Glucose transporters (GLUT and SGLT): Expanded families of sugar transport proteins

British Journal of Nutrition

Volumn 89, Issue 1, 2003, Pages 3-9

  Wood, I Stuart ^a   Trayhurn, Paul ^a  

^a UNIVERSITY OF LIVERPOOL   (United Kingdom)

Author keywords

Adipose tissue; Diabetes mellitus; Glucose transporter proteins; Muscle; Sugar transport

Indexed keywords

GALACTOSE; GENE PRODUCT; GLUCOSE TRANSPORTER; GLUCOSE TRANSPORTER 1; GLUCOSE TRANSPORTER 10; GLUCOSE TRANSPORTER 11; GLUCOSE TRANSPORTER 12; GLUCOSE TRANSPORTER 2; GLUCOSE TRANSPORTER 3; GLUCOSE TRANSPORTER 4; GLUCOSE TRANSPORTER 5; GLUCOSE TRANSPORTER 6; GLUCOSE TRANSPORTER 7; GLUCOSE TRANSPORTER 8; GLUCOSE TRANSPORTER 9; PROTON COUPLED INOSITOL TRANSPORTER; SODIUM DEPENDENT GLUCOSE TRANSPORTER 3; SODIUM DEPENDENT GLUCOSE TRANSPORTER 4; SODIUM DEPENDENT GLUCOSE TRANSPORTER 5; SODIUM DEPENDENT GLUCOSE TRANSPORTER 6; SODIUM GLUCOSE COTRANSPORTER; SODIUM GLUCOSE COTRANSPORTER 1; SODIUM GLUCOSE COTRANSPORTER 2; UNCLASSIFIED DRUG;

ADIPOCYTE; CHROMOSOME 1; CHROMOSOME MAP; DIABETIC OBESITY; GENE; GENE EXPRESSION; GENE IDENTIFICATION; GLUCOSE TRANSPORT SYSTEM; GLYCOSYLATION; HUMAN; INSULIN RESISTANCE; KINETICS; NON INSULIN DEPENDENT DIABETES MELLITUS; NONHUMAN; PHENOTYPE; PROTEIN EXPRESSION; PROTEIN TRANSPORT; PSEUDOGENE; REVIEW; SKELETAL MUSCLE; SODIUM TRANSPORT; SUGAR TRANSPORT; WHITE ADIPOSE TISSUE;

ADIPOSE TISSUE; BIOLOGICAL TRANSPORT, ACTIVE; DIABETES MELLITUS, TYPE 2; GLUCOSE; HUMANS; MONOSACCHARIDE TRANSPORT PROTEINS; MUSCLES;

EID: 0037267005     PISSN: 00071145     EISSN: None     Source Type: Journal    
DOI: 10.1079/BJN2002763     Document Type: Review

References (51)

1. Abel ED, Peroni O, Kim JK, Kim YB, Boss O, Hadro E, Minnemann T, Shulman GI & Kahn BB (2001) Adipose-selective targeting of the GLUT4 gene impairs insulin action in muscle and liver. Nature 409, 729-733.
2. Asano T, Katagiri H, Takata K, Lin JL, Ishihara H, Inukai K, Tsukuda K, Kikuchi M, Hirano H, Yazaki Y, et al. (1991) The role of N-glycosylation of GLUT1 for glucose transport activity. Journal of Biological Chemistry 266, 24632-24636.
3. Astrup A & Finer N (2000) Redefining type 2 diabetes: 'Diabesity' or 'obesity dependent diabetes mellitus'? Obesity Reviews 1, 57-59.
4. Bryant NJ, Govers R & James DE (2002) Regulated transport of the glucose transporter GLUT4. Nature Reviews Molecular Cell Biology 3, 267-277.
5. Burchell A (1998) A re-evaluation of GLUT7. Biochemical Journal 331, 973.
6. Carayannopoulos MO, Chi MM, Cui Y, Pingsterhaus JM, McKnight RA, Mueckler M, Devaskar SU & Moley KH (2000) GLUT8 is a glucose transporter responsible for insulin-stimulated glucose uptake in the blastocyst. Proceedings of the National Academy of Sciences USA 97, 7313-7318.
7. Davidson NO, Hausman AM, Ifkovits CA, Buse JB, Gould GW, Burant CF & Bell GI (1992) Human intestinal glucose transporter expression and localization of GLUT5. American Journal of Physiology 262, C795-C800.
8. Dawson PA, Mychaleckyj JC, Fossey SC, Mihic SJ, Craddock AL & Bowden DW (2001) Sequence and functional analysis of GLUT10: A glucose transporter in the Type 2 diabetes-linked region of chromosome 20q12-13.1. Molecular Genetics and Metabolism 74, 186-199.
9. DiabetesUK (2000) Fact Sheet no. 2. Diabetes: The Figures. http://www.diabetes.org.uk/infocentre/fact/fact2.htm
10. Doege H, Bocianski A, Joost HG & Schurmann A (2000a) Activity and genomic organization of human glucose transporter 9 (GLUT9), a novel member of the family of sugar-transport facilitators predominantly expressed in brain and leucocytes. Biochemical Journal 350, 771-776.
11. Doege H, Bocianski a, Scheepers A, Axer H, Eckel J, Joost HG & Schurmann A (2001) Characterization of human glucose transporter (GLUT) 11 (encoded by SLC2A11), a novel sugar-transport facilitator specifically expressed in heart and skeletal muscle. Biochemical Journal 359, 443-449.
12. Doege H, Schurmann A, Bahrenberg G, Brauers A & Joost HG (2000b) GLUT8, a novel member of the sugar transport facilitator family with glucose transport activity. Journal of Biological Chemistry 275, 16275-16280.
13. Felsenstein J (1989) PHYLIP - Phylogeny inference package (version 3.2). Cladistics 5, 164-166.
14. Froesch ER (1972) Fructose metabolism in adipose tissue. Acta Medica Scandinavica 542, Suppl., 37-46.
15. Fukumoto H, Kayano T, Buse JB, Edwards Y, Pilch PF, Bell GI & Seino S (1989) Cloning and characterization of the major insulin-responsive glucose transporter expressed in human skeletal muscle and other insulin-responsive tissues. Journal of Biological Chemistry 264, 7776-7779.
16. Fukumoto H, Seino S, Imura H, Seino Y, Eddy RL, Fukushima Y, Byers MG, Shows TB & Bell GI (1988) Sequence, tissue distribution, and chromosomal localization of mRNA encoding a human glucose transporter-like protein. Proceedings of the National Academy of Sciences USA 85, 5434-5438.
17. Gould GW, