , pp. 109-114
    • Decamp, E.1    Schneider, J.S.2
  • 34
    • 77953433969 scopus 로고    scopus 로고
    • Evidence in favor of Braak staging of Parkinson's disease
    • Dickson D.W., et al. Evidence in favor of Braak staging of Parkinson's disease. Mov. Disord. 2010, 25(Suppl. 1):S78-S82.
    • (2010) Mov. Disord. , vol.25 , Issue.SUPPL. 1
    • Dickson, D.W.1
  • 35
    • 2942711637 scopus 로고    scopus 로고
    • Quantitative measurement of pain sensation in patients with Parkinson disease
    • Djaldetti R., et al. Quantitative measurement of pain sensation in patients with Parkinson disease. Neurology 2004, 62:2171-2175.
    • (2004) Neurology , vol.62 , pp. 2171-2175
    • Djaldetti, R.1
  • 36
    • 0026767832 scopus 로고
    • 1-Methyl-4-phenyl-1,2,3,6-tetrahydropyridine (MPTP) reduces norepinephrine concentrations in the olfactory bulbs of male mice
    • Dluzen D.E. 1-Methyl-4-phenyl-1,2,3,6-tetrahydropyridine (MPTP) reduces norepinephrine concentrations in the olfactory bulbs of male mice. Brain Res. 1992, 586:144-147.
    • (1992) Brain Res. , vol.586 , pp. 144-147
    • Dluzen, D.E.1
  • 37
    • 33846572874 scopus 로고    scopus 로고
    • Projected number of people with Parkinson disease in the most populous nations, 2005 through 2030
    • Dorsey E.R., et al. Projected number of people with Parkinson disease in the most populous nations, 2005 through 2030. Neurology 2007, 68:384-386.
    • (2007) Neurology , vol.68 , pp. 384-386
    • Dorsey, E.R.1
  • 38
    • 0026697838 scopus 로고
    • Lack of major olfactory dysfunction in MPTP-induced parkinsonism
    • Doty R.L., et al. Lack of major olfactory dysfunction in MPTP-induced parkinsonism. Ann. Neurol. 1992, 32:97-100.
    • (1992) Ann. Neurol. , vol.32 , pp. 97-100
    • Doty, R.L.1
  • 39
    • 69749124032 scopus 로고    scopus 로고
    • Chronic rotenone exposure reproduces Parkinson's disease gastrointestinal neuropathology
    • Drolet R.E., et al. Chronic rotenone exposure reproduces Parkinson's disease gastrointestinal neuropathology. Neurobiol. Dis. 2009, 36:96-102.
    • (2009) Neurobiol. Dis. , vol.36 , pp. 96-102
    • Drolet, R.E.1
  • 40
    • 0025892067 scopus 로고
    • Gastrointestinal symptoms in Parkinson's disease
    • Edwards L.L., et al. Gastrointestinal symptoms in Parkinson's disease. Mov. Disord. 1991, 6:151-156.
    • (1991) Mov. Disord. , vol.6 , pp. 151-156
    • Edwards, L.L.1
  • 41
    • 41249095982 scopus 로고    scopus 로고
    • Current status of symptomatic medical therapy in Parkinson's disease
    • Factor S.A. Current status of symptomatic medical therapy in Parkinson's disease. Neurotherapeutics 2008, 5:164-180.
    • (2008) Neurotherapeutics , vol.5 , pp. 164-180
    • Factor, S.A.1
  • 42
    • 84860841805 scopus 로고    scopus 로고
    • Lippincott Williams & Wilkins, New York, P.T. Rowland LP (Ed.)
    • Fahn S., P.S. Parkinsonism 2010, 751-769. Lippincott Williams & Wilkins, New York. P.T. Rowland LP (Ed.).
    • (2010) Parkinsonism , pp. 751-769
    • Fahn, S.P.S.1
  • 43
    • 0014481719 scopus 로고
    • Changes in dopamine levels in the corpus striatum following lesions in the substantia nigra
    • Faull R.L., Laverty R. Changes in dopamine levels in the corpus striatum following lesions in the substantia nigra. Exp. Neurol. 1969, 23:332-340.
    • (1969) Exp. Neurol. , vol.23 , pp. 332-340
    • Faull, R.L.1    Laverty, R.2
  • 44
    • 0025954066 scopus 로고
    • Ageing and Parkinson's disease: substantia nigra regional selectivity
    • Fearnley J.M., Lees A.J. Ageing and Parkinson's disease: substantia nigra regional selectivity. Brain 1991, 114(Pt. 5):2283-2301.
    • (1991) Brain , vol.114 , Issue.PART. 5 , pp. 2283-2301
    • Fearnley, J.M.1    Lees, A.J.2
  • 45
    • 0036161616 scopus 로고    scopus 로고
    • Experimental models of Parkinson's disease
    • Feger J., et al. Experimental models of Parkinson's disease. Ann. Pharm. Fr. 2002, 60:3-21.
    • (2002) Ann. Pharm. Fr. , vol.60 , pp. 3-21
    • Feger, J.1
  • 46
    • 37249011444 scopus 로고    scopus 로고
    • Behavioral and histopathological consequences of paraquat intoxication in mice: effects of alpha-synuclein over-expression
    • Fernagut P.O., et al. Behavioral and histopathological consequences of paraquat intoxication in mice: effects of alpha-synuclein over-expression. Synapse 2007, 61:991-1001.
    • (2007) Synapse , vol.61 , pp. 991-1001
    • Fernagut, P.O.1
  • 47
    • 0029552596 scopus 로고
    • Long-term cognitive impairment in MPTP-treated rhesus monkeys
    • Fernandez-Ruiz J., et al. Long-term cognitive impairment in MPTP-treated rhesus monkeys. Neuroreport 1995, 7:102-104.
    • (1995) Neuroreport , vol.7 , pp. 102-104
    • Fernandez-Ruiz, J.1
  • 48
    • 0031005815 scopus 로고    scopus 로고
    • Systemic administration of rotenone produces selective damage in the striatum and globus pallidus, but not in the substantia nigra
    • Ferrante R.J., et al. Systemic administration of rotenone produces selective damage in the striatum and globus pallidus, but not in the substantia nigra. Brain Res. 1997, 753:157-162.
    • (1997) Brain Res. , vol.753 , pp. 157-162
    • Ferrante, R.J.1
  • 49
    • 26444486315 scopus 로고    scopus 로고
    • Comparison of bilaterally 6-OHDA- and MPTP-lesioned rats as models of the early phase of Parkinson's disease: histological, neurochemical, motor and memory alterations
    • Ferro M.M., et al. Comparison of bilaterally 6-OHDA- and MPTP-lesioned rats as models of the early phase of Parkinson's disease: histological, neurochemical, motor and memory alterations. J. Neurosci. Methods 2005, 148:78-87.
    • (2005) J. Neurosci. Methods , vol.148 , pp. 78-87
    • Ferro, M.M.1
  • 50
    • 7044270767 scopus 로고    scopus 로고
    • Early and progressive sensorimotor anomalies in mice overexpressing wild-type human alpha-synuclein
    • Fleming S.M., et al. Early and progressive sensorimotor anomalies in mice overexpressing wild-type human alpha-synuclein. J. Neurosci. 2004, 24:9434-9440.
    • (2004) J. Neurosci. , vol.24 , pp. 9434-9440
    • Fleming, S.M.1
  • 51
    • 2342662120 scopus 로고    scopus 로고
    • Behavioral and immunohistochemical effects of chronic intravenous and subcutaneous infusions of varying doses of rotenone
    • Fleming S.M., et al. Behavioral and immunohistochemical effects of chronic intravenous and subcutaneous infusions of varying doses of rotenone. Exp. Neurol. 2004, 187:418-429.
    • (2004) Exp. Neurol. , vol.187 , pp. 418-429
    • Fleming, S.M.1
  • 52
    • 33750300797 scopus 로고    scopus 로고
    • Behavioral effects of dopaminergic agonists in transgenic mice overexpressing human wildtype alpha-synuclein
    • Fleming S.M., et al. Behavioral effects of dopaminergic agonists in transgenic mice overexpressing human wildtype alpha-synuclein. Neuroscience 2006, 142:1245-1253.
