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Volumn 177, Issue 1, 2002, Pages 88-94

Heterogeneity of nigral and cortical Lewy bodies differentiated by amplified triple-labeling for alpha-synuclein, ubiquitin, and thiazin red

Author keywords

Alpha synuclein; Campbell Switzer method; CARD; Cingulate gyrus; Confocal laser microscope; Lewy body; Substantia nigra; Thiazin red; Triple labeling immunohistochemical study; Ubiquitin

Indexed keywords

ALPHA SYNUCLEIN; ANTIBODY; POLYCLONAL ANTIBODY; THIAZINE DERIVATIVE; UBIQUITIN;

EID: 0036434291     PISSN: 00144886     EISSN: None     Source Type: Journal    
DOI: 10.1006/exnr.2002.7961     Document Type: Article
Times cited : (42)

References (45)
  • 1
    • 0026563548 scopus 로고
    • Filaments of Lewy bodies contain insoluble cytoskeletal elements
    • Galloway, P. G., P. Mulvihill, and G. Perry. 1992. Filaments of Lewy bodies contain insoluble cytoskeletal elements. Am. J. Pathol. 140: 809-822.
    • (1992) Am. J. Pathol. , vol.140 , pp. 809-822
    • Galloway, P.G.1    Mulvihill, P.2    Perry, G.3
  • 2
    • 0033973421 scopus 로고    scopus 로고
    • NACP/alpha-synuclein-positive filamentous inclusions in astrocytes and oligodendrocytes of Parkinson's disease brains
    • Wakabayashi, K., S. Hayashi, M. Yoshimoto, H. Kudo, and H. Takahashi. 2000. NACP/alpha-synuclein-positive filamentous inclusions in astrocytes and oligodendrocytes of Parkinson's disease brains. Acta Neuropathol. (Berlin) 99: 14-20.
    • (2000) Acta Neuropathol. (Berlin) , vol.99 , pp. 14-20
    • Wakabayashi, K.1    Hayashi, S.2    Yoshimoto, M.3    Kudo, H.4    Takahashi, H.5
  • 3
    • 0343527226 scopus 로고    scopus 로고
    • Alpha-synuclein immunoreactivity in dementia with Lewy bodies: Morphological staging and comparison with ubiquitin immunostaining
    • Gomez-Tortosa, E., K. Newell, M. C. Irizarry, J. L. Sanders, and B. T. Hyman. 2000. Alpha-synuclein immunoreactivity in dementia with Lewy bodies: Morphological staging and comparison with ubiquitin immunostaining. Acta Neuropathol. (Berlin) 99: 352-357.
    • (2000) Acta Neuropathol. (Berlin) , vol.99 , pp. 352-357
    • Gomez-Tortosa, E.1    Newell, K.2    Irizarry, M.C.3    Sanders, J.L.4    Hyman, B.T.5
  • 4
    • 0033669319 scopus 로고    scopus 로고
    • In situ and in vitro study of colocalization and segregation of alpha-synuclein, ubiquitin, and lipids in Lewy bodies
    • Gai, W. P., H. X. Yuan, X. Q. Li, J. T. Power, P. C. Blumbergs, and P. H. Jensen. 2000. In situ and in vitro study of colocalization and segregation of alpha-synuclein, ubiquitin, and lipids in Lewy bodies. Exp. Neurol. 166: 324-333.
    • (2000) Exp. Neurol. , vol.166 , pp. 324-333
    • Gai, W.P.1    Yuan, H.X.2    Li, X.Q.3    Power, J.T.4    Blumbergs, P.C.5    Jensen, P.H.6
  • 5
    • 0025807172 scopus 로고
    • Epitopes located in spatially separate domains of each neurofilament subunit are present in Parkinson's disease Lewy bodies
    • Hill, W. D., V. M. Lee, H. I. Hurtig, J. M. Murray, and J. Q. Trojanowski. 1991. Epitopes located in spatially separate domains of each neurofilament subunit are present in Parkinson's disease Lewy bodies. J. Comp. Neurol. 309: 150-160.
