-
1
-
-
32444449392
-
Lewy bodies
-
1. CW Shults 2006 Lewy bodies Proc Natl Acad Sci USA 103 1661 1668 1:CAS:528:DC%2BD28XhslehsLg%3D 16449387 10.1073/pnas.0509567103 Shults CW (2006) Lewy bodies. Proc Natl Acad Sci USA 103:1661–1668
-
(2006)
Proc Natl Acad Sci USA
, vol.103
, pp. 1661-1668
-
-
Shults, CW1
-
2
-
-
45749155306
-
A critical reappraisal of current staging of Lewy-related pathology in human brain
-
2. KA Jellinger 2008 A critical reappraisal of current staging of Lewy-related pathology in human brain Acta Neuropathol 116 1 16 1:CAS:528:DC%2BD1cXosVOjtbw%3D 18592254 10.1007/s00401-008-0406-y Jellinger KA (2008) A critical reappraisal of current staging of Lewy-related pathology in human brain. Acta Neuropathol 116:1–16
-
(2008)
Acta Neuropathol
, vol.116
, pp. 1-16
-
-
Jellinger, KA1
-
3
-
-
68749116710
-
A critical evaluation of current staging of alpha-synuclein pathology in Lewy body disorders
-
3. KA Jellinger 2009 A critical evaluation of current staging of alpha-synuclein pathology in Lewy body disorders Biochim Biophys Acta 1792 730 740 1:CAS:528:DC%2BD1MXnsFygs7k%3D 18718530 10.1016/j.bbadis.2008.07.006 Jellinger KA (2009) A critical evaluation of current staging of alpha-synuclein pathology in Lewy body disorders. Biochim Biophys Acta 1792:730–740
-
(2009)
Biochim Biophys Acta
, vol.1792
, pp. 730-740
-
-
Jellinger, KA1
-
4
-
-
34447307401
-
Dementia with Lewy bodies
-
4. TJ Ferman BF Boeve 2007 Dementia with Lewy bodies Neurol Clin 25 741 760 17659188 10.1016/j.ncl.2007.03.001 Ferman TJ, Boeve BF (2007) Dementia with Lewy bodies. Neurol Clin 25:741–760
-
(2007)
Neurol Clin
, vol.25
, pp. 741-760
-
-
Ferman, TJ1
Boeve, BF2
-
5
-
-
0030744876
-
Mutation in the alpha-synuclein gene identified in families with Parkinson’s disease
-
5. MH Polymeropoulos C Lavedan E Leroy 1997 Mutation in the alpha-synuclein gene identified in families with Parkinson’s disease Science 276 2045 2047 1:CAS:528:DyaK2sXkt1altr4%3D 9197268 10.1126/science.276.5321.2045 Polymeropoulos MH, Lavedan C, Leroy E et al (1997) Mutation in the alpha-synuclein gene identified in families with Parkinson’s disease. Science 276:2045–2047
-
(1997)
Science
, vol.276
, pp. 2045-2047
-
-
Polymeropoulos, MH1
Lavedan, C2
Leroy, E3
-
6
-
-
0031990490
-
Ala30Pro mutation in the gene encoding alpha-synuclein in Parkinson’s disease
-
6. R Krüger W Kuhn T Müller D Woitalla M Graeber S Kösel H Przuntek JT Epplen L Schöls O Riess 1998 Ala30Pro mutation in the gene encoding alpha-synuclein in Parkinson’s disease Nat Genet 18 106 108 9462735 10.1038/ng0298-106 Krüger R, Kuhn W, Müller T, Woitalla D, Graeber M, Kösel S, Przuntek H, Epplen JT, Schöls L, Riess O (1998) Ala30Pro mutation in the gene encoding alpha-synuclein in Parkinson’s disease. Nat Genet 18:106–108
-
(1998)
Nat Genet
, vol.18
, pp. 106-108
-
-
Krüger, R1
Kuhn, W2
Müller, T3
Woitalla, D4
Graeber, M5
Kösel, S6
Przuntek, H7
Epplen, JT8
Schöls, L9
Riess, O10
-
7
-
-
10744230149
-
The new mutation, E46K, of alpha-synuclein causes Parkinson and Lewy body dementia
-
7. JJ Zarranz J Alegre JC Gómez-Esteban 2004 The new mutation, E46K, of alpha-synuclein causes Parkinson and Lewy body dementia Ann Neurol 55 164 173 1:CAS:528:DC%2BD2cXhs1Sgtb0%3D 14755719 10.1002/ana.10795 Zarranz JJ, Alegre J, Gómez-Esteban JC et al (2004) The new mutation, E46K, of alpha-synuclein causes Parkinson and Lewy body dementia. Ann Neurol 55:164–173
-
(2004)
Ann Neurol
, vol.55
, pp. 164-173
-
-
Zarranz, JJ1
Alegre, J2
Gómez-Esteban, JC3
-
8
-
-
0141725659
-
Neuropathological spectrum of synucleinopathies
-
8. KA Jellinger 2003 Neuropathological spectrum of synucleinopathies Mov Disord 18 Suppl 6 S2 S12 14502650 10.1002/mds.10557 Jellinger KA (2003) Neuropathological spectrum of synucleinopathies. Mov Disord 18(Suppl 6):S2–S12
-
(2003)
Mov Disord
, vol.18
, Issue.Suppl 6
, pp. S2-S12
-
-
Jellinger, KA1
-
9
-
-
0030668423
-
Diagnostic criteria for neuropathological assessment of Alzheimer’s disease
-
9. H Braak E Braak 1997 Diagnostic criteria for neuropathological assessment of Alzheimer’s disease Neurobiol Aging 18 S85 S88 1:STN:280:DyaK2svnt1Sluw%3D%3D 9330992 10.1016/S0197-4580(97)00062-6 Braak H, Braak E (1997) Diagnostic criteria for neuropathological assessment of Alzheimer’s disease. Neurobiol Aging 18:S85–S88
-
(1997)
Neurobiol Aging
, vol.18
, pp. S85-S88
-
-
Braak, H1
Braak, E2
-
10
-
-
9144224226
-
Dementia with Lewy bodies
-
10. I McKeith J Mintzer D Aarsland 2004 Dementia with Lewy bodies Lancet Neurol 3 19 28 14693108 10.1016/S1474-4422(03)00619-7 McKeith I, Mintzer J, Aarsland D et al (2004) Dementia with Lewy bodies. Lancet Neurol 3:19–28
-
(2004)
Lancet Neurol
, vol.3
, pp. 19-28
-
-
McKeith, I1
Mintzer, J2
Aarsland, D3
-
11
-
-
33144489150
-
Diagnosis and management of dementia with Lewy bodies: third report of the DLB Consortium
-
11. IG McKeith DW Dickson J Lowe 2005 Diagnosis and management of dementia with Lewy bodies: third report of the DLB Consortium Neurology 65 1863 1872 1:STN:280:DC%2BD2Mnpt1GqsQ%3D%3D 16237129 10.1212/01.wnl.0000187889.17253.b1 McKeith IG, Dickson DW, Lowe J et al (2005) Diagnosis and management of dementia with Lewy bodies: third report of the DLB Consortium. Neurology 65:1863–1872
-
(2005)
Neurology
, vol.65
, pp. 1863-1872
-
-
McKeith, IG1
Dickson, DW2
Lowe, J3
-
12
-
-
0032568534
-
Alpha-Snuclein in filamentous inclusions of Lewy bodies from Parkinson’s disease and dementia with lewy bodies
-
12. MG Spillantini RA Crowther R Jakes M Hasegawa M Goedert 1998 Alpha-Snuclein in filamentous inclusions of Lewy bodies from Parkinson’s disease and dementia with lewy bodies Proc Natl Acad Sci U S A 95 6469 6473 1:CAS:528:DyaK1cXjtlKgtLo%3D 9600990 10.1073/pnas.95.11.6469 Spillantini MG, Crowther RA, Jakes R, Hasegawa M, Goedert M (1998) Alpha-Snuclein in filamentous inclusions of Lewy bodies from Parkinson’s disease and dementia with lewy bodies. Proc Natl Acad Sci U S A 95:6469–6473
-
(1998)
Proc Natl Acad Sci U S A
, vol.95
, pp. 6469-6473
-
-
Spillantini, MG1
Crowther, RA2
Jakes, R3
Hasegawa, M4
Goedert, M5
-
13
-
-
33846997878
-
Presynaptic alpha-synuclein aggregates, not Lewy bodies, cause neurodegeneration in dementia with Lewy bodies
-
13. ML Kramer WJ Schulz-Schaeffer 2007 Presynaptic alpha-synuclein aggregates, not Lewy bodies, cause neurodegeneration in dementia with Lewy bodies J Neurosci 27 1405 1410 1:CAS:528:DC%2BD2sXhvFCrurg%3D 17287515 10.1523/JNEUROSCI.4564-06.2007 Kramer ML, Schulz-Schaeffer WJ (2007) Presynaptic alpha-synuclein aggregates, not Lewy bodies, cause neurodegeneration in dementia with Lewy bodies. J Neurosci 27:1405–1410
-
(2007)
J Neurosci
, vol.27
, pp. 1405-1410
-
-
Kramer, ML1
Schulz-Schaeffer, WJ2
-
14
-
-
0141733169
-
Structural organization of alpha-synuclein fibrils studied by site-directed spin labeling
-
14. A Der-Sarkissian CC Jao J Chen R Langen 2003 Structural organization of alpha-synuclein fibrils studied by site-directed spin labeling J Biol Chem 278 37530 37535 1:CAS:528:DC%2BD3sXnsV2lsLo%3D 12815044 10.1074/jbc.M305266200 Der-Sarkissian A, Jao CC, Chen J, Langen R (2003) Structural organization of alpha-synuclein fibrils studied by site-directed spin labeling. J Biol Chem 278:37530–37535
-
(2003)
J Biol Chem
, vol.278
, pp. 37530-37535
-
-
Der-Sarkissian, A1
Jao, CC2
Chen, J3
Langen, R4
-
15
-
-
0029127954
-
Characterization of a novel protein regulated during the critical period for song learning in the zebra finch
-
15. JM George H Jin WS Woods DF Clayton 1995 Characterization of a novel protein regulated during the critical period for song learning in the zebra finch Neuron 15 361 372 1:CAS:528:DyaK2MXnvVWlsbc%3D 7646890 10.1016/0896-6273(95)90040-3 George JM, Jin H, Woods WS, Clayton DF (1995) Characterization of a novel protein regulated during the critical period for song learning in the zebra finch. Neuron 15:361–372
-
(1995)
Neuron
, vol.15
, pp. 361-372
-
-
George, JM1
Jin, H2
Woods, WS3
Clayton, DF4
-
16
-
-
0032102455
-
The synucleins: a family of proteins involved in synaptic function, plasticity, neurodegeneration and disease
-
16. DF Clayton JM George 1998 The synucleins: a family of proteins involved in synaptic function, plasticity, neurodegeneration and disease Trends Neurosci 21 249 254 1:CAS:528:DyaK1cXjs1Kms78%3D 9641537 10.1016/S0166-2236(97)01213-7 Clayton DF, George JM (1998) The synucleins: a family of proteins involved in synaptic function, plasticity, neurodegeneration and disease. Trends Neurosci 21:249–254
-
(1998)
Trends Neurosci
, vol.21
, pp. 249-254
-
-
Clayton, DF1
George, JM2
-
17
-
-
15744362063
-
Structure and dynamics of micelle-bound human alpha-synuclein
-
17. TS Ulmer A Bax NB Cole RL Nussbaum 2005 Structure and dynamics of micelle-bound human alpha-synuclein J Biol Chem 280 9595 9603 1:CAS:528:DC%2BD2MXitVChs7Y%3D 15615727 10.1074/jbc.M411805200 Ulmer TS, Bax A, Cole NB, Nussbaum RL (2005) Structure and dynamics of micelle-bound human alpha-synuclein. J Biol Chem 280:9595–9603
-
(2005)
J Biol Chem
, vol.280
, pp. 9595-9603
-
-
Ulmer, TS1
Bax, A2
Cole, NB3
Nussbaum, RL4
-
18
-
-
30044450420
-
Comparison of structure and dynamics of micelle-bound human alpha-synuclein and Parkinson disease variants
-
18. TS Ulmer A Bax 2005 Comparison of structure and dynamics of micelle-bound human alpha-synuclein and Parkinson disease variants J Biol Chem 280 43179 43187 1:CAS:528:DC%2BD2MXhtlCmsb3N 16166095 10.1074/jbc.M507624200 Ulmer TS, Bax A (2005) Comparison of structure and dynamics of micelle-bound human alpha-synuclein and Parkinson disease variants. J Biol Chem 280:43179–43187
-
(2005)
J Biol Chem
, vol.280
, pp. 43179-43187
-
-
Ulmer, TS1
Bax, A2
-
19
-
-
0027489773
-
Molecular cloning of cDNA encoding an unrecognized component of amyloid in Alzheimer disease
-
19. K Uéda H Fukushima E Masliah Y Xia A Iwai M Yoshimoto DA Otero J Kondo Y Ihara T Saitoh 1993 Molecular cloning of cDNA encoding an unrecognized component of amyloid in Alzheimer disease Proc Natl Acad Sci U S A 90 11282 11286 8248242 10.1073/pnas.90.23.11282 Uéda K, Fukushima H, Masliah E, Xia Y, Iwai A, Yoshimoto M, Otero DA, Kondo J, Ihara Y, Saitoh T (1993) Molecular cloning of cDNA encoding an unrecognized component of amyloid in Alzheimer disease. Proc Natl Acad Sci U S A 90:11282–11286
-
(1993)
Proc Natl Acad Sci U S A
, vol.90
, pp. 11282-11286
-
-
Uéda, K1
Fukushima, H2
Masliah, E3
Xia, Y4
Iwai, A5
Yoshimoto, M6
Otero, DA7
Kondo, J8
Ihara, Y9
Saitoh, T10
-
20
-
-
0029257497
-
The core Alzheimer’s peptide NAC forms amyloid fibrils which seed and are seeded by beta-amyloid: is NAC a common trigger or target in neurodegenerative disease?