    • (2006) Neuroscience , vol.142 , pp. 1245-1253
    • Fleming, S.M.1
  • 53
    • 84873067288 scopus 로고    scopus 로고
    • Impaired reversal learning in transgenic mice overexpressing human wildtype alpha-synuclein
    • Fleming S.M., et al. Impaired reversal learning in transgenic mice overexpressing human wildtype alpha-synuclein. Soc. Neurosci. Abstr. 2008, 341.1:N3.
    • (2008) Soc. Neurosci. Abstr.
    • Fleming, S.M.1
  • 54
    • 48249109112 scopus 로고    scopus 로고
    • Olfactory deficits in mice overexpressing human wildtype alpha-synuclein
    • Fleming S.M., et al. Olfactory deficits in mice overexpressing human wildtype alpha-synuclein. Eur. J. Neurosci. 2008, 28:247-256.
    • (2008) Eur. J. Neurosci. , vol.28 , pp. 247-256
    • Fleming, S.M.1
  • 55
    • 84873072626 scopus 로고    scopus 로고
    • Alterations in heart rate variability in transgenic mice overexpressing human wildtype alpha synuclein
    • Fleming S.M., et al. Alterations in heart rate variability in transgenic mice overexpressing human wildtype alpha synuclein. Soc. Neurosci. Abstr. 2009, 531.9:K8.
    • (2009) Soc. Neurosci. Abstr.
    • Fleming, S.M.1
  • 56
    • 34447570901 scopus 로고    scopus 로고
    • Age-dependent cognitive decline and amygdala pathology in alpha-synuclein transgenic mice
    • Freichel C., et al. Age-dependent cognitive decline and amygdala pathology in alpha-synuclein transgenic mice. Neurobiol. Aging 2007, 28:1421-1435.
    • (2007) Neurobiol. Aging , vol.28 , pp. 1421-1435
    • Freichel, C.1
  • 57
    • 62349116838 scopus 로고    scopus 로고
    • The transcription factor PITX3 is associated with sporadic Parkinson's disease
    • Fuchs J., et al. The transcription factor PITX3 is associated with sporadic Parkinson's disease. Neurobiol. Aging 2009, 30:731-738.
    • (2009) Neurobiol. Aging , vol.30 , pp. 731-738
    • Fuchs, J.1
  • 58
    • 41149140758 scopus 로고    scopus 로고
    • Alpha-synuclein transgenic mice exhibit reduced anxiety-like behaviour
    • George S., et al. Alpha-synuclein transgenic mice exhibit reduced anxiety-like behaviour. Exp. Neurol. 2008, 210:788-792.
    • (2008) Exp. Neurol. , vol.210 , pp. 788-792
    • George, S.1
  • 60
    • 0035330026 scopus 로고    scopus 로고
    • Caffeine reverses the memory disruption induced by intra-nigral MPTP-injection in rats
    • Gevaerd M.S., et al. Caffeine reverses the memory disruption induced by intra-nigral MPTP-injection in rats. Brain Res. Bull. 2001, 55:101-106.
    • (2001) Brain Res. Bull. , vol.55 , pp. 101-106
    • Gevaerd, M.S.1
  • 61
    • 31144476794 scopus 로고    scopus 로고
    • Gain-of-function haplotypes in the vesicular monoamine transporter promoter are protective for Parkinson disease in women
    • Glatt C.E., et al. Gain-of-function haplotypes in the vesicular monoamine transporter promoter are protective for Parkinson disease in women. Hum. Mol. Genet. 2006, 15:299-305.
    • (2006) Hum. Mol. Genet. , vol.15 , pp. 299-305
    • Glatt, C.E.1
  • 62
    • 0141891953 scopus 로고    scopus 로고
    • Parkin-deficient mice exhibit nigrostriatal deficits but not loss of dopaminergic neurons
    • Goldberg M.S., et al. Parkin-deficient mice exhibit nigrostriatal deficits but not loss of dopaminergic neurons. J. Biol. Chem. 2003, 278:43628-43635.
    • (2003) J. Biol. Chem. , vol.278 , pp. 43628-43635
    • Goldberg, M.S.1
  • 63
    • 13844253723 scopus 로고    scopus 로고
    • Nigrostriatal dopaminergic deficits and hypokinesia caused by inactivation of the familial parkinsonism-linked gene DJ-1
    • Goldberg M.S., et al. Nigrostriatal dopaminergic deficits and hypokinesia caused by inactivation of the familial parkinsonism-linked gene DJ-1. Neuron 2005, 45:489-496.
    • (2005) Neuron , vol.45 , pp. 489-496
    • Goldberg, M.S.1
  • 64
    • 0042934211 scopus 로고    scopus 로고
    • Sympathetic innervation in the 1-methyl-4-phenyl-1,2,3,6-tetrahydropyridine primate model of Parkinson's disease
    • Goldstein D.S., et al. Sympathetic innervation in the 1-methyl-4-phenyl-1,2,3,6-tetrahydropyridine primate model of Parkinson's disease. J. Pharmacol. Exp. Ther. 2003, 306:855-860.
    • (2003) J. Pharmacol. Exp. Ther. , vol.306 , pp. 855-860
    • Goldstein, D.S.1
  • 65
    • 0030668234 scopus 로고    scopus 로고
    • Symptoms and duration of the prodromal phase in Parkinson's disease
    • Gonera E.G., et al. Symptoms and duration of the prodromal phase in Parkinson's disease. Mov. Disord. 1997, 12:871-876.
    • (1997) Mov. Disord. , vol.12 , pp. 871-876
    • Gonera, E.G.1
  • 66
    • 80054887573 scopus 로고    scopus 로고
    • Global Depletion of Dopamine Using Intracerebroventricular 6-Hydroxydopamine Injection Disrupts Normal Circadian Wheel-Running Patterns and PERIOD2 Expression in the Rat Forebrain
    • Gravotta L., et al. Global Depletion of Dopamine Using Intracerebroventricular 6-Hydroxydopamine Injection Disrupts Normal Circadian Wheel-Running Patterns and PERIOD2 Expression in the Rat Forebrain. J. Mol. Neurosci. 2011, 45 (2):162-171.
    • (2011) J. Mol. Neurosci. , pp. 162-171
    • Gravotta, L.1
  • 67
    • 67349122370 scopus 로고    scopus 로고
    • Delayed gastric emptying and enteric nervous system dysfunction in the rotenone model of Parkinson's disease
    • Greene J.G., et al. Delayed gastric emptying and enteric nervous system dysfunction in the rotenone model of Parkinson's disease. Exp. Neurol. 2009, 218:154-161.
    • (2009) Exp. Neurol. , vol.218 , pp. 154-161
    • Greene, J.G.1
  • 68
    • 66149143952 scopus 로고    scopus 로고
    • Protective actions of the vesicular monoamine transporter 2 (VMAT2) in monoaminergic neurons
    • Guillot T.S., Miller G.W. Protective actions of the vesicular monoamine transporter 2 (VMAT2) in monoaminergic neurons. Mol. Neurobiol. 2009, 39:149-170.
    • (2009) Mol. Neurobiol. , vol.39 , pp. 149-170
    • Guillot, T.S.1    Miller, G.W.2
  • 69
    • 80052374159 scopus 로고    scopus 로고
    • The prevalence of symptomatic orthostatic hypotension in patients with Parkinson's disease and atypical parkinsonism
    • Ha A.D., et al. The prevalence of symptomatic orthostatic hypotension in patients with Parkinson's disease and atypical parkinsonism. Parkinsonism Relat. Disord. 2011, 17:625-628.
    • (2011) Parkinsonism Relat. Disord. , vol.17 , pp. 625-628
    • Ha, A.D.1
  • 70
    • 0025099780 scopus 로고
    • Loss of brainstem serotonin- and substance P-containing neurons in Parkinson's disease
    • Halliday G.M., et al. Loss of brainstem serotonin- and substance P-containing neurons in Parkinson's disease. Brain Res. 1990, 510:104-107.
    • (1990) Brain Res. , vol.510 , pp. 104-107
    • Halliday, G.M.1
  • 71
    • 79957586330 scopus 로고    scopus 로고
    • Milestones in Parkinson's disease-clinical and pathologic features
    • Halliday G., et al. Milestones in Parkinson's disease-clinical and pathologic features. Mov. Disord. 2011, 26:1015-1021.
