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Volumn 128, Issue 2, 2018, Pages 545-555

Fructose metabolism and metabolic disease

Author keywords

[No Author keywords available]

Indexed keywords

FRUCTOSE; CARBOHYDRATE; GLUCOSE; GLUCOSE TRANSPORTER 2; SLC2A2 PROTEIN, HUMAN;

EID: 85041470176     PISSN: 00219738     EISSN: 15588238     Source Type: Journal    
DOI: 10.1172/JCI96702     Document Type: Review
Times cited : (375)

References (193)
  • 1
    • 84879432733 scopus 로고    scopus 로고
    • Trends in sugar-sweetened beverage consumption among youth and adults in the United States: 1999–2010
    • Kit BK, Fakhouri TH, Park S, Nielsen SJ, Ogden CL. Trends in sugar-sweetened beverage consumption among youth and adults in the United States: 1999–2010. Am J Clin Nutr. 2013;98(1):180–188.
    • (2013) Am J Clin Nutr , vol.98 , Issue.1 , pp. 180-188
    • Kit, B.K.1    Fakhouri, T.H.2    Park, S.3    Nielsen, S.J.4    Ogden, C.L.5
  • 2
    • 79952741343 scopus 로고    scopus 로고
    • ODPHP Website. Accessed December 12, 2017
    • Office of Disease Prevention and Health Promotion. Dietary Guidelines for Americans 2015–2020. ODPHP Website. http://health.gov/dietaryguidelines/2015/guidelines/. Accessed December 12, 2017.
    • Dietary Guidelines for Americans 2015–2020
  • 3
    • 85016115600 scopus 로고    scopus 로고
    • Sugar-sweetened beverage consumption among u.S. Youth, 2011–2014
    • Rosinger A, Herrick K, Gahche J, Park S. Sugar-sweetened beverage consumption among U.S. youth, 2011–2014. NCHSDataBrief. 2017(271):1–8.
    • (2017) NCHSDataBrief , Issue.271 , pp. 1-8
    • Rosinger, A.1    Herrick, K.2    Gahche, J.3    Park, S.4
  • 4
    • 84983325966 scopus 로고    scopus 로고
    • Added sugars and cardiovascular disease risk in children: A scientific statement from the American Heart Association
    • Vos MB, et al. Added sugars and cardiovascular disease risk in children: a scientific statement from the American Heart Association. Circulation. 2017;135(19):e1017–e1034.
    • (2017) Circulation , vol.135 , Issue.19 , pp. e1017-e1034
    • Vos, M.B.1
  • 5
    • 85000836814 scopus 로고    scopus 로고
    • Controversies about sugars: Results from systematic reviews and meta-analyses on obesity, cardiometabolic disease and diabetes
    • Khan TA, Sievenpiper JL. Controversies about sugars: results from systematic reviews and meta-analyses on obesity, cardiometabolic disease and diabetes. Eur J Nutr. 2016;55(suppl 2):25–43.
    • (2016) Eur J Nutr , vol.55 , pp. 25-43
    • Khan, T.A.1    Sievenpiper, J.L.2
  • 6
    • 85029178130 scopus 로고    scopus 로고
    • Fructose consumption, lipogenesis, and non-alcoholic fatty liver disease
    • Ter Horst KW, Serlie MJ. Fructose consumption, lipogenesis, and non-alcoholic fatty liver disease. Nutrients. 2017;9(9):E981.
    • (2017) Nutrients , vol.9 , Issue.9 , pp. E981
    • Ter Horst, K.W.1    Serlie, M.J.2
  • 7
    • 84956705329 scopus 로고    scopus 로고
    • Sugar consumption, metabolic disease and obesity: The state of the controversy
    • Stanhope KL. Sugar consumption, metabolic disease and obesity: the state of the controversy. Crit Rev Clin Lab Sci. 2016;53(1):52–67.
    • (2016) Crit Rev Clin Lab Sci , vol.53 , Issue.1 , pp. 52-67
    • Stanhope, K.L.1
  • 8
    • 84884895878 scopus 로고    scopus 로고
    • Sugar-sweetened beverages and weight gain in children and adults: A systematic review and meta-analysis
    • Malik VS, Pan A, Willett WC, Hu FB. Sugar-sweetened beverages and weight gain in children and adults: a systematic review and meta-analysis. Am J Clin Nutr. 2013;98(4):1084–1102.
    • (2013) Am J Clin Nutr , vol.98 , Issue.4 , pp. 1084-1102
    • Malik, V.S.1    Pan, A.2    Willett, W.C.3    Hu, F.B.4
  • 9
    • 84954348953 scopus 로고    scopus 로고
    • Sugar-sweetened beverage consumption is associated with change of visceral adipose tissue over 6 years of follow-up
    • Ma J, McKeown NM, Hwang SJ, Hoffmann U, Jacques PF, Fox CS. Sugar-sweetened beverage consumption is associated with change of visceral adipose tissue over 6 years of follow-up. Circulation. 2016;133(4):370–377.
    • (2016) Circulation , vol.133 , Issue.4 , pp. 370-377
    • Ma, J.1    McKeown, N.M.2    Hwang, S.J.3    Hoffmann, U.4    Jacques, P.F.5    Fox, C.S.6
  • 10
    • 84856376705 scopus 로고    scopus 로고
    • Sucrose-sweetened beverages increase fat storage in the liver, muscle, and visceral fat depot: A 6-mo randomized intervention study
    • Maersk M, et al. Sucrose-sweetened beverages increase fat storage in the liver, muscle, and visceral fat depot: a 6-mo randomized intervention study. Am J Clin Nutr. 2012;95(2):283–289.
    • (2012) Am J Clin Nutr , vol.95 , Issue.2 , pp. 283-289
    • Maersk, M.1
  • 11
    • 84899988517 scopus 로고    scopus 로고
    • Sugar-sweetened beverages and prevalence of the metabolically abnormal phenotype in the framingham heart study
    • Green AK, Jacques PF, Rogers G, Fox CS, Meigs JB, McKeown NM. Sugar-sweetened beverages and prevalence of the metabolically abnormal phenotype in the Framingham Heart Study. Obesity (Silver Spring). 2014;22(5):E157–E163.
    • (2014) Obesity (Silver Spring) , vol.22 , Issue.5 , pp. E157-E163
    • Green, A.K.1    Jacques, P.F.2    Rogers, G.3    Fox, C.S.4    Meigs, J.B.5    McKeown, N.M.6
  • 12
    • 84940071994 scopus 로고    scopus 로고
    • Consumption of sugar sweetened beverages, artificially sweetened beverages, and fruit juice and incidence of type 2 diabetes: Systematic review, meta-analysis, and estimation of population attributable fraction
    • Imamura F, et al. Consumption of sugar sweetened beverages, artificially sweetened beverages, and fruit juice and incidence of type 2 diabetes: systematic review, meta-analysis, and estimation of population attributable fraction. BMJ. 2015;351:h3576.
    • (2015) BMJ , vol.351 , pp. h3576
    • Imamura, F.1
  • 13
    • 84859524909 scopus 로고    scopus 로고
    • Sweetened beverage consumption, incident coronary heart disease, and biomarkers of risk in men
    • de Koning L, Malik VS, Kellogg MD, Rimm EB, Willett WC, Hu FB. Sweetened beverage consumption, incident coronary heart disease, and biomarkers of risk in men. Circulation. 2012;125(14):1735–1741.
    • (2012) Circulation , vol.125 , Issue.14 , pp. 1735-1741
    • De Koning, L.1    Malik, V.S.2    Kellogg, M.D.3    Rimm, E.B.4    Willett, W.C.5    Hu, F.B.6
  • 14
    • 84892371987 scopus 로고    scopus 로고
    • Decreased consumption of sugar-sweetened beverages improved selected biomarkers of chronic disease risk among US adults: 1999 to 2010
    • Hert KA, Fisk PS, Rhee YS, Brunt AR. Decreased consumption of sugar-sweetened beverages improved selected biomarkers of chronic disease risk among US adults: 1999 to 2010. Nutr Res. 2014;34(1):58–65.
    • (2014) Nutr Res , vol.34 , Issue.1 , pp. 58-65
    • Hert, K.A.1    Fisk, P.S.2    Rhee, Y.S.3    Brunt, A.R.4
  • 15
    • 34548396882 scopus 로고    scopus 로고
    • Soft drink consumption and risk of developing cardiometabolic risk factors and the metabolic syndrome in middle-aged adults in the community
    • Dhingra R, et al. Soft drink consumption and risk of developing cardiometabolic risk factors and the metabolic syndrome in middle-aged adults in the community. Circulation. 2007;116(5):480–488.
    • (2007) Circulation , vol.116 , Issue.5 , pp. 480-488
    • Dhingra, R.1
  • 17
    • 84942900410 scopus 로고    scopus 로고
    • Sugar-sweetened beverage consumption and incident hypertension: A systematic review and meta-analysis of prospective cohorts
    • Jayalath VH, et al. Sugar-sweetened beverage consumption and incident hypertension: a systematic review and meta-analysis of prospective cohorts. Am J Clin Nutr. 2015;102(4):914–921.
    • (2015) Am J Clin Nutr , vol.102 , Issue.4 , pp. 914-921
    • Jayalath, V.H.1
  • 18
    • 0024160877 scopus 로고
    • Banting lecture 1988. Role of insulin resistance in human disease
    • Reaven GM. Banting lecture 1988. Role of insulin resistance in human disease. Diabetes. 1988;37(12):1595–1607.
    • (1988) Diabetes , vol.37 , Issue.12 , pp. 1595-1607
    • Reaven, G.M.1
  • 19
    • 0025976627 scopus 로고
    • Insulin resistance and compensatory hyperinsulinemia: Role in hypertension, dyslipidemia, and coronary heart disease
    • Reaven GM. Insulin resistance and compensatory hyperinsulinemia: role in hypertension, dyslipidemia, and coronary heart disease. Am Heart J. 1991;121(4 pt 2):1283–1288.
    • (1991) Am Heart J , vol.121 , Issue.4 , pp. 1283-1288
    • Reaven, G.M.1
  • 20
    • 66449093225 scopus 로고    scopus 로고
    • Consuming fructose-sweetened, not glucose-sweetened, beverages increases visceral adiposity and lipids and decreases insulin sensitivity in overweight/obese humans
    • Stanhope KL, et al. Consuming fructose-sweetened, not glucose-sweetened, beverages increases visceral adiposity and lipids and decreases insulin sensitivity in overweight/obese humans. J Clin Invest. 2009;119(5):1322–1334.
    • (2009) J Clin Invest , vol.119 , Issue.5 , pp. 1322-1334
    • Stanhope, K.L.1
  • 21
    • 84980413778 scopus 로고    scopus 로고
    • No differential effect of beverages sweetened with fructose, high-fructose corn syrup, or glucose on systemic or adipose tissue inflammation in normal-weight to obese adults: A randomized controlled trial
    • Kuzma JN, et al. No differential effect of beverages sweetened with fructose, high-fructose corn syrup, or glucose on systemic or adipose tissue inflammation in normal-weight to obese adults: a randomized controlled trial. Am J Clin Nutr. 2016;104(2):306–314.
    • (2016) Am J Clin Nutr , vol.104 , Issue.2 , pp. 306-314
    • Kuzma, J.N.1
  • 22
    • 66749107383 scopus 로고    scopus 로고
    • National estimates of dietary fructose intake increased from 1977 to 2004 in the United States
    • Marriott BP, Cole N, Lee E. National estimates of dietary fructose intake increased from 1977 to 2004 in the United States. J Nutr. 2009;139(6):1228S–1235S.
    • (2009) J Nutr , vol.139 , Issue.6 , pp. 1228S-1235S
    • Marriott, B.P.1    Cole, N.2    Lee, E.3
  • 23
    • 84907334403 scopus 로고    scopus 로고
    • Fructose, high-fructose corn syrup, sucrose, and nonalcoholic fatty liver disease or indexes of liver health: A systematic review and meta-analysis
    • Chung M, Ma J, Patel K, Berger S, Lau J, Lichtenstein AH. Fructose, high-fructose corn syrup, sucrose, and nonalcoholic fatty liver disease or indexes of liver health: a systematic review and meta-analysis. Am J Clin Nutr. 2014;100(3):833–849.
    • (2014) Am J Clin Nutr , vol.100 , Issue.3 , pp. 833-849
    • Chung, M.1    Ma, J.2    Patel, K.3    Berger, S.4    Lau, J.5    Lichtenstein, A.H.6
  • 24
    • 84897106960 scopus 로고    scopus 로고
    • Association of fructose consumption and components of metabolic syndrome in human studies: A systematic review and meta-analysis
    • Kelishadi R, Mansourian M, Heidari-Beni M. Association of fructose consumption and components of metabolic syndrome in human studies: a systematic review and meta-analysis. Nutrition. 2014;30(5):503–510.
    • (2014) Nutrition , vol.30 , Issue.5 , pp. 503-510
    • Kelishadi, R.1    Mansourian, M.2    Heidari-Beni, M.3
  • 25
    • 84930419045 scopus 로고    scopus 로고
    • A dose-response study of consuming high-fructose corn syrup-sweetened beverages on lipid/lipoprotein risk factors for cardiovascular disease in young adults
    • Stanhope KL, et al. A dose-response study of consuming high-fructose corn syrup-sweetened beverages on lipid/lipoprotein risk factors for cardiovascular disease in young adults. Am J Clin Nutr. 2015;101(6):1144–1154.
    • (2015) Am J Clin Nutr , vol.101 , Issue.6 , pp. 1144-1154
    • Stanhope, K.L.1
  • 26
    • 84961792818 scopus 로고    scopus 로고
    • Physiological handling of dietary fructose-containing sugars: Implications for health
    • Campos VC, Tappy L. Physiological handling of dietary fructose-containing sugars: implications for health. Int J Obes (Lond). 2016;40(suppl 1):S6–S11.
    • (2016) Int J Obes (Lond) , vol.40 , pp. S6-S11
    • Campos, V.C.1    Tappy, L.2
  • 27
    • 84880131754 scopus 로고    scopus 로고
    • Adverse metabolic effects of dietary fructose: Results from the recent epidemiological, clinical, and mechanistic studies
    • Stanhope KL, Schwarz JM, Havel PJ. Adverse metabolic effects of dietary fructose: results from the recent epidemiological, clinical, and mechanistic studies. Curr Opin Lipidol. 2013;24(3):198–206.
    • (2013) Curr Opin Lipidol , vol.24 , Issue.3 , pp. 198-206
    • Stanhope, K.L.1    Schwarz, J.M.2    Havel, P.J.3
  • 28
    • 84965086105 scopus 로고    scopus 로고
    • Transport, metabolism, and endosomal trafficking-dependent regulation of intestinal fructose absorption
    • Patel C, Douard V, Yu S, Gao N, Ferraris RP. Transport, metabolism, and endosomal trafficking-dependent regulation of intestinal fructose absorption. FASEB J. 2015;29(9):4046–4058.
    • (2015) FASEB J , vol.29 , Issue.9 , pp. 4046-4058
    • Patel, C.1    Douard, V.2    Yu, S.3    Gao, N.4    Ferraris, R.P.5
  • 29
    • 64149110202 scopus 로고    scopus 로고
    • Slc2a5 (Glut5) is essential for the absorption of fructose in the intestine and generation of fructose-induced hypertension
    • Barone S, et al. Slc2a5 (Glut5) is essential for the absorption of fructose in the intestine and generation of fructose-induced hypertension. J Biol Chem. 2009;284(8):5056–5066.
    • (2009) J Biol Chem , vol.284 , Issue.8 , pp. 5056-5066
    • Barone, S.1
  • 31
    • 67449135893 scopus 로고    scopus 로고
    • The role of diet in symptoms of irritable bowel syndrome in adults: A narrative review
    • Heizer WD, Southern S, McGovern S. The role of diet in symptoms of irritable bowel syndrome in adults: a narrative review. J Am Diet Assoc. 2009;109(7):1204–1214.
    • (2009) J Am Diet Assoc , vol.109 , Issue.7 , pp. 1204-1214
    • Heizer, W.D.1    Southern, S.2    McGovern, S.3
  • 32
    • 0026687619 scopus 로고
    • Fructose and related food carbohydrates. Sources, intake, absorption, and clinical implications
    • Rumessen JJ. Fructose and related food carbohydrates. Sources, intake, absorption, and clinical implications. Scand J Gastroenterol. 1992;27(10):819–828.
    • (1992) Scand J Gastroenterol , vol.27 , Issue.10 , pp. 819-828
    • Rumessen, J.J.1
  • 33
    • 0022533765 scopus 로고
    • Absorption capacity of fructose in healthy adults. Comparison with sucrose and its constituent monosac-charides
    • Rumessen JJ, Gudmand-Høyer E. Absorption capacity of fructose in healthy adults. Comparison with sucrose and its constituent monosac-charides. Gut. 1986;27(10):1161–1168.
    • (1986) Gut , vol.27 , Issue.10 , pp. 1161-1168
    • Rumessen, J.J.1    Gudmand-Høyer, E.2
  • 34
    • 7044272753 scopus 로고    scopus 로고
    • Dietary fructose and gastrointestinal symptoms: A review
    • Skoog SM, Bharucha AE. Dietary fructose and gastrointestinal symptoms: a review. Am J Gastroenterol. 2004;99(10):2046–2050.
    • (2004) Am J Gastroenterol , vol.99 , Issue.10 , pp. 2046-2050
    • Skoog, S.M.1    Bharucha, A.E.2
  • 35
    • 0035644193 scopus 로고    scopus 로고
    • Dietary and developmental regulation of intestinal sugar transport
    • Ferraris RP. Dietary and developmental regulation of intestinal sugar transport. Biochem J. 2001;360(pt 2):265–276.
    • (2001) Biochem J , vol.360 , pp. 265-276
    • Ferraris, R.P.1
  • 36
    • 84991302315 scopus 로고    scopus 로고
    • Diabetes regulates fructose absorption through thioredoxin-interacting protein
    • Dotimas JR, et al. Diabetes regulates fructose absorption through thioredoxin-interacting protein. Elife. 2016;5:e18313.
    • (2016) Elife , vol.5 , pp. e18313
    • Dotimas, J.R.1
  • 37
    • 2442435802 scopus 로고    scopus 로고
    • Deficiency of carbohydrate response element-binding protein (ChREBP) reduces lipogenesis as well as glycolysis
    • Iizuka K, Bruick RK, Liang G, Horton JD, Uyeda K. Deficiency of carbohydrate response element-binding protein (ChREBP) reduces lipogenesis as well as glycolysis. Proc Natl Acad Sci U S A. 2004;101(19):7281–7286.
    • (2004) Proc Natl Acad Sci U S A , vol.101 , Issue.19 , pp. 7281-7286
    • Iizuka, K.1    Bruick, R.K.2    Liang, G.3    Horton, J.D.4    Uyeda, K.5
  • 38
    • 85120005458 scopus 로고    scopus 로고
    • Intestinal, but not hepatic, ChREBP is required for fructose tolerance
    • Kim M, et al. Intestinal, but not hepatic, ChREBP is required for fructose tolerance. JCI Insight. 2017;2(24):e96703.
    • (2017) JCI Insight , vol.2 , Issue.24 , pp. e96703
    • Kim, M.1
  • 39
    • 77958597757 scopus 로고    scopus 로고
    • Lowering of postprandial hyperfructosemia in humans by eucalyptus leaf extract: A randomized, double-blind, placebo-controlled crossover study
    • Sugimoto K, et al. Lowering of postprandial hyperfructosemia in humans by eucalyptus leaf extract: a randomized, double-blind, placebo-controlled crossover study. FoodSciTechnolRes. 2010;16(5):509–512.
    • (2010) FoodSciTechnolRes , vol.16 , Issue.5 , pp. 509-512
    • Sugimoto, K.1
  • 40
    • 72649093084 scopus 로고    scopus 로고
    • Measurement of glucose and fructose in clinical samples using gas chromatography/mass spectrometry
    • Wahjudi PN, Patterson ME, Lim S, Yee JK, Mao CS, Lee WN. Measurement of glucose and fructose in clinical samples using gas chromatography/mass spectrometry. Clin Biochem. 2010; 43(1–2):198–207.
    • (2010) Clin Biochem , vol.43 , Issue.1-2 , pp. 198-207
    • Wahjudi, P.N.1    Patterson, M.E.2    Lim, S.3    Yee, J.K.4    Mao, C.S.5    Lee, W.N.6
  • 41
    • 77952305136 scopus 로고    scopus 로고
    • Elevated serum sorbitol and not fructose in type 2 diabetic patients
    • Preston GM, Calle RA. Elevated serum sorbitol and not fructose in type 2 diabetic patients. Bio-markInsights. 2010;5:33–38.
    • (2010) Bio-markInsights , vol.5 , pp. 33-38
    • Preston, G.M.1    Calle, R.A.2
  • 42
    • 85041490755 scopus 로고    scopus 로고
    • Effects of consuming dietary fructose versus glucose on de novo lipogenesis in overweight and obese human subjects
    • Lam P. Effects of consuming dietary fructose versus glucose on de novo lipogenesis in overweight and obese human subjects. Berkeley Scientific Journal. https://escholarship.org/uc/item/7vv7z7zw.
    • Berkeley Scientific Journal
    • Lam, P.1
  • 43
    • 84870389895 scopus 로고    scopus 로고
    • Does fructose consumption contribute to non-alcoholic fatty liver disease?
    • Tappy L, Lê KA. Does fructose consumption contribute to non-alcoholic fatty liver disease? Clin Res Hepatol Gastroenterol. 2012;36(6):554–560.
    • (2012) Clin Res Hepatol Gastroenterol , vol.36 , Issue.6 , pp. 554-560
    • Tappy, L.1    Lê, K.A.2
  • 44
    • 77952534433 scopus 로고    scopus 로고
    • Eucalyptus leaf extract suppresses the postprandial elevation of portal, cardiac and peripheral fructose concentrations after sucrose ingestion in rats
    • Sugimoto K, et al. Eucalyptus leaf extract suppresses the postprandial elevation of portal, cardiac and peripheral fructose concentrations after sucrose ingestion in rats. J Clin Biochem Nutr. 2010;46(3):205–211.
    • (2010) J Clin Biochem Nutr , vol.46 , Issue.3 , pp. 205-211
    • Sugimoto, K.1
  • 46
    • 0037267005 scopus 로고    scopus 로고
    • Glucose transporters (GLUT and SGLT): Expanded families of sugar transport proteins
    • Wood IS, Trayhurn P. Glucose transporters (GLUT and SGLT): expanded families of sugar transport proteins. Br J Nutr. 2003;89(1):3–9.
    • (2003) Br J Nutr , vol.89 , Issue.1 , pp. 3-9
    • Wood, I.S.1    Trayhurn, P.2
  • 47
    • 84877776461 scopus 로고    scopus 로고
    • Hepatic expression and cellular distribution of the glucose transporter family
    • Karim S, Adams DH, Lalor PF. Hepatic expression and cellular distribution of the glucose transporter family. World J Gastroenterol. 2012;18(46):6771–6781.
    • (2012) World J Gastroenterol , vol.18 , Issue.46 , pp. 6771-6781
    • Karim, S.1    Adams, D.H.2    Lalor, P.F.3
  • 48
    • 84898940633 scopus 로고    scopus 로고
    • Glucose transporter 8 (GLUT8) mediates fructose-induced de novo lipogenesis and macroste-atosis
    • Debosch BJ, Chen Z, Saben JL, Finck BN, Moley KH. Glucose transporter 8 (GLUT8) mediates fructose-induced de novo lipogenesis and macroste-atosis. JBiolChem. 2014;289(16):10989–10998.
    • (2014) JBiolChem , vol.289 , Issue.16 , pp. 10989-10998
    • Debosch, B.J.1    Chen, Z.2    Saben, J.L.3    Finck, B.N.4    Moley, K.H.5
  • 49
    • 0000772785 scopus 로고
    • Is phosphofructokinase the rate-limiting step of glycolysis?
    • Boscá L, Corredor C. Is phosphofructokinase the rate-limiting step of glycolysis? Trends Biochem Sci. 1984;9(9):372–373.
    • (1984) Trends Biochem Sci , vol.9 , Issue.9 , pp. 372-373
    • Boscá, L.1    Corredor, C.2
  • 50
    • 0020483680 scopus 로고
    • Fructose 2,6-bis-phosphate 2 years after its discovery
    • Hers HG, Van Schaftingen E. Fructose 2,6-bis-phosphate 2 years after its discovery. Biochem J. 1982;206(1):1–12.
    • (1982) Biochem J , vol.206 , Issue.1 , pp. 1-12
    • Hers, H.G.1    Van Schaftingen, E.2
  • 51
    • 0016365205 scopus 로고
    • Determination of the kinetic constants of fructose transport and phosphorylation in the perfused rat liver
    • Sestoft L, Fleron P. Determination of the kinetic constants of fructose transport and phosphorylation in the perfused rat liver. Biochim Biophys Acta. 1974;345(1):27–38.
    • (1974) Biochim Biophys Acta , vol.345 , Issue.1 , pp. 27-38
    • Sestoft, L.1    Fleron, P.2
  • 52
    • 0020029683 scopus 로고
    • Role of the kidney in the metabolism of fructose in 60-hour fasted humans
    • Björkman O, Felig P. Role of the kidney in the metabolism of fructose in 60-hour fasted humans. Diabetes. 1982;31(6 pt 1):516–520.
    • (1982) Diabetes , vol.31 , Issue.6 , pp. 516-520
    • Björkman, O.1    Felig, P.2
  • 53
    • 0015233148 scopus 로고
    • Effects of fructose infusion on lactate and uric acid metabolism
    • Sahebjami H, Scalettar R. Effects of fructose infusion on lactate and uric acid metabolism. Lancet. 1971;1(7695):366–369.
    • (1971) Lancet , vol.1 , Issue.7695 , pp. 366-369
    • Sahebjami, H.1    Scalettar, R.2
  • 54
    • 0014669576 scopus 로고
    • Metabolic intermediates in liver of rats given large amounts of fructose or dihydroxyacetone
    • Burch HB, Max P, Ghyu K, Lowry OH. Metabolic intermediates in liver of rats given large amounts of fructose or dihydroxyacetone. Biochem Biophys Res Commun. 1969;34(5):619–626.
    • (1969) Biochem Biophys Res Commun , vol.34 , Issue.5 , pp. 619-626
    • Burch, H.B.1    Max, P.2    Ghyu, K.3    Lowry, O.H.4
  • 55
    • 0017086945 scopus 로고
    • Comparative effects of fructose and glucose on the lipid and carbohydrate metabolism of perfused rat liver
    • Topping DL, Mayes PA. Comparative effects of fructose and glucose on the lipid and carbohydrate metabolism of perfused rat liver. Br J Nutr. 1976;36(1):113–126.
    • (1976) Br J Nutr , vol.36 , Issue.1 , pp. 113-126
    • Topping, D.L.1    Mayes, P.A.2
  • 56
    • 0015936184 scopus 로고
    • Metabolism of fructose in the small intestine. 1. The effect of fructose feeding on fructose transport and metabolism in rat small intestine
    • Mavrias DA, Mayer RJ. Metabolism of fructose in the small intestine. 1. The effect of fructose feeding on fructose transport and metabolism in rat small intestine. Biochim Biophys Acta. 1973;291(2):531–537.
    • (1973) Biochim Biophys Acta , vol.291 , Issue.2 , pp. 531-537
    • Mavrias, D.A.1    Mayer, R.J.2
  • 57
    • 7244259518 scopus 로고
    • On the conversion of fructose to glucose by Guinea pig intestine
    • Ginsburg V, Hers HG. On the conversion of fructose to glucose by Guinea pig intestine. Biochim Biophys Acta. 1960;38:427–434.
    • (1960) Biochim Biophys Acta , vol.38 , pp. 427-434
    • Ginsburg, V.1    Hers, H.G.2
  • 58
    • 0027255879 scopus 로고
    • Sequence, tissue distribution, and functional characterization of the rat fructose transporter GLUT5
    • Rand EB, Depaoli AM, Davidson NO, Bell GI, Burant CF. Sequence, tissue distribution, and functional characterization of the rat fructose transporter GLUT5. Am J Physiol. 1993; 264(6 pt 1):G1169–G1176.
    • (1993) Am J Physiol , vol.264 , Issue.6 , pp. G1169-G1176
    • Rand, E.B.1    Depaoli, A.M.2    Davidson, N.O.3    Bell, G.I.4    Burant, C.F.5
  • 59
    • 4844219870 scopus 로고    scopus 로고
    • Fructose-responsive genes in the small intestine of neonatal rats
    • Cui XL, Soteropoulos P, Tolias P, Ferraris RP. Fructose-responsive genes in the small intestine of neonatal rats. PhysiolGenomics. 2004;18(2):206–217.
    • (2004) PhysiolGenomics , vol.18 , Issue.2 , pp. 206-217
    • Cui, X.L.1    Soteropoulos, P.2    Tolias, P.3    Ferraris, R.P.4
  • 60
    • 84940652690 scopus 로고    scopus 로고
    • Fructose-induced increases in expression of intestinal fructolytic and gluconeogenic genes are regulated by GLUT5 and KHK
    • Patel C, Douard V, Yu S, Tharabenjasin P, Gao N, Ferraris RP. Fructose-induced increases in expression of intestinal fructolytic and gluconeogenic genes are regulated by GLUT5 and KHK. Am J Physiol Regul Integr Comp Physiol. 2015;309(5):R499–R509.
    • (2015) Am J Physiol Regul Integr Comp Physiol , vol.309 , Issue.5 , pp. R499-R509
    • Patel, C.1    Douard, V.2    Yu, S.3    Tharabenjasin, P.4    Gao, N.5    Ferraris, R.P.6
  • 61
    • 0027315703 scopus 로고
    • Conversion of fructose to glucose in the rabbit small intestine. a reappraisal of the direct pathway
    • Bismut H, Hers HG, Van Schaftingen E. Conversion of fructose to glucose in the rabbit small intestine. A reappraisal of the direct pathway. Eur JBiochem. 1993;213(2):721–726.
    • (1993) Eur JBiochem , vol.213 , Issue.2 , pp. 721-726
    • Bismut, H.1    Hers, H.G.2    Van Schaftingen, E.3
  • 63
    • 0030953106 scopus 로고    scopus 로고
    • Glucokinase regulatory protein May interact with glucokinase in the hepatocyte nucleus
    • Brown KS, Kalinowski SS, Megill JR, Durham SK, Mookhtiar KA. Glucokinase regulatory protein May interact with glucokinase in the hepatocyte nucleus. Diabetes. 1997;46(2):179–186.
    • (1997) Diabetes , vol.46 , Issue.2 , pp. 179-186
    • Brown, K.S.1    Kalinowski, S.S.2    Megill, J.R.3    Durham, S.K.4    Mookhtiar, K.A.5
  • 64
    • 0031016101 scopus 로고    scopus 로고
    • Investigation on the mechanism by which fructose, hexitols and other compounds regulate the translocation of glucokinase in rat hepatocytes
    • Niculescu L, Veiga-da-Cunha M, Van Schaftingen E. Investigation on the mechanism by which fructose, hexitols and other compounds regulate the translocation of glucokinase in rat hepatocytes. Biochem J. 1997;321(pt 1):239–246.
    • (1997) Biochem J , vol.321 , pp. 239-246
    • Niculescu, L.1    Veiga-Da-Cunha, M.2    Van Schaftingen, E.3
  • 65
    • 49649099805 scopus 로고    scopus 로고
    • Glucokinase and molecular aspects of liver glycogen metabolism
    • Agius L. Glucokinase and molecular aspects of liver glycogen metabolism. Biochem J. 2008;414(1):1–18.
    • (2008) Biochem J , vol.414 , Issue.1 , pp. 1-18
    • Agius, L.1
  • 67
    • 0016213009 scopus 로고
    • Decrease and inhibition of liver glycogen phosphorylase after fructose. An experimental model for the study of hereditary fructose intolerance
    • Thurston JH, Jones EM, Hauhart RE. Decrease and inhibition of liver glycogen phosphorylase after fructose. An experimental model for the study of hereditary fructose intolerance. Diabetes. 1974;23(7):597–604.
    • (1974) Diabetes , vol.23 , Issue.7 , pp. 597-604
    • Thurston, J.H.1    Jones, E.M.2    Hauhart, R.E.3
  • 68
    • 0001288417 scopus 로고
    • Effect of administration of the fructose on the glycogeno-lytic action of glucagon. An investigation of the pathogeny of hereditary fructose intolerance
    • Van Den Berghe G, Hue L, Hers HG. Effect of administration of the fructose on the glycogeno-lytic action of glucagon. An investigation of the pathogeny of hereditary fructose intolerance. Biochem J. 1973;134(2):637–645.
    • (1973) Biochem J , vol.134 , Issue.2 , pp. 637-645
    • Van Den Berghe, G.1    Hue, L.2    Hers, H.G.3
  • 69
    • 0002900710 scopus 로고
    • Activation of liver pyruvate kinase by fructose-1-phosphate
    • Eggleston LV, Woods HF. Activation of liver pyruvate kinase by fructose-1-phosphate. FEBS Lett. 1970;6(1):43–45.
    • (1970) FEBS Lett , vol.6 , Issue.1 , pp. 43-45
    • Eggleston, L.V.1    Woods, H.F.2
  • 70
    • 0021503277 scopus 로고
    • Metabolic effects of oral fructose in the liver of fasted rats
    • Niewoehner CB, Gilboe DP, Nuttall GA, Nuttall FQ. Metabolic effects of oral fructose in the liver of fasted rats. Am J Physiol. 1984; 247(4 pt 1):E505–E512.
    • (1984) Am J Physiol , vol.247 , Issue.4 , pp. E505-E512
    • Niewoehner, C.B.1    Gilboe, D.P.2    Nuttall, G.A.3    Nuttall, F.Q.4
  • 71
    • 0024543929 scopus 로고
    • A protein from rat liver confers to glucokinase the property of being antagonistically regulated by fructose 6-phos-phate and fructose 1-phosphate
    • Van Schaftingen E. A protein from rat liver confers to glucokinase the property of being antagonistically regulated by fructose 6-phos-phate and fructose 1-phosphate. Eur J Biochem. 1989;179(1):179–184.
    • (1989) Eur J Biochem , vol.179 , Issue.1 , pp. 179-184
    • Van Schaftingen, E.1
  • 73
    • 0017328813 scopus 로고
    • The mechanism of adenosine triphosphate depletion in the liver after a load of fructose. a kinetic study of liver adenylate deaminase
    • van den Berghe G, Bronfman M, Vanneste R, Hers HG. The mechanism of adenosine triphosphate depletion in the liver after a load of fructose. A kinetic study of liver adenylate deaminase. Biochem J. 1977;162(3):601–609.
    • (1977) Biochem J , vol.162 , Issue.3 , pp. 601-609
    • Van Den Berghe, G.1    Bronfman, M.2    Vanneste, R.3    Hers, H.G.4
  • 75
    • 84990032723 scopus 로고    scopus 로고
    • Fructose intake and risk of gout and Hyperuricemia: A systematic review and meta-analysis of prospective cohort studies
    • Jamnik J, et al. Fructose intake and risk of gout and Hyperuricemia: a systematic review and meta-analysis of prospective cohort studies. BMJ Open. 2016;6(10):e013191.
    • (2016) BMJ Open , vol.6 , Issue.10 , pp. e013191
    • Jamnik, J.1
  • 76
    • 72149100521 scopus 로고    scopus 로고
    • Relationship between Hyperuricemia (HUC) and metabolic syndrome (MS) in institutionalized elderly men
    • Chang CH, et al. Relationship between Hyperuricemia (HUC) and metabolic syndrome (MS) in institutionalized elderly men. ArchGerontol Geriatr. 2009;49(suppl 2):S46–S49.
    • (2009) ArchGerontol Geriatr , vol.49 , pp. S46-S49
    • Chang, C.H.1
  • 77
    • 84930163758 scopus 로고    scopus 로고
    • Association between serum uric acid level and metabolic syndrome and its sex difference in a Chinese community elderly population
    • Liu M, et al. Association between serum uric acid level and metabolic syndrome and its sex difference in a Chinese community elderly population. Int J Endocrinol. 2014;2014:754678.
    • (2014) Int J Endocrinol , vol.2014 , pp. 754678
    • Liu, M.1
  • 78
    • 40349089500 scopus 로고    scopus 로고
    • Hyperuricemia, gout and the metabolic syndrome
    • Puig JG, Martínez MA. Hyperuricemia, gout and the metabolic syndrome. Curr Opin Rheumatol. 2008;20(2):187–191.
    • (2008) Curr Opin Rheumatol , vol.20 , Issue.2 , pp. 187-191
    • Puig, J.G.1    Martínez, M.A.2
  • 79
    • 84869996114 scopus 로고    scopus 로고
    • Uric acid induces hepatic steatosis by generation of mitochondrial oxidative stress: Potential role in fructose-dependent and -independent fatty liver
    • Lanaspa MA, et al. Uric acid induces hepatic steatosis by generation of mitochondrial oxidative stress: potential role in fructose-dependent and -independent fatty liver. JBiol Chem. 2012;287(48):40732–40744.
    • (2012) JBiol Chem , vol.287 , Issue.48 , pp. 40732-40744
    • Lanaspa, M.A.1
  • 80
    • 34547733397 scopus 로고    scopus 로고
    • Adverse effects of the classic antioxidant uric acid in adipocytes: NADPH oxidase-mediated oxidative/nitrosative stress
    • Sautin YY, Nakagawa T, Zharikov S, Johnson RJ. Adverse effects of the classic antioxidant uric acid in adipocytes: NADPH oxidase-mediated oxidative/nitrosative stress. Am J Physiol Cell Physiol. 2007;293(2):C584–C596.
    • (2007) Am J Physiol Cell Physiol , vol.293 , Issue.2 , pp. C584-C596
    • Sautin, Y.Y.1    Nakagawa, T.2    Zharikov, S.3    Johnson, R.J.4
  • 81
    • 84877929095 scopus 로고    scopus 로고
    • Synergistic effect of uricase blockade plus physiological amounts of fructose-glucose on glomerular hypertension and oxidative stress in rats
    • Tapia E, et al. Synergistic effect of uricase blockade plus physiological amounts of fructose-glucose on glomerular hypertension and oxidative stress in rats. Am J Physiol Renal Physiol. 2013;304(6):F727–F736.
    • (2013) Am J Physiol Renal Physiol , vol.304 , Issue.6 , pp. F727-F736
    • Tapia, E.1
  • 82
    • 84903749182 scopus 로고    scopus 로고
    • Uric acid induces endothelial dysfunction by vascular insulin resistance associated with the impairment of nitric oxide synthesis
    • Choi YJ, et al. Uric acid induces endothelial dysfunction by vascular insulin resistance associated with the impairment of nitric oxide synthesis. FASEB J. 2014;28(7):3197–3204.
    • (2014) FASEB J , vol.28 , Issue.7 , pp. 3197-3204
    • Choi, Y.J.1
  • 83
    • 84868149993 scopus 로고    scopus 로고
    • Uric acid stimulates fructokinase and accelerates fructose metabolism in the development of fatty liver
    • Lanaspa MA, et al. Uric acid stimulates fructokinase and accelerates fructose metabolism in the development of fatty liver. PLoS One. 2012;7(10):e47948.
    • (2012) PLoS One , vol.7 , Issue.10 , pp. e47948
    • Lanaspa, M.A.1
  • 84
    • 85020442980 scopus 로고    scopus 로고
    • Serum uric acid levels and multiple health outcomes: Umbrella review of evidence from observational studies, randomised controlled trials, and mendelian randomisation studies
    • Li X, et al. Serum uric acid levels and multiple health outcomes: umbrella review of evidence from observational studies, randomised controlled trials, and Mendelian randomisation studies. BMJ. 2017;357:j2376.
    • (2017) BMJ , vol.357 , pp. j2376
    • Li, X.1
  • 85
    • 0024514071 scopus 로고
    • The glucose-6-phosphatase/glucokinase ratio in the liver of obese-diabetic subjects
    • Belfiore F, Romeo F, Iannello S, Salamone C. The glucose-6-phosphatase/glucokinase ratio in the liver of obese-diabetic subjects. Biochem Med Metab Biol. 1989;41(1):77–80.
    • (1989) Biochem Med Metab Biol , vol.41 , Issue.1 , pp. 77-80
    • Belfiore, F.1    Romeo, F.2    Iannello, S.3    Salamone, C.4
  • 86
    • 0024456545 scopus 로고
    • Activity of hepatic glucose phosphorylating and NADPH generating enzymes in zucker rats
    • Huupponen R, Karvonen I, Sotaniemi E. Activity of hepatic glucose phosphorylating and NADPH generating enzymes in Zucker rats. Diabetes Res. 1989;10(3):143–146.
    • (1989) Diabetes Res , vol.10 , Issue.3 , pp. 143-146
    • Huupponen, R.1    Karvonen, I.2    Sotaniemi, E.3
  • 87
    • 0028142878 scopus 로고
    • Molecular basis of essential fructosuria: Molecular cloning and mutational analysis of human ketohexokinase (fructokinase)
    • Bonthron DT, Brady N, Donaldson IA, Stein-mann B. Molecular basis of essential fructosuria: molecular cloning and mutational analysis of human ketohexokinase (fructokinase). Hum Mol Genet. 1994;3(9):1627–1631.
    • (1994) Hum Mol Genet , vol.3 , Issue.9 , pp. 1627-1631
    • Bonthron, D.T.1    Brady, N.2    Donaldson, I.A.3    Steinmann, B.4
  • 88
    • 0032188919 scopus 로고    scopus 로고
    • Structure and alternative splicing of the ketohexokinase gene
    • Hayward BE, Bonthron DT. Structure and alternative splicing of the ketohexokinase gene. Eur J Biochem. 1998;257(1):85–91.
    • (1998) Eur J Biochem , vol.257 , Issue.1 , pp. 85-91
    • Hayward, B.E.1    Bonthron, D.T.2
  • 89
    • 69249216656 scopus 로고    scopus 로고
    • Ketohexokinase: Expression and localization of the principal fructose-metabolizing enzyme
    • Diggle CP, et al. Ketohexokinase: expression and localization of the principal fructose-metabolizing enzyme. J Histochem Cytochem. 2009;57(8):763–774.
    • (2009) J Histochem Cytochem , vol.57 , Issue.8 , pp. 763-774
    • Diggle, C.P.1
  • 90
    • 0041819987 scopus 로고    scopus 로고
    • Properties of normal and mutant recombinant human ketohexokinases and implications for the pathogenesis of essential fructosuria
    • Asipu A, Hayward BE, O’Reilly J, Bonthron DT. Properties of normal and mutant recombinant human ketohexokinases and implications for the pathogenesis of essential fructosuria. Diabetes. 2003;52(9):2426–2432.
    • (2003) Diabetes , vol.52 , Issue.9 , pp. 2426-2432
    • Asipu, A.1    Hayward, B.E.2    O’Reilly, J.3    Bonthron, D.T.4
  • 91
    • 84863279522 scopus 로고    scopus 로고
    • Opposing effects of fructokinase c and a isoforms on fructose-induced metabolic syndrome in mice
    • Ishimoto T, et al. Opposing effects of fructokinase C and A isoforms on fructose-induced metabolic syndrome in mice. Proc Natl Acad Sci U S A. 2012;109(11):4320–4325.
    • (2012) Proc Natl Acad Sci U S A , vol.109 , Issue.11 , pp. 4320-4325
    • Ishimoto, T.1
  • 92
    • 0014688331 scopus 로고
    • Essential fructosuria and hereditary fructose intolerance
    • Steinitz H, Mizrahy O. Essential fructosuria and hereditary fructose intolerance. N Engl J Med. 1969;280(4):222.
    • (1969) N Engl J Med , vol.280 , Issue.4 , pp. 222
    • Steinitz, H.1    Mizrahy, O.2
  • 93
    • 85032896266 scopus 로고    scopus 로고
    • Divergent effects of glucose and fructose on hepatic lipogenesis and insulin signaling
    • Softic S, et al. Divergent effects of glucose and fructose on hepatic lipogenesis and insulin signaling. J Clin Invest. 2017;127(11):4059–4074.
    • (2017) J Clin Invest , vol.127 , Issue.11 , pp. 4059-4074
    • Softic, S.1
  • 94
    • 84933056653 scopus 로고    scopus 로고
    • HIF-driven SF3B1 induces KHK-C to enforce fructolysis and heart disease
    • Mirtschink P, et al. HIF-driven SF3B1 induces KHK-C to enforce fructolysis and heart disease. Nature. 2015;522(7557):444–449.
    • (2015) Nature , vol.522 , Issue.7557 , pp. 444-449
    • Mirtschink, P.1
  • 95
    • 84964317491 scopus 로고    scopus 로고
    • A splicing switch from ketohexokinase-C to ketohexokinase-A drives hepatocellular carcinoma formation
    • Li X, et al. A splicing switch from ketohexokinase-C to ketohexokinase-A drives hepatocellular carcinoma formation. Nat Cell Biol. 2016;18(5):561–571.
    • (2016) Nat Cell Biol , vol.18 , Issue.5 , pp. 561-571
    • Li, X.1
  • 96
    • 73049131540 scopus 로고
    • Anomaly of hepatic aldolase in intolerance to fructose
    • Hers HG, Joassin G. [Anomaly of hepatic aldolase in intolerance to fructose]. Enzymol Biol Clin (Basel). 1961;1:4–14.
    • (1961) Enzymol Biol Clin (Basel) , vol.1 , pp. 4-14
    • Hers, H.G.1    Joassin, G.2
  • 97
    • 0031945356 scopus 로고    scopus 로고
    • Hereditary fructose intolerance
    • Ali M, Rellos P, Cox TM. Hereditary fructose intolerance. J Med Genet. 1998;35(5):353–365.
    • (1998) J Med Genet , vol.35 , Issue.5 , pp. 353-365
    • Ali, M.1    Rellos, P.2    Cox, T.M.3
  • 98
    • 84924133141 scopus 로고    scopus 로고
    • Aldolase-B knockout in mice phenocopies hereditary fructose intolerance in humans
    • Oppelt SA, Sennott EM, Tolan DR. Aldolase-B knockout in mice phenocopies hereditary fructose intolerance in humans. MolGenetMetab. 2015;114(3):445–450.
    • (2015) MolGenetMetab , vol.114 , Issue.3 , pp. 445-450
    • Oppelt, S.A.1    Sennott, E.M.2    Tolan, D.R.3
  • 99
    • 84984930218 scopus 로고    scopus 로고
    • Endogenous fructose production and metabolism in the liver contributes to the development of metabolic syndrome
    • Lanaspa MA, et al. Endogenous fructose production and metabolism in the liver contributes to the development of metabolic syndrome. Nat Commun. 2013;4:2434.
    • (2013) Nat Commun , vol.4 , pp. 2434
    • Lanaspa, M.A.1
  • 100
    • 0036369809 scopus 로고    scopus 로고
    • Polyol pathway and diabetic peripheral Neuropathy
    • Oates PJ. Polyol pathway and diabetic peripheral Neuropathy. Int Rev Neurobiol. 2002;50:325–392.
    • (2002) Int Rev Neurobiol , vol.50 , pp. 325-392
    • Oates, P.J.1
  • 101
    • 85051771806 scopus 로고    scopus 로고
    • The human brain produces fructose from glucose
    • Hwang JJ, et al. The human brain produces fructose from glucose. JCIInsight. 2017;2(4):e90508.
    • (2017) JCIInsight , vol.2 , Issue.4 , pp. e90508
    • Hwang, J.J.1
  • 102
    • 0022650672 scopus 로고
    • The effect of high glucose and oxidative stress on lens metabolism, aldose reductase, and senile cataractogenesis
    • Cheng HM, González RG. The effect of high glucose and oxidative stress on lens metabolism, aldose reductase, and senile cataractogenesis. MetabClinExp. 1986;35(4 suppl 1):10–14.
    • (1986) MetabClinExp , vol.35 , Issue.4 , pp. 10-14
    • Cheng, H.M.1    González, R.G.2
  • 104
    • 33644505508 scopus 로고    scopus 로고
    • Polyol pathway in human epididymis and semen
    • Frenette G, Thabet M, Sullivan R. Polyol pathway in human epididymis and semen. JAndrol. 2006;27(2):233–239.
    • (2006) JAndrol , vol.27 , Issue.2 , pp. 233-239
    • Frenette, G.1    Thabet, M.2    Sullivan, R.3
  • 105
    • 77954409583 scopus 로고    scopus 로고
    • Overweight and seminal quality: A study of 794 patients
    • Martini AC, et al. Overweight and seminal quality: a study of 794 patients. FertilSteril. 2010;94(5):1739–1743.
    • (2010) FertilSteril , vol.94 , Issue.5 , pp. 1739-1743
    • Martini, A.C.1
  • 106
    • 84929939689 scopus 로고    scopus 로고
    • Identification of biochemical differences between different forms of male infertility by nuclear magnetic resonance (NMR) spectroscopy
    • Jayaraman V, Ghosh S, Sengupta A, Srivastava S, Sonawat HM, Narayan PK. Identification of biochemical differences between different forms of male infertility by nuclear magnetic resonance (NMR) spectroscopy. J Assist Reprod Genet. 2014;31(9):1195–1204.
    • (2014) J Assist Reprod Genet , vol.31 , Issue.9 , pp. 1195-1204
    • Jayaraman, V.1    Ghosh, S.2    Sengupta, A.3    Srivastava, S.4    Sonawat, H.M.5    Narayan, P.K.6
  • 107
    • 84934971212 scopus 로고    scopus 로고
    • Fructose levels are markedly elevated in cerebrospinal fluid compared to plasma in pregnant women
    • Hwang JJ, et al. Fructose levels are markedly elevated in cerebrospinal fluid compared to plasma in pregnant women. PLoSOne. 2015;10(6):e0128582.
    • (2015) PLoSOne , vol.10 , Issue.6 , pp. e0128582
    • Hwang, J.J.1
  • 108
    • 34547935418 scopus 로고    scopus 로고
    • The polyol pathway as a mechanism for diabetic retinopathy: Attractive, elusive, and resilient
    • Lorenzi M. The polyol pathway as a mechanism for diabetic retinopathy: attractive, elusive, and resilient. Exp Diabetes Res. 2007;2007:61038.
    • (2007) Exp Diabetes Res , vol.2007 , pp. 61038
    • Lorenzi, M.1
  • 109
    • 84990044586 scopus 로고    scopus 로고
    • Polyol pathway: A possible mechanism of diabetes complications in the eye
    • Art.
    • Mathebula SD. Polyol pathway: a possible mechanism of diabetes complications in the eye. Afr Vision Eye Health. 2015;74(1):Art. #13.
    • (2015) Afr Vision Eye Health , vol.74 , Issue.1
    • Mathebula, S.D.1
  • 111
    • 0022359247 scopus 로고
    • Activation of aldose reductase from human tissues
    • Das B, Srivastava SK. Activation of aldose reductase from human tissues. Diabetes. 1985;34(11):1145–1151.
    • (1985) Diabetes , vol.34 , Issue.11 , pp. 1145-1151
    • Das, B.1    Srivastava, S.K.2
  • 112
    • 84908075908 scopus 로고    scopus 로고
    • Endogenous fructose production and fructokinase activation mediate renal injury in diabetic nephropathy
    • Lanaspa MA, et al. Endogenous fructose production and fructokinase activation mediate renal injury in diabetic nephropathy. J Am Soc Nephrol. 2014;25(11):2526–2538.
    • (2014) J Am Soc Nephrol , vol.25 , Issue.11 , pp. 2526-2538
    • Lanaspa, M.A.1
  • 113
    • 84878682420 scopus 로고    scopus 로고
    • The genotype-tissue expression (GTEx) project
    • GTEx Consortium. The Genotype-Tissue Expression (GTEx) project. Nat Genet. 2013;45(6):580–585.
    • (2013) Nat Genet , vol.45 , Issue.6 , pp. 580-585
  • 114
    • 77953292372 scopus 로고    scopus 로고
    • Effects of short-term overfeeding with fructose, fat and fructose plus fat on plasma and hepatic lipids in healthy men
    • Sobrecases H, et al. Effects of short-term overfeeding with fructose, fat and fructose plus fat on plasma and hepatic lipids in healthy men. Diabetes Metab. 2010;36(3):244–246.
    • (2010) Diabetes Metab , vol.36 , Issue.3 , pp. 244-246
    • Sobrecases, H.1
  • 116
    • 0015250464 scopus 로고
    • The immediate effects of insulin and fructose on the metabolism of the perfused liver. Changes in lipoprotein secretion, fatty acid oxidation and esterification, lipogenesis and carbohydrate metabolism
    • Topping DL, Mayes PA. The immediate effects of insulin and fructose on the metabolism of the perfused liver. Changes in lipoprotein secretion, fatty acid oxidation and esterification, lipogenesis and carbohydrate metabolism. Biochem J. 1972;126(2):295–311.
    • (1972) Biochem J , vol.126 , Issue.2 , pp. 295-311
    • Topping, D.L.1    Mayes, P.A.2
  • 117
    • 0029846701 scopus 로고    scopus 로고
    • Regulation of hepatic de novo lipogenesis in humans
    • Hellerstein MK, Schwarz JM, Neese RA. Regulation of hepatic de novo lipogenesis in humans. Annu Rev Nutr. 1996;16:523–557.
    • (1996) Annu Rev Nutr , vol.16 , pp. 523-557
    • Hellerstein, M.K.1    Schwarz, J.M.2    Neese, R.A.3
  • 118
    • 44449096155 scopus 로고    scopus 로고
    • Dietary sugars stimulate fatty acid synthesis in adults
    • Parks EJ, Skokan LE, Timlin MT, Dingfelder CS. Dietary sugars stimulate fatty acid synthesis in adults. J Nutr. 2008;138(6):1039–1046.
    • (2008) J Nutr , vol.138 , Issue.6 , pp. 1039-1046
    • Parks, E.J.1    Skokan, L.E.2    Timlin, M.T.3    Dingfelder, C.S.4
  • 119
    • 0020458928 scopus 로고
    • Studies of the mechanism of fructose-induced hypertriglyceridemia in the rat
    • Zavaroni I, Chen YD, Reaven GM. Studies of the mechanism of fructose-induced hypertriglyceridemia in the rat. Metab Clin Exp. 1982;31(11):1077–1083.