-
20. H Han PH Weinreb PT Lansbury Jr 1995 The core Alzheimer’s peptide NAC forms amyloid fibrils which seed and are seeded by beta-amyloid: is NAC a common trigger or target in neurodegenerative disease? Chem Biol 2 163 169 1:CAS:528:DyaK2MXlvF2rt74%3D 9383418 10.1016/1074-5521(95)90071-3 Han H, Weinreb PH, Lansbury PT Jr (1995) The core Alzheimer’s peptide NAC forms amyloid fibrils which seed and are seeded by beta-amyloid: is NAC a common trigger or target in neurodegenerative disease? Chem Biol 2:163–169
-
(1995)
Chem Biol
, vol.2
, pp. 163-169
-
-
Han, H1
Weinreb, PH2
Lansbury, PT3
-
21
-
-
0035951869
-
A hydrophobic stretch of 12 amino acid residues in the middle of alpha-synuclein is essential for filament assembly
-
21. BI Giasson IV Murray JQ Trojanowski VM Lee 2001 A hydrophobic stretch of 12 amino acid residues in the middle of alpha-synuclein is essential for filament assembly J Biol Chem 276 2380 1386 1:CAS:528:DC%2BD3MXhtVGjsrw%3D 11060312 10.1074/jbc.M008919200 Giasson BI, Murray IV, Trojanowski JQ, Lee VM (2001) A hydrophobic stretch of 12 amino acid residues in the middle of alpha-synuclein is essential for filament assembly. J Biol Chem 276:2380–1386
-
(2001)
J Biol Chem
, vol.276
, pp. 2380-1386
-
-
Giasson, BI1
Murray, IV2
Trojanowski, JQ3
Lee, VM4
-
22
-
-
34548620297
-
Neuropathology, biochemistry, and biophysics of alpha-synuclein aggregation
-
22. VN Uversky 2007 Neuropathology, biochemistry, and biophysics of alpha-synuclein aggregation J Neurochem 103 17 37 1:CAS:528:DC%2BD2sXhtF2qu7nM 17623039 Uversky VN (2007) Neuropathology, biochemistry, and biophysics of alpha-synuclein aggregation. J Neurochem 103:17–37
-
(2007)
J Neurochem
, vol.103
, pp. 17-37
-
-
Uversky, VN1
-
23
-
-
79960712793
-
Conserved C-terminal charge exerts a profound influence on the aggregation rate of α-synuclein
-
23. K Levitan D Chereau SI Cohen TP Knowles CM Dobson AL Fink JP Anderson JM Goldstein GL Millhauser 2011 Conserved C-terminal charge exerts a profound influence on the aggregation rate of α-synuclein J Mol Biol 411 329 333 1:CAS:528:DC%2BC3MXpt1ygtrw%3D 21689664 10.1016/j.jmb.2011.05.046 Levitan K, Chereau D, Cohen SI, Knowles TP, Dobson CM, Fink AL, Anderson JP, Goldstein JM, Millhauser GL (2011) Conserved C-terminal charge exerts a profound influence on the aggregation rate of α-synuclein. J Mol Biol 411:329–333
-
(2011)
J Mol Biol
, vol.411
, pp. 329-333
-
-
Levitan, K1
Chereau, D2
Cohen, SI3
Knowles, TP4
Dobson, CM5
Fink, AL6
Anderson, JP7
Goldstein, JM8
Millhauser, GL9
-
24
-
-
80052398365
-
α-Synuclein occurs physiologically as a helically folded tetramer that resists aggregation
-
24. T Bartels JG Choi DJ Selkoe 2011 α-Synuclein occurs physiologically as a helically folded tetramer that resists aggregation Nature 477 107 110 1:CAS:528:DC%2BC3MXhtFWku7nM 21841800 10.1038/nature10324 Bartels T, Choi JG, Selkoe DJ (2011) α-Synuclein occurs physiologically as a helically folded tetramer that resists aggregation. Nature 477:107–110
-
(2011)
Nature
, vol.477
, pp. 107-110
-
-
Bartels, T1
Choi, JG2
Selkoe, DJ3
-
25
-
-
0034614415
-
Constitutive phosphorylation of the Parkinson’s disease associated alpha-synuclein
-
25. M Okochi J Walter A Koyama S Nakajo M Baba T Iwatsubo L Meijer PJ Kahle C Haass 2000 Constitutive phosphorylation of the Parkinson’s disease associated alpha-synuclein J Biol Chem 275 390 397 1:CAS:528:DC%2BD3cXjvVKjug%3D%3D 10617630 10.1074/jbc.275.1.390 Okochi M, Walter J, Koyama A, Nakajo S, Baba M, Iwatsubo T, Meijer L, Kahle PJ, Haass C (2000) Constitutive phosphorylation of the Parkinson’s disease associated alpha-synuclein. J Biol Chem 275:390–397
-
(2000)
J Biol Chem
, vol.275
, pp. 390-397
-
-
Okochi, M1
Walter, J2
Koyama, A3
Nakajo, S4
Baba, M5
Iwatsubo, T6
Meijer, L7
Kahle, PJ8
Haass, C9
-
26
-
-
0034527763
-
Physiology and pathophysiology of alpha-synuclein. Cell culture and transgenic animal models based on a Parkinson’s disease-associated protein
-
26. PJ Kahle M Neumann L Ozmen C Haass 2000 Physiology and pathophysiology of alpha-synuclein. Cell culture and transgenic animal models based on a Parkinson’s disease-associated protein Ann N Y Acad Sci 920 33 41 1:CAS:528:DC%2BD3MXotlWruw%3D%3D 11193173 10.1111/j.1749-6632.2000.tb06902.x Kahle PJ, Neumann M, Ozmen L, Haass C (2000) Physiology and pathophysiology of alpha-synuclein. Cell culture and transgenic animal models based on a Parkinson’s disease-associated protein. Ann N Y Acad Sci 920:33–41
-
(2000)
Ann N Y Acad Sci
, vol.920
, pp. 33-41
-
-
Kahle, PJ1
Neumann, M2
Ozmen, L3
Haass, C4
-
27
-
-
0036174010
-
Alpha-synuclein is phosphorylated in synucleinopathy lesions
-
27. H Fujiwara M Hasegawa N Dohmae A Kawashima E Masliah MS Goldberg J Shen K Takio T Iwatsubo 2002 Alpha-synuclein is phosphorylated in synucleinopathy lesions Nat Cell Biol 4 160 164 1:CAS:528:DC%2BD38Xms1ahtLo%3D 11813001 10.1038/ncb841 Fujiwara H, Hasegawa M, Dohmae N, Kawashima A, Masliah E, Goldberg MS, Shen J, Takio K, Iwatsubo T (2002) Alpha-synuclein is phosphorylated in synucleinopathy lesions. Nat Cell Biol 4:160–164
-
(2002)
Nat Cell Biol
, vol.4
, pp. 160-164
-
-
Fujiwara, H1
Hasegawa, M2
Dohmae, N3
Kawashima, A4
Masliah, E5
Goldberg, MS6
Shen, J7
Takio, K8
Iwatsubo, T9
-
28
-
-
0037461582
-
Phosphorylation of alpha-synuclein characteristic of synucleinopathy lesions is recapitulated in alpha-synuclein transgenic Drosophila
-
28. M Takahashi H Kanuka H Fujiwara A Koyama M Hasegawa M Miura T Iwatsubo 2003 Phosphorylation of alpha-synuclein characteristic of synucleinopathy lesions is recapitulated in alpha-synuclein transgenic Drosophila Neurosci Lett 336 155 158 1:CAS:528:DC%2BD38XpslSmtrk%3D 12505616 10.1016/S0304-3940(02)01258-2 Takahashi M, Kanuka H, Fujiwara H, Koyama A, Hasegawa M, Miura M, Iwatsubo T (2003) Phosphorylation of alpha-synuclein characteristic of synucleinopathy lesions is recapitulated in alpha-synuclein transgenic Drosophila. Neurosci Lett 336:155–158
-
(2003)
Neurosci Lett
, vol.336
, pp. 155-158
-
-
Takahashi, M1
Kanuka, H2
Fujiwara, H3
Koyama, A4
Hasegawa, M5
Miura, M6
Iwatsubo, T7
-
29
-
-
33749570292
-
Phosphorylation of Ser-129 is the dominant pathological modification of alpha-synuclein in familial and sporadic Lewy body disease
-
29. JP Anderson DE Walker JM Goldstein 2006 Phosphorylation of Ser-129 is the dominant pathological modification of alpha-synuclein in familial and sporadic Lewy body disease J Biol Chem 281 29739 29752 1:CAS:528:DC%2BD28XhtVahsb%2FI 16847063 10.1074/jbc.M600933200 Anderson JP, Walker DE, Goldstein JM et al (2006) Phosphorylation of Ser-129 is the dominant pathological modification of alpha-synuclein in familial and sporadic Lewy body disease. J Biol Chem 281:29739–29752
-
(2006)
J Biol Chem
, vol.281
, pp. 29739-29752
-
-
Anderson, JP1
Walker, DE2
Goldstein, JM3
-
30
-
-
17844406856
-
Alpha-synuclein phosphorylation controls neurotoxicity and inclusion formation in a Drosophila model of Parkinson disease
-
30. L Chen MB Feany 2005 Alpha-synuclein phosphorylation controls neurotoxicity and inclusion formation in a Drosophila model of Parkinson disease Nat Neurosci 8 657 663 1:CAS:528:DC%2BD2MXjsFyktL0%3D 15834418 10.1038/nn1443 Chen L, Feany MB (2005) Alpha-synuclein phosphorylation controls neurotoxicity and inclusion formation in a Drosophila model of Parkinson disease. Nat Neurosci 8:657–663
-
(2005)
Nat Neurosci
, vol.8
, pp. 657-663
-
-
Chen, L1
Feany, MB2
-
31
-
-
0035830913
-
Alpha-synuclein is phosphorylated by members of the Src family of protein-tyrosine kinases
-
31. CE Ellis PL Schwartzberg TL Grider DW Fink RL Nussbaum 2001 Alpha-synuclein is phosphorylated by members of the Src family of protein-tyrosine kinases J Biol Chem 276 3879 3884 1:CAS:528:DC%2BD3MXht1GgtLc%3D 11078745 10.1074/jbc.M010316200 Ellis CE, Schwartzberg PL, Grider TL, Fink DW, Nussbaum RL (2001) Alpha-synuclein is phosphorylated by members of the Src family of protein-tyrosine kinases. J Biol Chem 276:3879–3884
-
(2001)
J Biol Chem
, vol.276
, pp. 3879-3884
-
-
Ellis, CE1
Schwartzberg, PL2
Grider, TL3
Fink, DW4
Nussbaum, RL5
-
32
-
-
0034813638
-
Activated Fyn phosphorylates alpha-synuclein at tyrosine residue 125
-
32. T Nakamura H Yamashita T Takahashi S Nakamura 2001 Activated Fyn phosphorylates alpha-synuclein at tyrosine residue 125 Biochem Biophys Res Commun 280 1085 1092 1:CAS:528:DC%2BD3MXnvFKqsA%3D%3D 11162638 10.1006/bbrc.2000.4253 Nakamura T, Yamashita H, Takahashi T, Nakamura S (2001) Activated Fyn phosphorylates alpha-synuclein at tyrosine residue 125. Biochem Biophys Res Commun 280:1085–1092
-
(2001)
Biochem Biophys Res Commun
, vol.280
, pp. 1085-1092
-
-
Nakamura, T1
Yamashita, H2
Takahashi, T3
Nakamura, S4
-
33
-
-
70449347241
-
Tyrosine and serine phosphorylation of alpha-synuclein have opposing effects on neurotoxicity and soluble oligomer formation
-
33. L Chen M Periquet X Wang A Negro PJ McLean BT Hyman MB Feany 2009 Tyrosine and serine phosphorylation of alpha-synuclein have opposing effects on neurotoxicity and soluble oligomer formation J Clin Invest 119 3257 3265 1:CAS:528:DC%2BD1MXntVCjtLs%3D 19855133 10.1172/JCI35314 Chen L, Periquet M, Wang X, Negro A, McLean PJ, Hyman BT, Feany MB (2009) Tyrosine and serine phosphorylation of alpha-synuclein have opposing effects on neurotoxicity and soluble oligomer formation. J Clin Invest 119:3257–3265
-
(2009)
J Clin Invest
, vol.119
, pp. 3257-3265
-
-
Chen, L1
Periquet, M2
Wang, X3
Negro, A4
McLean, PJ5
Hyman, BT6
Feany, MB7
-
34
-
-
0034714204
-
Synucleins are a novel class of substrates for G protein-coupled receptor kinases
-
34. AN Pronin AJ Morris A Surguchov JL Benovic 2000 Synucleins are a novel class of substrates for G protein-coupled receptor kinases J Biol Chem 275 26515 26522 1:CAS:528:DC%2BD3cXmt1Oktbo%3D 10852916 10.1074/jbc.M003542200 Pronin AN, Morris AJ, Surguchov A, Benovic JL (2000) Synucleins are a novel class of substrates for G protein-coupled receptor kinases. J Biol Chem 275:26515–26522
-
(2000)
J Biol Chem
, vol.275
, pp. 26515-26522
-
-
Pronin, AN1
Morris, AJ2
Surguchov, A3
Benovic, JL4
-
35
-
-
33748483511
-
The role of G-protein-coupled receptor kinase 5 in pathogenesis of sporadic Parkinson’s disease
-
35. S Arawaka M Wada S Goto 2006 The role of G-protein-coupled receptor kinase 5 in pathogenesis of sporadic Parkinson’s disease J Neurosci 26 9227 9238 1:CAS:528:DC%2BD28XpvFWqtbo%3D 16957079 10.1523/JNEUROSCI.0341-06.2006 Arawaka S, Wada M, Goto S et al (2006) The role of G-protein-coupled receptor kinase 5 in pathogenesis of sporadic Parkinson’s disease. J Neurosci 26:9227–9238
-
(2006)
J Neurosci
, vol.26
, pp. 9227-9238
-
-
Arawaka, S1
Wada, M2
Goto, S3
-
36
-
-
59149090357
-
Polo-like kinase 2 (PLK2) phosphorylates alpha-synuclein at serine 129 in central nervous system
-
36. KJ Inglis D Chereau EF Brigham 2009 Polo-like kinase 2 (PLK2) phosphorylates alpha-synuclein at serine 129 in central nervous system J Biol Chem 284 2598 25602 1:CAS:528:DC%2BD1MXpsVyqug%3D%3D 19004816 10.1074/jbc.C800206200 Inglis KJ, Chereau D, Brigham EF et al (2009) Polo-like kinase 2 (PLK2) phosphorylates alpha-synuclein at serine 129 in central nervous system. J Biol Chem 284:2598–25602
-
(2009)
J Biol Chem
, vol.284
, pp. 2598-25602
-
-
Inglis, KJ1
Chereau, D2
Brigham, EF3
-
37
-
-
77449113371
-
Phosphorylation of synucleins by members of the Polo-like kinase family
-
37. MK Mbefo KE Paleologou A Boucharaba A Oueslati H Schell M Fournier D Olschewski G Yin M Zweckstetter E Masliah PJ Kahle H Hirling HA Lashuel 2010 Phosphorylation of synucleins by members of the Polo-like kinase family J Biol Chem 285 2807 2822 1:CAS:528:DC%2BC3cXlvFCruw%3D%3D 19889641 10.1074/jbc.M109.081950 Mbefo MK, Paleologou KE, Boucharaba A, Oueslati A, Schell H, Fournier M, Olschewski D, Yin G, Zweckstetter M, Masliah E, Kahle PJ, Hirling H, Lashuel HA (2010) Phosphorylation of synucleins by members of the Polo-like kinase family. J Biol Chem 285:2807–2822