    • (2011) Mov. Disord. , vol.26 , pp. 1015-1021
    • Halliday, G.1
  • 72
    • 0036844873 scopus 로고    scopus 로고
    • Clinical correlates of selective pathology in the amygdala of patients with Parkinson's disease
    • Harding A.J., et al. Clinical correlates of selective pathology in the amygdala of patients with Parkinson's disease. Brain 2002, 125:2431-2445.
    • (2002) Brain , vol.125 , pp. 2431-2445
    • Harding, A.J.1
  • 73
    • 75749135592 scopus 로고    scopus 로고
    • A timeline for Parkinson's disease
    • Hawkes C.H., et al. A timeline for Parkinson's disease. Parkinsonism Relat. Disord. 2010, 16:79-84.
    • (2010) Parkinsonism Relat. Disord. , vol.16 , pp. 79-84
    • Hawkes, C.H.1
  • 74
    • 0037786542 scopus 로고    scopus 로고
    • Selective loss of dopaminergic neurons in the substantia nigra of Pitx3-deficient aphakia mice
    • Hwang D.Y., et al. Selective loss of dopaminergic neurons in the substantia nigra of Pitx3-deficient aphakia mice. Brain Res. Mol. Brain Res. 2003, 114:123-131.
    • (2003) Brain Res. Mol. Brain Res. , vol.114 , pp. 123-131
    • Hwang, D.Y.1
  • 75
    • 14244261010 scopus 로고    scopus 로고
    • 3,4-Dihydroxyphenylalanine reverses the motor deficits in Pitx3-deficient aphakia mice: behavioral characterization of a novel genetic model of Parkinson's disease
    • Hwang D.Y., et al. 3,4-Dihydroxyphenylalanine reverses the motor deficits in Pitx3-deficient aphakia mice: behavioral characterization of a novel genetic model of Parkinson's disease. J. Neurosci. 2005, 25:2132-2137.
    • (2005) J. Neurosci. , vol.25 , pp. 2132-2137
    • Hwang, D.Y.1
  • 76
    • 33744991945 scopus 로고    scopus 로고
    • Rapid-eye-movement sleep behaviour disorder as an early marker for a neurodegenerative disorder: a descriptive study
    • Iranzo A., et al. Rapid-eye-movement sleep behaviour disorder as an early marker for a neurodegenerative disorder: a descriptive study. Lancet Neurol. 2006, 5:572-577.
    • (2006) Lancet Neurol. , vol.5 , pp. 572-577
    • Iranzo, A.1
  • 77
    • 0000340348 scopus 로고
    • Parkinsonism-inducing neurotoxin, N-methyl-4-phenyl-1,2,3,6 -tetrahydropyridine: uptake of the metabolite N-methyl-4-phenylpyridine by dopamine neurons explains selective toxicity
    • Javitch J.A., et al. Parkinsonism-inducing neurotoxin, N-methyl-4-phenyl-1,2,3,6 -tetrahydropyridine: uptake of the metabolite N-methyl-4-phenylpyridine by dopamine neurons explains selective toxicity. Proc. Natl. Acad. Sci. U. S. A. 1985, 82:2173-2177.
    • (1985) Proc. Natl. Acad. Sci. U. S. A. , vol.82 , pp. 2173-2177
    • Javitch, J.A.1
  • 78
    • 69549116777 scopus 로고    scopus 로고
    • Formation and development of Lewy pathology: a critical update
    • Jellinger K.A. Formation and development of Lewy pathology: a critical update. J. Neurol. 2009, 256(Suppl. 3):270-279.
    • (2009) J. Neurol. , vol.256 , Issue.SUPPL. 3 , pp. 270-279
    • Jellinger, K.A.1
  • 79
    • 0037378026 scopus 로고    scopus 로고
    • Oxidative stress in Parkinson's disease
    • (discussion S36-8)
    • Jenner P. Oxidative stress in Parkinson's disease. Ann. Neurol. 2003, 53(Suppl. 3):S26-S36. (discussion S36-8).
    • (2003) Ann. Neurol. , vol.53 , Issue.SUPPL. 3
    • Jenner, P.1
  • 80
    • 58349099832 scopus 로고    scopus 로고
    • Functional models of Parkinson's disease: a valuable tool in the development of novel therapies
    • Jenner P. Functional models of Parkinson's disease: a valuable tool in the development of novel therapies. Ann. Neurol. 2008, 64(Suppl. 2):S16-S29.
    • (2008) Ann. Neurol. , vol.64 , Issue.SUPPL. 2
    • Jenner, P.1
  • 81
    • 72649092503 scopus 로고    scopus 로고
    • From the MPTP-treated primate to the treatment of motor complications in Parkinson's disease
    • Jenner P. From the MPTP-treated primate to the treatment of motor complications in Parkinson's disease. Parkinsonism Relat. Disord. 2009, 15(Suppl. 4):S18-S23.
    • (2009) Parkinsonism Relat. Disord. , vol.15 , Issue.SUPPL. 4
    • Jenner, P.1
  • 82
    • 0032876499 scopus 로고    scopus 로고
    • Akinesia and postural abnormality after unilateral dopamine depletion
    • Johnson R.E., et al. Akinesia and postural abnormality after unilateral dopamine depletion. Behav. Brain Res. 1999, 104:189-196.
    • (1999) Behav. Brain Res. , vol.104 , pp. 189-196
    • Johnson, R.E.1
  • 83
    • 79959206608 scopus 로고    scopus 로고
    • Neurobiology of depression and anxiety in Parkinson's disease
    • Kano O., et al. Neurobiology of depression and anxiety in Parkinson's disease. Parkinsons Dis. 2011, 2011:143547.
    • (2011) Parkinsons Dis. , vol.2011 , pp. 143547
    • Kano, O.1
  • 84
    • 79961208135 scopus 로고    scopus 로고
    • Protective effect of lycopene on oxidative stress and cognitive decline in rotenone induced model of Parkinson's disease
    • Kaur H., et al. Protective effect of lycopene on oxidative stress and cognitive decline in rotenone induced model of Parkinson's disease. Neurochem. Res. 2011, 36:1435-1443.
    • (2011) Neurochem. Res. , vol.36 , pp. 1435-1443
    • Kaur, H.1
  • 85
    • 78349310514 scopus 로고    scopus 로고
    • Neuropsychological and clinical heterogeneity of cognitive impairment and dementia in patients with Parkinson's disease
    • Kehagia A.A., et al. Neuropsychological and clinical heterogeneity of cognitive impairment and dementia in patients with Parkinson's disease. Lancet Neurol. 2010, 9:1200-1213.
    • (2010) Lancet Neurol. , vol.9 , pp. 1200-1213
    • Kehagia, A.A.1
  • 86
    • 20144389422 scopus 로고    scopus 로고
    • Hypersensitivity of DJ-1-deficient mice to 1-methyl-4-phenyl-1,2,3,6-tetrahydropyrindine (MPTP) and oxidative stress
    • Kim R.H., et al. Hypersensitivity of DJ-1-deficient mice to 1-methyl-4-phenyl-1,2,3,6-tetrahydropyrindine (MPTP) and oxidative stress. Proc. Natl. Acad. Sci. U. S. A. 2005, 102:5215-5220.
    • (2005) Proc. Natl. Acad. Sci. U. S. A. , vol.102 , pp. 5215-5220
    • Kim, R.H.1
  • 87
    • 78349273066 scopus 로고    scopus 로고
    • Brain stem pathology in Parkinson's disease: an evaluation of the Braak staging model
    • Kingsbury A.E., et al. Brain stem pathology in Parkinson's disease: an evaluation of the Braak staging model. Mov. Disord. 2010, 25:2508-2515.
    • (2010) Mov. Disord. , vol.25 , pp. 2508-2515
    • Kingsbury, A.E.1
  • 88
    • 0031990490 scopus 로고    scopus 로고
    • Ala30Pro mutation in the gene encoding alpha-synuclein in Parkinson's disease
    • Kruger R., et al. Ala30Pro mutation in the gene encoding alpha-synuclein in Parkinson's disease. Nat. Genet. 1998, 18:106-108.
    • (1998) Nat. Genet. , vol.18 , pp. 106-108
    • Kruger, R.1
  • 89
    • 80053932171 scopus 로고    scopus 로고
    • Circadian dysfunction in a mouse model of Parkinson's disease
    • Kudo T., et al. Circadian dysfunction in a mouse model of Parkinson's disease. Exp. Neurol. 2011, 232:66-75.
