A dual sugar challenge test for lipogenic sensitivity to dietary fructose

Journal of Clinical Endocrinology and Metabolism

Volumn 96, Issue 3, 2011, Pages 861-868

  Hudgins, Lisa C ^a   Parker, Thomas S ^a   Levine, Daniel M ^a   Hellerstein, Marc K ^b  

^a ROGOSIN INSTITUTE   (United States)

^b UNIVERSITY OF CALIFORNIA   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

APOLIPOPROTEIN A1; FRUCTOSE; GLUCOSE; HIGH DENSITY LIPOPROTEIN CHOLESTEROL; INSULIN; LOW DENSITY LIPOPROTEIN CHOLESTEROL; PALMITIC ACID; TRIACYLGLYCEROL; VERY LOW DENSITY LIPOPROTEIN;

ADULT; AGED; AREA UNDER THE CURVE; ARTICLE; CHOLESTEROL BLOOD LEVEL; CONTROLLED STUDY; ENDOCRINE FUNCTION TEST; FATTY ACID ANALYSIS; FEMALE; GLUCOSE BLOOD LEVEL; HUMAN; HUMAN EXPERIMENT; INSULIN BLOOD LEVEL; LIPOGENESIS; LIPOGENIC SENSITIVITY TEST; LIPOPROTEIN BLOOD LEVEL; MALE; OUTPATIENT; PRIORITY JOURNAL; SUGAR INTAKE; TRIACYLGLYCEROL BLOOD LEVEL;

ADIPOSE TISSUE; ADULT; BLOOD GLUCOSE; CROSS-OVER STUDIES; DIET; DIETARY CARBOHYDRATES; FATTY ACIDS; FEMALE; FRUCTOSE; GLUCOSE; HUMANS; ISOTOPE LABELING; LIPID METABOLISM; LIPOPROTEINS, VLDL; LIVER; MALE; MIDDLE AGED; OVERWEIGHT; PALMITATES; TRIGLYCERIDES; YOUNG ADULT;

EID: 79952303537     PISSN: 0021972X     EISSN: 0021972X     Source Type: Journal    
DOI: 10.1210/jc.2010-2007     Document Type: Article

References (25)

1. Vartanian LR, Schwartz MB, Brownell KD 2007 Effects of soft drink consumption on nutrition and health: a systematic review and meta-analysis. Am J Public Health 97:667-675 (Pubitemid 47280164)
2. Johnson RK, Appel LJ, Brands M, Howard BV, Lefevre M, Lustig RH, Sacks F, Steffen LM, Wylie-Rosett J 2009 Dietary sugars intake and cardiovascular health: a scientific statement from the American Heart Association. Circulation 120:1011-1020
3. Parks EJ, Hellerstein MK 2000 Carbohydrate-induced hypertriacylglycerolemia: historical perspective and review of biological mechanisms. Am J Clin Nutr 71:412-433 (Pubitemid 30061218)
4. Hudgins LC, Hellerstein MK, Seidman CE, Neese RA, Tremaroli JD, Hirsch J 2000 Relationship between carbohydrate-induced hypertriglyceridemia and fatty acid synthesis in lean and obese subjects. J Lipid Res 41:595-604 (Pubitemid 30220663)
5. Hudgins LC, Hellerstein M, Seidman C, Neese R, Diakun J, Hirsch J 1996 Human fatty acid synthesis is stimulated by a eucaloric low fat, high carbohydrate diet. J Clin Invest 97:2081-2091 (Pubitemid 26143963)
6. Hudgins LC, Seidman CE, Diakun J, Hirsch J 1998 Human fatty acid synthesis is reduced after the substitution of dietary starch for sugar. Am J Clin Nutr 67:631-639 (Pubitemid 28153165)
7. Aarsland A, Wolfe RR 1998 Hepatic secretion of VLDL fatty acids during stimulated lipogenesis in men. J Lipid Res 39:1280-1286 (Pubitemid 28270092)
8. Schwartz JM, Neese RA, Shackleton C, Hellerstein MK 1993 De novo lipogenesis during fasting and oral fructose in lean and obese hyperinsulinemic subjects. Diabetes 42(Suppl 1):39A
9. Parks EJ, Skokan LE, Timlin MT, Dingfelder CS 2008 Dietary sugars stimulate fatty acid synthesis in adults. J Nutr 138:1039-1046 (Pubitemid 351769126)
10. Chong MF, Fielding BA, Frayn KN 2007 Mechanisms for the acute effect of fructose on postprandial lipemia. Am J Clin Nutr 85:1511-1520 (Pubitemid 46890417)
11. Stanhope KL, Havel PJ 2008 Fructose consumption: potential mechanisms for its effects to increase visceral adiposity and induce dyslipidemia and insulin resistance. Curr Opin Lipidol 19:16-24
12. Johnson RJ, Segal MS, Sautin Y, Nakagawa T, Feig DI, Kang DH, Gersch MS, Benner S, Sánchez-Lozada LG 2007 Potential role of sugar (fructose) in the epidemic of hypertension, obesity and the metabolic syndrome, diabetes, kidney disease, and cardiovascular disease. Am J Clin Nutr 86:899-906 (Pubitemid 47538288)
13. Bray GA 2010 Soft drink consumption and obesity: it is all about fructose. Curr Opin Lipidol 21:51-57
14. Petersen KF, Dufour S, Savage DB, Bilz S, Solomon G, Yonemitsu S, Cline GW, Befroy D, Zemany L, Kahn BB, Papademetris X, Rothman DL, Shulman GI 2007 The role of skeletal muscle insulin resistance in the pathogenesis of the metabolic syndrome. Proc Natl Acad Sci USA 104:12587-12594 (Pubitemid 47255198)
15. Donnelly KL, Smith CI, Schwarzenberg SJ, Jessurun J, Boldt MD, Parks EJ 2005 Sources of fatty acids stored in liver and secreted via lipoproteins in patients with nonalcoholic fatty liver disease. J Clin Invest 115:1343-1351 (Pubitemid 40629054)
16. Parks EJ, Hellerstein MK 2006 Thematic review series: patient-oriented research. Recent advances in liver triacylglycerol and fatty acid metabolism using stable isotope labeling techniques. J Lipid Res 47:1651-1660 (Pubitemid 44222817)
17. Truswell AS, Seach JM, Thorburn AW 1988 Incomplete absorption of pure fructose in healthy subjects and the facilitating effect of glucose. Am J Clin Nutr 48:1424-1430 (Pubitemid 19008575)
18. Choi YK, Johlin Jr FC, Summers RW, Jackson M, Rao SS 2003 Fructose intolerance: an under-recognized problem. Am J Gastroenterol 98:1348-1353 (Pubitemid 36741533)
19. Ravich WJ, Bayless TM, Thomas M 1983 Fructose: incomplete intestinal absorption in humans. Gastroenterology 84:26-29 (Pubitemid 13198285)
20. Kneepkens CM, Vonk RJ, Fernandes J 1984 Incomplete intestinal absorption of fructose. Arch Dis Child 59:735-738 (Pubitemid 14059458)
21. Rumessen JJ, Gudmand-Høyer E 1986 Absorption capacity of fructose in healthy adults. Comparison with sucrose and its constituent monosaccharides. Gut 27:1161-1168
22. Bizeau ME, Pagliassotti MJ 2005 Hepatic adaptations to sucrose and fructose. Metabolism 54:1189-1201 (Pubitemid 41206880)
23. Moore MC, Cherrington AD, Mann SL, Davis SN 2000 Acute fructose administration decreases the glycemic response to an oral glucose tolerance test in normal adults. J Clin Endocrinol Metab 85:4515-4519 (Pubitemid 32157626)
24. Duffey KJ, Popkin BM 2008 High-fructose corn syrup: is this what's for dinner? Am J Clin Nutr 88:1722S-1732S
25. Stanhope KL, Griffen SC, Bair BR, Swarbrick MM, Keim NL, Havel PJ 2008 Twenty-four-hour endocrine and metabolic profiles following consumption of high-fructose corn syrup-, sucrose-, fructose-, and glucose-sweetened beverages with meals. Am J Clin Nutr 87:1194-1203 (Pubitemid 351679758)