-
(2010)
J Biol Chem
, vol.285
, pp. 2807-2822
-
-
Mbefo, MK1
Paleologou, KE2
Boucharaba, A3
Oueslati, A4
Schell, H5
Fournier, M6
Olschewski, D7
Yin, G8
Zweckstetter, M9
Masliah, E10
Kahle, PJ11
Hirling, H12
Lashuel, HA13
-
38
-
-
78650203006
-
Characterization of kinases involved in the phosphorylation of aggregated α-synuclein
-
38. EA Waxman BI Giasson 2011 Characterization of kinases involved in the phosphorylation of aggregated α-synuclein J Neurosci Res 89 231 247 1:CAS:528:DC%2BC3cXhsFKjur7M 21162130 10.1002/jnr.22537 Waxman EA, Giasson BI (2011) Characterization of kinases involved in the phosphorylation of aggregated α-synuclein. J Neurosci Res 89:231–247
-
(2011)
J Neurosci Res
, vol.89
, pp. 231-247
-
-
Waxman, EA1
Giasson, BI2
-
39
-
-
77749341497
-
Phosphorylation at S87 is enhanced in synucleinopathies, inhibits alpha-synuclein oligomerization, and influences synuclein-membrane interactions
-
39. KE Paleologou A Oueslati G Shakked 2010 Phosphorylation at S87 is enhanced in synucleinopathies, inhibits alpha-synuclein oligomerization, and influences synuclein-membrane interactions J Neurosci 30 3184 3198 1:CAS:528:DC%2BC3cXjtFahtLo%3D 20203178 10.1523/JNEUROSCI.5922-09.2010 Paleologou KE, Oueslati A, Shakked G et al (2010) Phosphorylation at S87 is enhanced in synucleinopathies, inhibits alpha-synuclein oligomerization, and influences synuclein-membrane interactions. J Neurosci 30:3184–3198
-
(2010)
J Neurosci
, vol.30
, pp. 3184-3198
-
-
Paleologou, KE1
Oueslati, A2
Shakked, G3
-
40
-
-
38749131954
-
Localization of CKII beta subunits in Lewy bodies of Parkinson’s disease
-
40. MY Ryu DW Kim K Arima MM Mouradian SU Kim G Lee 2008 Localization of CKII beta subunits in Lewy bodies of Parkinson’s disease J Neurol Sci 266 9 12 1:CAS:528:DC%2BD1cXhslGhsrk%3D 17884098 10.1016/j.jns.2007.08.027 Ryu MY, Kim DW, Arima K, Mouradian MM, Kim SU, Lee G (2008) Localization of CKII beta subunits in Lewy bodies of Parkinson’s disease. J Neurol Sci 266:9–12
-
(2008)
J Neurol Sci
, vol.266
, pp. 9-12
-
-
Ryu, MY1
Kim, DW2
Arima, K3
Mouradian, MM4
Kim, SU5
Lee, G6
-
41
-
-
79958169700
-
Changes in the solubility and phosphorylation of α-synuclein over the course of Parkinson’s disease
-
41. J Zhou M Broe Y Huang JP Anderson WP Gai EA Milward M Porritt D Howells AJ Hughes X Wang GM Halliday 2011 Changes in the solubility and phosphorylation of α-synuclein over the course of Parkinson’s disease Acta Neuropathol 121 695 704 1:CAS:528:DC%2BC3MXmsVWrtrg%3D 21400129 10.1007/s00401-011-0815-1 Zhou J, Broe M, Huang Y, Anderson JP, Gai WP, Milward EA, Porritt M, Howells D, Hughes AJ, Wang X, Halliday GM (2011) Changes in the solubility and phosphorylation of α-synuclein over the course of Parkinson’s disease. Acta Neuropathol 121:695–704
-
(2011)
Acta Neuropathol
, vol.121
, pp. 695-704
-
-
Zhou, J1
Broe, M2
Huang, Y3
Anderson, JP4
Gai, WP5
Milward, EA6
Porritt, M7
Howells, D8
Hughes, AJ9
Wang, X10
Halliday, GM11
-
42
-
-
0037604508
-
Accumulation of phosphorylated alpha-synuclein in aging human brain
-
42. Y Saito A Kawashima NN Ruberu H Fujiwara S Koyama M Sawabe T Arai H Nagura H Yamanouchi M Hasegawa T Iwatsubo S Murayama 2003 Accumulation of phosphorylated alpha-synuclein in aging human brain J Neuropathol Exp Neurol 62 644 654 1:CAS:528:DC%2BD3sXlt1yqu78%3D 12834109 Saito Y, Kawashima A, Ruberu NN, Fujiwara H, Koyama S, Sawabe M, Arai T, Nagura H, Yamanouchi H, Hasegawa M, Iwatsubo T, Murayama S (2003) Accumulation of phosphorylated alpha-synuclein in aging human brain. J Neuropathol Exp Neurol 62:644–654
-
(2003)
J Neuropathol Exp Neurol
, vol.62
, pp. 644-654
-
-
Saito, Y1
Kawashima, A2
Ruberu, NN3
Fujiwara, H4
Koyama, S5
Sawabe, M6
Arai, T7
Nagura, H8
Yamanouchi, H9
Hasegawa, M10
Iwatsubo, T11
Murayama, S12
-
43
-
-
77957264418
-
The synaptic pathology of alpha-synuclein aggregation in dementia with Lewy bodies, Parkinson’s disease and Parkinson’s disease dementia
-
43. WJ Schulz-Schaeffer 2010 The synaptic pathology of alpha-synuclein aggregation in dementia with Lewy bodies, Parkinson’s disease and Parkinson’s disease dementia Acta Neuropathol 120 131 143 1:CAS:528:DC%2BC3cXotVKnsbw%3D 20563819 10.1007/s00401-010-0711-0 Schulz-Schaeffer WJ (2010) The synaptic pathology of alpha-synuclein aggregation in dementia with Lewy bodies, Parkinson’s disease and Parkinson’s disease dementia. Acta Neuropathol 120:131–143
-
(2010)
Acta Neuropathol
, vol.120
, pp. 131-143
-
-
Schulz-Schaeffer, WJ1
-
44
-
-
77957266699
-
Proteinase K-resistant alpha-synuclein is deposited in presynapses in human Lewy body disease and A53T alpha-synuclein transgenic mice
-
44. K Tanji F Mori J Mimura K Itoh A Kakita H Takahashi K Wakabayashi 2010 Proteinase K-resistant alpha-synuclein is deposited in presynapses in human Lewy body disease and A53T alpha-synuclein transgenic mice Acta Neuropathol 120 145 154 1:CAS:528:DC%2BC3cXotVKnsbs%3D 20339856 10.1007/s00401-010-0676-z Tanji K, Mori F, Mimura J, Itoh K, Kakita A, Takahashi H, Wakabayashi K (2010) Proteinase K-resistant alpha-synuclein is deposited in presynapses in human Lewy body disease and A53T alpha-synuclein transgenic mice. Acta Neuropathol 120:145–154
-
(2010)
Acta Neuropathol
, vol.120
, pp. 145-154
-
-
Tanji, K1
Mori, F2
Mimura, J3
Itoh, K4
Kakita, A5
Takahashi, H6
Wakabayashi, K7
-
45
-
-
80053912079
-
Effect of Ser-129 phosphorylation on interaction of {alpha}-synuclein with synaptic and cellular membranes
-
45. NP Visanji S Wislet-Gendebien LW Oschipok G Zhang I Aubert PE Fraser A Tandon 2011 Effect of Ser-129 phosphorylation on interaction of {alpha}-synuclein with synaptic and cellular membranes J Biol Chem 286 35863 35873 1:CAS:528:DC%2BC3MXht1yhtrbN 21849493 10.1074/jbc.M111.253450 Visanji NP, Wislet-Gendebien S, Oschipok LW, Zhang G, Aubert I, Fraser PE, Tandon A (2011) Effect of Ser-129 phosphorylation on interaction of {alpha}-synuclein with synaptic and cellular membranes. J Biol Chem 286:35863–35873
-
(2011)
J Biol Chem
, vol.286
, pp. 35863-35873
-
-
Visanji, NP1
Wislet-Gendebien, S2
Oschipok, LW3
Zhang, G4
Aubert, I5
Fraser, PE6
Tandon, A7
-
46
-
-
33845937335
-
Dyrk1A phosphorylates alpha-synuclein and enhances intracellular inclusion formation
-
46. EJ Kim JY Sung HJ Lee H Rhim M Hasegawa T Iwatsubo S Min do J Kim SR Paik KC Chung 2006 Dyrk1A phosphorylates alpha-synuclein and enhances intracellular inclusion formation J Biol Chem 281 33250 33257 1:CAS:528:DC%2BD28XhtFegsb7P 16959772 10.1074/jbc.M606147200 Kim EJ, Sung JY, Lee HJ, Rhim H, Hasegawa M, Iwatsubo T, Min do S, Kim J, Paik SR, Chung KC (2006) Dyrk1A phosphorylates alpha-synuclein and enhances intracellular inclusion formation. J Biol Chem 281:33250–33257
-
(2006)
J Biol Chem
, vol.281
, pp. 33250-33257
-
-
Kim, EJ1
Sung, JY2
Lee, HJ3
Rhim, H4
Hasegawa, M5
Iwatsubo, T6
Min do, S7
Kim, J8
Paik, SR9
Chung, KC10
-
47
-
-
77955493107
-
Mechanisms of mono- and poly-ubiquitination: ubiquitination specificity depends on compatibility between the E2 catalytic core and amino acid residues proximal to the lysine
-
47. M Sadowski B Sarcevic 2010 Mechanisms of mono-and poly-ubiquitination: ubiquitination specificity depends on compatibility between the E2 catalytic core and amino acid residues proximal to the lysine Cell Div 5 19 20704751 10.1186/1747-1028-5-19 1:CAS:528:DC%2BC3cXhtVGnt7%2FN Sadowski M, Sarcevic B (2010) Mechanisms of mono-and poly-ubiquitination: ubiquitination specificity depends on compatibility between the E2 catalytic core and amino acid residues proximal to the lysine. Cell Div 5:19
-
(2010)
Cell Div
, vol.5
, pp. 19
-
-
Sadowski, M1
Sarcevic, B2
-
48
-
-
0037756792
-
Context of multiubiquitin chain attachment influences the rate of Sic1 degradation
-
48. MD Petroski RJ Deshaies 2003 Context of multiubiquitin chain attachment influences the rate of Sic1 degradation Mol Cell 11 1435 1444 1:CAS:528:DC%2BD3sXltlSkuro%3D 12820958 10.1016/S1097-2765(03)00221-1 Petroski MD, Deshaies RJ (2003) Context of multiubiquitin chain attachment influences the rate of Sic1 degradation. Mol Cell 11:1435–1444
-
(2003)
Mol Cell
, vol.11
, pp. 1435-1444
-
-
Petroski, MD1
Deshaies, RJ2
-
49
-
-
11244351579
-
Function and regulation of cullin-RING ubiquitin ligases
-
49. M Petroski R Deshaies 2005 Function and regulation of cullin-RING ubiquitin ligases Nat Rev Mol Cell Biol 6 8 20 10.1038/nrm1547 1:CAS:528:DC%2BD2MXlvVWg Petroski M, Deshaies R (2005) Function and regulation of cullin-RING ubiquitin ligases. Nat Rev Mol Cell Biol 6:8–20
-
(2005)
Nat Rev Mol Cell Biol
, vol.6
, pp. 8-20
-
-
Petroski, M1
Deshaies, R2
-
50
-
-
9444262440
-
Activation of the human homologue of the Drosophila sina gene in apoptosis and tumor suppression
-
50. M Nemani G Linares-Cruz H Bruzzoni-Giovanelli 1996 Activation of the human homologue of the Drosophila sina gene in apoptosis and tumor suppression Proc Natl Acad Sci USA 93 9039 9042 1:CAS:528:DyaK28Xlt1Chsr0%3D 8799150 10.1073/pnas.93.17.9039 Nemani M, Linares-Cruz G, Bruzzoni-Giovanelli H et al (1996) Activation of the human homologue of the Drosophila sina gene in apoptosis and tumor suppression. Proc Natl Acad Sci USA 93:9039–9042
-
(1996)
Proc Natl Acad Sci USA
, vol.93
, pp. 9039-9042
-
-
Nemani, M1
Linares-Cruz, G2
Bruzzoni-Giovanelli, H3
-
51
-
-
2242472974
-
Phosphorylated a-synuclein is ubiquitinated in a-synucleinopathy lesions
-
51. M Hasegawa H Fujiwara T Nonaka K Wakabayashi H Takahashi VM Lee JQ Trojanowski D Mann T Iwatsubo 2002 Phosphorylated a-synuclein is ubiquitinated in a-synucleinopathy lesions J Biol Chem 277 49071 49076 1:CAS:528:DC%2BD38Xptlems7o%3D 12377775 10.1074/jbc.M208046200 Hasegawa M, Fujiwara H, Nonaka T, Wakabayashi K, Takahashi H, Lee VM, Trojanowski JQ, Mann D, Iwatsubo T (2002) Phosphorylated a-synuclein is ubiquitinated in a-synucleinopathy lesions. J Biol Chem 277:49071–49076
-
(2002)
J Biol Chem
, vol.277
, pp. 49071-49076
-
-
Hasegawa, M1
Fujiwara, H2
Nonaka, T3
Wakabayashi, K4
Takahashi, H5
Lee, VM6
Trojanowski, JQ7
Mann, D8
Iwatsubo, T9
-
52
-
-
0242666359
-
Ubiquitination of a-synuclein in Lewy bodies is a pathological event not associated with impairment of proteasome function
-
52. GK Tofaris A Razzaq B Ghetti KS Lilley MG Spillantini 2003 Ubiquitination of a-synuclein in Lewy bodies is a pathological event not associated with impairment of proteasome function J Biol Chem 278 44405 44411 1:CAS:528:DC%2BD3sXoslWmur8%3D 12923179 10.1074/jbc.M308041200 Tofaris GK, Razzaq A, Ghetti B, Lilley KS, Spillantini MG (2003) Ubiquitination of a-synuclein in Lewy bodies is a pathological event not associated with impairment of proteasome function. J Biol Chem 278:44405–44411
-
(2003)
J Biol Chem
, vol.278
, pp. 44405-44411
-
-
Tofaris, GK1
Razzaq, A2
Ghetti, B3
Lilley, KS4
Spillantini, MG5
-
53
-
-
11844306551
-
Ubiquitination of alpha-synuclein
-
53. T Nonaka T Iwatsubo M Hasegawa 2005 Ubiquitination of alpha-synuclein Biochemistry 44 361 368 1:CAS:528:DC%2BD2cXhtVCmsLnF 15628878 10.1021/bi0485528 Nonaka T, Iwatsubo T, Hasegawa M (2005) Ubiquitination of alpha-synuclein. Biochemistry 44:361–368
-
(2005)
Biochemistry
, vol.44
, pp. 361-368
-
-
Nonaka, T1
Iwatsubo, T2
Hasegawa, M3
-
54
-
-
0035854437
-
Ubiquitination of a new form of alpha-synuclein by parkin from human brain: implications for Parkinson’s disease
-
54. H Shimura MG Schlossmacher N Hattori MP Frosch A Trockenbacher R Schneider Y Mizuno KS Kosik DJ Selkoe 2001 Ubiquitination of a new form of alpha-synuclein by parkin from human brain: implications for Parkinson’s disease Science 293 263 269 1:CAS:528:DC%2BD3MXlt1yitL4%3D 11431533 10.1126/science.1060627 Shimura H, Schlossmacher MG, Hattori N, Frosch MP, Trockenbacher A, Schneider R, Mizuno Y, Kosik KS, Selkoe DJ (2001) Ubiquitination of a new form of alpha-synuclein by parkin from human brain: implications for Parkinson’s disease. Science 293:263–269