    • (2011) Exp. Neurol. , vol.232 , pp. 66-75
    • Kudo, T.1
  • 90
    • 0034033238 scopus 로고    scopus 로고
    • Role of dopamine in learning and memory: implications for the treatment of cognitive dysfunction in patients with Parkinson's disease
    • Kulisevsky J. Role of dopamine in learning and memory: implications for the treatment of cognitive dysfunction in patients with Parkinson's disease. Drugs Aging 2000, 16:365-379.
    • (2000) Drugs Aging , vol.16 , pp. 365-379
    • Kulisevsky, J.1
  • 91
    • 77952478217 scopus 로고    scopus 로고
    • Extensive enteric nervous system abnormalities in mice transgenic for artificial chromosomes containing Parkinson disease-associated alpha-synuclein gene mutations precede central nervous system changes
    • Kuo Y.M., et al. Extensive enteric nervous system abnormalities in mice transgenic for artificial chromosomes containing Parkinson disease-associated alpha-synuclein gene mutations precede central nervous system changes. Hum. Mol. Genet. 2010, 19:1633-1650.
    • (2010) Hum. Mol. Genet. , vol.19 , pp. 1633-1650
    • Kuo, Y.M.1
  • 92
    • 43349090683 scopus 로고    scopus 로고
    • MPTP-treated mice: long-lasting loss of nigral TH-ir neurons but not paradoxical sleep alterations
    • Laloux C., et al. MPTP-treated mice: long-lasting loss of nigral TH-ir neurons but not paradoxical sleep alterations. Exp. Brain Res. 2008, 186:635-642.
    • (2008) Exp. Brain Res. , vol.186 , pp. 635-642
    • Laloux, C.1
  • 93
    • 79955629341 scopus 로고    scopus 로고
    • Elevated tonic extracellular dopamine concentration and altered dopamine modulation of synaptic activity precede dopamine loss in the striatum of mice overexpressing human alpha-synuclein
    • Lam H.A., et al. Elevated tonic extracellular dopamine concentration and altered dopamine modulation of synaptic activity precede dopamine loss in the striatum of mice overexpressing human alpha-synuclein. J. Neurosci. Res. 2011, 89:1091-1102.
    • (2011) J. Neurosci. Res. , vol.89 , pp. 1091-1102
    • Lam, H.A.1
  • 94
    • 0032829070 scopus 로고    scopus 로고
    • Evidence of active nerve cell degeneration in the substantia nigra of humans years after 1-methyl-4-phenyl-1,2,3,6-tetrahydropyridine exposure
    • Langston J.W., et al. Evidence of active nerve cell degeneration in the substantia nigra of humans years after 1-methyl-4-phenyl-1,2,3,6-tetrahydropyridine exposure. Ann. Neurol. 1999, 46:598-605.
    • (1999) Ann. Neurol. , vol.46 , pp. 598-605
    • Langston, J.W.1
  • 95
    • 77955846610 scopus 로고    scopus 로고
    • The Drosophila vesicular monoamine transporter reduces pesticide-induced loss of dopaminergic neurons
    • Lawal H.O., et al. The Drosophila vesicular monoamine transporter reduces pesticide-induced loss of dopaminergic neurons. Neurobiol. Dis. 2010, 40:102-112.
    • (2010) Neurobiol. Dis. , vol.40 , pp. 102-112
    • Lawal, H.O.1
  • 96
    • 79953049313 scopus 로고    scopus 로고
    • Transcription factor PITX3 gene in Parkinson's disease
    • Le W., et al. Transcription factor PITX3 gene in Parkinson's disease. Neurobiol. Aging 2011, 32:750-753.
    • (2011) Neurobiol. Aging , vol.32 , pp. 750-753
    • Le, W.1
  • 97
    • 60549085946 scopus 로고    scopus 로고
    • Overview of the extranigral aspects of Parkinson disease
    • Lim S.Y., et al. Overview of the extranigral aspects of Parkinson disease. Arch. Neurol. 2009, 66:167-172.
    • (2009) Arch. Neurol. , vol.66 , pp. 167-172
    • Lim, S.Y.1
  • 98
    • 79960069979 scopus 로고    scopus 로고
    • Alpha-Syn suppression reverses synaptic and memory defects in a mouse model of dementia with Lewy bodies
    • Lim Y., et al. Alpha-Syn suppression reverses synaptic and memory defects in a mouse model of dementia with Lewy bodies. J. Neurosci. 2011, 31:10076-10087.
    • (2011) J. Neurosci. , vol.31 , pp. 10076-10087
    • Lim, Y.1
  • 99
    • 36849078759 scopus 로고    scopus 로고
    • The role of the substantia nigra pars compacta in regulating sleep patterns in rats
    • Lima M.M., et al. The role of the substantia nigra pars compacta in regulating sleep patterns in rats. PLoS One 2007, 2:e513.
    • (2007) PLoS One , vol.2
    • Lima, M.M.1
  • 100
    • 49249135134 scopus 로고    scopus 로고
    • Cyclooxygenase-2 deficiency modifies the neurochemical effects, motor impairment and co-morbid anxiety provoked by paraquat administration in mice
    • Litteljohn D., et al. Cyclooxygenase-2 deficiency modifies the neurochemical effects, motor impairment and co-morbid anxiety provoked by paraquat administration in mice. Eur. J. Neurosci. 2008, 28:707-716.
    • (2008) Eur. J. Neurosci. , vol.28 , pp. 707-716
    • Litteljohn, D.1
  • 101
    • 0342368772 scopus 로고    scopus 로고
    • Association between early-onset Parkinson's disease and mutations in the parkin gene
    • Lucking C.B., et al. Association between early-onset Parkinson's disease and mutations in the parkin gene. N. Engl. J. Med. 2000, 342:1560-1567.
    • (2000) N. Engl. J. Med. , vol.342 , pp. 1560-1567
    • Lucking, C.B.1
  • 102
    • 77957245642 scopus 로고    scopus 로고
    • Genetic mouse models of Parkinson's disease: the state of the art
    • Magen I., Chesselet M.F. Genetic mouse models of Parkinson's disease: the state of the art. Prog. Brain Res. 2010, 184:53-87.
    • (2010) Prog. Brain Res. , vol.184 , pp. 53-87
    • Magen, I.1    Chesselet, M.F.2
  • 103
    • 0037127197 scopus 로고    scopus 로고
    • The herbicide paraquat causes up-regulation and aggregation of alpha-synuclein in mice: paraquat and alpha-synuclein
    • Manning-Bog A.B., et al. The herbicide paraquat causes up-regulation and aggregation of alpha-synuclein in mice: paraquat and alpha-synuclein. J. Biol. Chem. 2002, 277:1641-1644.
    • (2002) J. Biol. Chem. , vol.277 , pp. 1641-1644
    • Manning-Bog, A.B.1
  • 104
    • 80955181036 scopus 로고    scopus 로고
    • The importance of non-motor disturbances to quality of life in Parkinson's disease
    • Martinez-Martin P. The importance of non-motor disturbances to quality of life in Parkinson's disease. J. Neurol. Sci. 2011.
    • (2011) J. Neurol. Sci.
    • Martinez-Martin, P.1
  • 105
    • 79955757052 scopus 로고    scopus 로고
    • Passive immunization reduces behavioral and neuropathological deficits in an alpha-synuclein transgenic model of Lewy body disease
    • Masliah E., et al. Passive immunization reduces behavioral and neuropathological deficits in an alpha-synuclein transgenic model of Lewy body disease. PLoS One 2011, 6:e19338.
    • (2011) PLoS One , vol.6
    • Masliah, E.1
  • 106
    • 0036075892 scopus 로고    scopus 로고
    • Environmental risk factors and Parkinson's disease: selective degeneration of nigral dopaminergic neurons caused by the herbicide paraquat
    • McCormack A.L., et al. Environmental risk factors and Parkinson's disease: selective degeneration of nigral dopaminergic neurons caused by the herbicide paraquat. Neurobiol. Dis. 2002, 10:119-127.
    • (2002) Neurobiol. Dis. , vol.10 , pp. 119-127
    • McCormack, A.L.1
  • 107
    • 77957819556 scopus 로고    scopus 로고
    • Sleep alterations in an environmental neurotoxin-induced model of parkinsonism
    • McDowell K.A., et al. Sleep alterations in an environmental neurotoxin-induced model of parkinsonism. Exp. Neurol. 2010, 226:84-89.
