FGF21 mediates endocrine control of simple sugar intake and sweet taste preference by the liver

Cell Metabolism

Volumn 23, Issue 2, 2016, Pages 335-343

  Von Holstein Rathlou, Stephanie ^a   Bondurant, Lucas D ^f   Peltekian, Lila ^f   Naber, Meghan C ^f   Yin, Terry C ^f   Claflin, Kristin E ^f   Urizar, Adriana Ibarra ^a   Madsen, Andreas N ^a,b   Ratner, Cecilia ^a,b   Holst, Birgitte ^a,b   Karstoft, Kristian ^d   Vandenbeuch, Aurelie ^c   Anderson, Catherine B ^c   Cassell, Martin D ^f   Thompson, Anthony P ^f   Solomon, Thomas P ^a,e   Rahmouni, Kamal ^f   Kinnamon, Sue C ^c   Pieper, Andrew A ^f   Gillum, Matthew P ^a,f   Potthoff, Matthew J ^f   more..

^a UNIVERSITY OF COPENHAGEN   (Denmark)

^b Capital Region   (Denmark)

^c UNIVERSITY OF COLORADO SCHOOL OF MEDICINE   (United States)

^d University of Copenhagen   (Denmark)

^e UNIVERSITY OF BIRMINGHAM   (United Kingdom)

^f UNIVERSITY OF IOWA   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

BINDING PROTEIN; CARBOHYDRATE; CARBOHYDRATE RESPONSE ELEMENT BINDING PROTEIN; FIBROBLAST GROWTH FACTOR 21; SUCROSE; UNCLASSIFIED DRUG; FIBROBLAST GROWTH FACTOR; MLXIPL PROTEIN, MOUSE; NUCLEAR PROTEIN; TRANSCRIPTION FACTOR;

ANIMAL EXPERIMENT; ARTICLE; CARBOHYDRATE INTAKE; CONTROLLED STUDY; ENDOCRINE FUNCTION; FOOD PREFERENCE; GENE EXPRESSION; HYPOTHALAMIC PARAVENTRICULAR NUCLEUS; LIVER FUNCTION; MACRONUTRIENT; MOUSE; NEGATIVE FEEDBACK; NONHUMAN; PRIORITY JOURNAL; SATIETY; SIGNAL TRANSDUCTION; SUGAR INTAKE; SWEETNESS; TASTE BUD; ANIMAL; DRUG EFFECTS; ENDOCRINE SYSTEM; FEEDING BEHAVIOR; KNOCKOUT MOUSE; LIVER; MALE; METABOLISM; TASTE;

ANIMALS; ENDOCRINE SYSTEM; FEEDING BEHAVIOR; FIBROBLAST GROWTH FACTORS; FOOD PREFERENCES; LIVER; MALE; MICE, KNOCKOUT; NUCLEAR PROTEINS; SIGNAL TRANSDUCTION; SUCROSE; TASTE; TRANSCRIPTION FACTORS;

EID: 84957975315     PISSN: 15504131     EISSN: 19327420     Source Type: Journal    
DOI: 10.1016/j.cmet.2015.12.003     Document Type: Article

References (33)