-
(2001)
Science
, vol.293
, pp. 263-269
-
-
Shimura, H1
Schlossmacher, MG2
Hattori, N3
Frosch, MP4
Trockenbacher, A5
Schneider, R6
Mizuno, Y7
Kosik, KS8
Selkoe, DJ9
-
55
-
-
0034776095
-
Parkin ubiquitinates the alpha-synuclein-interacting protein, synphilin-1: implications for Lewy-body formation in Parkinson disease
-
55. KK Chung Y Zhang KL Lim Y Tanaka H Huang J Gao CA Ross VL Dawson TM Dawson 2001 Parkin ubiquitinates the alpha-synuclein-interacting protein, synphilin-1: implications for Lewy-body formation in Parkinson disease Nat Med 7 1144 1150 1:CAS:528:DC%2BD3MXns12kurg%3D 11590439 10.1038/nm1001-1144 Chung KK, Zhang Y, Lim KL, Tanaka Y, Huang H, Gao J, Ross CA, Dawson VL, Dawson TM (2001) Parkin ubiquitinates the alpha-synuclein-interacting protein, synphilin-1: implications for Lewy-body formation in Parkinson disease. Nat Med 7:1144–1150
-
(2001)
Nat Med
, vol.7
, pp. 1144-1150
-
-
Chung, KK1
Zhang, Y2
Lim, KL3
Tanaka, Y4
Huang, H5
Gao, J6
Ross, CA7
Dawson, VL8
Dawson, TM9
-
56
-
-
0037155924
-
Regulation of synaptophysin degradation by mammalian homologues of seven in absentia
-
56. TC Wheeler LS Chin Y Li FL Roudabush L Li 2002 Regulation of synaptophysin degradation by mammalian homologues of seven in absentia J Biol Chem 277 10273 10282 1:CAS:528:DC%2BD38XisVyltbc%3D 11786535 10.1074/jbc.M107857200 Wheeler TC, Chin LS, Li Y, Roudabush FL, Li L (2002) Regulation of synaptophysin degradation by mammalian homologues of seven in absentia. J Biol Chem 277:10273–10282
-
(2002)
J Biol Chem
, vol.277
, pp. 10273-10282
-
-
Wheeler, TC1
Chin, LS2
Li, Y3
Roudabush, FL4
Li, L5
-
57
-
-
11144358336
-
Ubiquitylation of synphilin-1 and alpha-synuclein by SIAH and its presence in cellular inclusions and Lewy bodies imply a role in Parkinson’s disease
-
57. E Liani A Eyal E Avraham R Shemer R Szargel D Berg A Bornemann O Riess CA Ross R Rott S Engelender 2004 Ubiquitylation of synphilin-1 and alpha-synuclein by SIAH and its presence in cellular inclusions and Lewy bodies imply a role in Parkinson’s disease Proc Natl Acad Sci USA 101 5500 5505 1:CAS:528:DC%2BD2cXjsVagurw%3D 15064394 10.1073/pnas.0401081101 Liani E, Eyal A, Avraham E, Shemer R, Szargel R, Berg D, Bornemann A, Riess O, Ross CA, Rott R, Engelender S (2004) Ubiquitylation of synphilin-1 and alpha-synuclein by SIAH and its presence in cellular inclusions and Lewy bodies imply a role in Parkinson’s disease. Proc Natl Acad Sci USA 101:5500–5505
-
(2004)
Proc Natl Acad Sci USA
, vol.101
, pp. 5500-5505
-
-
Liani, E1
Eyal, A2
Avraham, E3
Shemer, R4
Szargel, R5
Berg, D6
Bornemann, A7
Riess, O8
Ross, CA9
Rott, R10
Engelender, S11
-
58
-
-
41249090880
-
Monoubiquitination of a-synuclein by SIAH promotes its aggregation in dopaminergic cells
-
58. R Rott R Szargel J Haskin V Shani A Shainskaya I Manov E Liani E Avraham S Engelender 2007 Monoubiquitination of a-synuclein by SIAH promotes its aggregation in dopaminergic cells J Biol Chem 283 3316 3328 18070888 10.1074/jbc.M704809200 1:CAS:528:DC%2BD1cXhtlyjurs%3D Rott R, Szargel R, Haskin J, Shani V, Shainskaya A, Manov I, Liani E, Avraham E, Engelender S (2007) Monoubiquitination of a-synuclein by SIAH promotes its aggregation in dopaminergic cells. J Biol Chem 283:3316–3328
-
(2007)
J Biol Chem
, vol.283
, pp. 3316-3328
-
-
Rott, R1
Szargel, R2
Haskin, J3
Shani, V4
Shainskaya, A5
Manov, I6
Liani, E7
Avraham, E8
Engelender, S9
-
59
-
-
40549090917
-
Ubiquitination of alpha-synuclein by Siah-1 promotes alpha-synuclein aggregation and apoptotic cell death
-
59. JT Lee TC Wheeler L Li LS Chin 2008 Ubiquitination of alpha-synuclein by Siah-1 promotes alpha-synuclein aggregation and apoptotic cell death Hum Mol Genet 17 906 917 1:CAS:528:DC%2BD1cXis1Glur8%3D 18065497 10.1093/hmg/ddm363 Lee JT, Wheeler TC, Li L, Chin LS (2008) Ubiquitination of alpha-synuclein by Siah-1 promotes alpha-synuclein aggregation and apoptotic cell death. Hum Mol Genet 17:906–917
-
(2008)
Hum Mol Genet
, vol.17
, pp. 906-917
-
-
Lee, JT1
Wheeler, TC2
Li, L3
Chin, LS4
-
60
-
-
33645958587
-
Elucidation of the substrate binding site of Siah ubiquitin ligase
-
60. CM House NC Hancock A Möller BA Cromer V Fedorov DD Bowtell MW Parker G Polekhina 2006 Elucidation of the substrate binding site of Siah ubiquitin ligase Structure 14 695 701 1:CAS:528:DC%2BD28Xjs1Glu7o%3D 16615911 10.1016/j.str.2005.12.013 House CM, Hancock NC, Möller A, Cromer BA, Fedorov V, Bowtell DD, Parker MW, Polekhina G (2006) Elucidation of the substrate binding site of Siah ubiquitin ligase. Structure 14:695–701
-
(2006)
Structure
, vol.14
, pp. 695-701
-
-
House, CM1
Hancock, NC2
Möller, A3
Cromer, BA4
Fedorov, V5
Bowtell, DD6
Parker, MW7
Polekhina, G8
-
61
-
-
0035899897
-
Cooperation of a ubiquitin domain protein and an E3 ubiquitin ligase during chaperone/proteasome coupling
-
61. J Demand S Alberti C Patterson J Hohfeld 2001 Cooperation of a ubiquitin domain protein and an E3 ubiquitin ligase during chaperone/proteasome coupling Curr Biol 11 1569 1577 1:CAS:528:DC%2BD3MXnvFGjsLY%3D 11676916 10.1016/S0960-9822(01)00487-0 Demand J, Alberti S, Patterson C, Hohfeld J (2001) Cooperation of a ubiquitin domain protein and an E3 ubiquitin ligase during chaperone/proteasome coupling. Curr Biol 11:1569–1577
-
(2001)
Curr Biol
, vol.11
, pp. 1569-1577
-
-
Demand, J1
Alberti, S2
Patterson, C3
Hohfeld, J4
-
62
-
-
0035684430
-
CHIP is a chaperone-dependent E3 ligase that ubiquitylates unfolded protein
-
62. S Murata Y Minami M Minami T Chiba K Tanaka 2001 CHIP is a chaperone-dependent E3 ligase that ubiquitylates unfolded protein EMBO Rep 2 1133 1138 1:CAS:528:DC%2BD38Xjt1Ciug%3D%3D 11743028 10.1093/embo-reports/kve246 Murata S, Minami Y, Minami M, Chiba T, Tanaka K (2001) CHIP is a chaperone-dependent E3 ligase that ubiquitylates unfolded protein. EMBO Rep 2:1133–1138
-
(2001)
EMBO Rep
, vol.2
, pp. 1133-1138
-
-
Murata, S1
Minami, Y2
Minami, M3
Chiba, T4
Tanaka, K5
-
63
-
-
79951925183
-
Ubiquitinylation of α-synuclein by carboxyl terminus Hsp70-interacting protein (CHIP) is regulated by Bcl-2-associated athanogene 5 (BAG5)
-
63. LV Kalia SK Kalia H Chau AM Lozano BT Hyman PJ McLean 2011 Ubiquitinylation of α-synuclein by carboxyl terminus Hsp70-interacting protein (CHIP) is regulated by Bcl-2-associated athanogene 5 (BAG5) PLoS One 6 e14695 1:CAS:528:DC%2BC3MXislCntrw%3D 21358815 10.1371/journal.pone.0014695 Kalia LV, Kalia SK, Chau H, Lozano AM, Hyman BT, McLean PJ (2011) Ubiquitinylation of α-synuclein by carboxyl terminus Hsp70-interacting protein (CHIP) is regulated by Bcl-2-associated athanogene 5 (BAG5). PLoS One 6:e14695
-
(2011)
PLoS One
, vol.6
, pp. e14695
-
-
Kalia, LV1
Kalia, SK2
Chau, H3
Lozano, AM4
Hyman, BT5
McLean, PJ6
-
64
-
-
21244499845
-
The cochaperone carboxyl terminus of Hsp70-interacting protein (CHIP) mediates alpha-synuclein degradation decisions between proteasomal and lysosomal pathways
-
64. Y Shin J Klucken C Patterson BT Hyman PJ McLean 2005 The cochaperone carboxyl terminus of Hsp70-interacting protein (CHIP) mediates alpha-synuclein degradation decisions between proteasomal and lysosomal pathways J Biol Chem 280 23727 23734 1:CAS:528:DC%2BD2MXltlKhsr4%3D 15845543 10.1074/jbc.M503326200 Shin Y, Klucken J, Patterson C, Hyman BT, McLean PJ (2005) The cochaperone carboxyl terminus of Hsp70-interacting protein (CHIP) mediates alpha-synuclein degradation decisions between proteasomal and lysosomal pathways. J Biol Chem 280:23727–23734
-
(2005)
J Biol Chem
, vol.280
, pp. 23727-23734
-
-
Shin, Y1
Klucken, J2
Patterson, C3
Hyman, BT4
McLean, PJ5
-
65
-
-
49649125680
-
CHIP targets toxic alpha-synuclein oligomers for degradation
-
65. JE Tetzlaff P Putcha TF Outeiro A Ivanov O Berezovska BT Hyman PJ McLean 2008 CHIP targets toxic alpha-synuclein oligomers for degradation J Biol Chem 283 17962 17968 1:CAS:528:DC%2BD1cXnsVCgtrg%3D 18436529 10.1074/jbc.M802283200 Tetzlaff JE, Putcha P, Outeiro TF, Ivanov A, Berezovska O, Hyman BT, McLean PJ (2008) CHIP targets toxic alpha-synuclein oligomers for degradation. J Biol Chem 283:17962–17968
-
(2008)
J Biol Chem
, vol.283
, pp. 17962-17968
-
-
Tetzlaff, JE1
Putcha, P2
Outeiro, TF3
Ivanov, A4
Berezovska, O5
Hyman, BT6
McLean, PJ7
-
66
-
-
10444241856
-
BAG5 inhibits parkin and enhances dopaminergic neuron degeneration
-
66. SK Kalia S Lee PD Smith L Liu SJ Crocker TE Thorarinsdottir JR Glover EA Fon DS Park AM Lozano 2004 BAG5 inhibits parkin and enhances dopaminergic neuron degeneration Neuron 44 931 945 1:CAS:528:DC%2BD2MXhsFejsw%3D%3D 15603737 10.1016/j.neuron.2004.11.026 Kalia SK, Lee S, Smith PD, Liu L, Crocker SJ, Thorarinsdottir TE, Glover JR, Fon EA, Park DS, Lozano AM (2004) BAG5 inhibits parkin and enhances dopaminergic neuron degeneration. Neuron 44:931–945
-
(2004)
Neuron
, vol.44
, pp. 931-945
-
-
Kalia, SK1
Lee, S2
Smith, PD3
Liu, L4
Crocker, SJ5
Thorarinsdottir, TE6
Glover, JR7
Fon, EA8
Park, DS9
Lozano, AM10
-
67
-
-
79957606041
-
Etiology and pathogenesis of Parkinson’s disease
-
67. AH Schapira P Jenner 2011 Etiology and pathogenesis of Parkinson’s disease Mov Disord 26 1049 1055 21626550 10.1002/mds.23732 Schapira AH, Jenner P (2011) Etiology and pathogenesis of Parkinson’s disease. Mov Disord 26:1049–1055
-
(2011)
Mov Disord
, vol.26
, pp. 1049-1055
-
-
Schapira, AH1
Jenner, P2
-
68
-
-
77956213267
-
Mitochondrial dysfunction in Parkinson’s disease
-
68. J Zhu CT Chu 2010 Mitochondrial dysfunction in Parkinson’s disease J Alzheimers Dis 20 Suppl 2 S325 S334 1:CAS:528:DC%2BC3cXnt12gsr0%3D 20442495 Zhu J, Chu CT (2010) Mitochondrial dysfunction in Parkinson’s disease. J Alzheimers Dis 20(Suppl 2):S325–S334
-
(2010)
J Alzheimers Dis
, vol.20
, Issue.Suppl 2
, pp. S325-S334
-
-
Zhu, J1
Chu, CT2
-
69
-
-
77953890085
-
Parkinson’s disease: insights from pathways
-
69. MR Cookson O Bandmann 2010 Parkinson’s disease: insights from pathways Hum Mol Genet 19 R21 R27 1:CAS:528:DC%2BC3cXmsVSrtb8%3D 20421364 10.1093/hmg/ddq167 Cookson MR, Bandmann O (2010) Parkinson’s disease: insights from pathways. Hum Mol Genet 19:R21–R27
-
(2010)
Hum Mol Genet
, vol.19
, pp. R21-R27
-
-
Cookson, MR1
Bandmann, O2
-
70
-
-
76949107595
-
The mitochondrial kinase PINK1, stress response and Parkinson’s disease
-
70. M Jendrach S Gispert F Ricciardi M Klinkenberg R Schemm G Auburger 2009 The mitochondrial kinase PINK1, stress response and Parkinson’s disease J Bioenerg Biomembr 41 481 486 1:CAS:528:DC%2BC3cXjtVCkuw%3D%3D 19941155 10.1007/s10863-009-9256-0 Jendrach M, Gispert S, Ricciardi F, Klinkenberg M, Schemm R, Auburger G (2009) The mitochondrial kinase PINK1, stress response and Parkinson’s disease. J Bioenerg Biomembr 41:481–486
-
(2009)
J Bioenerg Biomembr
, vol.41
, pp. 481-486
-
-
Jendrach, M1
Gispert, S2
Ricciardi, F3
Klinkenberg, M4
Schemm, R5
Auburger, G6
-
71
-
-
62049085927
-
Formation of dopamine-mediated alpha-synuclein-soluble oligomers requires methionine oxidation
-
71. SL Leong CL Pham D Galatis MT Fodero-Tavoletti K Perez AF Hill CL Masters FE Ali KJ Barnham R Cappai 2009 Formation of dopamine-mediated alpha-synuclein-soluble oligomers requires methionine oxidation Free Radic Biol Med 46 1328 1337 1:CAS:528:DC%2BD1MXkvVWntr8%3D 19248830 10.1016/j.freeradbiomed.2009.02.009 Leong SL, Pham CL, Galatis D, Fodero-Tavoletti MT, Perez K, Hill AF, Masters CL, Ali FE, Barnham KJ, Cappai R (2009) Formation of dopamine-mediated alpha-synuclein-soluble oligomers requires methionine oxidation. Free Radic Biol Med 46:1328–1337
-
(2009)
Free Radic Biol Med
, vol.46