    • (1982) Metab Clin Exp , vol.31 , Issue.11 , pp. 1077-1083
    • Zavaroni, I.1    Chen, Y.D.2    Reaven, G.M.3
  • 120
    • 84879550625 scopus 로고    scopus 로고
    • Increased hepatic de novo lipogenesis and mitochondrial efficiency in a model of obesity induced by diets rich in fructose
    • Crescenzo R, Bianco F, Falcone I, Coppola P, Liv-erini G, Iossa S. Increased hepatic de novo lipogenesis and mitochondrial efficiency in a model of obesity induced by diets rich in fructose. Eur J Nutr. 2013;52(2):537–545.
    • (2013) Eur J Nutr , vol.52 , Issue.2 , pp. 537-545
    • Crescenzo, R.1    Bianco, F.2    Falcone, I.3    Coppola, P.4    Liverini, G.5    Iossa, S.6
  • 121
    • 0036092239 scopus 로고    scopus 로고
    • Banting lecture 2001: Dysregulation of fatty acid metabolism in the etiology of type 2 diabetes
    • McGarry JD. Banting Lecture 2001: Dysregulation of fatty acid metabolism in the etiology of type 2 diabetes. Diabetes. 2002;51(1):7–18.
    • (2002) Diabetes , vol.51 , Issue.1 , pp. 7-18
    • McGarry, J.D.1
  • 122
    • 84977079006 scopus 로고    scopus 로고
    • The sweet path to metabolic demise: Fructose and lipid synthesis
    • Herman MA, Samuel VT. The sweet path to metabolic demise: fructose and lipid synthesis. Trends EndocrinolMetab. 2016;27(10):719–730.
    • (2016) Trends EndocrinolMetab , vol.27 , Issue.10 , pp. 719-730
    • Herman, M.A.1    Samuel, V.T.2
  • 123
    • 77649264504 scopus 로고    scopus 로고
    • Bifurcation of insulin signaling pathway in rat liver: mTORC1 required for stimulation of lipogenesis, but not inhibition of gluconeogenesis
    • Li S, Brown MS, Goldstein JL. Bifurcation of insulin signaling pathway in rat liver: mTORC1 required for stimulation of lipogenesis, but not inhibition of gluconeogenesis. Proc Natl Acad Sci U S A. 2010;107(8):3441–3446.
    • (2010) Proc Natl Acad Sci U S A , vol.107 , Issue.8 , pp. 3441-3446
    • Li, S.1    Brown, M.S.2    Goldstein, J.L.3
  • 124
    • 79961165137 scopus 로고    scopus 로고
    • MTOR complex 1 regulates lipin 1 localization to control the SREBP pathway
    • Peterson TR, et al. mTOR complex 1 regulates lipin 1 localization to control the SREBP pathway. Cell. 2011;146(3):408–420.
    • (2011) Cell , vol.146 , Issue.3 , pp. 408-420
    • Peterson, T.R.1
  • 125
    • 84862023939 scopus 로고    scopus 로고
    • Hepatic insulin signaling is required for obesity-dependent expression of SREBP-1c mRNA but not for feeding-dependent expression
    • Haas JT, et al. Hepatic insulin signaling is required for obesity-dependent expression of SREBP-1c mRNA but not for feeding-dependent expression. CellMetab. 2012;15(6):873–884.
    • (2012) CellMetab , vol.15 , Issue.6 , pp. 873-884
    • Haas, J.T.1
  • 126
    • 70350131993 scopus 로고    scopus 로고
    • Replacing dietary glucose with fructose increases ChREBP activity and SREBP-1 protein in rat liver nucleus
    • Koo HY, Miyashita M, Cho BH, Nakamura MT. Replacing dietary glucose with fructose increases ChREBP activity and SREBP-1 protein in rat liver nucleus. Biochem Biophys Res Commun. 2009;390(2):285–289.
    • (2009) Biochem Biophys Res Commun , vol.390 , Issue.2 , pp. 285-289
    • Koo, H.Y.1    Miyashita, M.2    Cho, B.H.3    Nakamura, M.T.4
  • 127
    • 66449137379 scopus 로고    scopus 로고
    • GRP78 expression inhibits insulin and ER stress-induced SREBP-1c activation and reduces hepatic steatosis in mice
    • Kammoun HL, et al. GRP78 expression inhibits insulin and ER stress-induced SREBP-1c activation and reduces hepatic steatosis in mice. JClin Invest. 2009;119(5):1201–1215.
    • (2009) JClin Invest , vol.119 , Issue.5 , pp. 1201-1215
    • Kammoun, H.L.1
  • 129
    • 45849137877 scopus 로고    scopus 로고
    • Regulation of hepatic lipogenesis by the transcription factor XBP1
    • Lee AH, Scapa EF, Cohen DE, Glimcher LH. Regulation of hepatic lipogenesis by the transcription factor XBP1. Science. 2008;320(5882):1492–1496.
    • (2008) Science , vol.320 , Issue.5882 , pp. 1492-1496
    • Lee, A.H.1    Scapa, E.F.2    Cohen, D.E.3    Glimcher, L.H.4
  • 130
    • 33746536677 scopus 로고    scopus 로고
    • Carbohydrate response element binding protein, ChREBP, a transcription factor coupling hepatic glucose utilization and lipid synthesis
    • Uyeda K, Repa JJ. Carbohydrate response element binding protein, ChREBP, a transcription factor coupling hepatic glucose utilization and lipid synthesis. Cell Metab. 2006;4(2):107–110.
    • (2006) Cell Metab , vol.4 , Issue.2 , pp. 107-110
    • Uyeda, K.1    Repa, J.J.2
  • 131
    • 84861809881 scopus 로고    scopus 로고
    • The lipogenic transcription factor ChREBP dissociates hepatic steatosis from insulin resistance in mice and humans
    • Benhamed F, et al. The lipogenic transcription factor ChREBP dissociates hepatic steatosis from insulin resistance in mice and humans. JClin Invest. 2012;122(6):2176–2194.
    • (2012) JClin Invest , vol.122 , Issue.6 , pp. 2176-2194
    • Benhamed, F.1
  • 132
    • 79953886811 scopus 로고    scopus 로고
    • ChREBP mediates glucose repression of peroxisome proliferator-activated receptor alpha expression in pancreatic beta-cells
    • Boergesen M, Poulsen Ll, Schmidt SF, Frigerio F, Maechler P, Mandrup S. ChREBP mediates glucose repression of peroxisome proliferator-activated receptor alpha expression in pancreatic beta-cells. JBiolChem. 2011;286(15):13214–13225.
    • (2011) JBiolChem , vol.286 , Issue.15 , pp. 13214-13225
    • Boergesen, M.1    Ll, P.2    Schmidt, S.F.3    Frigerio, F.4    Maechler, P.5    Mandrup, S.6
  • 133
    • 84994666911 scopus 로고    scopus 로고
    • ChREBP regulates fructose-induced glucose production independently of insulin signaling
    • Kim MS, et al. ChREBP regulates fructose-induced glucose production independently of insulin signaling. JClinInvest. 2016;126(11):4372–4386.
    • (2016) JClinInvest , vol.126 , Issue.11 , pp. 4372-4386
    • Kim, M.S.1
  • 134
    • 84859921736 scopus 로고    scopus 로고
    • A novel ChREBP isoform in adipose tissue regulates systemic glucose metabolism
    • Herman MA, et al. A novel ChREBP isoform in adipose tissue regulates systemic glucose metabolism. Nature. 2012;484(7394):333–338.
    • (2012) Nature , vol.484 , Issue.7394 , pp. 333-338
    • Herman, M.A.1
  • 135
    • 83555160898 scopus 로고    scopus 로고
    • Glucose 6-phosphate, rather than xylulose 5-phosphate, is required for the activation of ChREBP in response to glucose in the liver
    • Dentin R, et al. Glucose 6-phosphate, rather than xylulose 5-phosphate, is required for the activation of ChREBP in response to glucose in the liver. J Hepatol. 2012;56(1):199–209.
    • (2012) J Hepatol , vol.56 , Issue.1 , pp. 199-209
    • Dentin, R.1
  • 138
    • 84871709488 scopus 로고    scopus 로고
    • The role of the carbohydrate response element-binding protein in male fructose-fed rats
    • Erion DM, et al. The role of the carbohydrate response element-binding protein in male fructose-fed rats. Endocrinology. 2013;154(1):36–44.
    • (2013) Endocrinology , vol.154 , Issue.1 , pp. 36-44
    • Erion, D.M.1
  • 139
    • 38649084407 scopus 로고    scopus 로고
    • Genome-wide scan identifies variation in MLXIPL associated with plasma triglycerides
    • Kooner JS, et al. Genome-wide scan identifies variation in MLXIPL associated with plasma triglycerides. Nat Genet. 2008;40(2):149–151.
    • (2008) Nat Genet , vol.40 , Issue.2 , pp. 149-151
    • Kooner, J.S.1
  • 140
    • 38649132270 scopus 로고    scopus 로고
    • Six new loci associated with blood low-density lipoprotein cholesterol, high-density lipoprotein cholesterol or triglycerides in humans
    • Kathiresan S, et al. Six new loci associated with blood low-density lipoprotein cholesterol, high-density lipoprotein cholesterol or triglycerides in humans. NatGenet. 2008;40(2):189–197.
    • (2008) NatGenet , vol.40 , Issue.2 , pp. 189-197
    • Kathiresan, S.1
  • 141
    • 85021364651 scopus 로고    scopus 로고
    • Adverse effects of fructose on cardiometabolic risk factors and hepatic lipid metabolism in subjects with abdominal obesity
    • Taskinen MR, et al. Adverse effects of fructose on cardiometabolic risk factors and hepatic lipid metabolism in subjects with abdominal obesity. J Intern Med. 2017;282(2):187–201.
    • (2017) J Intern Med , vol.282 , Issue.2 , pp. 187-201
    • Taskinen, M.R.1
  • 142
    • 18244382304 scopus 로고    scopus 로고
    • Sources of fatty acids stored in liver and secreted via lipoproteins in patients with nonalcoholic fatty liver disease
    • Donnelly KL, Smith CI, Schwarzenberg SJ, Jes-surun J, Boldt MD, Parks EJ. Sources of fatty acids stored in liver and secreted via lipoproteins in patients with nonalcoholic fatty liver disease. J Clin Invest. 2005;115(5):1343–1351.
    • (2005) J Clin Invest , vol.115 , Issue.5 , pp. 1343-1351
    • Donnelly, K.L.1    Smith, C.I.2    Schwarzenberg, S.J.3    Jessurun, J.4    Boldt, M.D.5    Parks, E.J.6
  • 143
    • 79952119879 scopus 로고    scopus 로고
    • Transcriptional activation of apolipoprotein CIII expression by glucose May contribute to diabetic dyslipidemia
    • Caron S, et al. Transcriptional activation of apolipoprotein CIII expression by glucose May contribute to diabetic dyslipidemia. Arterioscler Thromb Vasc Biol. 2011;31(3):513–519.
    • (2011) Arterioscler Thromb Vasc Biol , vol.31 , Issue.3 , pp. 513-519
    • Caron, S.1
  • 144
    • 84901470603 scopus 로고    scopus 로고
    • Elevated circulating lipasin/beta-trophin in human type 2 diabetes and obesity
    • Fu Z, Berhane F, Fite A, Seyoum B, Abou-Samra AB, Zhang R. Elevated circulating lipasin/beta-trophin in human type 2 diabetes and obesity. Sci Rep. 2014;4:5013.
