Added sugars and cardiovascular disease risk in children: A scientific statement from the American Heart Association

Circulation

Volumn 135, Issue 19, 2017, Pages e1017-e1034

  Vos, Miriam B ^a   Kaar, Jill L ^a   Welsh, Jean A ^a   Van Horn, Linda V ^a   Feig, Daniel I ^a   Anderson, Cheryl A M ^a   Patel, Mahesh J ^a   Cruz Munos, Jessica ^a   Krebs, Nancy F ^a   Xanthakos, Stavra A ^a   Johnson, Rachel K ^a  

^a NONE

Author keywords

AHA Scientific Statements; child; diet; nutritional status; obesity; sugar; sweetening agents

Indexed keywords

CARBOHYDRATE; LIPID; NONNUTRITIVE SWEETENER; SUGAR; SWEETENING AGENT; URIC ACID; SUGAR INTAKE;

ARTICLE; BLOOD PRESSURE; CARDIOVASCULAR DISEASE; CARDIOVASCULAR RISK; CROSS-SECTIONAL STUDY; DIABETES MELLITUS; DIET; DOSE RESPONSE; DYSLIPIDEMIA; ELEVATED BLOOD PRESSURE; EXPERIMENTAL STUDY; FOOD; GENETICS; HEALTH; HUMAN; INSULIN RESISTANCE; LIQUID; MEDICAL SOCIETY; NONALCOHOLIC FATTY LIVER; OBESITY; OUTCOME ASSESSMENT; PRACTICE GUIDELINE; PRIORITY JOURNAL; PROSPECTIVE STUDY; SATIETY RESPONSE; SUGAR INTAKE; ADMINISTRATION AND DOSAGE; ADVERSE EFFECTS; CALORIC INTAKE; CARDIOVASCULAR DISEASES; CHILD; DENTAL CARIES; FEEDING BEHAVIOR; HYPERTENSION; PHYSIOLOGY; RISK FACTOR; RISK REDUCTION; UNITED STATES;

AMERICAN HEART ASSOCIATION; CARDIOVASCULAR DISEASES; CHILD; DENTAL CARIES; DIABETES MELLITUS; DIETARY SUCROSE; ENERGY INTAKE; FEEDING BEHAVIOR; HUMANS; HYPERTENSION; INSULIN RESISTANCE; OBESITY; RISK FACTORS; RISK REDUCTION BEHAVIOR; UNITED STATES;

EID: 84983325966     PISSN: 00097322     EISSN: 15244539     Source Type: Journal    
DOI: 10.1161/CIR.0000000000000439     Document Type: Article

References (127)

1. Morrison JA, Glueck CJ, Woo JG, Wang P, Risk factors for cardiovascular disease and type 2 diabetes retained from childhood to adulthood predict adult outcomes: the Princeton LRC Follow-up Study. Int J Pediatr Endocrinol 2012 2012 6. doi: 10.1186/1687-9856-2012-6
2. Ceponiene I, Klumbiene J, Tamuleviciute-Prasciene E, Motiejunaite J, Sakyte E, Ceponis J, Slapikas R, Petkeviciene J, Associations between risk factors in childhood (12-13 years) and adulthood (48-49 years) and subclinical atherosclerosis: the Kaunas Cardiovascular Risk Cohort Study. BMC Cardiovasc Disord 2015 15 89. doi: 10.1186/s12872-015-0087-0
3. Pacifico L, Chiesa C, Anania C, De Merulis A, Osborn JF, Romaggioli S, Gaudio E, Nonalcoholic fatty liver disease and the heart in children and adolescents. World J Gastroenterol 2014 20 9055 9071. doi: 10.3748/wjg.v20.i27.9055
4. Welsh JA, Sharma AJ, Grellinger L, Vos MB, Consumption of added sugars is decreasing in the United States. Am J Clin Nutr 2011 94 726 734. doi: 10.3945/ajcn.111.018366
5. Jacobs AK, Anderson JL, Halperin JL, Anderson JL, Halperin JL, Albert NM, Bozkurt B, Brindis RG, Curtis LH, DeMets D, Fleisher LA, Gidding S, Hochman JS, Kovacs RJ, Ohman EM, Pressler SJ, Sellke FW, Shen WK, Wijeysundera DN, The evolution and future of ACC/AHA clinical practice guidelines: a 30-year journey: a report of the American College of Cardiology/American Heart Association Task Force on Practice Guidelines. Circulation 2014 130 1208 1217. doi: 10.1161/CIR.0000000000000090
6. Cummings JH, Stephen AM, Carbohydrate terminology and classification. Eur J Clin Nutr 2007 61 suppl 1 S5 S18. doi: 10.1038/sj.ejcn.1602936
7. Food and Agriculture Organization of the United Nations Carbohydrates in Human Nutrition: Report of a Joint FAO/WHO Expert Consultation: Food and Agriculture Organization. April 1997; reprinted 1998. http://www.fao.org/docrep/w8079e/w8079e00.htm. Accessed October 20, 2015
8. Otten JJ, Hellwig JP, Meyers LD, Dietary Reference Intakes: The Essential Guide to Nutrient Requirements: Institute of Medicine of the National Academies 2006 Washington, DC National Academies Press
9. Garza C, Murphy S, Deckelbaum R, Dwyer J, Grundy S, Johnson R, Kumanyika S, Lichtenstein A, Stampfer M, Tinker L, Weinsier R, Report of the Dietary Guidelines Advisory Committee on the Dietary Guidelines for Americans, 2000 2000 Washington, DC US Government Printing Office
