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Volumn 18, Issue 3, 2008, Pages 415-422

Three-layered structure shared between Lewy bodies and Lewy neurites - Three-dimensional reconstruction of triple-labeled sections

Author keywords

Lewy bodies; Lewy neurites; Three dimensional reconstruction

Indexed keywords

ALPHA SYNUCLEIN; UBIQUITIN;

EID: 44649167579     PISSN: 10156305     EISSN: None     Source Type: Journal    
DOI: 10.1111/j.1750-3639.2008.00140.x     Document Type: Article
Times cited : (50)

References (48)
  • 1
    • 0344808098 scopus 로고    scopus 로고
    • Immunoelectron-microscopic demonstration of NACP/alpha-synuclein-epitopes on the filamentous component of Lewy bodies in Parkinson's disease and in dementia with Lewy bodies
    • Arima K, Uéda K, Sunohara N, Hirai S, Izumiyama Y, Tonozuka-Uehara H, Kawai M (1998) Immunoelectron-microscopic demonstration of NACP/alpha-synuclein-epitopes on the filamentous component of Lewy bodies in Parkinson's disease and in dementia with Lewy bodies. Brain Res 808 : 93 100.
    • (1998) Brain Res , vol.808 , pp. 93-100
    • Arima, K.1    Uéda, K.2    Sunohara, N.3    Hirai, S.4    Izumiyama, Y.5    Tonozuka-Uehara, H.6    Kawai, M.7
  • 2
    • 0031941058 scopus 로고    scopus 로고
    • Aggregation of alpha-synuclein in Lewy bodies of sporadic Parkinson's disease and dementia with Lewy bodies
    • Baba M, Nakajo S, Tu PH, Tomita T, Nakaya K, Lee VM et al (1998) Aggregation of alpha-synuclein in Lewy bodies of sporadic Parkinson's disease and dementia with Lewy bodies. Am J Pathol 152 : 879 884.
    • (1998) Am J Pathol , vol.152 , pp. 879-884
    • Baba, M.1    Nakajo, S.2    Tu, P.H.3    Tomita, T.4    Nakaya, K.5    Lee, V.M.6    Al, E.7
  • 5
    • 0033538002 scopus 로고    scopus 로고
    • Extensive axonal Lewy neurites in Parkinson's disease: A novel pathological feature revealed by alpha-synuclein immunocytochemistry
    • Braak H, Sandmann-Keil D, Gai WP, Braak E (1999) Extensive axonal Lewy neurites in Parkinson's disease: a novel pathological feature revealed by alpha-synuclein immunocytochemistry. Neurosci Lett 265 : 67 69.
    • (1999) Neurosci Lett , vol.265 , pp. 67-69
    • Braak, H.1    Sandmann-Keil, D.2    Gai, W.P.3    Braak, E.4
  • 9
    • 0025943418 scopus 로고
    • Hippocampal degeneration differentiates diffuse Lewy body disease (DLBD) from Alzheimer's disease: Light and electron microscopic immunocytochemistry of CA2-3 neurites specific to DLBD
    • Dickson DW, Ruan D, Crystal H, Mark MH, Davies P, Kress Y, Yen SH (1991) Hippocampal degeneration differentiates diffuse Lewy body disease (DLBD) from Alzheimer's disease: light and electron microscopic immunocytochemistry of CA2-3 neurites specific to DLBD. Neurology 41 : 1402 1409.
    • (1991) Neurology , vol.41 , pp. 1402-1409
    • Dickson, D.W.1    Ruan, D.2    Crystal, H.3    Mark, M.H.4    Davies, P.5    Kress, Y.6    Yen, S.H.7
  • 11
    • 84937088414 scopus 로고
    • Phase and electron microscopic observations of Lewy bodies and melanin granules in the substantia nigra and locus cearuleus in Parkinson's disease
    • Duffy PE, Tennyson VM (1965) Phase and electron microscopic observations of Lewy bodies and melanin granules in the substantia nigra and locus cearuleus in Parkinson's disease. J Neuropathol Exp Neurol 24 : 398 414.
    • (1965) J Neuropathol Exp Neurol , vol.24 , pp. 398-414
    • Duffy, P.E.1    Tennyson, V.M.2
  • 12
    • 0017288256 scopus 로고
    • Ultrastructure of Lewy bodies in the stellate ganglion
    • Forno LS, Norville RL (1976) Ultrastructure of Lewy bodies in the stellate ganglion. Acta Neuropathol (Berl) 34 : 183 197.