    • (1991) J. Comp. Neurol. , vol.309 , pp. 150-160
    • Hill, W.D.1    Lee, V.M.2    Hurtig, H.I.3    Murray, J.M.4    Trojanowski, J.Q.5
  • 6
    • 0002358095 scopus 로고
    • The incidence and characteristic of Lewy bodies in idiopathic paralysis agitans (Parkinson's disease)
    • Bethlem, J., and W. A. D. H. Jager. 1960. The incidence and characteristic of Lewy bodies in idiopathic paralysis agitans (Parkinson's disease). J. Neurol. Neurosurg. Phychiatry 23: 74-80.
    • (1960) J. Neurol. Neurosurg. Phychiatry , vol.23 , pp. 74-80
    • Bethlem, J.1    Jager, W.A.D.H.2
  • 7
    • 0017288256 scopus 로고
    • Ultrastructure of Lewy bodies in the stellate ganglion
    • Forno, L. S., and R. L. Norville. 1976. Ultrastructure of Lewy bodies in the stellate ganglion. Acta Neuropathol. (Berlin) 34: 183-197.
    • (1976) Acta Neuropathol. (Berlin) , vol.34 , pp. 183-197
    • Forno, L.S.1    Norville, R.L.2
  • 8
    • 0028819404 scopus 로고
    • Diffuse Lewy body disease as substrate of primary lateral sclerosis
    • Hainfellner, J. A., P. Pilz, H. Lassmann, G. Ladurner, and H. Budka. 1995. Diffuse Lewy body disease as substrate of primary lateral sclerosis. J. Neurol. 242: 59-63.
    • (1995) J. Neurol. , vol.242 , pp. 59-63
    • Hainfellner, J.A.1    Pilz, P.2    Lassmann, H.3    Ladurner, G.4    Budka, H.5
  • 9
    • 0025125113 scopus 로고
    • Lobar atrophy with dense-core (brain stem type) Lewy bodies in a patient with dementia
    • Masliah, E., D. Galasko, C. A. Wiley, and L. A. Hansen. 1990. Lobar atrophy with dense-core (brain stem type) Lewy bodies in a patient with dementia. Acta Neuropathol. (Berlin) 80: 453-458.
    • (1990) Acta Neuropathol. (Berlin) , vol.80 , pp. 453-458
    • Masliah, E.1    Galasko, D.2    Wiley, C.A.3    Hansen, L.A.4
  • 10
    • 0023255221 scopus 로고
    • The Lewy body in Parkinson's disease
    • Forno, L. S. 1987. The Lewy body in Parkinson's disease. Adv Neurol. 45: 35-43.
    • (1987) Adv Neurol. , vol.45 , pp. 35-43
    • Forno, L.S.1
  • 11
    • 0027503917 scopus 로고
    • Immunohistochemistry of neuronal inclusions in the cerebral cortex and brain-stem in Lewy body disease
    • Fukuda, T., J. Tanaka, K. Watabe, R. T. Numoto, and M. Minamitani. 1993. Immunohistochemistry of neuronal inclusions in the cerebral cortex and brain-stem in Lewy body disease. Acta Pathol. Jpn. 43: 545-551.
    • (1993) Acta Pathol. Jpn. , vol.43 , pp. 545-551
    • Fukuda, T.1    Tanaka, J.2    Watabe, K.3    Numoto, R.T.4    Minamitani, M.5
  • 12
    • 0023845490 scopus 로고
    • Colloid (hyaline) inclusion bodies in the central nervous system: Their presence in the substantia nigra is diagnostic of Parkinson's disease
    • Pappolla, M. A., D. L. Shank, J. Alzofon, and A. W. Dudley. 1988. Colloid (hyaline) inclusion bodies in the central nervous system: Their presence in the substantia nigra is diagnostic of Parkinson's disease. Hum. Pathol. 19: 27-31.
    • (1988) Hum. Pathol. , vol.19 , pp. 27-31
    • Pappolla, M.A.1    Shank, D.L.2    Alzofon, J.3    Dudley, A.W.4
  • 13
    • 0014569375 scopus 로고
    • Ultrastructural observations in Parkinsonism
    • Roy, S., and L. Wolman. 1969. Ultrastructural observations in Parkinsonism. J. Pathol. 99: 39-44.