10. Report of the Great Britain Panel on Dietary Sugars, Committee on Medical Aspects of Food Policy Dietary Sugars and Human Disease 1989 London, UK Her Majesty's Stationery Office
11. World Health Organization Nutrition and the Prevention of Chronic Diseases: Report of a Joint WHO/FAO Expert Consultation 2004 Geneva, Switzerland World Health Organization. WHO Technical Report Series No. 916
12. Gidding SS, Dennison BA, Birch LL, Daniels SR, Gillman MW, Gilman MW, Lichtenstein AH, Rattay KT, Steinberger J, Stettler N, Van Horn L, American Heart Association; American Academy of Pediatrics Dietary recommendations for children and adolescents: a guide for practitioners: consensus statement from the American Heart Association [published corrections appear in Circulation. 2005;112:2375 and Circulation. 2006;113:e857]. Circulation 2005 112 2061 2075. doi: 10.1161/CIRCULATIONAHA.105.169251
13. US Department of Agriculture and US Department of Health and Human Services Dietary Guidelines for Americans, 2010 Washington, DC US Government Printing Office. December 2010. http://www.health.gov/dietaryguidelines/dga2010/DietaryGuidelines2010.pdf. Accessed October 15, 2015
14. Johnson RK, Appel LJ, Brands M, Howard BV, Lefevre M, Lustig RH, Sacks F, Steffen LM, Wylie-Rosett J, on behalf of the American Heart Association Nutrition Committee of the Council on Nutrition, Physical Activity, and Metabolism and the Council on Epidemiology and Prevention Dietary sugars intake and cardiovascular health: a scientific statement from the American Heart Association. Circulation 2009 120 1011 1020. doi: 10.1161/CIRCULATIONAHA.109.192627
15. US Department of Health and Human Services. Scientific Report of the 2015 Dietary Guidelines Advisory Committee 2015 Washington, DC US Government Printing Office. http://www.health.gov/dietaryguidelines/2015-scientific-advisory-report/PDFs/Scientific-Report-of-the-2015-Dietary-Guidelines-Advisory-Committee.pdf. Accessed October 15, 2015
16. World Health Organization Guidelines: sugars intake for adults and children: WHO guidelines approved by the Guidelines Review Committee. 2015. http://www.ncbi.nlm.nih.gov/pubmed/25905159. Accessed October 15, 2015
17. CDC National Center for Health Statistics National Health and Nutrition Examination Survey: 2011-2012: data documentation, codebook, and frequencies rates. 2014. http://wwwn.cdc.gov/nchs/nhanes/2011-2012/DR1IFF-g.htm. Accessed November 20, 2015
18. Trumbo P, Schlicker S, Yates AA, Poos M, Food and Nutrition Board of the Institute of Medicine, The National Academies Dietary reference intakes for energy, carbohydrate, fiber, fat, fatty acids, cholesterol, protein and amino acids [published correction appears in J Am Diet Assoc. 2003;103:563]. J Am Diet Assoc 2002 102 1621 1630
19. Freedman LS, Commins JM, Moler JE, Arab L, Baer DJ, Kipnis V, Midthune D, Moshfegh AJ, Neuhouser ML, Prentice RL, Schatzkin A, Spiegelman D, Subar AF, Tinker LF, Willett W, Pooled results from 5 validation studies of dietary self-report instruments using recovery biomarkers for energy and protein intake. Am J Epidemiol 2014 180 172 188. doi: 10.1093/aje/kwu116
20. National Cancer Institute, Division of Cancer Control & Population Sciences. Usual Dietary Intakes: Food Intakes, U.S. Population, 2007-10: Epidemiology Research Program website. http://epi.grants.cancer.gov/diet/usualintakes/pop/2007-10/. Updated May 20, 2015. Accessed November 1, 2015
21. Ervin RB, Kit BK, Carroll MD, Ogden CL, Centers for Disease Control and Prevention's National Center for Health Statistics, Division of Health and Nutrition Examination Surveys Consumption of Added Sugar Among U.S. Children and Adolescents, 2005-2008 2012 Washington DC National Center for Health Statistics. Data Brief No. 87
22. Geissler C, Powers H, Human Nutrition 2011 12th ed Philadelphia, PA Churchill Livingstone Elsevier
23. Parks EJ, Skokan LE, Timlin MT, Dingfelder CS, Dietary sugars stimulate fatty acid synthesis in adults. J Nutr 2008 138 1039 1046