    • (1976) Acta Neuropathol (Berl) , vol.34 , pp. 183-197
    • Forno, L.S.1    Norville, R.L.2
  • 15
    • 0029611219 scopus 로고
    • Ubiquitin-positive degenerating neurites in the brainstem in Parkinson's disease
    • Gai WP, Blessing WW, Blumbergs PC (1995) Ubiquitin-positive degenerating neurites in the brainstem in Parkinson's disease. Brain 118 : 1447 1459.
    • (1995) Brain , vol.118 , pp. 1447-1459
    • Gai, W.P.1    Blessing, W.W.2    Blumbergs, P.C.3
  • 16
    • 0026563548 scopus 로고
    • Filaments of Lewy bodies contain insoluble cytoskeletal elements
    • Galloway PG, Mulvihill P, Perry G (1992) Filaments of Lewy bodies contain insoluble cytoskeletal elements. Am J Pathol 140 : 809 822.
    • (1992) Am J Pathol , vol.140 , pp. 809-822
    • Galloway, P.G.1    Mulvihill, P.2    Perry, G.3
  • 17
    • 0037118259 scopus 로고    scopus 로고
    • Neuronal alpha-synucleinopathy with severe movement disorder in mice expressing A53T human alpha-synuclein
    • Giasson BI, Duda JE, Quinn SM, Zhang B, Trojanowski JQ, Lee VM (2002) Neuronal alpha-synucleinopathy with severe movement disorder in mice expressing A53T human alpha-synuclein. Neuron 34 : 521 533.
    • (2002) Neuron , vol.34 , pp. 521-533
    • Giasson, B.I.1    Duda, J.E.2    Quinn, S.M.3    Zhang, B.4    Trojanowski, J.Q.5    Lee, V.M.6
  • 18
    • 0025976482 scopus 로고
    • Neuronal inclusions of Parkinson's disease
    • Gibb WR, Scott T, Lees AJ (1991) Neuronal inclusions of Parkinson's disease. Mov Disord 6 : 2 11.
    • (1991) Mov Disord , vol.6 , pp. 2-11
    • Gibb, W.R.1    Scott, T.2    Lees, A.J.3
  • 19
    • 0020517951 scopus 로고
    • Lewy bodies of Parkinson's disease contain neurofilament antigens
    • Goldman JE, Yen SH, Chiu FC, Peress NS (1983) Lewy bodies of Parkinson's disease contain neurofilament antigens. Science 221 : 1082 1084.
    • (1983) Science , vol.221 , pp. 1082-1084
    • Goldman, J.E.1    Yen, S.H.2    Chiu, F.C.3    Peress, N.S.4
  • 20
    • 0343527226 scopus 로고    scopus 로고
    • α-synuclein immunoreactivity in dementia with Lewy bodies: Morphological staging and comparison with ubiquitin immunostaining
    • Gómez-Tortosa E, Newell K, Irizarry MC, Sanders JL, Hyman BT (2000) α-synuclein immunoreactivity in dementia with Lewy bodies: morphological staging and comparison with ubiquitin immunostaining. Acta Neuropathol (Berl) 99 : 352 357.
    • (2000) Acta Neuropathol (Berl) , vol.99 , pp. 352-357
    • Gómez-Tortosa, E.1    Newell, K.2    Irizarry, M.C.3    Sanders, J.L.4    Hyman, B.T.5
  • 22
    • 0027538111 scopus 로고
    • An early cytoplasmic change before Lewy body maturation: An ultrastructural study of the substantia nigra from an autopsy case of juvenile parkinsonism
    • Hayashida K, Oyanagi S, Mizutani Y, Yokochi M (1993) An early cytoplasmic change before Lewy body maturation: an ultrastructural study of the substantia nigra from an autopsy case of juvenile parkinsonism. Acta Neuropathol (Berl) 85 : 445 448.