    • (2014) Sci Rep. , vol.4 , pp. 5013
    • Fu, Z.1    Berhane, F.2    Fite, A.3    Seyoum, B.4    Abou-Samra, A.B.5    Zhang, R.6
  • 145
    • 0037127204 scopus 로고    scopus 로고
    • Peroxisome proliferator-activated receptor gamma coactivator 1beta (PGC-1beta), a novel PGC-1-related transcription coactivator associated with host cell factor
    • Lin J, Puigserver P, Donovan J, Tarr P, Spiegelman BM. Peroxisome proliferator-activated receptor gamma coactivator 1beta (PGC-1beta), a novel PGC-1-related transcription coactivator associated with host cell factor. JBiolChem. 2002;277(3):1645–1648.
    • (2002) JBiolChem , vol.277 , Issue.3 , pp. 1645-1648
    • Lin, J.1    Puigserver, P.2    Donovan, J.3    Tarr, P.4    Spiegelman, B.M.5
  • 146
    • 24144463983 scopus 로고    scopus 로고
    • Metabolic control through the PGC-1 family of transcription coactivators
    • Lin J, Handschin C, Spiegelman BM. Metabolic control through the PGC-1 family of transcription coactivators. CellMetab. 2005;1(6):361–370.
    • (2005) CellMetab , vol.1 , Issue.6 , pp. 361-370
    • Lin, J.1    Handschin, C.2    Spiegelman, B.M.3
  • 147
    • 19944430411 scopus 로고    scopus 로고
    • Hyperlipidemic effects of dietary saturated fats mediated through PGC-1β coactivation of SREBP
    • Lin J, et al. Hyperlipidemic effects of dietary saturated fats mediated through PGC-1β coactivation of SREBP. Cell. 2005;120(2):261–273.
    • (2005) Cell , vol.120 , Issue.2 , pp. 261-273
    • Lin, J.1
  • 148
    • 84883229757 scopus 로고    scopus 로고
    • PGC-1β and ChREBP partner to cooperatively regulate hepatic lipogenesis in a glucose concentration-dependent manner
    • Chambers KT, et al. PGC-1β and ChREBP partner to cooperatively regulate hepatic lipogenesis in a glucose concentration-dependent manner. Mol Metab. 2013;2(3):194–204.
    • (2013) Mol Metab , vol.2 , Issue.3 , pp. 194-204
    • Chambers, K.T.1
  • 150
    • 84878218164 scopus 로고    scopus 로고
    • Activation of PPARα ameliorates hepatic insulin resistance and steatosis in high fructose-fed mice despite increased endoplasmic reticulum stress
    • Chan SM, et al. Activation of PPARα ameliorates hepatic insulin resistance and steatosis in high fructose-fed mice despite increased endoplasmic reticulum stress. Diabetes. 2013;62(6):2095–2105.
    • (2013) Diabetes , vol.62 , Issue.6 , pp. 2095-2105
    • Chan, S.M.1
  • 151
    • 79952708723 scopus 로고    scopus 로고
    • Endoplasmic reticulum stress in liver disease
    • Malhi H, Kaufman RJ. Endoplasmic reticulum stress in liver disease. J Hepatol. 2011;54(4):795–809.
    • (2011) J Hepatol , vol.54 , Issue.4 , pp. 795-809
    • Malhi, H.1    Kaufman, R.J.2
  • 152
    • 85021736691 scopus 로고    scopus 로고
    • Lipogenic transcription factor ChREBP mediates fructose-induced metabolic adaptations to prevent hepatotoxicity
    • Zhang D, et al. Lipogenic transcription factor ChREBP mediates fructose-induced metabolic adaptations to prevent hepatotoxicity. JClin Invest. 2017;127(7):2855–2867.
    • (2017) JClin Invest , vol.127 , Issue.7 , pp. 2855-2867
    • Zhang, D.1
  • 153
    • 0024346320 scopus 로고
    • Effects of mannose and fructose on the synthesis and secretion of insulin
    • Curry DL. Effects of mannose and fructose on the synthesis and secretion of insulin. Pancreas. 1989;4(1):2–9.
    • (1989) Pancreas , vol.4 , Issue.1 , pp. 2-9
    • Curry, D.L.1
  • 154
    • 44249123276 scopus 로고    scopus 로고
    • Metabolic and endocrine profiles in response to systemic infusion of fructose and glucose in rhesus macaques
    • Adams SH, Stanhope KL, Grant RW, Cummings BP, Havel PJ. Metabolic and endocrine profiles in response to systemic infusion of fructose and glucose in rhesus macaques. Endocrinology. 2008;149(6):3002–3008.
    • (2008) Endocrinology , vol.149 , Issue.6 , pp. 3002-3008
    • Adams, S.H.1    Stanhope, K.L.2    Grant, R.W.3    Cummings, B.P.4    Havel, P.J.5
  • 155
    • 0019494049 scopus 로고
    • Long-term effects of moderate fructose feeding on glucose tolerance parameters in rats
    • Blakely SR, Hallfrisch J, Reiser S, Prather ES. Long-term effects of moderate fructose feeding on glucose tolerance parameters in rats. J Nutr. 1981;111(2):307–314.
    • (1981) J Nutr , vol.111 , Issue.2 , pp. 307-314
    • Blakely, S.R.1    Hallfrisch, J.2    Reiser, S.3    Prather, E.S.4
  • 156
    • 0018864257 scopus 로고
    • Impaired cellular insulin binding and insulin sensitivity induced by high-fructose feeding in normal subjects
    • Beck-Nielsen H, Pedersen O, Lindskov HO. Impaired cellular insulin binding and insulin sensitivity induced by high-fructose feeding in normal subjects. Am J Clin Nutr. 1980;33(2):273–278.
    • (1980) Am J Clin Nutr , vol.33 , Issue.2 , pp. 273-278
    • Beck-Nielsen, H.1    Pedersen, O.2    Lindskov, H.O.3
  • 157
    • 85001948863 scopus 로고    scopus 로고
    • Effect of fructose consumption on insulin sensitivity in nondiabetic subjects: A systematic review and meta-analysis of diet-intervention trials
    • Ter Horst KW, Schene MR, Holman R, Romijn JA, Serlie MJ. Effect of fructose consumption on insulin sensitivity in nondiabetic subjects: a systematic review and meta-analysis of diet-intervention trials. Am J Clin Nutr. 2016;104(6):1562–1576.
    • (2016) Am J Clin Nutr , vol.104 , Issue.6 , pp. 1562-1576
    • Ter Horst, K.W.1    Schene, M.R.2    Holman, R.3    Romijn, J.A.4    Serlie, M.J.5
  • 158
    • 60649109153 scopus 로고    scopus 로고
    • The role of peroxisome proliferator-activated receptor gamma coactivator 1 beta (PGC-1β) in the pathogenesis of fructose-induced insulin resistance
    • Nagai Y, et al. The role of peroxisome proliferator-activated receptor gamma coactivator 1 beta (PGC-1β) in the pathogenesis of fructose-induced insulin resistance. CellMetab. 2009;9(3):252–264.
    • (2009) CellMetab , vol.9 , Issue.3 , pp. 252-264
    • Nagai, Y.1
  • 159
    • 3543029821 scopus 로고    scopus 로고
    • Mechanism of hepatic insulin resistance in non-alcoholic fatty liver disease
    • Samuel VT, et al. Mechanism of hepatic insulin resistance in non-alcoholic fatty liver disease. JBiolChem. 2004;279(31):32345–32353.
    • (2004) JBiolChem , vol.279 , Issue.31 , pp. 32345-32353
    • Samuel, V.T.1
  • 160
    • 80053627289 scopus 로고    scopus 로고
    • Cellular mechanism of insulin resistance in nonalcoholic fatty liver disease
    • Kumashiro N, et al. Cellular mechanism of insulin resistance in nonalcoholic fatty liver disease. Proc NatlAcadSciUSA. 2011;108(39):16381–16385.
    • (2011) Proc NatlAcadSciUSA , vol.108 , Issue.39 , pp. 16381-16385
    • Kumashiro, N.1
  • 161
    • 84860455885 scopus 로고    scopus 로고
    • The problem of establishing relationships between hepatic steatosis and hepatic insulin resistance
    • Farese RV Jr., Zechner R, Newgard CB, Walther TC. The problem of establishing relationships between hepatic steatosis and hepatic insulin resistance. CellMetab. 2012;15(5):570–573.
    • (2012) CellMetab , vol.15 , Issue.5 , pp. 570-573
    • Jr, F.R.V.1    Zechner, R.2    Newgard, C.B.3    Walther, T.C.4
  • 162
    • 85023641978 scopus 로고    scopus 로고
    • Insulin action and resistance in obesity and type 2 diabetes
    • Czech MP. Insulin action and resistance in obesity and type 2 diabetes. NatMed. 2017;23(7):804–814.
    • (2017) NatMed , vol.23 , Issue.7 , pp. 804-814
    • Czech, M.P.1
  • 163
    • 85022080943 scopus 로고    scopus 로고
    • Reduced circulating insulin enhances insulin sensitivity in old mice and extends lifespan
    • Templeman NM, et al. Reduced circulating insulin enhances insulin sensitivity in old mice and extends lifespan. CellRep. 2017;20(2):451–463.
    • (2017) CellRep , vol.20 , Issue.2 , pp. 451-463
    • Templeman, N.M.1
  • 164
    • 0015814678 scopus 로고
    • The effectiveness of some sugars in stimulating licking behavior in the rat
    • Davis JD. The effectiveness of some sugars in stimulating licking behavior in the rat. Physiol Behav. 1973;11(1):39–45.
    • (1973) Physiol Behav , vol.11 , Issue.1 , pp. 39-45
    • Davis, J.D.1
  • 165
    • 36049003996 scopus 로고    scopus 로고
    • Examining the addictive-like properties of binge eating using an animal model of sugar dependence
    • Avena NM. Examining the addictive-like properties of binge eating using an animal model of sugar dependence. Exp Clin Psychopharmacol. 2007;15(5):481–491.
    • (2007) Exp Clin Psychopharmacol , vol.15 , Issue.5 , pp. 481-491
    • Avena, N.M.1
  • 166
    • 33646100092 scopus 로고    scopus 로고
    • Implications of an animal model of sugar addiction, withdrawal and relapse for human health
    • Wideman CH, Nadzam GR, Murphy HM. Implications of an animal model of sugar addiction, withdrawal and relapse for human health. Nutr Neurosci. 2005;8(5–6):269–276.
    • (2005) Nutr Neurosci , vol.8 , Issue.5-6 , pp. 269-276
    • Wideman, C.H.1    Nadzam, G.R.2    Murphy, H.M.3
  • 168
    • 84959164602 scopus 로고    scopus 로고
    • Separate circuitries encode the hedonic and nutritional values of sugar
    • Tellez LA, et al. Separate circuitries encode the hedonic and nutritional values of sugar. Nat Neurosci. 2016;19(3):465–470.