24. Jacome-Sosa MM, Parks EJ, Fatty acid sources and their fluxes as they contribute to plasma triglyceride concentrations and fatty liver in humans. Curr Opin Lipidol 2014 25 213 220. doi: 10.1097/MOL.0000000000000080
25. Davis JN, Lê KA, Walker RW, Vikman S, Spruijt-Metz D, Weigensberg MJ, Allayee H, Goran MI, Increased hepatic fat in overweight Hispanic youth influenced by interaction between genetic variation in PNPLA3 and high dietary carbohydrate and sugar consumption. Am J Clin Nutr 2010 92 1522 1527. doi: 10.3945/ajcn.2010.30185
26. Wong JM, Gut microbiota and cardiometabolic outcomes: influence of dietary patterns and their associated components. Am J Clin Nutr 2014 100 suppl 1 369S 377S. doi: 10.3945/ajcn.113.071639
27. DiMeglio DP, Mattes RD, Liquid versus solid carbohydrate: effects on food intake and body weight. Int J Obes Relat Metab Disord 2000 24 794 800
28. Pan A, Hu FB, Effects of carbohydrates on satiety: differences between liquid and solid food. Curr Opin Clin Nutr Metab Care 2011 14 385 390. doi: 10.1097/MCO.0b013e328346df36
29. Haber GB, Heaton KW, Murphy D, Burroughs LF, Depletion and disruption of dietary fibre: effects on satiety, plasma-glucose, and serum-insulin. Lancet 1977 2 679 682
30. Houchins JA, Tan SY, Campbell WW, Mattes RD, Effects of fruit and vegetable, consumed in solid vs beverage forms, on acute and chronic appetitive responses in lean and obese adults. Int J Obes (Lond) 2013 37 1109 1115. doi: 10.1038/ijo.2012.183
31. Olsen NJ, Andersen LB, Wedderkopp N, Kristensen PL, Heitmann BL, Intake of liquid and solid sucrose in relation to changes in body fatness over 6 years among 8- to 10-year-old children: the European Youth Heart Study. Obes Facts 2012 5 506 512. doi: 10.1159/000341631
32. Houchins JA, Burgess JR, Campbell WW, Daniel JR, Ferruzzi MG, McCabe GP, Mattes RD, Beverage vs. solid fruits and vegetables: effects on energy intake and body weight. Obesity (Silver Spring) 2012 20 1844 1850. doi: 10.1038/oby.2011.192
33. Lee AK, Chowdhury R, Welsh JA, Sugars and adiposity: the long term effects of consuming added and naturally occurring sugars in foods and beverages. Obes Sci Pract 2015 1 41 49
34. Coppinger T, Jeanes Y, Mitchell M, Reeves S, Beverage consumption and BMI of British schoolchildren aged 9-13 years. Public Health Nutr 2013 16 1244 1249. doi: 10.1017/S1368980011002795
35. Davis JN, Alexander KE, Ventura EE, Kelly LA, Lane CJ, Byrd-Williams CE, Toledo-Corral CM, Roberts CK, Spruijt-Metz D, Weigensberg MJ, Goran MI, Associations of dietary sugar and glycemic index with adiposity and insulin dynamics in overweight Latino youth. Am J Clin Nutr 2007 86 1331 1338
36. Denova-Gutiérrez E, Jiménez-Aguilar A, Halley-Castillo E, Huitrón-Bravo G, Talavera JO, Pineda-Pérez D, Díaz-Montiel JC, Salmerón J, Association between sweetened beverage consumption and body mass index, proportion of body fat and body fat distribution in Mexican adolescents. Ann Nutr Metab 2008 53 245 251. doi: 10.1159/000189127
37. Gibson S, Neate D, Sugar intake, soft drink consumption and body weight among British children: further analysis of National Diet and Nutrition Survey data with adjustment for under-reporting and physical activity. Int J Food Sci Nutr 2007 58 445 460. doi: 10.1080/09637480701288363
38. Gómez-Martínez S, Martín A, Romeo J, Castillo M, Mesena M, Baraza JC, Jiménez-Pavón D, Redondo C, Zamora S, Marcos A, Is soft drink consumption associated with body composition? A cross-sectional study in Spanish adolescents. Nutr Hosp 2009 24 97 102
39. Jimenez-Aguilar A, Flores M, Shamah-Levy T, Sugar-sweetened beverages consumption and BMI in Mexican adolescents: Mexican National Health and Nutrition Survey 2006. Salud Publica Mex 2009 51 suppl 4 S604 S612
40. Kosova EC, Auinger P, Bremer AA, The relationships between sugar-sweetened beverage intake and cardiometabolic markers in young children. J Acad Nutr Diet 2013 113 219 227. doi: 10.1016/j.jand.2012.10.020
41. LaRowe TL, Moeller SM, Adams AK, Beverage patterns, diet quality, and body mass index of US preschool and school-aged children. J Am Diet Assoc 2007 107 1124 1133. doi: 10.1016/j.jada.2007.04.013