    • (1993) Acta Neuropathol (Berl) , vol.85 , pp. 445-448
    • Hayashida, K.1    Oyanagi, S.2    Mizutani, Y.3    Yokochi, M.4
  • 23
    • 0031944830 scopus 로고    scopus 로고
    • Nigral and cortical Lewy bodies and dystrophic nigral neurites in Parkinson's disease and cortical Lewy body disease contain alpha-synuclein immunoreactivity
    • Irizarry MC, Growdon W, Gomez-Isla T, Newell K, George JM, Clayton DF, Hyman BT (1998) Nigral and cortical Lewy bodies and dystrophic nigral neurites in Parkinson's disease and cortical Lewy body disease contain alpha-synuclein immunoreactivity. J Neuropathol Exp Neurol 57 : 334 337.
    • (1998) J Neuropathol Exp Neurol , vol.57 , pp. 334-337
    • Irizarry, M.C.1    Growdon, W.2    Gomez-Isla, T.3    Newell, K.4    George, J.M.5    Clayton, D.F.6    Hyman, B.T.7
  • 24
    • 0029866793 scopus 로고    scopus 로고
    • Purification and characterization of Lewy bodies from the brains of patients with diffuse Lewy body disease
    • Iwatsubo T, Yamaguchi H, Fujimuro M, Yokosawa H, Ihara Y, Trojanowski JQ, Lee VM (1996) Purification and characterization of Lewy bodies from the brains of patients with diffuse Lewy body disease. Am J Pathol 148 : 1517 1529.
    • (1996) Am J Pathol , vol.148 , pp. 1517-1529
    • Iwatsubo, T.1    Yamaguchi, H.2    Fujimuro, M.3    Yokosawa, H.4    Ihara, Y.5    Trojanowski, J.Q.6    Lee, V.M.7
  • 25
    • 0028864640 scopus 로고
    • Ubiquitin-positive CA2/3 neurites in hippocampus coexist with cortical Lewy bodies
    • Kim H, Gearing M, Mirra SS (1995) Ubiquitin-positive CA2/3 neurites in hippocampus coexist with cortical Lewy bodies. Neurology 45 : 1768 1770.
    • (1995) Neurology , vol.45 , pp. 1768-1770
    • Kim, H.1    Gearing, M.2    Mirra, S.S.3
  • 26
    • 0344305371 scopus 로고    scopus 로고
    • Morphogenesis of Lewy bodies: Dissimilar incorporation of alpha-synuclein, ubiquitin, and p62
    • Kuusisto E, Parkkinen L, Alafuzoff I (2003) Morphogenesis of Lewy bodies: dissimilar incorporation of alpha-synuclein, ubiquitin, and p62. J Neuropathol Exp Neurol 62 : 1241 1253.
    • (2003) J Neuropathol Exp Neurol , vol.62 , pp. 1241-1253
    • Kuusisto, E.1    Parkkinen, L.2    Alafuzoff, I.3
  • 27
    • 0023931333 scopus 로고
    • Lewy bodies are ubiquitinated. a light and electron microscopic immunocytochemical study
    • Kuzuhara S, Mori H, Izumiyama N, Yoshimura M, Ihara Y (1988) Lewy bodies are ubiquitinated. A light and electron microscopic immunocytochemical study. Acta Neuropathol (Berl) 75 : 345 353.
    • (1988) Acta Neuropathol (Berl) , vol.75 , pp. 345-353
    • Kuzuhara, S.1    Mori, H.2    Izumiyama, N.3    Yoshimura, M.4    Ihara, Y.5
  • 28
    • 0034681471 scopus 로고    scopus 로고
    • Dopaminergic loss and inclusion body formation in alpha-synuclein mice: Implications for neurodegenerative disorders
    • Masliah E, Rockenstein E, Veinbergs I, Mallory M, Hashimoto M, Takeda A et al (2000) Dopaminergic loss and inclusion body formation in alpha-synuclein mice: implications for neurodegenerative disorders. Science 287 : 1265 1269.
    • (2000) Science , vol.287 , pp. 1265-1269
    • Masliah, E.1    Rockenstein, E.2    Veinbergs, I.3    Mallory, M.4    Hashimoto, M.5    Takeda, A.6    Al, E.7
  • 29
    • 3042794162 scopus 로고    scopus 로고
    • Systemic exposure to proteasome inhibitors causes a progressive model of Parkinson's disease
    • McNaught KS, Perl DP, Brownell AL, Olanow CW (2004) Systemic exposure to proteasome inhibitors causes a progressive model of Parkinson's disease. Ann Neurol 56 : 149 162.