, pp. 1328-1337
-
-
Leong, SL1
Pham, CL2
Galatis, D3
Fodero-Tavoletti, MT4
Perez, K5
Hill, AF6
Masters, CL7
Ali, FE8
Barnham, KJ9
Cappai, R10
-
72
-
-
74849125564
-
Methionine oxidation stabilizes non-toxic oligomers of alpha-synuclein through strengthening the auto-inhibitory intra-molecular long-range interactions
-
72. W Zhou C Long SH Reaney DA Monte Di AL Fink VN Uversky 2010 Methionine oxidation stabilizes non-toxic oligomers of alpha-synuclein through strengthening the auto-inhibitory intra-molecular long-range interactions Biochim Biophys Acta 1802 322 330 1:CAS:528:DC%2BC3cXhtlCqur0%3D 20026206 10.1016/j.bbadis.2009.12.004 Zhou W, Long C, Reaney SH, Di Monte DA, Fink AL, Uversky VN (2010) Methionine oxidation stabilizes non-toxic oligomers of alpha-synuclein through strengthening the auto-inhibitory intra-molecular long-range interactions. Biochim Biophys Acta 1802:322–330
-
(2010)
Biochim Biophys Acta
, vol.1802
, pp. 322-330
-
-
Zhou, W1
Long, C2
Reaney, SH3
Monte, DA4
Fink, AL5
Uversky, VN6
-
73
-
-
54849423681
-
Inhibition of alpha-synuclein fibrillization by dopamine is mediated by interactions with five C-terminal residues and with E83 in the NAC region
-
73. FE Herrera A Chesi KE Paleologou A Schmid A Munoz M Vendruscolo S Gustincich HA Lashuel P Carloni 2008 Inhibition of alpha-synuclein fibrillization by dopamine is mediated by interactions with five C-terminal residues and with E83 in the NAC region PLoS One 3 e3394 18852892 10.1371/journal.pone.0003394 1:CAS:528:DC%2BD1cXhtlChtLjO Herrera FE, Chesi A, Paleologou KE, Schmid A, Munoz A, Vendruscolo M, Gustincich S, Lashuel HA, Carloni P (2008) Inhibition of alpha-synuclein fibrillization by dopamine is mediated by interactions with five C-terminal residues and with E83 in the NAC region. PLoS One 3:e3394
-
(2008)
PLoS One
, vol.3
, pp. e3394
-
-
Herrera, FE1
Chesi, A2
Paleologou, KE3
Schmid, A4
Munoz, A5
Vendruscolo, M6
Gustincich, S7
Lashuel, HA8
Carloni, P9
-
74
-
-
0034602442
-
Oxidative damage linked to neurodegeneration by selective alpha-synuclein nitration in synucleinopathy lesions
-
74. BI Giasson JE Duda IV Murray Q Chen JM Souza HI Hurtig H Ischiropoulos JQ Trojanowski VM Lee 2000 Oxidative damage linked to neurodegeneration by selective alpha-synuclein nitration in synucleinopathy lesions Science 290 985 989 1:CAS:528:DC%2BD3cXnvVWkurY%3D 11062131 10.1126/science.290.5493.985 Giasson BI, Duda JE, Murray IV, Chen Q, Souza JM, Hurtig HI, Ischiropoulos H, Trojanowski JQ, Lee VM (2000) Oxidative damage linked to neurodegeneration by selective alpha-synuclein nitration in synucleinopathy lesions. Science 290:985–989
-
(2000)
Science
, vol.290
, pp. 985-989
-
-
Giasson, BI1
Duda, JE2
Murray, IV3
Chen, Q4
Souza, JM5
Hurtig, HI6
Ischiropoulos, H7
Trojanowski, JQ8
Lee, VM9
-
75
-
-
80051617317
-
A novel molecular mechanism for nitrated alpha-synuclein-induced cell death
-
75. Y Liu M Qiang Y Wei R He 2011 A novel molecular mechanism for nitrated alpha-synuclein-induced cell death J Mol Cell Biol 3 239 249 1:CAS:528:DC%2BC3MXhtFCjtL%2FE 21733982 10.1093/jmcb/mjr011 Liu Y, Qiang M, Wei Y, He R (2011) A novel molecular mechanism for nitrated alpha-synuclein-induced cell death. J Mol Cell Biol 3:239–249
-
(2011)
J Mol Cell Biol
, vol.3
, pp. 239-249
-
-
Liu, Y1
Qiang, M2
Wei, Y3
He, R4
-
76
-
-
70349144524
-
Preferentially increased nitration of alpha-synuclein at tyrosine-39 in a cellular oxidative model of Parkinson’s disease
-
76. SR Danielson JM Held B Schilling M Oo BW Gibson JK Andersen 2009 Preferentially increased nitration of alpha-synuclein at tyrosine-39 in a cellular oxidative model of Parkinson’s disease Anal Chem 81 7823 7828 1:CAS:528:DC%2BD1MXhtVens73I 19697948 10.1021/ac901176t Danielson SR, Held JM, Schilling B, Oo M, Gibson BW, Andersen JK (2009) Preferentially increased nitration of alpha-synuclein at tyrosine-39 in a cellular oxidative model of Parkinson’s disease. Anal Chem 81:7823–7828
-
(2009)
Anal Chem
, vol.81
, pp. 7823-7828
-
-
Danielson, SR1
Held, JM2
Schilling, B3
Oo, M4
Gibson, BW5
Andersen, JK6
-
77
-
-
38949151035
-
Nitrated alpha-synuclein immunity accelerates degeneration of nigral dopaminergic neurons
-
77. EJ Benner R Banerjee AD Reynolds S Sherman VM Pisarev V Tsiperson C Nemachek P Ciborowski S Przedborski RL Mosley HE Gendelman 2008 Nitrated alpha-synuclein immunity accelerates degeneration of nigral dopaminergic neurons PLoS One 3 e1376 18167537 10.1371/journal.pone.0001376 1:CAS:528:DC%2BD1cXhtVSnu74%3D Benner EJ, Banerjee R, Reynolds AD, Sherman S, Pisarev VM, Tsiperson V, Nemachek C, Ciborowski P, Przedborski S, Mosley RL, Gendelman HE (2008) Nitrated alpha-synuclein immunity accelerates degeneration of nigral dopaminergic neurons. PLoS One 3:e1376
-
(2008)
PLoS One
, vol.3
, pp. e1376
-
-
Benner, EJ1
Banerjee, R2
Reynolds, AD3
Sherman, S4
Pisarev, VM5
Tsiperson, V6
Nemachek, C7
Ciborowski, P8
Przedborski, S9
Mosley, RL10
Gendelman, HE11
-
78
-
-
77956298994
-
Nitrated alpha-synuclein induces the loss of dopaminergic neurons in the substantia nigra of rats
-
78. Z Yu X Xu Z Xiang J Zhou Z Zhang C Hu C He 2010 Nitrated alpha-synuclein induces the loss of dopaminergic neurons in the substantia nigra of rats PLoS One 5 e9956 20386702 10.1371/journal.pone.0009956 1:CAS:528:DC%2BC3cXkvFyntLs%3D Yu Z, Xu X, Xiang Z, Zhou J, Zhang Z, Hu C, He C (2010) Nitrated alpha-synuclein induces the loss of dopaminergic neurons in the substantia nigra of rats. PLoS One 5:e9956
-
(2010)
PLoS One
, vol.5
, pp. e9956
-
-
Yu, Z1
Xu, X2
Xiang, Z3
Zhou, J4
Zhang, Z5
Hu, C6
He, C7
-
79
-
-
50549085408
-
Neuroinflammation and oxidation/nitration of alpha-synuclein linked to dopaminergic neurodegeneration
-
79. HM Gao PT Kotzbauer K Uryu S Leight JQ Trojanowski VM Lee 2008 Neuroinflammation and oxidation/nitration of alpha-synuclein linked to dopaminergic neurodegeneration J Neurosci 28 7687 7698 1:CAS:528:DC%2BD1cXpt12muro%3D 18650345 10.1523/JNEUROSCI.0143-07.2008 Gao HM, Kotzbauer PT, Uryu K, Leight S, Trojanowski JQ, Lee VM (2008) Neuroinflammation and oxidation/nitration of alpha-synuclein linked to dopaminergic neurodegeneration. J Neurosci 28:7687–7698
-
(2008)
J Neurosci
, vol.28
, pp. 7687-7698
-
-
Gao, HM1
Kotzbauer, PT2
Uryu, K3
Leight, S4
Trojanowski, JQ5
Lee, VM6
-
80
-
-
0037173006
-
Human alpha-synuclein-harboring familial Parkinson’s disease-linked Ala-53 –> Thr mutation causes neurodegenerative disease with alpha-synuclein aggregation in transgenic mice
-
80. MK Lee W Stirling Y Xu X Xu D Qui AS Mandir TM Dawson NG Copeland NA Jenkins DL Price 2002 Human alpha-synuclein-harboring familial Parkinson’s disease-linked Ala-53–> Thr mutation causes neurodegenerative disease with alpha-synuclein aggregation in transgenic mice Proc Natl Acad Sci U S A 99 8968 8973 1:CAS:528:DC%2BD38XltF2htbk%3D 12084935 10.1073/pnas.132197599 Lee MK, Stirling W, Xu Y, Xu X, Qui D, Mandir AS, Dawson TM, Copeland NG, Jenkins NA, Price DL (2002) Human alpha-synuclein-harboring familial Parkinson’s disease-linked Ala-53–> Thr mutation causes neurodegenerative disease with alpha-synuclein aggregation in transgenic mice. Proc Natl Acad Sci U S A 99:8968–8973
-
(2002)
Proc Natl Acad Sci U S A
, vol.99
, pp. 8968-8973
-
-
Lee, MK1
Stirling, W2
Xu, Y3
Xu, X4
Qui, D5
Mandir, AS6
Dawson, TM7
Copeland, NG8
Jenkins, NA9
Price, DL10
-
81
-
-
0037118259
-
Neuronal alpha-synucleinopathy with severe movement disorder in mice expressing A53T human alpha-synuclein
-
81. BI Giasson JE Duda SM Quinn B Zhang JQ Trojanowski VM Lee 2002 Neuronal alpha-synucleinopathy with severe movement disorder in mice expressing A53T human alpha-synuclein Neuron 34 521 533 1:CAS:528:DC%2BD38XktFSmu74%3D 12062037 10.1016/S0896-6273(02)00682-7 Giasson BI, Duda JE, Quinn SM, Zhang B, Trojanowski JQ, Lee VM (2002) Neuronal alpha-synucleinopathy with severe movement disorder in mice expressing A53T human alpha-synuclein. Neuron 34:521–533
-
(2002)
Neuron
, vol.34
, pp. 521-533
-
-
Giasson, BI1
Duda, JE2
Quinn, SM3
Zhang, B4
Trojanowski, JQ5
Lee, VM6
-
82
-
-
0035163412
-
The solubility of alpha-synuclein in multiple system atrophy differs from that of dementia with Lewy bodies and Parkinson’s disease
-
82. BC Campbell CA McLean JG Culvenor WP Gai PC Blumbergs P Jäkälä K Beyreuther CL Masters QX Li 2001 The solubility of alpha-synuclein in multiple system atrophy differs from that of dementia with Lewy bodies and Parkinson’s disease J Neurochem 76 87 96 1:CAS:528:DC%2BD3MXhtVGlsL8%3D 11145981 10.1046/j.1471-4159.2001.00021.x Campbell BC, McLean CA, Culvenor JG, Gai WP, Blumbergs PC, Jäkälä P, Beyreuther K, Masters CL, Li QX (2001) The solubility of alpha-synuclein in multiple system atrophy differs from that of dementia with Lewy bodies and Parkinson’s disease. J Neurochem 76:87–96
-
(2001)
J Neurochem
, vol.76
, pp. 87-96
-
-
Campbell, BC1
McLean, CA2
Culvenor, JG3
Gai, WP4
Blumbergs, PC5
Jäkälä, P6
Beyreuther, K7
Masters, CL8
Li, QX9
-
83
-
-
0031941058
-
Aggregation of alpha-synuclein in Lewy bodies of sporadic Parkinson’s disease and dementia with Lewy bodies
-
83. M Baba S Nakajo PH Tu T Tomita K Nakaya VM Lee JQ Trojanowski T Iwatsubo 1998 Aggregation of alpha-synuclein in Lewy bodies of sporadic Parkinson’s disease and dementia with Lewy bodies Am J Pathol 152 879 884 1:CAS:528:DyaK1cXivVKgsbc%3D 9546347 Baba M, Nakajo S, Tu PH, Tomita T, Nakaya K, Lee VM, Trojanowski JQ, Iwatsubo T (1998) Aggregation of alpha-synuclein in Lewy bodies of sporadic Parkinson’s disease and dementia with Lewy bodies. Am J Pathol 152:879–884
-
(1998)
Am J Pathol
, vol.152
, pp. 879-884
-
-
Baba, M1
Nakajo, S2
Tu, PH3
Tomita, T4
Nakaya, K5
Lee, VM6
Trojanowski, JQ7
Iwatsubo, T8
-
84
-
-
13844320376
-
Aggregation promoting C-terminal truncation of alpha-synuclein is a normal cellular process and is enhanced by the familial Parkinson’s disease-linked mutations
-
84. W Li N West E Colla O Pletnikova JC Troncoso L Marsh TM Dawson P Jäkälä T Hartmann DL Price MK Lee 2005 Aggregation promoting C-terminal truncation of alpha-synuclein is a normal cellular process and is enhanced by the familial Parkinson’s disease-linked mutations Proc Natl Acad Sci U S A 102 2162 2167 1:CAS:528:DC%2BD2MXhvFGqs7g%3D 15684072 10.1073/pnas.0406976102 Li W, West N, Colla E, Pletnikova O, Troncoso JC, Marsh L, Dawson TM, Jäkälä P, Hartmann T, Price DL, Lee MK (2005) Aggregation promoting C-terminal truncation of alpha-synuclein is a normal cellular process and is enhanced by the familial Parkinson’s disease-linked mutations. Proc Natl Acad Sci U S A 102:2162–2167
-
(2005)
Proc Natl Acad Sci U S A
, vol.102
, pp. 2162-2167
-
-
Li, W1
West, N2
Colla, E3
Pletnikova, O4
Troncoso, JC5
Marsh, L6
Dawson, TM7
Jäkälä, P8
Hartmann, T9
Price, DL10
Lee, MK11
-
85
-
-
0034712918
-
Fiber diffraction of synthetic alpha-synuclein filaments shows amyloid-like cross-beta conformation
-
85. LC Serpell J Berriman R Jakes M Goedert RA Crowther 2000 Fiber diffraction of synthetic alpha-synuclein filaments shows amyloid-like cross-beta conformation Proc Natl Acad Sci U S A 97 4897 4902 1:CAS:528:DC%2BD3cXivFKju7k%3D 10781096 10.1073/pnas.97.9.4897 Serpell LC, Berriman J, Jakes R, Goedert M, Crowther RA (2000) Fiber diffraction of synthetic alpha-synuclein filaments shows amyloid-like cross-beta conformation. Proc Natl Acad Sci U S A 97:4897–4902
-
(2000)
Proc Natl Acad Sci U S A
, vol.97
, pp. 4897-4902
-
-
Serpell, LC1
Berriman, J2
Jakes, R3
Goedert, M4
Crowther, RA5
-
86
-
-
0038116620
-
Role of alpha-synuclein carboxy-terminus on fibril formation in vitro
-