42. Lewis CJ, Park YK, Dexter PB, Yetley EA, Nutrient intakes and body weights of persons consuming high and moderate levels of added sugars. J Am Diet Assoc 1992 92 708 713
43. Linardakis M, Sarri K, Pateraki MS, Sbokos M, Kafatos A, Sugar-added beverages consumption among kindergarten children of Crete: effects on nutritional status and risk of obesity. BMC Public Health 2008 8 279. doi: 10.1186/1471-2458-8-279
44. Nicklas TA, O'Neil CE, Liu Y, Intake of added sugars is not associated with weight measures in children 6 to 18 years: National Health and Nutrition Examination Surveys 2003-2006. Nutr Res 2011 31 338 346. doi: 10.1016/j.nutres.2011.03.014
45. O'Connor TM, Yang SJ, Nicklas TA, Beverage intake among preschool children and its effect on weight status. Pediatrics 2006 118 e1010 e1018. doi: 10.1542/peds.2005-2348
46. O'Neil CE, Nicklas TA, Liu Y, Franklin FA, Impact of dairy and sweetened beverage consumption on diet and weight of a multiethnic population of Head Start mothers. J Am Diet Assoc 2009 109 874 882. doi: 10.1016/j.jada.2009.02.012
47. Pollock NK, Bundy V, Kanto W, Davis CL, Bernard PJ, Zhu H, Gutin B, Dong Y, Greater fructose consumption is associated with cardiometabolic risk markers and visceral adiposity in adolescents [published correction appears in J Nutr. 2013;143:123]. J Nutr 2012 142 251 257. doi: 10.3945/jn.111.150219
48. Ruottinen S, Niinikoski H, Lagström H, Rönnemaa T, Hakanen M, Viikari J, Jokinen E, Simell O, High sucrose intake is associated with poor quality of diet and growth between 13 months and 9 years of age: the special Turku Coronary Risk Factor Intervention Project. Pediatrics 2008 121 e1676 e1685. doi: 10.1542/peds.2007-1642
49. Song WO, Wang Y, Chung CE, Song B, Lee W, Chun OK, Is obesity development associated with dietary sugar intake in the U.S.? Nutrition 2012 28 1137 1141. doi: 10.1016/j.nut.2012.03.008
50. Pan L, Li R, Park S, Galuska DA, Sherry B, Freedman DS, A longitudinal analysis of sugar-sweetened beverage intake in infancy and obesity at 6 years. Pediatrics 2014 134 suppl 1 S29 S35. doi: 10.1542/peds.2014-0646F
51. Davis JN, Koleilat M, Shearrer GE, Whaley SE, Association of infant feeding and dietary intake on obesity prevalence in low-income toddlers. Obesity (Silver Spring) 2014 22 1103 1111. doi: 10.1002/oby.20644
52. DeBoer MD, Scharf RJ, Demmer RT, Sugar-sweetened beverages and weight gain in 2- to 5-year-old children. Pediatrics 2013 132 413 420. doi: 10.1542/peds.2013-0570
53. Lim S, Zoellner JM, Lee JM, Burt BA, Sandretto AM, Sohn W, Ismail AI, Lepkowski JM, Obesity and sugar-sweetened beverages in African-American preschool children: a longitudinal study. Obesity (Silver Spring) 2009 17 1262 1268. doi: 10.1038/oby.2008.656
54. Dubois L, Farmer A, Girard M, Peterson K, Regular sugar-sweetened beverage consumption between meals increases risk of overweight among preschool-aged children. J Am Diet Assoc 2007 107 924 934. doi: 10.1016/j.jada.2007.03.004
55. Welsh JA, Cogswell ME, Rogers S, Rockett H, Mei Z, Grummer-Strawn LM, Overweight among low-income preschool children associated with the consumption of sweet drinks: Missouri, 1999-2002. Pediatrics 2005 115 e223 e229. doi: 10.1542/peds.2004-1148
56. Phillips SM, Bandini LG, Naumova EN, Cyr H, Colclough S, Dietz WH, Must A, Energy-dense snack food intake in adolescence: longitudinal relationship to weight and fatness. Obes Res 2004 12 461 472. doi: 10.1038/oby.2004.52
57. Ambrosini GL, Oddy WH, Huang RC, Mori TA, Beilin LJ, Jebb SA, Prospective associations between sugar-sweetened beverage intakes and cardiometabolic risk factors in adolescents. Am J Clin Nutr 2013 98 327 334. doi: 10.3945/ajcn.112.051383
58. Ludwig DS, Peterson KE, Gortmaker SL, Relation between consumption of sugar-sweetened drinks and childhood obesity: a prospective, observational analysis. Lancet 2001 357 505 508. doi: 10.1016/S0140-6736(00)04041-1
59. Tam CS, Garnett SP, Cowell CT, Campbell K, Cabrera G, Baur LA, Soft drink consumption and excess weight gain in Australian school students: results from the Nepean study. Int J Obes (Lond) 2006 30 1091 1093. doi: 10.1038/sj.ijo.0803328