    • (2004) Ann Neurol , vol.56 , pp. 149-162
    • McNaught, K.S.1    Perl, D.P.2    Brownell, A.L.3    Olanow, C.W.4
  • 30
    • 0023140474 scopus 로고
    • Ubiquitin is a component of paired helical filaments in Alzheimer's disease
    • Mori H, Kondo J, Ihara Y (1987) Ubiquitin is a component of paired helical filaments in Alzheimer's disease. Science 235 : 1641 1644.
    • (1987) Science , vol.235 , pp. 1641-1644
    • Mori, H.1    Kondo, J.2    Ihara, Y.3
  • 33
    • 0023028576 scopus 로고
    • Lewy bodies of Parkinson's disease. Immune electron microscopic demonstration of neurofilament antigens in constituent filaments
    • Pappolla MA (1986) Lewy bodies of Parkinson's disease. Immune electron microscopic demonstration of neurofilament antigens in constituent filaments. Arch Pathol Lab Med 110 : 1160 1163.
    • (1986) Arch Pathol Lab Med , vol.110 , pp. 1160-1163
    • Pappolla, M.A.1
  • 34
  • 35
    • 11144353869 scopus 로고    scopus 로고
    • Parkinson's disease alpha-synuclein mutations exhibit defective axonal transport in cultured neurons
    • Saha AR, Hill J, Utton MA, Asuni AA, Ackerley S, Grierson AJ et al (2004) Parkinson's disease alpha-synuclein mutations exhibit defective axonal transport in cultured neurons. J Cell Sci 117 : 1017 1024.
    • (2004) J Cell Sci , vol.117 , pp. 1017-1024
    • Saha, A.R.1    Hill, J.2    Utton, M.A.3    Asuni, A.A.4    Ackerley, S.5    Grierson, A.J.6    Al, E.7
  • 37
    • 0036434291 scopus 로고    scopus 로고
    • Heterogeneity of nigral and cortical Lewy bodies differentiated by amplified triple-labeling for alpha-synuclein, ubiquitin, and thiazin red
    • Sakamoto M, Uchihara T, Hayashi M, Nakamura A, Kikuchi E, Mizutani T et al (2002) Heterogeneity of nigral and cortical Lewy bodies differentiated by amplified triple-labeling for alpha-synuclein, ubiquitin, and thiazin red. Exp Neurol 177 : 88 94.
    • (2002) Exp Neurol , vol.177 , pp. 88-94
    • Sakamoto, M.1    Uchihara, T.2    Hayashi, M.3    Nakamura, A.4    Kikuchi, E.5    Mizutani, T.6    Al, E.7
  • 38
    • 0025833558 scopus 로고
    • Epitope map of neurofilament protein domains in cortical and peripheral nervous system Lewy bodies
    • Schmidt ML, Murray J, Lee VM, Hill WD, Wertkin A, Trojanowski JQ (1991) Epitope map of neurofilament protein domains in cortical and peripheral nervous system Lewy bodies. Am J Pathol 139 : 53 65.
    • (1991) Am J Pathol , vol.139 , pp. 53-65
    • Schmidt, M.L.1    Murray, J.2    Lee, V.M.3    Hill, W.D.4    Wertkin, A.5    Trojanowski, J.Q.6
  • 39
    • 0032568534 scopus 로고    scopus 로고
    • Alpha-synuclein in filamentous inclusions of Lewy bodies from Parkinson's disease and dementia with Lewy bodies
    • Spillantini MG (1998) Alpha-synuclein in filamentous inclusions of Lewy bodies from Parkinson's disease and dementia with Lewy bodies. Proc Natl Acad Sci USA 95 : 6469 6473.
    • (1998) Proc Natl Acad Sci USA , vol.95 , pp. 6469-6473
    • Spillantini, M.G.1
  • 41
    • 0035097503 scopus 로고    scopus 로고
    • Clinical and pathological features of a Parkinsonian syndrome in a family with an Ala53Thr alpha-synuclein mutation
    • Spira PJ, Sharpe DM, Halliday G, Cavanagh J, Nicholson GA (2001) Clinical and pathological features of a Parkinsonian syndrome in a family with an Ala53Thr alpha-synuclein mutation. Ann Neurol 49 : 313 319.