86. IV Murray BI Giasson SM Quinn V Koppaka PH Axelsen H Ischiropoulos JQ Trojanowski VM Lee 2003 Role of alpha-synuclein carboxy-terminus on fibril formation in vitro Biochemistry 42 8530 8540 1:CAS:528:DC%2BD3sXkvVaitbw%3D 12859200 10.1021/bi027363r Murray IV, Giasson BI, Quinn SM, Koppaka V, Axelsen PH, Ischiropoulos H, Trojanowski JQ, Lee VM (2003) Role of alpha-synuclein carboxy-terminus on fibril formation in vitro. Biochemistry 42:8530–8540
-
(2003)
Biochemistry
, vol.42
, pp. 8530-8540
-
-
Murray, IV1
Giasson, BI2
Quinn, SM3
Koppaka, V4
Axelsen, PH5
Ischiropoulos, H6
Trojanowski, JQ7
Lee, VM8
-
87
-
-
20744442130
-
A precipitating role for truncated alpha-synuclein and the proteasome in alpha-synuclein aggregation: implications for pathogenesis of Parkinson disease
-
87. CW Liu BI Giasson KA Lewis VM Lee GN Demartino PJ Thomas 2005 A precipitating role for truncated alpha-synuclein and the proteasome in alpha-synuclein aggregation: implications for pathogenesis of Parkinson disease J Biol Chem 280 22670 22678 1:CAS:528:DC%2BD2MXltVyhsb8%3D 15840579 10.1074/jbc.M501508200 Liu CW, Giasson BI, Lewis KA, Lee VM, Demartino GN, Thomas PJ (2005) A precipitating role for truncated alpha-synuclein and the proteasome in alpha-synuclein aggregation: implications for pathogenesis of Parkinson disease. J Biol Chem 280:22670–22678
-
(2005)
J Biol Chem
, vol.280
, pp. 22670-22678
-
-
Liu, CW1
Giasson, BI2
Lewis, KA3
Lee, VM4
Demartino, GN5
Thomas, PJ6
-
88
-
-
77955141273
-
Co-expression of C-terminal truncated alpha-synuclein enhances full-length alpha-synuclein-induced pathology
-
88. A Ulusoy F Febbraro PH Jensen D Kirik M Romero-Ramos 2010 Co-expression of C-terminal truncated alpha-synuclein enhances full-length alpha-synuclein-induced pathology Eur J Neurosci 32 409 422 20704592 10.1111/j.1460-9568.2010.07284.x Ulusoy A, Febbraro F, Jensen PH, Kirik D, Romero-Ramos M (2010) Co-expression of C-terminal truncated alpha-synuclein enhances full-length alpha-synuclein-induced pathology. Eur J Neurosci 32:409–422
-
(2010)
Eur J Neurosci
, vol.32
, pp. 409-422
-
-
Ulusoy, A1
Febbraro, F2
Jensen, PH3
Kirik, D4
Romero-Ramos, M5
-
89
-
-
0033607801
-
Degradation of alphasynuclein by proteasome
-
89. MC Bennett JF Bishop Y Leng PB Chock TN Chase MM Mouradian 1999 Degradation of alphasynuclein by proteasome J Biol Chem 274 33855 33858 1:CAS:528:DyaK1MXnslOltLk%3D 10567343 10.1074/jbc.274.48.33855 Bennett MC, Bishop JF, Leng Y, Chock PB, Chase TN, Mouradian MM (1999) Degradation of alphasynuclein by proteasome. J Biol Chem 274:33855–33858
-
(1999)
J Biol Chem
, vol.274
, pp. 33855-33858
-
-
Bennett, MC1
Bishop, JF2
Leng, Y3
Chock, PB4
Chase, TN5
Mouradian, MM6
-
90
-
-
0041589248
-
Alpha-synuclein is degraded by both autophagy and the proteasome
-
90. JL Webb B Ravikumar J Atkins JN Skepper DC Rubinsztein 2003 Alpha-synuclein is degraded by both autophagy and the proteasome J Biol Chem 278 25009 25013 1:CAS:528:DC%2BD3sXltVSlsbs%3D 12719433 10.1074/jbc.M300227200 Webb JL, Ravikumar B, Atkins J, Skepper JN, Rubinsztein DC (2003) Alpha-synuclein is degraded by both autophagy and the proteasome. J Biol Chem 278:25009–25013
-
(2003)
J Biol Chem
, vol.278
, pp. 25009-25013
-
-
Webb, JL1
Ravikumar, B2
Atkins, J3
Skepper, JN4
Rubinsztein, DC5
-
91
-
-
4344659685
-
Impaired degradation of mutant alphasynuclein by chaperone-mediated autophagy
-
91. AM Cuervo L Stefanis R Fredenburg PT Lansbury D Sulzer 2004 Impaired degradation of mutant alphasynuclein by chaperone-mediated autophagy Science 305 1292 1295 1:CAS:528:DC%2BD2cXmvFCit7w%3D 15333840 10.1126/science.1101738 Cuervo AM, Stefanis L, Fredenburg R, Lansbury PT, Sulzer D (2004) Impaired degradation of mutant alphasynuclein by chaperone-mediated autophagy. Science 305:1292–1295
-
(2004)
Science
, vol.305
, pp. 1292-1295
-
-
Cuervo, AM1
Stefanis, L2
Fredenburg, R3
Lansbury, PT4
Sulzer, D5
-
92
-
-
0035976835
-
alpha-synuclein metabolism and aggregation is linked to ubiquitin-independent degradation by the proteasome
-
92. GK Tofaris R Layfield MG Spillantini 2001 alpha-synuclein metabolism and aggregation is linked to ubiquitin-independent degradation by the proteasome FEBS Lett 509 22 26 1:CAS:528:DC%2BD3MXovVCisLY%3D 11734199 10.1016/S0014-5793(01)03115-5 Tofaris GK, Layfield R, Spillantini MG (2001) alpha-synuclein metabolism and aggregation is linked to ubiquitin-independent degradation by the proteasome. FEBS Lett 509:22–26
-
(2001)
FEBS Lett
, vol.509
, pp. 22-26
-
-
Tofaris, GK1
Layfield, R2
Spillantini, MG3
-
93
-
-
0037449572
-
Endoproteolytic activity of the proteasome
-
93. CW Liu MJ Corboy GN DeMartino PJ Thomas 2003 Endoproteolytic activity of the proteasome Science 299 408 411 1:CAS:528:DC%2BD3sXjsF2rtw%3D%3D 12481023 10.1126/science.1079293 Liu CW, Corboy MJ, DeMartino GN, Thomas PJ (2003) Endoproteolytic activity of the proteasome. Science 299:408–411
-
(2003)
Science
, vol.299
, pp. 408-411
-
-
Liu, CW1
Corboy, MJ2
DeMartino, GN3
Thomas, PJ4
-
94
-
-
77950021983
-
Accelerated formation of alpha-synuclein oligomers by concerted action of the 20S proteasome and familial Parkinson mutations
-
94. KA Lewis A Yaeger GN DeMartino PJ Thomas 2010 Accelerated formation of alpha-synuclein oligomers by concerted action of the 20S proteasome and familial Parkinson mutations J Bioenerg Biomembr 42 85 95 1:CAS:528:DC%2BC3cXjs1aisrc%3D 20148295 10.1007/s10863-009-9258-y Lewis KA, Yaeger A, DeMartino GN, Thomas PJ (2010) Accelerated formation of alpha-synuclein oligomers by concerted action of the 20S proteasome and familial Parkinson mutations. J Bioenerg Biomembr 42:85–95
-
(2010)
J Bioenerg Biomembr
, vol.42
, pp. 85-95
-
-
Lewis, KA1
Yaeger, A2
DeMartino, GN3
Thomas, PJ4
-
95
-
-
34547975971
-
Oxidative stress-induced phosphorylation, degradation and aggregation of alpha-synuclein are linked to upregulated CK2 and cathepsin D
-
95. M Takahashi LW Ko J Kulathingal P Jiang D Sevlever SH Yen 2007 Oxidative stress-induced phosphorylation, degradation and aggregation of alpha-synuclein are linked to upregulated CK2 and cathepsin D Eur J Neurosci 26 863 874 17714183 10.1111/j.1460-9568.2007.05736.x Takahashi M, Ko LW, Kulathingal J, Jiang P, Sevlever D, Yen SH (2007) Oxidative stress-induced phosphorylation, degradation and aggregation of alpha-synuclein are linked to upregulated CK2 and cathepsin D. Eur J Neurosci 26:863–874
-
(2007)
Eur J Neurosci
, vol.26
, pp. 863-874
-
-
Takahashi, M1
Ko, LW2
Kulathingal, J3
Jiang, P4
Sevlever, D5
Yen, SH6
-
96
-
-
51549106105
-
Cathepsin D is the main lysosomal enzyme involved in the degradation of alpha-synuclein and generation of its carboxy-terminally truncated species
-
96. D Sevlever P Jiang SH Yen 2008 Cathepsin D is the main lysosomal enzyme involved in the degradation of alpha-synuclein and generation of its carboxy-terminally truncated species Biochemistry 47 9678 9687 1:CAS:528:DC%2BD1cXpvFSlsL0%3D 18702517 10.1021/bi800699v Sevlever D, Jiang P, Yen SH (2008) Cathepsin D is the main lysosomal enzyme involved in the degradation of alpha-synuclein and generation of its carboxy-terminally truncated species. Biochemistry 47:9678–9687
-
(2008)
Biochemistry
, vol.47
, pp. 9678-9687
-
-
Sevlever, D1
Jiang, P2
Yen, SH3
-
97
-
-
0023931244
-
Proteolysis of tubulin and microtubule-associated proteins 1 and 2 by calpain I and II. Difference in sensitivity of assembled and disassembled microtubules
-
97. M Billger M Wallin JO Karlsson 1988 Proteolysis of tubulin and microtubule-associated proteins 1 and 2 by calpain I and II. Difference in sensitivity of assembled and disassembled microtubules Cell Calcium 9 33 44 1:CAS:528:DyaL1cXhs1eqsL0%3D 2834062 10.1016/0143-4160(88)90036-X Billger M, Wallin M, Karlsson JO (1988) Proteolysis of tubulin and microtubule-associated proteins 1 and 2 by calpain I and II. Difference in sensitivity of assembled and disassembled microtubules. Cell Calcium 9:33–44
-
(1988)
Cell Calcium
, vol.9
, pp. 33-44
-
-
Billger, M1
Wallin, M2
Karlsson, JO3
-
98
-
-
0029100373
-
Translational suppression of calpain I reduces NMDA-induced spectrin proteolysis and pathophysiology in cultured hippocampal slices
-
98. E Bednarski P Vanderklish C Gall TC Saido BA Bahr G Lynch 1995 Translational suppression of calpain I reduces NMDA-induced spectrin proteolysis and pathophysiology in cultured hippocampal slices Brain Res 694 147 157 1:CAS:528:DyaK2MXot1yrtLo%3D 8974639 10.1016/0006-8993(95)00851-G Bednarski E, Vanderklish P, Gall C, Saido TC, Bahr BA, Lynch G (1995) Translational suppression of calpain I reduces NMDA-induced spectrin proteolysis and pathophysiology in cultured hippocampal slices. Brain Res 694:147–157
-
(1995)
Brain Res
, vol.694
, pp. 147-157
-
-
Bednarski, E1
Vanderklish, P2
Gall, C3
Saido, TC4
Bahr, BA5
Lynch, G6
-
99
-
-
0029039987
-
Differential sensitivity to proteolysis by brain calpain of adult human tau, fetal human tau and PHF-tau
-
99. M Mercken F Grynspan RA Nixon 1995 Differential sensitivity to proteolysis by brain calpain of adult human tau, fetal human tau and PHF-tau FEBS Lett 368 10 14 1:CAS:528:DyaK2MXmvVemsrs%3D 7615058 10.1016/0014-5793(95)00590-6 Mercken M, Grynspan F, Nixon RA (1995) Differential sensitivity to proteolysis by brain calpain of adult human tau, fetal human tau and PHF-tau. FEBS Lett 368:10–14
-
(1995)
FEBS Lett
, vol.368
, pp. 10-14
-
-
Mercken, M1
Grynspan, F2
Nixon, RA3
-
100
-
-
0043233011
-
Distinct cleavage patterns of normal and pathologic forms of alpha-synuclein by calpain I in vitro
-
100. AJ Mishizen-Eberz RP Guttmann BI Giasson GA Day 3rd R Hodara H Ischiropoulos VM Lee JQ Trojanowski DR Lynch 2003 Distinct cleavage patterns of normal and pathologic forms of alpha-synuclein by calpain I in vitro J Neurochem 86 836 847 1:CAS:528:DC%2BD3sXmslOgs7Y%3D 12887682 10.1046/j.1471-4159.2003.01878.x Mishizen-Eberz AJ, Guttmann RP, Giasson BI, Day GA 3rd, Hodara R, Ischiropoulos H, Lee VM, Trojanowski JQ, Lynch DR (2003) Distinct cleavage patterns of normal and pathologic forms of alpha-synuclein by calpain I in vitro. J Neurochem 86:836–847
-
(2003)
J Neurochem
, vol.86
, pp. 836-847
-
-
Mishizen-Eberz, AJ1
Guttmann, RP2
Giasson, BI3
Day, GA4
Hodara, R5
Ischiropoulos, H6
Lee, VM7
Trojanowski, JQ8
Lynch, DR9
-
101
-
-
19644371237
-
Cleavage of alpha-synuclein by calpain: potential role in degradation of fibrillized and nitrated species of alpha-synuclein
-
101. AJ Mishizen-Eberz EH Norris BI Giasson R Hodara H Ischiropoulos VM Lee JQ Trojanowski DR Lynch 2005 Cleavage of alpha-synuclein by calpain: potential role in degradation of fibrillized and nitrated species of alpha-synuclein Biochemistry 44 7818 7829 1:CAS:528:DC%2BD2MXjvVeiurc%3D 15909996 10.1021/bi047846q Mishizen-Eberz AJ, Norris EH, Giasson BI, Hodara R, Ischiropoulos H, Lee VM, Trojanowski JQ, Lynch DR (2005) Cleavage of alpha-synuclein by calpain: potential role in degradation of fibrillized and nitrated species of alpha-synuclein. Biochemistry 44:7818–7829
-
(2005)
Biochemistry
, vol.44
, pp. 7818-7829
-
-
Mishizen-Eberz, AJ1
Norris, EH2
Giasson, BI3
Hodara, R4
Ischiropoulos, H5
Lee, VM6
Trojanowski, JQ7
Lynch, DR8
-
102
-
-
34250832784
-
Calpain-cleavage of alpha-synuclein: connecting proteolytic processing to disease-linked aggregation
-
102. BM Dufty LR Warner ST Hou SX Jiang T Gomez-Isla KM Leenhouts JT Oxford MB Feany E Masliah TT Rohn 2007 Calpain-cleavage of alpha-synuclein: connecting proteolytic processing to disease-linked aggregation Am J Pathol 170 1725 1738 1:CAS:528:DC%2BD2sXlvFCnsbo%3D 17456777 10.2353/ajpath.2007.061232 Dufty BM, Warner LR, Hou ST, Jiang SX, Gomez-Isla T, Leenhouts KM, Oxford JT, Feany MB, Masliah E, Rohn TT (2007) Calpain-cleavage of alpha-synuclein: connecting proteolytic processing to disease-linked aggregation. Am J Pathol 170:1725–1738
-
(2007)
Am J Pathol
, vol.170
, pp. 1725-1738
-
-
Dufty, BM1
Warner, LR2
Hou, ST3
Jiang, SX4
Gomez-Isla, T5
Leenhouts, KM6
Oxford, JT7
Feany, MB8
Masliah, E9
Rohn, TT10
-
103
-
-