    • (2010) Exp. Neurol. , vol.226 , pp. 84-89
    • McDowell, K.A.1
  • 108
    • 78649686234 scopus 로고    scopus 로고
    • The role of inflammatory cytokines in cognition and other non-motor symptoms of Parkinson's disease
    • Menza M., et al. The role of inflammatory cytokines in cognition and other non-motor symptoms of Parkinson's disease. Psychosomatics 2010, 51:474-479.
    • (2010) Psychosomatics , vol.51 , pp. 474-479
    • Menza, M.1
  • 109
    • 0033030440 scopus 로고    scopus 로고
    • Immunochemical analysis of vesicular monoamine transporter (VMAT2) protein in Parkinson's disease
    • Miller G.W., et al. Immunochemical analysis of vesicular monoamine transporter (VMAT2) protein in Parkinson's disease. Exp. Neurol. 1999, 156:138-148.
    • (1999) Exp. Neurol. , vol.156 , pp. 138-148
    • Miller, G.W.1
  • 110
    • 8144220168 scopus 로고    scopus 로고
    • Vigilance states in a parkinsonian model, the MPTP mouse
    • Monaca C., et al. Vigilance states in a parkinsonian model, the MPTP mouse. Eur. J. Neurosci. 2004, 20:2474-2478.
    • (2004) Eur. J. Neurosci. , vol.20 , pp. 2474-2478
    • Monaca, C.1
  • 111
    • 84873065664 scopus 로고    scopus 로고
    • Mice overexpressing human wildtype alpha-synuclein under the Thy-1 promoter exhibit anomalies in behavioral tests of anxiety
    • Mulligan C.K., et al. Mice overexpressing human wildtype alpha-synuclein under the Thy-1 promoter exhibit anomalies in behavioral tests of anxiety. Soc. Neurosci. Abstr. 2008, 742.19:U28.
    • (2008) Soc. Neurosci. Abstr.
    • Mulligan, C.K.1
  • 112
    • 0021810979 scopus 로고
    • Inhibition of NADH-linked oxidation in brain mitochondria by 1-methyl-4-phenyl-pyridine, a metabolite of the neurotoxin, 1-methyl-4-phenyl-1,2,5,6-tetrahydropyridine
    • Nicklas W.J., et al. Inhibition of NADH-linked oxidation in brain mitochondria by 1-methyl-4-phenyl-pyridine, a metabolite of the neurotoxin, 1-methyl-4-phenyl-1,2,5,6-tetrahydropyridine. Life Sci. 1985, 36:2503-2508.
    • (1985) Life Sci. , vol.36 , pp. 2503-2508
    • Nicklas, W.J.1
  • 113
    • 40449139321 scopus 로고    scopus 로고
    • Neurodegeneration and motor dysfunction in a conditional model of Parkinson's disease
    • Nuber S., et al. Neurodegeneration and motor dysfunction in a conditional model of Parkinson's disease. J. Neurosci. 2008, 28:2471-2484.
    • (2008) J. Neurosci. , vol.28 , pp. 2471-2484
    • Nuber, S.1
  • 114
    • 0037390135 scopus 로고    scopus 로고
    • Pitx3 is required for development of substantia nigra dopaminergic neurons
    • Nunes I., et al. Pitx3 is required for development of substantia nigra dopaminergic neurons. Proc. Natl. Acad. Sci. U. S. A. 2003, 100:4245-4250.
    • (2003) Proc. Natl. Acad. Sci. U. S. A. , vol.100 , pp. 4245-4250
    • Nunes, I.1
  • 115
    • 34548253979 scopus 로고    scopus 로고
    • Characteristics of orthostatic hypotension in Parkinson's disease
    • Oka H., et al. Characteristics of orthostatic hypotension in Parkinson's disease. Brain 2007, 130:2425-2432.
    • (2007) Brain , vol.130 , pp. 2425-2432
    • Oka, H.1
  • 116
    • 33646814708 scopus 로고    scopus 로고
    • Parkinson's disease and dementia
    • Padovani A., et al. Parkinson's disease and dementia. Neurol. Sci. 2006, 27(Suppl. 1):S40-S43.
    • (2006) Neurol. Sci. , vol.27 , Issue.SUPPL. 1
    • Padovani, A.1
  • 117
    • 0026076047 scopus 로고
    • The neuropathologic basis of different clinical subgroups of Parkinson's disease
    • Paulus W., Jellinger K. The neuropathologic basis of different clinical subgroups of Parkinson's disease. J. Neuropathol. Exp. Neurol. 1991, 50:743-755.
    • (1991) J. Neuropathol. Exp. Neurol. , vol.50 , pp. 743-755
    • Paulus, W.1    Jellinger, K.2
  • 118
    • 14944344707 scopus 로고    scopus 로고
    • No global loss of neocortical neurons in Parkinson's disease: a quantitative stereological study
    • Pedersen K.M., et al. No global loss of neocortical neurons in Parkinson's disease: a quantitative stereological study. Mov. Disord. 2005, 20:164-171.
    • (2005) Mov. Disord. , vol.20 , pp. 164-171
    • Pedersen, K.M.1
  • 119
    • 0024351767 scopus 로고
    • A 6-hydroxydopamine-induced selective parkinsonian rat model
    • Perese D.A., et al. A 6-hydroxydopamine-induced selective parkinsonian rat model. Brain Res. 1989, 494:285-293.
    • (1989) Brain Res. , vol.494 , pp. 285-293
    • Perese, D.A.1
  • 120
    • 67649303329 scopus 로고    scopus 로고
    • The neuropathology of parkinsonism
    • Perl D.P. The neuropathology of parkinsonism. Handb. Clin. Neurol. 2007, 83:205-215.
    • (2007) Handb. Clin. Neurol. , vol.83 , pp. 205-215
    • Perl, D.P.1
  • 121
    • 77950852274 scopus 로고    scopus 로고
    • DJ-1-deficient mice show less TH-positive neurons in the ventral tegmental area and exhibit non-motoric behavioural impairments
    • Pham T.T., et al. DJ-1-deficient mice show less TH-positive neurons in the ventral tegmental area and exhibit non-motoric behavioural impairments. Genes Brain Behav. 2010, 9:305-317.
    • (2010) Genes Brain Behav. , vol.9 , pp. 305-317
    • Pham, T.T.1
  • 122
    • 0030744876 scopus 로고    scopus 로고
    • Mutation in the alpha-synuclein gene identified in families with Parkinson's disease
    • Polymeropoulos M.H., et al. Mutation in the alpha-synuclein gene identified in families with Parkinson's disease. Science 1997, 276:2045-2047.
    • (1997) Science , vol.276 , pp. 2045-2047
    • Polymeropoulos, M.H.1
  • 123
    • 33750619116 scopus 로고    scopus 로고
    • The risk is in the air: intranasal administration of MPTP to rats reproducing clinical features of Parkinson's disease
    • Prediger R.D., et al. The risk is in the air: intranasal administration of MPTP to rats reproducing clinical features of Parkinson's disease. Exp. Neurol. 2006, 202:391-403.
    • (2006) Exp. Neurol. , vol.202 , pp. 391-403
    • Prediger, R.D.1
  • 124
    • 77449132053 scopus 로고    scopus 로고
    • Single intranasal administration of 1-methyl-4-phenyl-1,2,3,6-tetrahydropyridine in C57BL/6 mice models early preclinical phase of Parkinson's disease
    • Prediger R.D., et al. Single intranasal administration of 1-methyl-4-phenyl-1,2,3,6-tetrahydropyridine in C57BL/6 mice models early preclinical phase of Parkinson's disease. Neurotox. Res. 2010, 17:114-129.
    • (2010) Neurotox. Res. , vol.17 , pp. 114-129
    • Prediger, R.D.1
  • 125
    • 0029015394 scopus 로고
    • Dose-dependent lesions of the dopaminergic nigrostriatal pathway induced by intrastriatal injection of 6-hydroxydopamine
    • Przedborski S., et al. Dose-dependent lesions of the dopaminergic nigrostriatal pathway induced by intrastriatal injection of 6-hydroxydopamine. Neuroscience 1995, 67:631-647.