    • (2016) Nat Neurosci , vol.19 , Issue.3 , pp. 465-470
    • Tellez, L.A.1
  • 170
    • 65949093226 scopus 로고    scopus 로고
    • Feeding a high-fructose diet induces leptin resistance in rats
    • Chotiwat C, Sharp C, Teff K, Harris RBS. Feeding a high-fructose diet induces leptin resistance in rats. Appetite. 2007;49(1):284.
    • (2007) Appetite , vol.49 , Issue.1 , pp. 284
    • Chotiwat, C.1    Sharp, C.2    Teff, K.3    Harris, R.B.S.4
  • 171
    • 2942638040 scopus 로고    scopus 로고
    • Dietary fructose reduces circulating insulin and leptin, attenuates postprandial suppression of ghrelin, and increases triglycerides in women
    • Teff KL, et al. Dietary fructose reduces circulating insulin and leptin, attenuates postprandial suppression of ghrelin, and increases triglycerides in women. J Clin Endocrinol Metab. 2004;89(6):2963–2972.
    • (2004) J Clin Endocrinol Metab , vol.89 , Issue.6 , pp. 2963-2972
    • Teff, K.L.1
  • 172
    • 84929438671 scopus 로고    scopus 로고
    • Differential effects of fructose versus glucose on brain and appetitive responses to food cues and decisions for food rewards
    • Luo S, Monterosso JR, Sarpelleh K, Page KA. Differential effects of fructose versus glucose on brain and appetitive responses to food cues and decisions for food rewards. Proc Natl Acad Sci U S A. 2015;112(20):6509–6514.
    • (2015) Proc Natl Acad Sci U S A , vol.112 , Issue.20 , pp. 6509-6514
    • Luo, S.1    Monterosso, J.R.2    Sarpelleh, K.3    Page, K.A.4
  • 173
    • 84871750355 scopus 로고    scopus 로고
    • Effects of fructose vs glucose on regional cerebral blood flow in brain regions involved with appetite and reward pathways
    • Page KA, et al. Effects of fructose vs glucose on regional cerebral blood flow in brain regions involved with appetite and reward pathways. JAMA. 2013;309(1):63–70.
    • (2013) JAMA , vol.309 , Issue.1 , pp. 63-70
    • Page, K.A.1
  • 174
    • 34249711964 scopus 로고    scopus 로고
    • Hepatic fibroblast growth factor 21 is regulated by PPARalpha and is a key mediator of hepatic lipid metabolism in ketotic States
    • Badman MK, Pissios P, Kennedy AR, Koukos G, Flier JS, Maratos-Flier E. Hepatic fibroblast growth factor 21 is regulated by PPARalpha and is a key mediator of hepatic lipid metabolism in ketotic States. Cell Metab. 2007;5(6):426–437.
    • (2007) Cell Metab , vol.5 , Issue.6 , pp. 426-437
    • Badman, M.K.1    Pissios, P.2    Kennedy, A.R.3    Koukos, G.4    Flier, J.S.5    Maratos-Flier, E.6
  • 176
    • 34249686631 scopus 로고    scopus 로고
    • Endocrine regulation of the fasting response by PPARalpha-mediated induction of fibroblast growth factor 21
    • Inagaki T, et al. Endocrine regulation of the fasting response by PPARalpha-mediated induction of fibroblast growth factor 21. Cell Metab. 2007;5(6):415–425.
    • (2007) Cell Metab , vol.5 , Issue.6 , pp. 415-425
    • Inagaki, T.1
  • 177
    • 71949094496 scopus 로고    scopus 로고
    • Response to carbohydrate and fat refeeding in the expression of genes involved in nutrient partitioning and metabolism: Striking effects on fibroblast growth factor-21 induction
    • Sánchez J, Palou A, Picó C. Response to carbohydrate and fat refeeding in the expression of genes involved in nutrient partitioning and metabolism: striking effects on fibroblast growth factor-21 induction. Endocrinology. 2009;150(12):5341–5350.
    • (2009) Endocrinology , vol.150 , Issue.12 , pp. 5341-5350
    • Sánchez, J.1    Palou, A.2    Picó, C.3
  • 178
    • 84907015381 scopus 로고    scopus 로고
    • FGF21 is an endocrine signal of protein restriction
    • Laeger T, et al. FGF21 is an endocrine signal of protein restriction. J Clin Invest. 2014;124(9):3913–3922.
    • (2014) J Clin Invest , vol.124 , Issue.9 , pp. 3913-3922
    • Laeger, T.1
  • 179
    • 77955474305 scopus 로고    scopus 로고
    • Increased fibroblast growth factor 21 in obesity and nonalcoholic fatty liver disease
    • Dushay J, et al. Increased fibroblast growth factor 21 in obesity and nonalcoholic fatty liver disease. Gastroenterology. 2010;139(2):456–463.
    • (2010) Gastroenterology , vol.139 , Issue.2 , pp. 456-463
    • Dushay, J.1
  • 180
    • 68149091653 scopus 로고    scopus 로고
    • Circulating fibroblast growth factor-21 is elevated in impaired glucose tolerance and type 2 diabetes and correlates with muscle and hepatic insulin resistance
    • Chavez AO, Molina-Carrion M, Abdul-Ghani MA, Folli F, Defronzo RA, Tripathy D. Circulating fibroblast growth factor-21 is elevated in impaired glucose tolerance and type 2 diabetes and correlates with muscle and hepatic insulin resistance. DiabetesCare. 2009;32(8):1542–1546.
    • (2009) DiabetesCare , vol.32 , Issue.8 , pp. 1542-1546
    • Chavez, A.O.1    Molina-Carrion, M.2    Abdul-Ghani, M.A.3    Folli, F.4    Defronzo, R.A.5    Tripathy, D.6
  • 181
    • 78049297991 scopus 로고    scopus 로고
    • Obesity is a fibroblast growth factor 21 (FGF21)-resistant state
    • Fisher FM, et al. Obesity is a fibroblast growth factor 21 (FGF21)-resistant state. Diabetes. 2010;59(11):2781–2789.
    • (2010) Diabetes , vol.59 , Issue.11 , pp. 2781-2789
    • Fisher, F.M.1
  • 182
    • 69249238074 scopus 로고    scopus 로고
    • Glucose induces FGF21 mRNA expression through ChREBP activation in rat hepatocytes
    • Iizuka K, Takeda J, Horikawa Y. Glucose induces FGF21 mRNA expression through ChREBP activation in rat hepatocytes. FEBSLett. 2009;583(17):2882–2886.
    • (2009) FEBSLett , vol.583 , Issue.17 , pp. 2882-2886
    • Iizuka, K.1    Takeda, J.2    Horikawa, Y.3
  • 183
    • 85007579292 scopus 로고    scopus 로고
    • A critical role for ChREBP-mediated FGF21 secretion in hepatic fructose metabolism
    • Fisher FM, et al. A critical role for ChREBP-mediated FGF21 secretion in hepatic fructose metabolism. MolMetab. 2017;6(1):14–21.
    • (2017) MolMetab , vol.6 , Issue.1 , pp. 14-21
    • Fisher, F.M.1
  • 184
    • 84957975315 scopus 로고    scopus 로고
    • FGF21 mediates endocrine control of simple sugar intake and sweet taste preference by the liver
    • von Holstein-Rathlou S, et al. FGF21 mediates endocrine control of simple sugar intake and sweet taste preference by the liver. CellMetab. 2016;23(2):335–343.
    • (2016) CellMetab , vol.23 , Issue.2 , pp. 335-343
    • Von Holstein-Rathlou, S.1
  • 185
    • 84957949211 scopus 로고    scopus 로고
    • FGF21 regulates sweet and alcohol preference
    • Talukdar S, et al. FGF21 regulates sweet and alcohol preference. CellMetab. 2016;23(2):344–349.
    • (2016) CellMetab , vol.23 , Issue.2 , pp. 344-349
    • Talukdar, S.1
  • 186
    • 84875922294 scopus 로고    scopus 로고
    • Genome-wide meta-analysis of observational studies shows common genetic variants associated with macronutrient intake
    • Tanaka T, et al. Genome-wide meta-analysis of observational studies shows common genetic variants associated with macronutrient intake. Am J Clin Nutr. 2013;97(6):1395–1402.
    • (2013) Am J Clin Nutr , vol.97 , Issue.6 , pp. 1395-1402
    • Tanaka, T.1
  • 187
    • 84875914619 scopus 로고    scopus 로고
    • Novel locus including FGF21 is associated with dietary macronutrient intake
    • Chu AY, et al. Novel locus including FGF21 is associated with dietary macronutrient intake. Hum Mol Genet. 2013;22(9):1895–1902.
    • (2013) Hum Mol Genet , vol.22 , Issue.9 , pp. 1895-1902
    • Chu, A.Y.1
  • 188
    • 48649091964 scopus 로고    scopus 로고
    • Fructose-induced hypertension: Essential role of chloride and fructose absorbing transporters PAT1 and Glut5
    • Singh AK, et al. Fructose-induced hypertension: essential role of chloride and fructose absorbing transporters PAT1 and Glut5. Kidney Int. 2008;74(4):438–447.
    • (2008) Kidney Int , vol.74 , Issue.4 , pp. 438-447
    • Singh, A.K.1
  • 189
    • 0038119701 scopus 로고    scopus 로고
    • Is there a pathogenetic role for uric acid in hypertension and cardiovascular and renal disease?
    • Johnson RJ, et al. Is there a pathogenetic role for uric acid in hypertension and cardiovascular and renal disease? Hypertension. 2003;41(6):1183–1190.
    • (2003) Hypertension , vol.41 , Issue.6 , pp. 1183-1190
    • Johnson, R.J.1
  • 190
    • 84983658660 scopus 로고    scopus 로고
    • [Accessed December 12, 2017]
    • World Health Organization. Guideline: Sugars Intake For Adults and Children. WHO Website. http://www.who.int/nutrition/publications/guidelines/sugars_intake/en/. Accessed December 12, 2017.
    • Guideline: Sugars Intake For Adults and Children
  • 191
    • 70349768560 scopus 로고    scopus 로고
    • Dietary sugars intake and cardiovascular health: A scientific statement from the American Heart Association
    • Johnson RK, et al. Dietary sugars intake and cardiovascular health: a scientific statement from the American Heart Association. Circulation. 2009;120(11):1011–1020.
    • (2009) Circulation , vol.120 , Issue.11 , pp. 1011-1020
    • Johnson, R.K.1
  • 192
    • 84980351577 scopus 로고    scopus 로고
    • First-year evaluation of Mexico’s tax on nonessential energy-dense foods: An observational study
    • Batis C, Rivera JA, Popkin BM, Taillie LS. First-year evaluation of Mexico’s tax on nonessential energy-dense foods: an observational study. PLoS Med. 2016;13(7):e1002057.
    • (2016) PLoS Med , vol.13 , Issue.7 , pp. e1002057
    • Batis, C.1    Rivera, J.A.2    Popkin, B.M.3    Taillie, L.S.4


* 이 정보는 Elsevier사의 SCOPUS DB에서 KISTI가 분석하여 추출한 것입니다.