Immunoelectron-microscopic demonstration of NACP/α-synuclein-epitopes on the filamentous component of Lewy bodies in Parkinson's disease and in dementia with Lewy bodies

Brain Research

Volumn 808, Issue 1, 1998, Pages 93-100

  Arima, Kunimasa ^a,b   Uéda, Kenji ^a   Sunohara, Nobuhiko ^b   Hirai, Shigeo ^b   Izumiyama, Yoko ^a   Tonozuka Uehara, Haruko ^a   Kawai, Mitsuru ^b  

^a TOKYO METROPOLITAN INSTITUTE OF MEDICAL SCIENCE   (Japan)

^b National Center of Neurology and Psychiatry   (Japan)

Author keywords

Filament aggregation; Lewy body; NACP; Neuronal degeneration; Parkinson's disease; Synuclein

Indexed keywords

ALPHA SYNUCLEIN;

ADULT; AGED; ARTICLE; BRAIN BIOPSY; FEMALE; HUMAN; HUMAN TISSUE; IMMUNOHISTOCHEMISTRY; LEWY BODY; MALE; NERVE DEGENERATION; PARKINSONISM; PRIORITY JOURNAL; PROTEIN DETERMINATION;

BRAIN; BRAIN STEM; DEMENTIA; EPITOPES; HUMANS; HYPOTHALAMUS; IMMUNOHISTOCHEMISTRY; LEWY BODIES; MICROSCOPY, IMMUNOELECTRON; NERVE TISSUE PROTEINS; NEURITES; PARKINSON DISEASE; PHOSPHOPROTEINS; SYNUCLEINS;

EID: 0344808098     PISSN: 00068993     EISSN: None     Source Type: Journal    
DOI: 10.1016/S0006-8993(98)00734-3     Document Type: Article

References (19)

1. Baba M., Nakajo S., Tu P.H., Tomita T., Nakaya K., Lee V.M., Trojanowski J.Q., Iwatsubo T. Aggregation of alpha-synuclein in Lewy bodies of sporadic Parkinson's disease and dementia with Lewy bodies. Am. J. Pathol. 152:1998;879-884.
2. Dale G.E., Probst A., Luthert P., Martin J., Anderton B.H., Leigh P.N. Relationships between Lewy bodies and pale bodies in Parkinson's disease. Acta Neuropathol. 83:1992;525-529.
3. Gibb W.R., Lees A.J. The significance of the Lewy body in the diagnosis of idiopathic Parkinson's disease. Neuropathol. Appl. Neurobiol. 15:1989;27-44.
4. Gibb W.R., Scott T., Lees A.J. Neuronal inclusions of Parkinson's disease. Mov. Disord. 6:1991;2-11.
5. Goto S., Hirano A. Neuronal inputs to hippocampal formation in Alzheimer's disease and in parkinsonism-dementia complex on Guam. Acta Neuropathol. 79:1990;545-550.
6. Hayashida K., Oyanagi S., Mizutani Y., Yokochi M. An early cytoplasmic change before Lewy body maturation: an ultrastructural study of the substantia nigra from an autopsy case of juvenile parkinsonism. Acta Neuropathol. 85:1993;445-448.
7. Honer W.G., Dickson D.W., Gleeson J., Davies P. Regional synaptic pathology in Alzheimer's disease. Neurobiol. Aging. 13:1992;375-382.
8. Ishimaru H., Uéda K., Takahashi A., Maruyama Y. Changes in presynaptic protein NACP/α-synuclein in an ischemic gerbil hippocampus. Brain Res. 788:1998;311-314.
9. Iwai A., Masliah E., Yoshimoto M., Ge N., Flanagan L., de Silva H.A., Kittel A., Saitoh T. The precursor protein of non-A beta component of Alzheimer's disease amyloid is a presynaptic protein of the central nervous system. Neuron. 14:1995;467-475.
10. Jakes R., Spillantini M.G., Goedert M. Identification of two distinct synucleins from human brain. FEBS Lett. 345:1994;27-32.
11. Krüger R., Kuhn W., Müller T., Woitalla D., Graeber M., Kösel S., Przuntek H., Epplen J.T., Schöls L., Riess O. Ala30Pro mutation in the gene encoding α-synuclein in Parkinson's disease. Nature Gen. 18:1998;106-108.
12. Leigh P.N., Probst A., Dale G.E., Power D.P., Brion J.P., Dodson A., Anderton B.H. New aspects of the pathology of neurodegenerative disorders as revealed by ubiquitin antibodies. Acta Neuropathol. 79:1989;61-72.
13. Polymeropoulos M.H., Lavedan C., Leroy E., Ide S.E., Dehejia A., Dutra A., Pike B., Root H., Rubenstein J., Boyer R., Stenroos E.S., Chandrasekharappa S., Athanassiadou A., Papapetropoulos T., Johnson W.G., Lazzarini A.M., Duvoisin R.C., Di Iorio G., Golbe L.I., Nussbaum R.L. Mutation in the alpha-synuclein gene identified in families with Parkinson's disease. Science. 276:1997;2045-2047.
14. Spillantini M.G., Crowther R.A., Jakes R., Hasegawa M., Goedert M. Alpha-synuclein in filamentous inclusions of Lewy bodies from Parkinson's disease and dementia with Lewy bodies. Proc. Natl. Acad. Sci. USA. 95:1998;6469-6473.
15. Spillantini M.G., Schmidt M.L., Lee V.M., Trojanowski J.Q., Jakes R., Goedert M. Alpha-synuclein in Lewy bodies. Nature. 388:1997;839-840.
16. Takeda A., Mallory M., Sundsmo M., Honer W., Hansen L., Masliah E. Abnormal accumulation of NACP/alpha-synuclein in neurodegenerative disorders. Am. J. Pathol. 152:1998;367-372.
17. Uéda K., Fukushima H., Masliah E., Xia Y., Iwai A., Yoshimoto M., Otero D.A.C., Kondo J., Ihara Y., Saitoh T. Molecular cloning of cDNA encoding an unrecognized component of amyloid in Alzheimer disease. Proc. Natl. Acad. Sci. USA. 90:1993;11282-11286.
18. Wakabayashi K., Matsumoto K., Takayama K., Yoshimoto M., Takahashi H. NACP, a presynaptic protein, immunoreactivity in Lewy bodies in Parkinson's disease. Neurosci. Lett. 239:1997;45-48.
19. Zareparsi S., Kay J., Camicioli R., Kramer P., Nutt J., Bird T., Litt M., Payami H. Analysis of the α-synuclein G209A mutation in familial Parkinson's disease. Lancet. 351:1998;37-38.