    • (1995) Neuroscience , vol.67 , pp. 631-647
    • Przedborski, S.1
  • 126
    • 0034722010 scopus 로고    scopus 로고
    • Role of oxidative changes in the degeneration of dopamine terminals after injection of neurotoxic levels of dopamine
    • Rabinovic A.D., et al. Role of oxidative changes in the degeneration of dopamine terminals after injection of neurotoxic levels of dopamine. Neuroscience 2000, 101:67-76.
    • (2000) Neuroscience , vol.101 , pp. 67-76
    • Rabinovic, A.D.1
  • 127
    • 0034899258 scopus 로고    scopus 로고
    • Levodopa prolongs life expectancy and is non-toxic to substantia nigra
    • Rajput A.H. Levodopa prolongs life expectancy and is non-toxic to substantia nigra. Parkinsonism Relat. Disord. 2001, 8:95-100.
    • (2001) Parkinsonism Relat. Disord. , vol.8 , pp. 95-100
    • Rajput, A.H.1
  • 128
    • 0036605566 scopus 로고    scopus 로고
    • Differential neuropathological alterations in transgenic mice expressing alpha-synuclein from the platelet-derived growth factor and Thy-1 promoters
    • Rockenstein E., et al. Differential neuropathological alterations in transgenic mice expressing alpha-synuclein from the platelet-derived growth factor and Thy-1 promoters. J. Neurosci. Res. 2002, 68:568-578.
    • (2002) J. Neurosci. Res. , vol.68 , pp. 568-578
    • Rockenstein, E.1
  • 129
    • 9744283381 scopus 로고    scopus 로고
    • Reduced MPTP toxicity in noradrenaline transporter knockout mice
    • Rommelfanger K.S., et al. Reduced MPTP toxicity in noradrenaline transporter knockout mice. J. Neurochem. 2004, 91:1116-1124.
    • (2004) J. Neurochem. , vol.91 , pp. 1116-1124
    • Rommelfanger, K.S.1
  • 130
    • 0026528986 scopus 로고
    • Acute and long term effects of 1-methyl-4-phenyl-1,2,3,6-tetrahydropyridine (MPTP) in tests of nociception in mice
    • Rosland J.H., et al. Acute and long term effects of 1-methyl-4-phenyl-1,2,3,6-tetrahydropyridine (MPTP) in tests of nociception in mice. Pharmacol. Toxicol. 1992, 70:31-37.
    • (1992) Pharmacol. Toxicol. , vol.70 , pp. 31-37
    • Rosland, J.H.1
  • 131
    • 33749022060 scopus 로고    scopus 로고
    • Association of olfactory dysfunction with incidental Lewy bodies
    • Ross G.W., et al. Association of olfactory dysfunction with incidental Lewy bodies. Mov. Disord. 2006, 21:2062-2067.
    • (2006) Mov. Disord. , vol.21 , pp. 2062-2067
    • Ross, G.W.1
  • 132
    • 40449083312 scopus 로고    scopus 로고
    • Association of olfactory dysfunction with risk for future Parkinson's disease
    • Ross G.W., et al. Association of olfactory dysfunction with risk for future Parkinson's disease. Ann. Neurol. 2008, 63:167-173.
    • (2008) Ann. Neurol. , vol.63 , pp. 167-173
    • Ross, G.W.1
  • 133
    • 0029739397 scopus 로고    scopus 로고
    • Bilateral 6-hydroxydopamine-induced lesion of the nigrostriatal dopamine pathway reproduces the effects of unilateral lesion on substance P but not on enkephalin expression in rat basal ganglia
    • Salin P., et al. Bilateral 6-hydroxydopamine-induced lesion of the nigrostriatal dopamine pathway reproduces the effects of unilateral lesion on substance P but not on enkephalin expression in rat basal ganglia. Eur. J. Neurosci. 1996, 8:1746-1757.
    • (1996) Eur. J. Neurosci. , vol.8 , pp. 1746-1757
    • Salin, P.1
  • 134
    • 77955057715 scopus 로고    scopus 로고
    • Depressive-like behaviors alterations induced by intranigral MPTP, 6-OHDA, LPS and rotenone models of Parkinson's disease are predominantly associated with serotonin and dopamine
    • Santiago R.M., et al. Depressive-like behaviors alterations induced by intranigral MPTP, 6-OHDA, LPS and rotenone models of Parkinson's disease are predominantly associated with serotonin and dopamine. Prog. Neuropsychopharmacol. Biol. Psychiatry 2010, 34:1104-1114.
    • (2010) Prog. Neuropsychopharmacol. Biol. Psychiatry , vol.34 , pp. 1104-1114
    • Santiago, R.M.1
  • 135
    • 73349092154 scopus 로고    scopus 로고
    • Medical records documentation of constipation preceding Parkinson disease: a case-control study
    • Savica R., et al. Medical records documentation of constipation preceding Parkinson disease: a case-control study. Neurology 2009, 73:1752-1758.
    • (2009) Neurology , vol.73 , pp. 1752-1758
    • Savica, R.1
  • 136
    • 0025346258 scopus 로고
    • Chronic exposure to low doses of MPTP. I. Cognitive deficits in motor asymptomatic monkeys
    • Schneider J.S., Kovelowski C.J. Chronic exposure to low doses of MPTP. I. Cognitive deficits in motor asymptomatic monkeys. Brain Res. 1990, 519:122-128.
    • (1990) Brain Res. , vol.519 , pp. 122-128
    • Schneider, J.S.1    Kovelowski, C.J.2
  • 137
    • 0028825827 scopus 로고
    • Cognitive deficits precede motor deficits in a slowly progressing model of parkinsonism in the monkey
    • Schneider J.S., Pope-Coleman A. Cognitive deficits precede motor deficits in a slowly progressing model of parkinsonism in the monkey. Neurodegeneration 1995, 4:245-255.
    • (1995) Neurodegeneration , vol.4 , pp. 245-255
    • Schneider, J.S.1    Pope-Coleman, A.2
  • 138
    • 3442876461 scopus 로고    scopus 로고
    • Psychiatric aspects of Parkinson's disease-an update
    • Schrag A. Psychiatric aspects of Parkinson's disease-an update. J. Neurol. 2004, 251:795-804.
    • (2004) J. Neurol. , vol.251 , pp. 795-804
    • Schrag, A.1
  • 139
    • 0030272769 scopus 로고    scopus 로고
    • The unilateral 6-hydroxydopamine lesion model in behavioral brain research. Analysis of functional deficits, recovery and treatments
    • Schwarting R.K., Huston J.P. The unilateral 6-hydroxydopamine lesion model in behavioral brain research. Analysis of functional deficits, recovery and treatments. Prog. Neurobiol. 1996, 50:275-331.
    • (1996) Prog. Neurobiol. , vol.50 , pp. 275-331
    • Schwarting, R.K.1    Huston, J.P.2
  • 140
    • 77954073901 scopus 로고    scopus 로고
    • Environmental neurotoxin-induced progressive model of parkinsonism in rats
    • Shen W.B., et al. Environmental neurotoxin-induced progressive model of parkinsonism in rats. Ann. Neurol. 2010, 68:70-80.
    • (2010) Ann. Neurol. , vol.68 , pp. 70-80
    • Shen, W.B.1
  • 141
    • 79952303794 scopus 로고    scopus 로고
    • PARIS (ZNF746) repression of PGC-1alpha contributes to neurodegeneration in Parkinson's disease
    • Shin J.H., et al. PARIS (ZNF746) repression of PGC-1alpha contributes to neurodegeneration in Parkinson's disease. Cell 2011, 144:689-702.
    • (2011) Cell , vol.144 , pp. 689-702
    • Shin, J.H.1
  • 142
    • 0036131985 scopus 로고    scopus 로고
    • Non-recognition of depression and other non-motor symptoms in Parkinson's disease
    • Shulman L.M., et al. Non-recognition of depression and other non-motor symptoms in Parkinson's disease. Parkinsonism Relat. Disord. 2002, 8:193-197.
    • (2002) Parkinsonism Relat. Disord. , vol.8 , pp. 193-197
    • Shulman, L.M.1
  • 143
    • 79751509762 scopus 로고    scopus 로고
    • Parkinson's disease: genetics and pathogenesis
    • Shulman J.M., et al. Parkinson's disease: genetics and pathogenesis. Annu. Rev. Pathol. 2011, 6:193-222.