    • (1969) J. Pathol. , vol.99 , pp. 39-44
    • Roy, S.1    Wolman, L.2
  • 14
    • 0002521420 scopus 로고
    • Ultrastructural relationship between Lewy bodies and pale bodies studied in locus ceruleus neurons of a non-Parkinsonian patient
    • Takahashi, H., K. Iwanaga, S. Egawa, and F. Ikuta. 1994. Ultrastructural relationship between Lewy bodies and pale bodies studied in locus ceruleus neurons of a non-Parkinsonian patient. Neuropathology 14: 73-80.
    • (1994) Neuropathology , vol.14 , pp. 73-80
    • Takahashi, H.1    Iwanaga, K.2    Egawa, S.3    Ikuta, F.4
  • 17
    • 0031941058 scopus 로고    scopus 로고
    • Aggregation of alpha-synuclein in Lewy bodies of sporadic Parkinson's disease and dementia with Lewy bodies
    • Baba, M., S. Nakajo, P. H. Tu, T. Tomita, K. Nakaya, V. M. Lee, J. Q. Trojanowski, and T. Iwatsubo. 1998. Aggregation of alpha-synuclein in Lewy bodies of sporadic Parkinson's disease and dementia with Lewy bodies. Am. J. Pathol. 152: 879-884.
    • (1998) Am. J. Pathol. , vol.152 , pp. 879-884
    • Baba, M.1    Nakajo, S.2    Tu, P.H.3    Tomita, T.4    Nakaya, K.5    Lee, V.M.6    Trojanowski, J.Q.7    Iwatsubo, T.8
  • 18
    • 0031910093 scopus 로고    scopus 로고
    • Aggregation of neurofilament and alpha-synuclein proteins in Lewy bodies: Implications for the pathogenesis of Parkinson disease and Lewy body dementia
    • Trojanowski, J. Q., and V. M. Lee. 1998. Aggregation of neurofilament and alpha-synuclein proteins in Lewy bodies: Implications for the pathogenesis of Parkinson disease and Lewy body dementia. Arch. Neurol. 55: 151-152.
    • (1998) Arch. Neurol. , vol.55 , pp. 151-152
    • Trojanowski, J.Q.1    Lee, V.M.2
  • 19
    • 0031787871 scopus 로고    scopus 로고
    • Accelerated in vitro fibril formation by a mutant alpha-synuclein linked to early-onset Parkinson disease
    • Conway, K. A., J. D. Harper, and P. T. Lansbury. 1998. Accelerated in vitro fibril formation by a mutant alpha-synuclein linked to early-onset Parkinson disease. Nat. Med. 4: 1318-1320.
    • (1998) Nat. Med. , vol.4 , pp. 1318-1320
    • Conway, K.A.1    Harper, J.D.2    Lansbury, P.T.3
  • 20
    • 0031728689 scopus 로고    scopus 로고
    • Synthetic filaments assembled from C-terminally truncated alpha-synuclein
    • Crowther, R. A., R. Jakes, M. G. Spillantini, and M. Goedert. 1998. Synthetic filaments assembled from C-terminally truncated alpha-synuclein. FEBS Lett. 436: 309-312.
    • (1998) FEBS Lett. , vol.436 , pp. 309-312
    • Crowther, R.A.1    Jakes, R.2    Spillantini, M.G.3    Goedert, M.4
  • 21
    • 0034681471 scopus 로고    scopus 로고
    • Dopaminergic loss and inclusion body formation in alpha-synuclein mice: Implications for neurodegenerative disorders
    • Masliah, E., E. Rockenstein, I. Veinbergs, M. Mallory, M. Hashimoto, A. Takeda, Y. Sagara, A. Sisk, and L. Mucke. 2000. Dopaminergic loss and inclusion body formation in alpha-synuclein mice: Implications for neurodegenerative disorders. Science 287: 1265-1269.
    • (2000) Science , vol.287 , pp. 1265-1269
    • Masliah, E.1    Rockenstein, E.2    Veinbergs, I.3    Mallory, M.4    Hashimoto, M.5    Takeda, A.6    Sagara, Y.7    Sisk, A.8    Mucke, L.9
  • 22
    • 0034704752 scopus 로고    scopus 로고
    • A Drosophila model of Parkinson's disease
    • Feany, M. B., and W. W. Bender. 2000. A Drosophila model of Parkinson's disease. Nature 404: 394-398.