60. Fiorito LM, Marini M, Francis LA, Smiciklas-Wright H, Birch LL, Beverage intake of girls at age 5 y predicts adiposity and weight status in childhood and adolescence. Am J Clin Nutr 2009 90 935 942. doi: 10.3945/ajcn.2009.27623
61. Newby PK, Peterson KE, Berkey CS, Leppert J, Willett WC, Colditz GA, Beverage consumption is not associated with changes in weight and body mass index among low-income preschool children in North Dakota. J Am Diet Assoc 2004 104 1086 1094. doi: 10.1016/j.jada.2004.04.020
62. Johnson L, Mander AP, Jones LR, Emmett PM, Jebb SA, Is sugar-sweetened beverage consumption associated with increased fatness in children? Nutrition 2007 23 557 563. doi: 10.1016/j.nut.2007.05.005
63. Jensen BW, Nielsen BM, Husby I, Bugge A, El-Naaman B, Andersen LB, Trolle E, Heitmann BL, Association between sweet drink intake and adiposity in Danish children participating in a long-term intervention study. Pediatr Obes 2013 8 259 270. doi: 10.1111/j.2047-6310.2013.00170.x
64. Valente H, Teixeira V, Padrão P, Bessa M, Cordeiro T, Moreira A, Mitchell V, Lopes C, Mota J, Moreira P, Sugar-sweetened beverage intake and overweight in children from a Mediterranean country. Public Health Nutr 2011 14 127 132. doi: 10.1017/S1368980010002533
65. Berkey CS, Rockett HR, Field AE, Gillman MW, Colditz GA, Sugar-added beverages and adolescent weight change. Obes Res 2004 12 778 788. doi: 10.1038/oby.2004.94
66. Nissinen K, Mikkilä V, Männistö S, Lahti-Koski M, Räsänen L, Viikari J, Raitakari OT, Sweets and sugar-sweetened soft drink intake in childhood in relation to adult BMI and overweight: the Cardiovascular Risk in Young Finns Study. Public Health Nutr 2009 12 2018 2026. doi: 10.1017/S1368980009005849
67. De Ruyter JC, Olthof MR, Seidell JC, Katan MB, A trial of sugar-free or sugar-sweetened beverages and body weight in children. N Engl J Med 2012 367 1397 1406. doi: 10.1056/NEJMoa1203034
68. Herbst A, Diethelm K, Cheng G, Alexy U, Icks A, Buyken AE, Direction of associations between added sugar intake in early childhood and body mass index at age 7 years may depend on intake levels. J Nutr 2011 141 1348 1354. doi: 10.3945/jn.110.137000
69. Faith MS, Dennison BA, Edmunds LS, Stratton HH, Fruit juice intake predicts increased adiposity gain in children from low-income families: weight status-by-environment interaction. Pediatrics 2006 118 2066 2075. doi: 10.1542/peds.2006-1117
70. Ebbeling CB, Feldman HA, Chomitz VR, Antonelli TA, Gortmaker SL, Osganian SK, Ludwig DS, A randomized trial of sugar-sweetened beverages and adolescent body weight. N Engl J Med 2012 367 1407 1416. doi: 10.1056/NEJMoa1203388
71. Jalal DI, Smits G, Johnson RJ, Chonchol M, Increased fructose associates with elevated blood pressure. J Am Soc Nephrol 2010 21 1543 1549. doi: 10.1681/ASN.2009111111
72. Nguyen S, Choi H, Lustig R, Hsu C, The association of sugar sweetened beverage consumption on serum uric acid and blood pressure in a nationally representative sample of adolescents. J Pediatr 2009 154 807 813
73. Chen L, Caballero B, Mitchell DC, Loria C, Lin PH, Champagne CM, Elmer PJ, Ard JD, Batch BC, Anderson CA, Appel LJ, Reducing consumption of sugar-sweetened beverages is associated with reduced blood pressure: a prospective study among United States adults [published correction appears in Circulation. 2010;122:e408]. Circulation 2010 121 2398 2406. doi: 10.1161/CIRCULATIONAHA.109.911164
74. Perez-Pozo SE, Schold J, Nakagawa T, Sánchez-Lozada LG, Johnson RJ, Lillo JL, Excessive fructose intake induces the features of metabolic syndrome in healthy adult men: role of uric acid in the hypertensive response. Int J Obes (Lond) 2010 34 454 461. doi: 10.1038/ijo.2009.259
75. Brymora A, Flisiński M, Johnson RJ, Goszka G, Stefańska A, Manitius J, Low-fructose diet lowers blood pressure and inflammation in patients with chronic kidney disease. Nephrol Dial Transplant 2012 27 608 612. doi: 10.1093/ndt/gfr223