    • (2011) Annu. Rev. Pathol. , vol.6 , pp. 193-222
    • Shulman, J.M.1
  • 144
    • 0033031356 scopus 로고    scopus 로고
    • Frontal cognitive impairments and saccadic deficits in low-dose MPTP-treated monkeys
    • Slovin H., et al. Frontal cognitive impairments and saccadic deficits in low-dose MPTP-treated monkeys. J. Neurophysiol. 1999, 81:858-874.
    • (1999) J. Neurophysiol. , vol.81 , pp. 858-874
    • Slovin, H.1
  • 145
    • 78650170744 scopus 로고    scopus 로고
    • Selective noradrenergic vulnerability in alpha-synuclein transgenic mice
    • Sotiriou E., et al. Selective noradrenergic vulnerability in alpha-synuclein transgenic mice. Neurobiol. Aging 2010, 31:2103-2114.
    • (2010) Neurobiol. Aging , vol.31 , pp. 2103-2114
    • Sotiriou, E.1
  • 146
    • 0032568534 scopus 로고    scopus 로고
    • Alpha-synuclein in filamentous inclusions of Lewy bodies from Parkinson's disease and dementia with Lewy bodies
    • Spillantini M.G., et al. Alpha-synuclein in filamentous inclusions of Lewy bodies from Parkinson's disease and dementia with Lewy bodies. Proc. Natl. Acad. Sci. U. S. A. 1998, 95:6469-6473.
    • (1998) Proc. Natl. Acad. Sci. U. S. A. , vol.95 , pp. 6469-6473
    • Spillantini, M.G.1
  • 147
    • 36148939479 scopus 로고    scopus 로고
    • Prevalence and treatment of non-motor symptoms in Parkinson's disease
    • Sullivan K.L., et al. Prevalence and treatment of non-motor symptoms in Parkinson's disease. Parkinsonism Relat. Disord. 2007, 13:545.
    • (2007) Parkinsonism Relat. Disord. , vol.13 , pp. 545
    • Sullivan, K.L.1
  • 148
    • 0033951302 scopus 로고    scopus 로고
    • Probabilistic learning and reversal deficits in patients with Parkinson's disease or frontal or temporal lobe lesions: possible adverse effects of dopaminergic medication
    • Swainson R., et al. Probabilistic learning and reversal deficits in patients with Parkinson's disease or frontal or temporal lobe lesions: possible adverse effects of dopaminergic medication. Neuropsychologia 2000, 38:596-612.
    • (2000) Neuropsychologia , vol.38 , pp. 596-612
    • Swainson, R.1
  • 149
    • 54049128810 scopus 로고    scopus 로고
    • Emotional, cognitive and neurochemical alterations in a premotor stage model of Parkinson's disease
    • Tadaiesky M.T., et al. Emotional, cognitive and neurochemical alterations in a premotor stage model of Parkinson's disease. Neuroscience 2008, 156:830-840.
    • (2008) Neuroscience , vol.156 , pp. 830-840
    • Tadaiesky, M.T.1
  • 150
    • 0033955289 scopus 로고    scopus 로고
    • Cardiac sympathetic denervation from the early stage of Parkinson's disease: clinical and experimental studies with radiolabeled MIBG
    • Takatsu H., et al. Cardiac sympathetic denervation from the early stage of Parkinson's disease: clinical and experimental studies with radiolabeled MIBG. J. Nucl. Med. 2000, 41:71-77.
    • (2000) J. Nucl. Med. , vol.41 , pp. 71-77
    • Takatsu, H.1
  • 151
    • 79955557808 scopus 로고    scopus 로고
    • Rotenone, paraquat, and Parkinson's disease
    • Tanner C.M., et al. Rotenone, paraquat, and Parkinson's disease. Environ. Health Perspect. 2011, 119:866-872.
    • (2011) Environ. Health Perspect. , vol.119 , pp. 866-872
    • Tanner, C.M.1
  • 152
    • 67649379066 scopus 로고    scopus 로고
    • Nonmotor symptoms of Parkinson's disease revealed in an animal model with reduced monoamine storage capacity
    • Taylor T.N., et al. Nonmotor symptoms of Parkinson's disease revealed in an animal model with reduced monoamine storage capacity. J. Neurosci. 2009, 29:8103-8113.
    • (2009) J. Neurosci. , vol.29 , pp. 8103-8113
    • Taylor, T.N.1
  • 153
    • 78651109246 scopus 로고    scopus 로고
    • Diagnostic accuracy and agreement across three depression assessment measures for Parkinson's disease
    • Thompson A.W., et al. Diagnostic accuracy and agreement across three depression assessment measures for Parkinson's disease. Parkinsonism Relat. Disord. 2011, 17:40-45.
    • (2011) Parkinsonism Relat. Disord. , vol.17 , pp. 40-45
    • Thompson, A.W.1
  • 154
    • 0036447089 scopus 로고    scopus 로고
    • Detection of behavioral impairments correlated to neurochemical deficits in mice treated with moderate doses of 1-methyl-4-phenyl-1,2,3,6-tetrahydropyridine
    • Tillerson J.L., et al. Detection of behavioral impairments correlated to neurochemical deficits in mice treated with moderate doses of 1-methyl-4-phenyl-1,2,3,6-tetrahydropyridine. Exp. Neurol. 2002, 178:80-90.
    • (2002) Exp. Neurol. , vol.178 , pp. 80-90
    • Tillerson, J.L.1
  • 155
    • 84873072468 scopus 로고    scopus 로고
    • Mice overexpressing human alpha synuclein under the Thy1-promotor show increased fear conditioning and altered responses in anxiety related behavior
    • Torres E.S., et al. Mice overexpressing human alpha synuclein under the Thy1-promotor show increased fear conditioning and altered responses in anxiety related behavior. Soc. Neurosci. Abstr. 2010, 750.25:H18.
    • (2010) Soc. Neurosci. Abstr.
    • Torres, E.S.1
  • 156
    • 0014376793 scopus 로고
    • 6-Hydroxy-dopamine induced degeneration of central monoamine neurons
    • Ungerstedt U. 6-Hydroxy-dopamine induced degeneration of central monoamine neurons. Eur. J. Pharmacol. 1968, 5:107-110.
    • (1968) Eur. J. Pharmacol. , vol.5 , pp. 107-110
    • Ungerstedt, U.1
  • 157
    • 0015182655 scopus 로고
    • Adipsia and aphagia after 6-hydroxydopamine induced degeneration of the nigro-striatal dopamine system
    • Ungerstedt U. Adipsia and aphagia after 6-hydroxydopamine induced degeneration of the nigro-striatal dopamine system. Acta Physiol. Scand. Suppl. 1971, 367:95-122.
    • (1971) Acta Physiol. Scand. Suppl. , vol.367 , pp. 95-122
    • Ungerstedt, U.1
  • 158
    • 2442668926 scopus 로고    scopus 로고
    • Hereditary early-onset Parkinson's disease caused by mutations in PINK1
    • Valente E.M., et al. Hereditary early-onset Parkinson's disease caused by mutations in PINK1. Science 2004, 304:1158-1160.
    • (2004) Science , vol.304 , pp. 1158-1160
    • Valente, E.M.1
  • 159
    • 33748294247 scopus 로고    scopus 로고
    • Neuroprotective effects of modafinil in a marmoset Parkinson model: behavioral and neurochemical aspects
    • van Vliet S.A., et al. Neuroprotective effects of modafinil in a marmoset Parkinson model: behavioral and neurochemical aspects. Behav. Pharmacol. 2006, 17:453-462.
    • (2006) Behav. Pharmacol. , vol.17 , pp. 453-462
    • van Vliet, S.A.1
  • 160
    • 79957652863 scopus 로고    scopus 로고
    • The treatment of early Parkinson's disease: levodopa rehabilitated
    • Vlaar A., et al. The treatment of early Parkinson's disease: levodopa rehabilitated. Pract. Neurol. 2011, 11:145-152.
    • (2011) Pract. Neurol. , vol.11 , pp. 145-152
    • Vlaar, A.1
  • 161
    • 53749092558 scopus 로고    scopus 로고
    • Memory, mood, dopamine, and serotonin in the 1-methyl-4-phenyl-1,2,3,6-tetrahydropyridine-lesioned mouse model of basal ganglia injury
    • Vuckovic M.G., et al. Memory, mood, dopamine, and serotonin in the 1-methyl-4-phenyl-1,2,3,6-tetrahydropyridine-lesioned mouse model of basal ganglia injury. Neurobiol. Dis. 2008, 32:319-327.