    • (2000) Nature , vol.404 , pp. 394-398
    • Feany, M.B.1    Bender, W.W.2
  • 23
    • 0033771793 scopus 로고    scopus 로고
    • Is there a cause-and-effect relationship between alpha-synuclein fibrillization and Parkinson's disease?
    • Goldberg, M. S., and P. T. Lansbury, Jr. 2000. Is there a cause-and-effect relationship between alpha-synuclein fibrillization and Parkinson's disease? Nat. Cell Biol. 2: E115-119.
    • (2000) Nat. Cell Biol. , vol.2
    • Goldberg, M.S.1    Lansbury P.T., Jr.2
  • 26
    • 0034776095 scopus 로고    scopus 로고
    • Parkin ubiquitinates the alpha-synuclein-interacting protein, synphilin-1: Implications for Lewy-body formation in Parkinson disease
    • Chung, K. K., Y. Zhang, K. L. Lim, Y. Tanaka, H. Huang, J. Gao, C. A. Ross, V. L. Dawson, and T. M. Dawson. 2001. Parkin ubiquitinates the alpha-synuclein-interacting protein, synphilin-1: Implications for Lewy-body formation in Parkinson disease. Nat. Med. 7: 1144-1150.
    • (2001) Nat. Med. , vol.7 , pp. 1144-1150
    • Chung, K.K.1    Zhang, Y.2    Lim, K.L.3    Tanaka, Y.4    Huang, H.5    Gao, J.6    Ross, C.A.7    Dawson, V.L.8    Dawson, T.M.9
  • 27
    • 0033944507 scopus 로고    scopus 로고
    • Tau-positive neurons in corticobasal degeneration and Alzheimer's disease - Distinction by thiazin red and silver impregnations
    • Uchihara, T., A. Nakamura, M. Yamazaki, and O. Mori. 2000. Tau-positive neurons in corticobasal degeneration and Alzheimer's disease - Distinction by thiazin red and silver impregnations. Acta Neuropathol. (Berlin) 100: 385-389.
    • (2000) Acta Neuropathol. (Berlin) , vol.100 , pp. 385-389
    • Uchihara, T.1    Nakamura, A.2    Yamazaki, M.3    Mori, O.4
  • 28
    • 0034527417 scopus 로고    scopus 로고
    • Dual enhancement of double immunofluorescent signals by CARD: Participation of ubiquitin during formation of neurofibrillary tangles
    • Uchihara, T., A. Nakamura, U. Nagaoka, M. Yamazaki, and O. Mori. 2000. Dual enhancement of double immunofluorescent signals by CARD: Participation of ubiquitin during formation of neurofibrillary tangles. Histochem. Cell Biol. 114: 447-451.
    • (2000) Histochem. Cell Biol. , vol.114 , pp. 447-451
    • Uchihara, T.1    Nakamura, A.2    Nagaoka, U.3    Yamazaki, M.4    Mori, O.5
  • 29
    • 0032855251 scopus 로고    scopus 로고
    • Alpha-synuclein immunoreactive Lewy bodies and Lewy neurites in Parkinson's disease are detectable by an advanced silver-staining technique
    • Sandmann-Keil, D., H. Braak, M. Okochi, C. Haass, and E. Braak. 1999. Alpha-synuclein immunoreactive Lewy bodies and Lewy neurites in Parkinson's disease are detectable by an advanced silver-staining technique. Acta Neuropathol. (Berlin) 98: 461-464.
    • (1999) Acta Neuropathol. (Berlin) , vol.98 , pp. 461-464
    • Sandmann-Keil, D.1    Braak, H.2    Okochi, M.3    Haass, C.4    Braak, E.5
  • 31
    • 0026686751 scopus 로고
    • Biotin amplification of biotin and horseradish peroxidase signals in histochemical stains
    • Adams, J. C. 1992. Biotin amplification of biotin and horseradish peroxidase signals in histochemical stains. J. Histochem. Cytochem. 40: 1457-1463.
    • (1992) J. Histochem. Cytochem. , vol.40 , pp. 1457-1463
    • Adams, J.C.1
  • 32
    • 0029981526 scopus 로고    scopus 로고
    • Neuropathology of Parkinson's disease
    • Forno, L. S. 1996. Neuropathology of Parkinson's disease. J. Neuropathol. Exp. Neurol. 55: 259-272.