    • (2001) Ann Neurol , vol.49 , pp. 313-319
    • Spira, P.J.1    Sharpe, D.M.2    Halliday, G.3    Cavanagh, J.4    Nicholson, G.A.5
  • 42
    • 0031907128 scopus 로고    scopus 로고
    • Abnormal accumulation of NACP/alpha-synuclein in neurodegenerative disorders
    • Takeda A, Mallory M, Sundsmo M, Honer W, Hansen L, Masliah E (1998) Abnormal accumulation of NACP/alpha-synuclein in neurodegenerative disorders. Am J Pathol 152 : 367 372.
    • (1998) Am J Pathol , vol.152 , pp. 367-372
    • Takeda, A.1    Mallory, M.2    Sundsmo, M.3    Honer, W.4    Hansen, L.5    Masliah, E.6
  • 43
    • 0242666359 scopus 로고    scopus 로고
    • Ubiquitination of alpha-synuclein in Lewy bodies is a pathological event not associated with impairment of proteasome function
    • Tofaris GK, Razzaq A, Ghetti B, Lilley KS, Spillantini MG (2003) Ubiquitination of alpha-synuclein in Lewy bodies is a pathological event not associated with impairment of proteasome function. J Biol Chem 278 : 44405 44411.
    • (2003) J Biol Chem , vol.278 , pp. 44405-44411
    • Tofaris, G.K.1    Razzaq, A.2    Ghetti, B.3    Lilley, K.S.4    Spillantini, M.G.5
  • 44
    • 0041819808 scopus 로고    scopus 로고
    • Triple immunofluorolabeling with two rabbit polyclonal antibodies and a mouse monoclonal antibody allowing three-dimensional analysis of cotton wool plaques in Alzheimer disease
    • Uchihara T, Nakamura A, Nakayama H, Arima K, Ishizuka N, Mori H, Mizushima S (2003) Triple immunofluorolabeling with two rabbit polyclonal antibodies and a mouse monoclonal antibody allowing three-dimensional analysis of cotton wool plaques in Alzheimer disease. J Histochem Cytochem 51 : 1201 1206.
    • (2003) J Histochem Cytochem , vol.51 , pp. 1201-1206
    • Uchihara, T.1    Nakamura, A.2    Nakayama, H.3    Arima, K.4    Ishizuka, N.5    Mori, H.6    Mizushima, S.7
  • 45
    • 27844470590 scopus 로고    scopus 로고
    • Molecular motors implicated in the axonal transport of tau and alpha-synuclein
    • Utton MA, Noble WJ, Hill JE, Anderton BH, Hanger DP (2005) Molecular motors implicated in the axonal transport of tau and alpha-synuclein. J Cell Sci 118 : 4645 4654.
    • (2005) J Cell Sci , vol.118 , pp. 4645-4654
    • Utton, M.A.1    Noble, W.J.2    Hill, J.E.3    Anderton, B.H.4    Hanger, D.P.5
  • 47
    • 0036938071 scopus 로고    scopus 로고
    • Immunocytochemical localization of synphilin-1, an α-synuclein- associated protein, in neurodegenerative disorders
    • Wakabayashi K, Engelender S, Tanaka Y, Yoshimoto M, Mori F, Tsuji S et al (2002) Immunocytochemical localization of synphilin-1, an α-synuclein- associated protein, in neurodegenerative disorders. Acta Neuropathol (Berl) 103 : 209 214.
    • (2002) Acta Neuropathol (Berl) , vol.103 , pp. 209-214
    • Wakabayashi, K.1    Engelender, S.2    Tanaka, Y.3    Yoshimoto, M.4    Mori, F.5    Tsuji, S.6    Al, E.7
  • 48
    • 26444445118 scopus 로고    scopus 로고
    • Abundant neuritic inclusions and microvacuolar changes in a case of diffuse Lewy body disease with the A53T mutation in the alpha-synuclein gene
    • Yamaguchi K, Cochran EJ, Murrell JR, Polymeropoulos MH, Shannon KM, Crowther RA et al (2005) Abundant neuritic inclusions and microvacuolar changes in a case of diffuse Lewy body disease with the A53T mutation in the alpha-synuclein gene. Acta Neuropathol (Berl) 110 : 298 305.
    • (2005) Acta Neuropathol (Berl) , vol.110 , pp. 298-305
    • Yamaguchi, K.1    Cochran, E.J.2    Murrell, J.R.3    Polymeropoulos, M.H.4    Shannon, K.M.5    Crowther, R.A.6    Al, E.7


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