1. A.C. Adams, C.C. Cheng, T. Coskun, and A. Kharitonenkov FGF21 requires βklotho to act in vivo PLoS ONE 7 2012 e49977
2. A.L. Bookout, M.H. de Groot, B.M. Owen, S. Lee, L. Gautron, H.L. Lawrence, X. Ding, J.K. Elmquist, J.S. Takahashi, D.J. Mangelsdorf, and S.A. Kliewer FGF21 regulates metabolism and circadian behavior by acting on the nervous system Nat. Med. 19 2013 1147 1152
3. A.Y. Chu, T. Workalemahu, N.P. Paynter, L.M. Rose, F. Giulianini, T. Tanaka, J.S. Ngwa, Q. Qi, G.C. Curhan, E.B. Rimm, et al. CHARGE Nutrition Working Group DietGen Consortium Novel locus including FGF21 is associated with dietary macronutrient intake Hum. Mol. Genet. 22 2013 1895 1902
4. R.L. Davisson, G. Yang, T.G. Beltz, M.D. Cassell, A.K. Johnson, and C.D. Sigmund The brain renin-angiotensin system contributes to the hypertension in mice containing both the human renin and human angiotensinogen transgenes Circ. Res. 83 1998 1047 1058
5. X. Ding, J. Boney-Montoya, B.M. Owen, A.L. Bookout, K.C. Coate, D.J. Mangelsdorf, and S.A. Kliewer βKlotho is required for fibroblast growth factor 21 effects on growth and metabolism Cell Metab. 16 2012 387 393
6. N. Douris, D.M. Stevanovic, F.M. Fisher, T.I. Cisu, M.J. Chee, N.L. Nguyen, E. Zarebidaki, A.C. Adams, A. Kharitonenkov, J.S. Flier, and et al. Central Fibroblast Growth Factor 21 Browns White Fat via Sympathetic Action in Male Mice Endocrinology 156 2015 2470 2481
7. A. Drewnowski, J.A. Mennella, S.L. Johnson, and F. Bellisle Sweetness and food preference J. Nutr. 142 2012 1142S 1148S
8. J.R. Dushay, E. Toschi, E.K. Mitten, F.M. Fisher, M.A. Herman, and E. Maratos-Flier Fructose ingestion acutely stimulates circulating FGF21 levels in humans Mol. Metab. 4 2015 51 57
9. C. Fernandes-Santos, Z. Zhang, D.A. Morgan, D.F. Guo, A.F. Russo, and K. Rahmouni Amylin acts in the central nervous system to increase sympathetic nerve activity Endocrinology 154 2013 2481 2488
10. C. Hale, M.M. Chen, S. Stanislaus, N. Chinookoswong, T. Hager, M. Wang, M.M. Véniant, and J. Xu Lack of overt FGF21 resistance in two mouse models of obesity and insulin resistance Endocrinology 153 2012 69 80
11. K. Iizuka, R.K. Bruick, G. Liang, J.D. Horton, and K. Uyeda Deficiency of carbohydrate response element-binding protein (ChREBP) reduces lipogenesis as well as glycolysis Proc. Natl. Acad. Sci. USA 101 2004 7281 7286
12. K. Iizuka, J. Takeda, and Y. Horikawa Glucose induces FGF21 mRNA expression through ChREBP activation in rat hepatocytes FEBS Lett. 583 2009 2882 2886
13. F. Imamura, L. O'Connor, Z. Ye, J. Mursu, Y. Hayashino, S.N. Bhupathiraju, and N.G. Forouhi Consumption of sugar sweetened beverages, artificially sweetened beverages, and fruit juice and incidence of type 2 diabetes: systematic review, meta-analysis, and estimation of population attributable fraction BMJ 351 2015 h3576
14. T. Inagaki, P. Dutchak, G. Zhao, X. Ding, L. Gautron, V. Parameswara, Y. Li, R. Goetz, M. Mohammadi, V. Esser, and et al. Endocrine regulation of the fasting response by PPARalpha-mediated induction of fibroblast growth factor 21 Cell Metab. 5 2007 415 425
15. E.A. Ivan Multiple Reward Layers in Food Reinforcement J.A. Gottfried, Neurobiology of Sensation and Reward 2011 CRC Press 263 285
16. R.K. Johnson, L.J. Appel, M. Brands, B.V. Howard, M. Lefevre, R.H. Lustig, F. Sacks, L.M. Steffen, J. Wylie-Rosett American Heart Association Nutrition Committee of the Council on Nutrition, Physical Activity, and Metabolism and the Council on Epidemiology and Prevention Dietary sugars intake and cardiovascular health: a scientific statement from the American Heart Association Circulation 120 2009 1011 1020