    • (1996) J. Neuropathol. Exp. Neurol. , vol.55 , pp. 259-272
    • Forno, L.S.1
  • 34
    • 0035947372 scopus 로고    scopus 로고
    • Impairment of the ubiquitin-proteasome system by protein aggregation
    • Bence, N. F., R. M. Sampat, and R. R. Kopito. 2001. Impairment of the ubiquitin-proteasome system by protein aggregation. Science 292: 1552-1555.
    • (2001) Science , vol.292 , pp. 1552-1555
    • Bence, N.F.1    Sampat, R.M.2    Kopito, R.R.3
  • 37
    • 0035830913 scopus 로고    scopus 로고
    • Alpha-synuclein is phosphorylated by members of the Src family of protein-tyrosine kinases
    • Ellis, C. E., P. L. Schwartzberg, T. L. Grider, D. W. Fink, and R. L. Nussbaum. 2001. Alpha-synuclein is phosphorylated by members of the Src family of protein-tyrosine kinases. J. Biol. Chem. 276: 3879-3884.
    • (2001) J. Biol. Chem. , vol.276 , pp. 3879-3884
    • Ellis, C.E.1    Schwartzberg, P.L.2    Grider, T.L.3    Fink, D.W.4    Nussbaum, R.L.5
  • 39
    • 0034674652 scopus 로고    scopus 로고
    • Dityrosine cross-linking promotes formation of stable alpha-synuclein polymers. Implication of nitrative and oxidative stress in the pathogenesis of neurodegenerative synucleinopathies
    • Souza, J. M., B. I. Giasson, Q. Chen, V. M. Lee, and H. Ischiropoulos. 2000. Dityrosine cross-linking promotes formation of stable alpha-synuclein polymers. Implication of nitrative and oxidative stress in the pathogenesis of neurodegenerative synucleinopathies. J. Biol. Chem. 275: 18344-18349.
    • (2000) J. Biol. Chem. , vol.275 , pp. 18344-18349
    • Souza, J.M.1    Giasson, B.I.2    Chen, Q.3    Lee, V.M.4    Ischiropoulos, H.5
  • 41
    • 0035968129 scopus 로고    scopus 로고
    • Abnormal patterns of microtubule-associated protein-2 (MAP-2) immunolabeling in neuronal nuclei and Lewy bodies in Parkinson's disease substantia nigra brain tissues
    • D'Andrea, M. R., S. Ilyin, and C. R. Plata-Salaman. 2001. Abnormal patterns of microtubule-associated protein-2 (MAP-2) immunolabeling in neuronal nuclei and Lewy bodies in Parkinson's disease substantia nigra brain tissues. Neurosci. Lett. 306: 137-140.
    • (2001) Neurosci. Lett. , vol.306 , pp. 137-140
    • D'Andrea, M.R.1    Ilyin, S.2    Plata-Salaman, C.R.3
  • 42
    • 0034717256 scopus 로고    scopus 로고
    • Degeneration process of Lewy bodies in the brains of patients with dementia with Lewy bodies using alpha-synuclein-immunohistochemistry
    • Iseki, E., W. Marui, H. Akiyama, K. Ueda, and K. Kosaka. 2000. Degeneration process of Lewy bodies in the brains of patients with dementia with Lewy bodies using alpha-synuclein-immunohistochemistry. Neurosci. Lett. 286: 69-73.
    • (2000) Neurosci. Lett. , vol.286 , pp. 69-73
    • Iseki, E.1    Marui, W.2    Akiyama, H.3    Ueda, K.4    Kosaka, K.5
  • 43
    • 0035864974 scopus 로고    scopus 로고
    • Glial involvement in the degeneration process of Lewy body-bearing neurons and the degradation process of Lewy bodies in brains of dementia with Lewy bodies
    • Togo, T., E. Iseki, W. Marui, H. Akiyama, K. Ueda, and K. Kosaka. 2001. Glial involvement in the degeneration process of Lewy body-bearing neurons and the degradation process of Lewy bodies in brains of dementia with Lewy bodies. J. Neurol. Sci. 184: 71-75.
    • (2001) J. Neurol. Sci. , vol.184 , pp. 71-75
    • Togo, T.1    Iseki, E.2    Marui, W.3    Akiyama, H.4    Ueda, K.5    Kosaka, K.6


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