76. Fox IH, Kelley WN, Studies on the mechanism of fructose-induced hyperuricemia in man. Metabolism 1972 21 713 721
77. Hallfrisch J, Metabolic effects of dietary fructose. FASEB J 1990 4 2652 2660
78. Mazzali M, Hughes J, Kim YG, Jefferson JA, Kang DH, Gordon KL, Lan HY, Kivlighn S, Johnson RJ, Elevated uric acid increases blood pressure in the rat by a novel crystal-independent mechanism. Hypertension 2001 38 1101 1106
79. Mazzali M, Kanellis J, Han L, Feng L, Xia YY, Chen Q, Kang DH, Gordon KL, Watanabe S, Nakagawa T, Lan HY, Johnson RJ, Hyperuricemia induces a primary renal arteriolopathy in rats by a blood pressure-independent mechanism. Am J Physiol Renal Physiol 2002 282 F991 F997. doi: 10.1152/ajprenal.00283.2001
80. Rovda IuI, Kazakova LM, Plaksina EA, Parameters of uric acid metabolism in healthy children and in patients with arterial hypertension [in Russian]. Pediatriia 1990 8 19 22
81. Török E, Gyárfás I, Csukás M, Factors associated with stable high blood pressure in adolescents. J Hypertens Suppl 1985 3 S389 S390
82. Gruskin AB, The adolescent with essential hypertension. Am J Kidney Dis 1985 6 86 90
83. Feig DI, Johnson RJ, Hyperuricemia in childhood primary hypertension. Hypertension 2003 42 247 252. doi: 10.1161/01.HYP.0000085858.66548.59
84. Feig DI, Soletsky B, Johnson RJ, Effect of allopurinol on blood pressure of adolescents with newly diagnosed essential hypertension: a randomized trial. JAMA 2008 300 924 932. doi: 10.1001/jama.300.8.924
85. Soletsky B, Feig DI, Uric acid reduction rectifies prehypertension in obese adolescents. Hypertension 2012 60 1148 1156. doi: 10.1161/HYPERTENSIONAHA.112.196980
86. Perichart-Perera O, Balas-Nakash M, Rodríguez-Cano A, Muñoz-Manrique C, Monge-Urrea A, Vadillo-Ortega F, Correlates of dietary energy sources with cardiovascular disease risk markers in Mexican school-age children. J Am Diet Assoc 2010 110 253 260. doi: 10.1016/j.jada.2009.10.031
87. Wang JW, Mark S, Henderson M, O'Loughlin J, Tremblay A, Wortman J, Paradis G, Gray-Donald K, Adiposity and glucose intolerance exacerbate components of metabolic syndrome in children consuming sugar-sweetened beverages: QUALITY cohort study. Pediatr Obes 2013 8 284 293. doi: 10.1111/j.2047-6310.2012.00108.x
88. Aeberli I, Zimmermann MB, Molinari L, Lehmann R, l'Allemand D, Spinas GA, Berneis K, Fructose intake is a predictor of LDL particle size in overweight schoolchildren [published correction appears in Am J Clin Nutr. 2008;88:1707]. Am J Clin Nutr 2007 86 1174 1178
89. Bel-Serrat S, Mouratidou T, Börnhorst C, Peplies J, De Henauw S, Marild S, Molnár D, Siani A, Tornaritis M, Veidebaum T, Krogh V, Moreno LA, Food consumption and cardiovascular risk factors in European children: the IDEFICS study. Pediatr Obes 2013 8 225 236. doi: 10.1111/j.2047-6310.2012.00107.x
90. Bel-Serrat S, Mouratidou T, Santaliestra-Pasías AM, Iacoviello L, Kourides YA, Marild S, Molnár D, Reisch L, Siani A, Stomfai S, Vanaelst B, Veidebaum T, Pigeot I, Ahrens W, Krogh V, Moreno LA, IDEFICS Consortium Clustering of multiple lifestyle behaviours and its association to cardiovascular risk factors in children: the IDEFICS study. Eur J Clin Nutr 2013 67 848 854. doi: 10.1038/ejcn.2013.84
91. Bremer AA, Auinger P, Byrd RS, Relationship between insulin resistance-associated metabolic parameters and anthropometric measurements with sugar-sweetened beverage intake and physical activity levels in US adolescents: findings from the 1999-2004 National Health and Nutrition Examination Survey. Arch Pediatr Adolesc Med 2009 163 328 335. doi: 10.1001/archpediatrics.2009.21
92. Frank GC, Berenson GS, Webber LS, Dietary studies and the relationship of diet to cardiovascular disease risk factor variables in 10-year-old children: the Bogalusa Heart Study. Am J Clin Nutr 1978 31 328 340
93. Glueck CJ, Waldman G, McClish DK, Morrison JA, Khoury P, Larsen R, Salz K, Rifkind BM, Mattson FH, Relationships of nutrient intake to lipids and lipoproteins in 1234 white children: the Lipid Research Clinics Prevalence Study. Arteriosclerosis 1982 2 523 536
