Alpha-synuclein haplotypes implicated in risk of Parkinson's disease

Neurology

Volumn 62, Issue 1, 2004, Pages 128-131

  Tan, Eng King ^a,b,c   Chai, A ^a   Teo, Y Y ^e   Zhao, Y ^a   Tan, C ^a   Shen, H ^a   Chandran, V R ^a   Teoh, M L ^a   Yih, Y ^a   Pavanni, R ^a,b   Wong, M C ^a,b   Puvan, K ^a,b   Lo, Y L ^a,b   Yap, E ^d  

^a SINGAPORE GENERAL HOSPITAL   (Singapore)

^b NATIONAL NEUROSCIENCE INSTITUTE   (Singapore)

^c Singapore Health Services   (Singapore)

^d Defence Medical Research Institute   (Singapore)

^e NONE

Author keywords

[No Author keywords available]

Indexed keywords

ALPHA SYNUCLEIN; MICROSATELLITE DNA;

ADULT; AGED; ARTICLE; CHINESE; CONTROLLED STUDY; FEMALE; GENE LOCUS; GENETIC SUSCEPTIBILITY; HAPLOTYPE; HUMAN; LOGISTIC REGRESSION ANALYSIS; MAJOR CLINICAL STUDY; MALE; PARKINSON DISEASE; PRIORITY JOURNAL; SINGLE NUCLEOTIDE POLYMORPHISM;

EID: 9144266292     PISSN: 00283878     EISSN: None     Source Type: Journal    
DOI: 10.1212/01.WNL.0000101721.25345.DC     Document Type: Article

References (10)

1. Polymeropoulos MH, Laavedan C, Leroy E, et al. Mutation in the alpha-synuclein gene identified in families with Parkinson's disease. Science 1997;276:2045-2047.
2. Kobayashi H, Kruger R, Markopoulou K, et al. Haploinsufficiency at the alpha-synuclein gene underlies phenotypic severity in familial Parkinson's disease. Brain 2003;126:32-42.
3. Farrer M, Maraganore DM, Lockhart P, et al. Alpha-synuclein gene haplotypes are associated with Parkinson's disease. Hum Mol Genet 2001;10:1847-1851.
4. Tan EK, Matsuura T, Nagamitsu S, Khajavi M, Jankovic J, Ashizawa T. Polymorphism of NACP-Rep1 in Parkinson's disease: an etiologic link with essential tremor? Neurology 2000;54:1195-1198.
5. Tan EK, Tan C, Shen H, et al. Alpha synuclein promoter and risk of Parkinson's disease: microsatellite and allelic size variability. Neurosci Lett 2003;336:70-72.
6. Chiba-Falek O, Nussbaum RL. Effect of allelic variation at the NACP-Rep1 repeat upstream of the alpha-synuclein gene (SNCA) on transcription in a cell culture luciferase reporter system. Hum Mol Genet 2001;10:3101-3109.
7. Johnson GC, Esposito L, Barratt BJ, et al. Haplotype tagging for the identification of common disease genes. Nat Genet 2001;29:233-237.
8. Hughes AJ, Daniel SE, Kilford L, Lees AJ. Accuracy of clinical diagnosis of idiopathic Parkinson's disease: a clinico-pathological study of 100 cases. J Neurol Neurosurg Psychiatry 1992;55:181-184.
9. Tan EK, Khajavi M, Thornby JI, Nagamitsu S, Jankovic J, Ashizawa T. Variability and validity of polymorphism association studies in Parkinson's disease. Neurology 2000;55:533-538.
10. Drysdale CM, McGraw DW, Stack CB, et al. Complex promoter and coding region beta 2-adrenergic receptor haplotypes alter receptor expression and predict in vivo responsiveness. Proc Natl Acad Sci USA 2000;97:10483-10488.