17. T. Laeger, T.M. Henagan, D.C. Albarado, L.M. Redman, G.A. Bray, R.C. Noland, H. Münzberg, S.M. Hutson, T.W. Gettys, M.W. Schwartz, and C.D. Morrison FGF21 is an endocrine signal of protein restriction J. Clin. Invest. 124 2014 3913 3922
18. A.S. Levine, C.M. Kotz, and B.A. Gosnell Sugars: hedonic aspects, neuroregulation, and energy balance Am. J. Clin. Nutr. 78 2003 834S 842S
19. Q. Liang, L. Zhong, J. Zhang, Y. Wang, S.R. Bornstein, C.R. Triggle, H. Ding, K.S. Lam, and A. Xu FGF21 maintains glucose homeostasis by mediating the cross talk between liver and brain during prolonged fasting Diabetes 63 2014 4064 4075
20. K.R. Markan, and M.J. Potthoff Metabolic fibroblast growth factors (FGFs): Mediators of energy homeostasis Semin. Cell Dev. Biol. 2015 10.1016/j.semcdb.2015.09.021 Published online September 30, 2015
21. K.R. Markan, M.C. Naber, M.K. Ameka, M.D. Anderegg, D.J. Mangelsdorf, S.A. Kliewer, M. Mohammadi, and M.J. Potthoff Circulating FGF21 is liver derived and enhances glucose uptake during refeeding and overfeeding Diabetes 63 2014 4057 4063
22. C.D. Morrison, and T. Laeger Protein-dependent regulation of feeding and metabolism Trends Endocrinol. Metab. 26 2015 256 262
23. G. Nelson, M.A. Hoon, J. Chandrashekar, Y. Zhang, N.J. Ryba, and C.S. Zuker Mammalian sweet taste receptors Cell 106 2001 381 390
24. M.J. Potthoff, T. Inagaki, S. Satapati, X. Ding, T. He, R. Goetz, M. Mohammadi, B.N. Finck, D.J. Mangelsdorf, S.A. Kliewer, and S.C. Burgess FGF21 induces PGC-1alpha and regulates carbohydrate and fatty acid metabolism during the adaptive starvation response Proc. Natl. Acad. Sci. USA 106 2009 10853 10858
25. M. Russek Participation of hepatic glucoreceptors in the control of intake of food Nature 197 1963 79 80
26. M. Russek Demonstration of the influence of an hepatic glucosensitive mechanism on food-intake Physiol. Behav. 5 1970 1207 1209
27. M.M. Scott, K.W. Williams, J. Rossi, C.E. Lee, and J.K. Elmquist Leptin receptor expression in hindbrain Glp-1 neurons regulates food intake and energy balance in mice J. Clin. Invest. 121 2011 2413 2421
28. S.J. Simpson, D.G. Le Couteur, and D. Raubenheimer Putting the balance back in diet Cell 161 2015 18 23
29. T.P. Solomon, S.H. Knudsen, K. Karstoft, K. Winding, J.J. Holst, and B.K. Pedersen Examining the effects of hyperglycemia on pancreatic endocrine function in humans: evidence for in vivo glucotoxicity J. Clin. Endocrinol. Metab. 97 2012 4682 4691
30. T. Tanaka, J.S. Ngwa, F.J. van Rooij, M.C. Zillikens, M.K. Wojczynski, A.C. Frazier-Wood, D.K. Houston, S. Kanoni, R.N. Lemaitre, J. Luan, and et al. Genome-wide meta-analysis of observational studies shows common genetic variants associated with macronutrient intake Am. J. Clin. Nutr. 97 2013 1395 1402
31. T. Uebanso, Y. Taketani, H. Yamamoto, K. Amo, H. Ominami, H. Arai, Y. Takei, M. Masuda, A. Tanimura, N. Harada, and et al. Paradoxical regulation of human FGF21 by both fasting and feeding signals: is FGF21 a nutritional adaptation factor? PLoS ONE 6 2011 e22976
32. A. Vandenbeuch, E.D. Larson, C.B. Anderson, S.A. Smith, A.P. Ford, T.E. Finger, and S.C. Kinnamon Postsynaptic P2X3-containing receptors in gustatory nerve fibres mediate responses to all taste qualities in mice J. Physiol. 593 2015 1113 1125
33. C. Yang, D. Gagnon, P. Vachon, A. Tremblay, E. Levy, B. Massie, and J.L. Michaud Adenoviral-mediated modulation of Sim1 expression in the paraventricular nucleus affects food intake J. Neurosci. 26 2006 7116 7120