94. Morrison JA, Larsen R, Glatfelter L, Boggs D, Burton K, Smith C, Kelly K, Mellies MJ, Khoury P, Glueck CJ, Interrelationships between nutrient intake and plasma lipids and lipoproteins in schoolchildren aged 6 to 19: the Princeton School District Study. Pediatrics 1980 65 727 734
95. Welsh JA, Sharma A, Cunningham SA, Vos MB, Consumption of added sugars and indicators of cardiovascular disease risk among US adolescents. Circulation 2011 123 249 257. doi: 10.1161/CIRCULATIONAHA.110.972166
96. Williams CL, Strobino BA, Childhood diet, overweight, and CVD risk factors: the Healthy Start project. Prev Cardiol 2008 11 11 20
97. Ruottinen S, Rönnemaa T, Niinikoski H, Lagström H, Saarinen M, Pahkala K, Kaitosaari T, Viikari J, Simell O, Carbohydrate intake, serum lipids and apolipoprotein E phenotype show association in children. Acta Paediatr 2009 98 1667 1673. doi: 10.1111/j.1651-2227.2009.01399.x
98. Lee AK, Binongo JN, Chowdhury R, Stein AD, Gazmararian JA, Vos MB, Welsh JA, Consumption of less than 10% of total energy from added sugars is associated with increasing HDL in females during adolescence: a longitudinal analysis. J Am Heart Assoc 2014 3 e000615. doi: 10.1161/JAHA.113.000615
99. Lustig RH, Mulligan K, Noworolski SM, Tai VW, Wen MJ, Erkin-Cakmak A, Gugliucci A, Schwarz JM, Isocaloric fructose restriction and metabolic improvement in children with obesity and metabolic syndrome. Obesity (Silver Spring) 2016 24 453 460. doi: 10.1002/oby.21371
100. Burns SF, Lee SJ, Arslanian SA, Surrogate lipid markers for small dense low-density lipoprotein particles in overweight youth. J Pediatr 2012 161 991 996. doi: 10.1016/j.jpeds.2012.06.013
101. Welsh JA, Karpen S, Vos MB, Increasing prevalence of nonalcoholic fatty liver disease among United States adolescents, 1988-1994 to 2007-2010. J Peds 2013 162 496 500.e1. doi: 10.1016/j.jpeds.2012.08.043
102. Mager DR, Patterson C, So S, Rogenstein CD, Wykes LJ, Roberts EA, Dietary and physical activity patterns in children with fatty liver. Eur J Clin Nutr 2010 64 628 635. doi: 10.1038/ejcn.2010.35
103. Vos MB, Weber MB, Welsh J, Khatoon F, Jones DP, Whitington PF, McClain CJ, Fructose and oxidized low-density lipoprotein in pediatric nonalcoholic fatty liver disease: a pilot study. Arch Pediatr Adolesc Med 2009 163 674 675. doi: 10.1001/archpediatrics.2009.93
104. Mollard RC, Sénéchal M, MacIntosh AC, Hay J, Wicklow BA, Wittmeier KD, Sellers EA, Dean HJ, Ryner L, Berard L, McGavock JM, Dietary determinants of hepatic steatosis and visceral adiposity in overweight and obese youth at risk of type 2 diabetes. Am J Clin Nutr 2014 99 804 812. doi: 10.3945/ajcn.113.079277
105. O'Sullivan TA, Oddy WH, Bremner AP, Sherriff JL, Ayonrinde OT, Olynyk JK, Beilin LJ, Mori TA, Adams LA, Lower fructose intake may help protect against development of nonalcoholic fatty liver in adolescents with obesity. J Pediatr Gastroenterol Nutr 2014 58 624 631. doi: 10.1097/MPG.0000000000000267
106. Grønbæk H, Lange A, Birkebæk NH, Holland-Fischer P, Solvig J, Hørlyck A, Kristensen K, Rittig S, Vilstrup H, Effect of a 10-week weight loss camp on fatty liver disease and insulin sensitivity in obese Danish children. J Pediatr Gastroenterol Nutr 2012 54 223 228. doi: 10.1097/MPG.0b013e31822cdedf
107. Jin R, Welsh JA, Le NA, Holzberg J, Sharma P, Martin DR, Vos MB, Dietary fructose reduction improves markers of cardiovascular disease risk in Hispanic-American adolescents with NAFLD. Nutrients 2014 6 3187 3201. doi: 10.3390/nu6083187
108. Jin R, Le NA, Liu S, Farkas Epperson M, Ziegler TR, Welsh JA, Jones DP, McClain CJ, Vos MB, Children with NAFLD are more sensitive to the adverse metabolic effects of fructose beverages than children without NAFLD. J Clin Endocrinol Metab 2012 97 E1088 E1098. doi: 10.1210/jc.2012-1370
109. Heden TD, Liu Y, Park YM, Nyhoff LM, Winn NC, Kanaley JA, Moderate amounts of fructose- or glucose-sweetened beverages do not differentially alter metabolic health in male and female adolescents. Am J Clin Nutr 2014 100 796 805. doi: 10.3945/ajcn.113.081232