    • (2008) Neurobiol. Dis. , vol.32 , pp. 319-327
    • Vuckovic, M.G.1
  • 162
    • 0019125045 scopus 로고
    • Effects of nomifensine and desipramine on the sequelae of intracerebrally-injected 6-OHDA and 5,6-DHT
    • Waddington J.L. Effects of nomifensine and desipramine on the sequelae of intracerebrally-injected 6-OHDA and 5,6-DHT. Pharmacol. Biochem. Behav. 1980, 13:915-917.
    • (1980) Pharmacol. Biochem. Behav. , vol.13 , pp. 915-917
    • Waddington, J.L.1
  • 163
    • 0024781476 scopus 로고
    • Lewy bodies in the enteric nervous system in Parkinson's disease
    • (Suppl.)
    • Wakabayashi K., et al. Lewy bodies in the enteric nervous system in Parkinson's disease. Arch. Histol. Cytol. 1989, 52:191-194. (Suppl.).
    • (1989) Arch. Histol. Cytol. , vol.52 , pp. 191-194
    • Wakabayashi, K.1
  • 164
    • 43249106066 scopus 로고    scopus 로고
    • Abnormal colonic motility in mice overexpressing human wild-type alpha-synuclein
    • Wang L., et al. Abnormal colonic motility in mice overexpressing human wild-type alpha-synuclein. Neuroreport 2008, 19:873-876.
    • (2008) Neuroreport , vol.19 , pp. 873-876
    • Wang, L.1
  • 165
    • 85027950572 scopus 로고    scopus 로고
    • Parkinson's disease risk from ambient exposure to pesticides
    • Wang A., et al. Parkinson's disease risk from ambient exposure to pesticides. Eur. J. Epidemiol. 2011, 26:547-555.
    • (2011) Eur. J. Epidemiol. , vol.26 , pp. 547-555
    • Wang, A.1
  • 166
    • 41349108253 scopus 로고    scopus 로고
    • Parkinson's disease-Part 3: neuropsychiatric symptoms
    • Weintraub D., et al. Parkinson's disease-Part 3: neuropsychiatric symptoms. Am. J. Manag. Care 2008, 14:S59-S69.
    • (2008) Am. J. Manag. Care , vol.14
    • Weintraub, D.1
  • 167
    • 52649165557 scopus 로고    scopus 로고
    • Circadian rest-activity rhythm is altered in Parkinson's disease patients with hallucinations
    • Whitehead D.L., et al. Circadian rest-activity rhythm is altered in Parkinson's disease patients with hallucinations. Mov. Disord. 2008, 23:1137-1145.
    • (2008) Mov. Disord. , vol.23 , pp. 1137-1145
    • Whitehead, D.L.1
  • 168
    • 0042329888 scopus 로고    scopus 로고
    • Behavioral and neurological correlates of ALS-parkinsonism dementia complex in adult mice fed washed cycad flour
    • Wilson J.M., et al. Behavioral and neurological correlates of ALS-parkinsonism dementia complex in adult mice fed washed cycad flour. Neuromolecular Med. 2002, 1:207-221.
    • (2002) Neuromolecular Med. , vol.1 , pp. 207-221
    • Wilson, J.M.1
  • 169
    • 72149091508 scopus 로고    scopus 로고
    • Non-motor extranigral signs and symptoms in Parkinson's disease
    • Wolters E. Non-motor extranigral signs and symptoms in Parkinson's disease. Parkinsonism Relat. Disord. 2009, 15(Suppl. 3):S6-S12.
    • (2009) Parkinsonism Relat. Disord. , vol.15 , Issue.SUPPL. 3
    • Wolters, E.1
  • 170
    • 35748954034 scopus 로고    scopus 로고
    • Paraquat induces dopaminergic dysfunction and proteasome impairment in DJ-1-deficient mice
    • Yang W., et al. Paraquat induces dopaminergic dysfunction and proteasome impairment in DJ-1-deficient mice. Hum. Mol. Genet. 2007, 16:2900-2910.
    • (2007) Hum. Mol. Genet. , vol.16 , pp. 2900-2910
    • Yang, W.1
  • 171
    • 34247595320 scopus 로고    scopus 로고
    • Interleukin-1beta mediates sleep alteration in rats with rotenone-induced parkinsonism
    • Yi P.L., et al. Interleukin-1beta mediates sleep alteration in rats with rotenone-induced parkinsonism. Sleep 2007, 30:413-425.
    • (2007) Sleep , vol.30 , pp. 413-425
    • Yi, P.L.1
  • 172
    • 0029917194 scopus 로고    scopus 로고
    • Immunohistochemical detection of 4-hydroxynonenal protein adducts in Parkinson disease
    • Yoritaka A., et al. Immunohistochemical detection of 4-hydroxynonenal protein adducts in Parkinson disease. Proc. Natl. Acad. Sci. U. S. A. 1996, 93:2696-2701.
    • (1996) Proc. Natl. Acad. Sci. U. S. A. , vol.93 , pp. 2696-2701
    • Yoritaka, A.1
  • 173
    • 7944228088 scopus 로고    scopus 로고
    • Cognitive and behavioral dysfunction in Parkinson's disease: neurochemical and clinicopathological contributions
    • Zgaljardic D.J., et al. Cognitive and behavioral dysfunction in Parkinson's disease: neurochemical and clinicopathological contributions. J. Neural Transm. 2004, 111:1287-1301.
    • (2004) J. Neural Transm. , vol.111 , pp. 1287-1301
    • Zgaljardic, D.J.1
  • 174
    • 44349123056 scopus 로고    scopus 로고
    • Transgenic mice overexpressing tyrosine-to-cysteine mutant human alpha-synuclein: a progressive neurodegenerative model of diffuse Lewy body disease
    • Zhou W., et al. Transgenic mice overexpressing tyrosine-to-cysteine mutant human alpha-synuclein: a progressive neurodegenerative model of diffuse Lewy body disease. J. Biol. Chem. 2008, 283:9863-9870.
    • (2008) J. Biol. Chem. , vol.283 , pp. 9863-9870
    • Zhou, W.1
  • 175
    • 4644263680 scopus 로고    scopus 로고
    • Variable effects of chronic subcutaneous administration of rotenone on striatal histology
    • Zhu C., et al. Variable effects of chronic subcutaneous administration of rotenone on striatal histology. J. Comp. Neurol. 2004, 478:418-426.
    • (2004) J. Comp. Neurol. , vol.478 , pp. 418-426
    • Zhu, C.1
  • 176
    • 34848832883 scopus 로고    scopus 로고
    • Non-motor behavioural impairments in parkin-deficient mice
    • Zhu X.R., et al. Non-motor behavioural impairments in parkin-deficient mice. Eur. J. Neurosci. 2007, 26:1902-1911.
    • (2007) Eur. J. Neurosci. , vol.26 , pp. 1902-1911
    • Zhu, X.R.1
  • 177
    • 84873061537 scopus 로고    scopus 로고
    • Gastrointestinal dysfunction in a Parkinson's disease rat model and the changes of dopaminergic, nitric oxidergic, and cholinergic neurotransmitters in myenteric plexus
    • (7 Jun, Electronic publication ahead of print)
    • Zhu H.C., et al. Gastrointestinal dysfunction in a Parkinson's disease rat model and the changes of dopaminergic, nitric oxidergic, and cholinergic neurotransmitters in myenteric plexus. J. Mol. Neurosci. 2011, (7 Jun, Electronic publication ahead of print).
    • (2011) J. Mol. Neurosci.
    • Zhu, H.C.1
  • 178
    • 0034694199 scopus 로고    scopus 로고
    • Time course of degenerative alterations in nigral dopaminergic neurons following a 6-hydroxydopamine lesion
    • Zuch C.L., et al. Time course of degenerative alterations in nigral dopaminergic neurons following a 6-hydroxydopamine lesion. J. Comp. Neurol. 2000, 427:440-454.
    • (2000) J. Comp. Neurol. , vol.427 , pp. 440-454
    • Zuch, C.L.1


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