0142154275
-
Alpha-synuclein degradation by serine protease neurosin: implication for pathogenesis of synucleinopathies
-
103. A Iwata M Maruyama T Akagi T Hashikawa I Kanazawa S Tsuji N Nukina 2003 Alpha-synuclein degradation by serine protease neurosin: implication for pathogenesis of synucleinopathies Hum Mol Genet 12 2625 2635 1:CAS:528:DC%2BD3sXot1Cqt7g%3D 12928483 10.1093/hmg/ddg283 Iwata A, Maruyama M, Akagi T, Hashikawa T, Kanazawa I, Tsuji S, Nukina N (2003) Alpha-synuclein degradation by serine protease neurosin: implication for pathogenesis of synucleinopathies. Hum Mol Genet 12:2625–2635
-
(2003)
Hum Mol Genet
, vol.12
, pp. 2625-2635
-
-
Iwata, A1
Maruyama, M2
Akagi, T3
Hashikawa, T4
Kanazawa, I5
Tsuji, S6
Nukina, N7
-
104
-
-
41749115922
-
Cleavage of normal and pathological forms of alpha-synuclein by neurosin in vitro
-
104. T Kasai T Tokuda N Yamaguchi Y Watanabe F Kametani M Nakagawa T Mizuno 2008 Cleavage of normal and pathological forms of alpha-synuclein by neurosin in vitro Neurosci Lett 436 52 56 1:CAS:528:DC%2BD1cXks1art70%3D 18358605 10.1016/j.neulet.2008.02.057 Kasai T, Tokuda T, Yamaguchi N, Watanabe Y, Kametani F, Nakagawa M, Mizuno T (2008) Cleavage of normal and pathological forms of alpha-synuclein by neurosin in vitro. Neurosci Lett 436:52–56
-
(2008)
Neurosci Lett
, vol.436
, pp. 52-56
-
-
Kasai, T1
Tokuda, T2
Yamaguchi, N3
Watanabe, Y4
Kametani, F5
Nakagawa, M6
Mizuno, T7
-
105
-
-
33845977715
-
A pivotal role of matrix metalloproteinase-3 activity in dopaminergic neuronal degeneration via microglial activation
-
105. YS Kim DH Choi ML Block S Lorenzl L Yang YJ Kim S Sugama BP Cho O Hwang SE Browne SY Kim JS Hong MF Beal TH Joh 2007 A pivotal role of matrix metalloproteinase-3 activity in dopaminergic neuronal degeneration via microglial activation FASEB J 21 179 187 1:CAS:528:DC%2BD2sXmvFCisw%3D%3D 17116747 10.1096/fj.06-5865com Kim YS, Choi DH, Block ML, Lorenzl S, Yang L, Kim YJ, Sugama S, Cho BP, Hwang O, Browne SE, Kim SY, Hong JS, Beal MF, Joh TH (2007) A pivotal role of matrix metalloproteinase-3 activity in dopaminergic neuronal degeneration via microglial activation. FASEB J 21:179–187
-
(2007)
FASEB J
, vol.21
, pp. 179-187
-
-
Kim, YS1
Choi, DH2
Block, ML3
Lorenzl, S4
Yang, L5
Kim, YJ6
Sugama, S7
Cho, BP8
Hwang, O9
Browne, SE10
Kim, SY11
Hong, JS12
Beal, MF13
Joh, TH14
-
106
-
-
45249115717
-
A novel intracellular role of matrix metalloproteinase-3 during apoptosis of dopaminergic cells
-
106. DH Choi EM Kim HJ Son TH Joh YS Kim D Kim M Flint Beal O Hwang 2008 A novel intracellular role of matrix metalloproteinase-3 during apoptosis of dopaminergic cells J Neurochem 106 405 415 1:CAS:528:DC%2BD1cXot1Ogt78%3D 18397366 10.1111/j.1471-4159.2008.05399.x Choi DH, Kim EM, Son HJ, Joh TH, Kim YS, Kim D, Flint Beal M, Hwang O (2008) A novel intracellular role of matrix metalloproteinase-3 during apoptosis of dopaminergic cells. J Neurochem 106:405–415
-
(2008)
J Neurochem
, vol.106
, pp. 405-415
-
-
Choi, DH1
Kim, EM2
Son, HJ3
Joh, TH4
Kim, YS5
Kim, D6
Flint Beal, M7
Hwang, O8
-
107
-
-
79956128920
-
DJ-1 cleavage by matrix metalloproteinase 3 mediates oxidative stress-induced dopaminergic cell death
-
107. DH Choi O Hwang KH Lee J Lee MF Beal YS Kim 2011 DJ-1 cleavage by matrix metalloproteinase 3 mediates oxidative stress-induced dopaminergic cell death Antioxid Redox Signal 14 2137 2150 1:CAS:528:DC%2BC3MXlvFOis70%3D 20969476 10.1089/ars.2009.3059 Choi DH, Hwang O, Lee KH, Lee J, Beal MF, Kim YS (2011) DJ-1 cleavage by matrix metalloproteinase 3 mediates oxidative stress-induced dopaminergic cell death. Antioxid Redox Signal 14:2137–2150
-
(2011)
Antioxid Redox Signal
, vol.14
, pp. 2137-2150
-
-
Choi, DH1
Hwang, O2
Lee, KH3
Lee, J4
Beal, MF5
Kim, YS6
-
108
-
-
79954609544
-
Role of matrix metalloproteinase 3-mediated alpha-synuclein cleavage in dopaminergic cell death
-
108. DH Choi YJ Kim YG Kim TH Joh MF Beal YS Kim 2011 Role of matrix metalloproteinase 3-mediated alpha-synuclein cleavage in dopaminergic cell death J Biol Chem 286 14168 14177 1:CAS:528:DC%2BC3MXkslWju70%3D 21330369 10.1074/jbc.M111.222430 Choi DH, Kim YJ, Kim YG, Joh TH, Beal MF, Kim YS (2011) Role of matrix metalloproteinase 3-mediated alpha-synuclein cleavage in dopaminergic cell death. J Biol Chem 286:14168–14177
-
(2011)
J Biol Chem
, vol.286
, pp. 14168-14177
-
-
Choi, DH1
Kim, YJ2
Kim, YG3
Joh, TH4
Beal, MF5
Kim, YS6
-
109
-
-
0037014618
-
Amino acid determinants of alpha-synuclein aggregation: putting together pieces of the puzzle
-
109. VN Uversky AL Fink 2002 Amino acid determinants of alpha-synuclein aggregation: putting together pieces of the puzzle FEBS Lett 522 9 13 1:CAS:528:DC%2BD38XkvFGqs7s%3D 12095610 10.1016/S0014-5793(02)02883-1 Uversky VN, Fink AL (2002) Amino acid determinants of alpha-synuclein aggregation: putting together pieces of the puzzle. FEBS Lett 522:9–13
-
(2002)
FEBS Lett
, vol.522
, pp. 9-13
-
-
Uversky, VN1
Fink, AL2
-
110
-
-
0037023699
-
Biophysical properties of the synucleins and their propensities to fibrillate: inhibition of alpha-synuclein assembly by beta- and gamma-synucleins
-
110. VN Uversky J Li P Souillac IS Millett S Doniach R Jakes M Goedert AL Fink 2002 Biophysical properties of the synucleins and their propensities to fibrillate: inhibition of alpha-synuclein assembly by beta-and gamma-synucleins J Biol Chem 277 11970 11978 1:CAS:528:DC%2BD38XivVektrw%3D 11812782 10.1074/jbc.M109541200 Uversky VN, Li J, Souillac P, Millett IS, Doniach S, Jakes R, Goedert M, Fink AL (2002) Biophysical properties of the synucleins and their propensities to fibrillate: inhibition of alpha-synuclein assembly by beta-and gamma-synucleins. J Biol Chem 277:11970–11978
-
(2002)
J Biol Chem
, vol.277
, pp. 11970-11978
-
-
Uversky, VN1
Li, J2
Souillac, P3
Millett, IS4
Doniach, S5
Jakes, R6
Goedert, M7
Fink, AL8
-
111
-
-
69249094544
-
Structural characterization of alpha-synuclein in an aggregation prone state
-
111. MK Cho G Nodet HY Kim MR Jensen P Bernado CO Fernandez S Becker M Blackledge M Zweckstetter 2009 Structural characterization of alpha-synuclein in an aggregation prone state Protein Sci 18 1840 1846 1:CAS:528:DC%2BD1MXhtVKnt7zL 19554627 10.1002/pro.194 Cho MK, Nodet G, Kim HY, Jensen MR, Bernado P, Fernandez CO, Becker S, Blackledge M, Zweckstetter M (2009) Structural characterization of alpha-synuclein in an aggregation prone state. Protein Sci 18:1840–1846
-
(2009)
Protein Sci
, vol.18
, pp. 1840-1846
-
-
Cho, MK1
Nodet, G2
Kim, HY3
Jensen, MR4
Bernado, P5
Fernandez, CO6
Becker, S7
Blackledge, M8
Zweckstetter, M9
-
112
-
-
33744500490
-
Structure and topology of the non-amyloid-beta component fragment of human alpha-synuclein bound to micelles: implications for the aggregation process
-
112. M Bisaglia A Trolio M Bellanda E Bergantino L Bubacco S Mammi 2006 Structure and topology of the non-amyloid-beta component fragment of human alpha-synuclein bound to micelles: implications for the aggregation process Protein Sci 15 1408 1416 1:CAS:528:DC%2BD28XlsVKquro%3D 16731975 10.1110/ps.052048706 Bisaglia M, Trolio A, Bellanda M, Bergantino E, Bubacco L, Mammi S (2006) Structure and topology of the non-amyloid-beta component fragment of human alpha-synuclein bound to micelles: implications for the aggregation process. Protein Sci 15:1408–1416
-
(2006)
Protein Sci
, vol.15
, pp. 1408-1416
-
-
Bisaglia, M1
Trolio, A2
Bellanda, M3
Bergantino, E4
Bubacco, L5
Mammi, S6
-
113
-
-
75749093356
-
Differential phospholipid binding of alpha-synuclein variants implicated in Parkinson’s disease revealed by solution NMR spectroscopy
-
113. CR Bodner AS Maltsev CM Dobson A Bax 2010 Differential phospholipid binding of alpha-synuclein variants implicated in Parkinson’s disease revealed by solution NMR spectroscopy Biochemistry 49 862 871 1:CAS:528:DC%2BC3cXjt1Oruw%3D%3D 20041693 10.1021/bi901723p Bodner CR, Maltsev AS, Dobson CM, Bax A (2010) Differential phospholipid binding of alpha-synuclein variants implicated in Parkinson’s disease revealed by solution NMR spectroscopy. Biochemistry 49:862–871
-
(2010)
Biochemistry
, vol.49
, pp. 862-871
-
-
Bodner, CR1
Maltsev, AS2
Dobson, CM3
Bax, A4
-
114
-
-
14844335694
-
The E46K mutation in alpha-synuclein increases amyloid fibril formation
-
114. EA Greenbaum CL Graves AJ Mishizen-Eberz MA Lupoli DR Lynch SW Englander PH Axelsen BI Giasson 2005 The E46K mutation in alpha-synuclein increases amyloid fibril formation J Biol Chem 280 7800 7807 1:CAS:528:DC%2BD2MXhs1yitrw%3D 15632170 10.1074/jbc.M411638200 Greenbaum EA, Graves CL, Mishizen-Eberz AJ, Lupoli MA, Lynch DR, Englander SW, Axelsen PH, Giasson BI (2005) The E46K mutation in alpha-synuclein increases amyloid fibril formation. J Biol Chem 280:7800–7807
-
(2005)
J Biol Chem
, vol.280
, pp. 7800-7807
-
-
Greenbaum, EA1
Graves, CL2
Mishizen-Eberz, AJ3
Lupoli, MA4
Lynch, DR5
Englander, SW6
Axelsen, PH7
Giasson, BI8
-
115
-
-
0035834655
-
Exposure to long chain polyunsaturated fatty acids triggers rapid multimerization of synucleins
-
115. RJ Perrin WS Woods DF Clayton JM George 2001 Exposure to long chain polyunsaturated fatty acids triggers rapid multimerization of synucleins J Biol Chem 276 41958 41962 1:CAS:528:DC%2BD3MXosVGntLc%3D 11553616 10.1074/jbc.M105022200 Perrin RJ, Woods WS, Clayton DF, George JM (2001) Exposure to long chain polyunsaturated fatty acids triggers rapid multimerization of synucleins. J Biol Chem 276:41958–41962
-
(2001)
J Biol Chem
, vol.276
, pp. 41958-41962
-
-
Perrin, RJ1
Woods, WS2
Clayton, DF3
George, JM4
-
116
-
-
0035949542
-
Effect of familial Parkinson’s disease point mutations A30P and A53T on the structural properties, aggregation, and fibrillation of human alpha-synuclein
-
116. J Li VN Uversky AL Fink 2001 Effect of familial Parkinson’s disease point mutations A30P and A53T on the structural properties, aggregation, and fibrillation of human alpha-synuclein Biochemistry 40 11604 11613 1:CAS:528:DC%2BD3MXmtF2lsbo%3D 11560511 10.1021/bi010616g Li J, Uversky VN, Fink AL (2001) Effect of familial Parkinson’s disease point mutations A30P and A53T on the structural properties, aggregation, and fibrillation of human alpha-synuclein. Biochemistry 40:11604–11613
-
(2001)
Biochemistry
, vol.40
, pp. 11604-11613
-
-
Li, J1
Uversky, VN2
Fink, AL3
-
117
-
-
79960260042
-
Familial Parkinson disease mutations influence α-synuclein assembly
-
117. K Ono T Ikeda J Takasaki M Yamada 2011 Familial Parkinson disease mutations influence α-synuclein assembly Neurobiol Dis 43 715 724 1:CAS:528:DC%2BC3MXptVOjs7k%3D 21684335 10.1016/j.nbd.2011.05.025 Ono K, Ikeda T, Takasaki J, Yamada M (2011) Familial Parkinson disease mutations influence α-synuclein assembly. Neurobiol Dis 43:715–724
-
(2011)
Neurobiol Dis
, vol.43
, pp. 715-724
-
-
Ono, K1
Ikeda, T2
Takasaki, J3
Yamada, M4
-
118
-
-
80055078029
-
A soluble α-synuclein construct forms a dynamic tetramer
-
118. W Wang I Perovic J Chittuluru 2011 A soluble α-synuclein construct forms a dynamic tetramer Proc Natl Acad Sci U S A 108 17797 17802 1:CAS:528:DC%2BC3MXhsVGksLrE 22006323 10.1073/pnas.1113260108 Wang W, Perovic I, Chittuluru J et al (2011) A soluble α-synuclein construct forms a dynamic tetramer. Proc Natl Acad Sci U S A 108:17797–17802
-
(2011)
Proc Natl Acad Sci U S A
, vol.108
, pp. 17797-17802
-
-
Wang, W1
Perovic, I2
Chittuluru, J3
-
119
-
-
67650089623
-
Charge neutralization and collapse of the C-terminal tail of alpha-synuclein at low pH
-
119. S McClendon CC Rospigliosi D Eliezer 2009 Charge neutralization and collapse of the C-terminal tail of alpha-synuclein at low pH Protein Sci 18 1531 1540 1:CAS:528:DC%2BD1MXnvVChsLc%3D 19475665 10.1002/pro.149 McClendon S, Rospigliosi CC, Eliezer D (2009) Charge neutralization and collapse of the C-terminal tail of alpha-synuclein at low pH. Protein Sci 18:1531–1540