110. Moore LL, Singer MR, Qureshi MM, Bradlee ML, Daniels SR, Food group intake and micronutrient adequacy in adolescent girls. Nutrients 2012 4 1692 1708. doi: 10.3390/nu4111692
111. Striegel-Moore RH, Thompson D, Affenito SG, Franko DL, Obarzanek E, Barton BA, Schreiber GB, Daniels SR, Schmidt M, Crawford PB, Correlates of beverage intake in adolescent girls: the National Heart, Lung, and Blood Institute Growth and Health Study. J Pediatr 2006 148 183 187. doi: 10.1016/j.jpeds.2005.11.025
112. Frary CD, Johnson RK, Wang MQ, Children and adolescents' choices of foods and beverages high in added sugars are associated with intakes of key nutrients and food groups. J Adolesc Health 2004 34 56 63
113. Louie JC, Buyken AE, Brand-Miller JC, Flood VM, The link between dietary glycemic index and nutrient adequacy. Am J Clin Nutr 2012 95 694 702. doi: 10.3945/ajcn.111.015271
114. Grimes CA, Wright JD, Liu K, Nowson CA, Loria CM, Dietary sodium intake is associated with total fluid and sugar-sweetened beverage consumption in US children and adolescents aged 2-18 y: NHANES 2005-2008. Am J Clin Nutr 2013 98 189 196. doi: 10.3945/ajcn.112.051508
115. Cornwell TB, McAlister AR, Contingent choice: exploring the relationship between sweetened beverages and vegetable consumption. Appetite 2013 62 203 208. doi: 10.1016/j.appet.2012.05.001
116. Briefel RR, Wilson A, Cabili C, Hedley Dodd A, Reducing calories and added sugars by improving children's beverage choices. J Acad Nutr Diet 2013 113 269 275. doi: 10.1016/j.jand.2012.10.016
117. Council on School Health; Committee on Nutrition. Snacks, sweetened beverages, added sugars, and schools. Pediatrics 2015 135 575 583
118. Murphy MM, Douglass JS, Johnson RK, Spence LA, Drinking flavored or plain milk is positively associated with nutrient intake and is not associated with adverse effects on weight status in US children and adolescents. J Am Diet Assoc 2008 108 631 639. doi: 10.1016/j.jada.2008.01.004
119. Yon BA, Johnson RK, Elementary and middle school children's acceptance of lower calorie flavored milk as measured by milk shipment and participation in the National School Lunch Program. J Sch Health 2014 84 205 211. doi: 10.1111/josh.12135
120. Yon BA, Johnson RK, Stickle TR, School children's consumption of lower-calorie flavored milk: a plate waste study. J Acad Nutr Diet 2012 112 132 136. doi: 10.1016/j.jada.2011.09.011
121. Williams BM, O'Neil CE, Keast DR, Cho S, Nicklas TA, Are breakfast consumption patterns associated with weight status and nutrient adequacy in African-American children? Public Health Nutr 2009 12 489 496. doi: 10.1017/S1368980008002760
122. Harris JL, Schwartz MB, Ustjanauskas A, Ohri-Vachaspati P, Brownell KD, Effects of serving high-sugar cereals on children's breakfast-eating behavior. Pediatrics 2011 127 71 76. doi: 10.1542/peds.2010-0864
123. Liem DG, Mennella JA, Sweet and sour preferences during childhood: role of early experiences. Dev Psychobiol 2002 41 388 395. doi: 10.1002/dev.10067
124. Walker RW, Goran MI, Laboratory determined sugar content and composition of commercial infant formulas, baby foods and common grocery items targeted to children. Nutrients 2015 7 5850 5867. doi: 10.3390/nu7075254
125. Foreyt J, Kleinman R, Brown RJ, Lindstrom R, The use of low-calorie sweeteners by children: implications for weight management. J Nutr 2012 142 1155S 1162S. doi: 10.3945/jn.111.149609
126. Gardner C, Non-nutritive sweeteners: evidence for benefit vs. risk. Curr Opin Lipidol 2014 25 80 84. doi: 10.1097/MOL.0000000000000034
127. Gardner C, Wylie-Rosett J, Gidding SS, Steffen LM, Johnson RK, Reader D, Lichtenstein AH, on behalf of the American Heart Association Nutrition Committee of the Council on Nutrition, Physical Activity and Metabolism, Council on Arteriosclerosis, Thrombosis and Vascular Biology, Council on Cardiovascular Disease in the Young, and the American Diabetes Association Nonnutritive sweeteners: current use and health perspectives: a scientific statement from the American Heart Association and the American Diabetes Association. Circulation 2012 126 509 519. doi: 10.1161/CIR.0b013e31825c42ee.