-
(2009)
Protein Sci
, vol.18
, pp. 1531-1540
-
-
McClendon, S1
Rospigliosi, CC2
Eliezer, D3
-
120
-
-
80051591601
-
C-terminal part of α-synuclein mediates its activity in promoting proliferation of dopaminergic cells
-
120. J Yin J Han C Zhang QL Ma X Li F Cheng G Liu Y Li K Uéda P Chan S Yu 2011 C-terminal part of α-synuclein mediates its activity in promoting proliferation of dopaminergic cells J Neural Transm 118 1155 1164 1:CAS:528:DC%2BC3MXps1egsLo%3D 21331461 10.1007/s00702-011-0592-y Yin J, Han J, Zhang C, Ma QL, Li X, Cheng F, Liu G, Li Y, Uéda K, Chan P, Yu S (2011) C-terminal part of α-synuclein mediates its activity in promoting proliferation of dopaminergic cells. J Neural Transm 118:1155–1164
-
(2011)
J Neural Transm
, vol.118
, pp. 1155-1164
-
-
Yin, J1
Han, J2
Zhang, C3
Ma, QL4
Li, X5
Cheng, F6
Liu, G7
Li, Y8
Uéda, K9
Chan, P10
Yu, S11
-
121
-
-
2942555022
-
Structure of membrane-bound alpha-synuclein studied by site-directed spin labeling
-
121. CC Jao A Der-Sarkissian J Chen R Langen 2004 Structure of membrane-bound alpha-synuclein studied by site-directed spin labeling Proc Natl Acad Sci U S A 101 8331 8336 1:CAS:528:DC%2BD2cXkvFOmsL0%3D 15155902 10.1073/pnas.0400553101 Jao CC, Der-Sarkissian A, Chen J, Langen R (2004) Structure of membrane-bound alpha-synuclein studied by site-directed spin labeling. Proc Natl Acad Sci U S A 101:8331–8336
-
(2004)
Proc Natl Acad Sci U S A
, vol.101
, pp. 8331-8336
-
-
Jao, CC1
Der-Sarkissian, A2
Chen, J3
Langen, R4
-
122
-
-
27644518721
-
Molecular-level secondary structure, polymorphism, and dynamics of full-length alpha-synuclein fibrils studied by solid-state NMR
-
122. H Heise W Hoyer S Becker OC Andronesi D Riedel M Baldus 2005 Molecular-level secondary structure, polymorphism, and dynamics of full-length alpha-synuclein fibrils studied by solid-state NMR Proc Natl Acad Sci U S A 102 15871 15876 1:CAS:528:DC%2BD2MXht1Wru7bI 16247008 10.1073/pnas.0506109102 Heise H, Hoyer W, Becker S, Andronesi OC, Riedel D, Baldus M (2005) Molecular-level secondary structure, polymorphism, and dynamics of full-length alpha-synuclein fibrils studied by solid-state NMR. Proc Natl Acad Sci U S A 102:15871–15876
-
(2005)
Proc Natl Acad Sci U S A
, vol.102
, pp. 15871-15876
-
-
Heise, H1
Hoyer, W2
Becker, S3
Andronesi, OC4
Riedel, D5
Baldus, M6
-
123
-
-
9444233904
-
Differential expression of alpha-synuclein isoforms in dementia with Lewy bodies
-
123. K Beyer JI Lao C Carrato JL Mate D López I Ferrer A Ariza 2004 Differential expression of alpha-synuclein isoforms in dementia with Lewy bodies Neuropathol Appl Neurobiol 30 601 607 1:CAS:528:DC%2BD2cXhtFGms73P 15541000 10.1111/j.1365-2990.2004.00572.x Beyer K, Lao JI, Carrato C, Mate JL, López D, Ferrer I, Ariza A (2004) Differential expression of alpha-synuclein isoforms in dementia with Lewy bodies. Neuropathol Appl Neurobiol 30:601–607
-
(2004)
Neuropathol Appl Neurobiol
, vol.30
, pp. 601-607
-
-
Beyer, K1
Lao, JI2
Carrato, C3
Mate, JL4
López, D5
Ferrer, I6
Ariza, A7
-
124
-
-
46149119425
-
Differential expression of alpha-synuclein, parkin, and synphilin-1 isoforms in Lewy body disease
-
124. K Beyer M Domingo-Sàbat J Humbert C Carrato I Ferrer A Ariza 2008 Differential expression of alpha-synuclein, parkin, and synphilin-1 isoforms in Lewy body disease Neurogenetics 9 163 172 1:CAS:528:DC%2BD1cXnvVOhs78%3D 18335262 10.1007/s10048-008-0124-6 Beyer K, Domingo-Sàbat M, Humbert J, Carrato C, Ferrer I, Ariza A (2008) Differential expression of alpha-synuclein, parkin, and synphilin-1 isoforms in Lewy body disease. Neurogenetics 9:163–172
-
(2008)
Neurogenetics
, vol.9
, pp. 163-172
-
-
Beyer, K1
Domingo-Sàbat, M2
Humbert, J3
Carrato, C4
Ferrer, I5
Ariza, A6
-
125
-
-
73449099224
-
Oxidants induce alternative splicing of alpha-synuclein: implications for Parkinson’s disease
-
125. SV Kalivendi D Yedlapudi CJ Hillard B Kalyanaraman 2010 Oxidants induce alternative splicing of alpha-synuclein: implications for Parkinson’s disease Free Radic Biol Med 48 377 383 1:CAS:528:DC%2BC3cXktVGqtw%3D%3D 19857570 10.1016/j.freeradbiomed.2009.10.045 Kalivendi SV, Yedlapudi D, Hillard CJ, Kalyanaraman B (2010) Oxidants induce alternative splicing of alpha-synuclein: implications for Parkinson’s disease. Free Radic Biol Med 48:377–383
-
(2010)
Free Radic Biol Med
, vol.48
, pp. 377-383
-
-
Kalivendi, SV1
Yedlapudi, D2
Hillard, CJ3
Kalyanaraman, B4
-
126
-
-
34247857737
-
Complement activation by islet amyloid polypeptide (IAPP) and alpha-synuclein 112
-
126. A Klegeris PL McGeer 2007 Complement activation by islet amyloid polypeptide (IAPP) and alpha-synuclein 112 Biochem Biophys Res Commun 357 1096 1099 1:CAS:528:DC%2BD2sXlt1Wqt7c%3D 17459337 10.1016/j.bbrc.2007.04.055 Klegeris A, McGeer PL (2007) Complement activation by islet amyloid polypeptide (IAPP) and alpha-synuclein 112. Biochem Biophys Res Commun 357:1096–1099
-
(2007)
Biochem Biophys Res Commun
, vol.357
, pp. 1096-1099
-
-
Klegeris, A1
McGeer, PL2
-
127
-
-
33750802218
-
Complement activation in the Parkinson’s disease substantia nigra: an immunocytochemical study
-
127. DA Loeffler DM Camp SB Conant 2006 Complement activation in the Parkinson’s disease substantia nigra: an immunocytochemical study J Neuroinflammation 3 29 17052351 10.1186/1742-2094-3-29 1:CAS:528:DC%2BD28XhtFOitrbL Loeffler DA, Camp DM, Conant SB (2006) Complement activation in the Parkinson’s disease substantia nigra: an immunocytochemical study. J Neuroinflammation 3:29
-
(2006)
J Neuroinflammation
, vol.3
, pp. 29
-
-
Loeffler, DA1
Camp, DM2
Conant, SB3
-
128
-
-
1942454250
-
Inflammation and neurodegeneration in Parkinson’s disease
-
128. PL McGeer EG McGeer 2004 Inflammation and neurodegeneration in Parkinson’s disease Parkinsonism Relat Disord 10 Suppl 1 S3 S7 15109580 10.1016/j.parkreldis.2004.01.005 McGeer PL, McGeer EG (2004) Inflammation and neurodegeneration in Parkinson’s disease. Parkinsonism Relat Disord 10(Suppl 1):S3–S7
-
(2004)
Parkinsonism Relat Disord
, vol.10
, Issue.Suppl 1
, pp. S3-S7
-
-
McGeer, PL1
McGeer, EG2
-
129
-
-
79951549421
-
The effect of SNCA 3′ region on the levels of SNCA-112 splicing variant
-
129. JJ McCarthy C Linnertz L Saucier JR Burke CM Hulette KA Welsh-Bohmer O Chiba-Falek 2011 The effect of SNCA 3′ region on the levels of SNCA-112 splicing variant Neurogenetics 12 59 64 1:CAS:528:DC%2BC3MXht1yrs7k%3D 21046180 10.1007/s10048-010-0263-4 McCarthy JJ, Linnertz C, Saucier L, Burke JR, Hulette CM, Welsh-Bohmer KA, Chiba-Falek O (2011) The effect of SNCA 3′ region on the levels of SNCA-112 splicing variant. Neurogenetics 12:59–64
-
(2011)
Neurogenetics
, vol.12
, pp. 59-64
-
-
McCarthy, JJ1
Linnertz, C2
Saucier, L3
Burke, JR4
Hulette, CM5
Welsh-Bohmer, KA6
Chiba-Falek, O7
-
130
-
-
20144387092
-
Multiple regions of alpha-synuclein are associated with Parkinson’s disease
-
130. JC Mueller J Fuchs A Hofer A Zimprich P Lichtner T Illig D Berg U Wüllner T Meitinger T Gasser 2005 Multiple regions of alpha-synuclein are associated with Parkinson’s disease Ann Neurol 57 535 541 1:CAS:528:DC%2BD2MXjs1Onsr8%3D 15786467 10.1002/ana.20438 Mueller JC, Fuchs J, Hofer A, Zimprich A, Lichtner P, Illig T, Berg D, Wüllner U, Meitinger T, Gasser T (2005) Multiple regions of alpha-synuclein are associated with Parkinson’s disease. Ann Neurol 57:535–541
-
(2005)
Ann Neurol
, vol.57
, pp. 535-541
-
-
Mueller, JC1
Fuchs, J2
Hofer, A3
Zimprich, A4
Lichtner, P5
Illig, T6
Berg, D7
Wüllner, U8
Meitinger, T9
Gasser, T10
-
131
-
-
4844222408
-
Alpha-synuclein promoter confers susceptibility to Parkinson’s disease
-
131. P Pals S Lincoln J Manning M Heckman L Skipper M Hulihan M Broeck Van den T Pooter De P Cras J Crook C Broeckhoven Van MJ Farrer 2004 Alpha-synuclein promoter confers susceptibility to Parkinson’s disease Ann Neurol 56 591 595 1:CAS:528:DC%2BD2cXps1KitL8%3D 15455394 10.1002/ana.20268 Pals P, Lincoln S, Manning J, Heckman M, Skipper L, Hulihan M, Van den Broeck M, De Pooter T, Cras P, Crook J, Van Broeckhoven C, Farrer MJ (2004) Alpha-synuclein promoter confers susceptibility to Parkinson’s disease. Ann Neurol 56:591–595
-
(2004)
Ann Neurol
, vol.56
, pp. 591-595
-
-
Pals, P1
Lincoln, S2
Manning, J3
Heckman, M4
Skipper, L5
Hulihan, M6
Broeck, M7
Pooter, T8
Cras, P9
Crook, J10
Broeckhoven, C11
Farrer, MJ12
-
132
-
-
0037333666
-
Staging of brain pathology related to sporadic Parkinson’s disease
-
132. H Braak K Tredici Del U Rüb RA Vos de EN Jansen Steur E Braak 2003 Staging of brain pathology related to sporadic Parkinson’s disease Neurobiol Aging 24 197 211 12498954 10.1016/S0197-4580(02)00065-9 Braak H, Del Tredici K, Rüb U, de Vos RA, Jansen Steur EN, Braak E (2003) Staging of brain pathology related to sporadic Parkinson’s disease. Neurobiol Aging 24:197–211
-
(2003)
Neurobiol Aging
, vol.24
, pp. 197-211
-
-
Braak, H1
Tredici, K2
Rüb, U3
Vos, RA4
Jansen Steur, EN5
Braak, E6
-
133
-
-
34248162352
-
A variable poly-T sequence modulates alpha-synuclein isoform expression and is associated with aging
-
133. K Beyer J Humbert A Ferrer JI Lao P Latorre D Lopez E Tolosa I Ferrer A Ariza 2007 A variable poly-T sequence modulates alpha-synuclein isoform expression and is associated with aging J Neurosci Res 85 1538 1546 1:CAS:528:DC%2BD2sXlsVWlurc%3D 17387688 10.1002/jnr.21270 Beyer K, Humbert J, Ferrer A, Lao JI, Latorre P, Lopez D, Tolosa E, Ferrer I, Ariza A (2007) A variable poly-T sequence modulates alpha-synuclein isoform expression and is associated with aging. J Neurosci Res 85:1538–1546
-
(2007)
J Neurosci Res
, vol.85
, pp. 1538-1546
-
-
Beyer, K1
Humbert, J2
Ferrer, A3
Lao, JI4
Latorre, P5
Lopez, D6
Tolosa, E7
Ferrer, I8
Ariza, A9
-
134
-
-
38649119157
-
Identification and characterization of a new alpha-synuclein isoform and its role in Lewy body diseases
-
134. K Beyer M Domingo-Sábat JI Lao C Carrato I Ferrer A Ariza 2008 Identification and characterization of a new alpha-synuclein isoform and its role in Lewy body diseases Neurogenetics 9 15 23 17955272 10.1007/s10048-007-0106-0 Beyer K, Domingo-Sábat M, Lao JI, Carrato C, Ferrer I, Ariza A (2008) Identification and characterization of a new alpha-synuclein isoform and its role in Lewy body diseases. Neurogenetics 9:15–23
-
(2008)
Neurogenetics
, vol.9
, pp. 15-23
-
-
Beyer, K1
Domingo-Sábat, M2
Lao, JI3
Carrato, C4
Ferrer, I5
Ariza, A6
-
135
-
-
79951580097
-
Over-expression of α-synuclein 98 triggers intracellular oxidative stress and enhances susceptibility to rotenone
-
135. KL Ma YH Yuan LK Song N Han NH Chen 2011 Over-expression of α-synuclein 98 triggers intracellular oxidative stress and enhances susceptibility to rotenone Neurosci Lett 491 148 152 1:CAS:528:DC%2BC3MXit1Kms74%3D 21238542 10.1016/j.neulet.2011.01.026 Ma KL, Yuan YH, Song LK, Han N, Chen NH (2011) Over-expression of α-synuclein 98 triggers intracellular oxidative stress and enhances susceptibility to rotenone. Neurosci Lett 491:148–152
-
(2011)
Neurosci Lett
, vol.491
, pp. 148-152
-
-
Ma, KL1
Yuan, YH2
Song, LK3
Han, N4
Chen, NH5
-
136
-
-
79951936156
-
The decrease of β-synuclein in cortical brain areas defines a molecular subgroup of dementia with Lewy bodies
-
136. K Beyer M Domingo-Sàbat C Santos E Tolosa I Ferrer A Ariza 2010 The decrease of β-synuclein in cortical brain areas defines a molecular subgroup of dementia with Lewy bodies Brain 133 3724 3733 20959308 10.1093/brain/awq275 Beyer K, Domingo-Sàbat M, Santos C, Tolosa E, Ferrer I, Ariza A (2010) The decrease of β-synuclein in cortical brain areas defines a molecular subgroup of dementia with Lewy bodies. Brain 133:3724–3733
-
(2010)
Brain
, vol.133
, pp. 3724-3733
-
-
Beyer, K1
Domingo-Sàbat, M2
Santos, C3
Tolosa, E4
Ferrer, I5
Ariza, A6
|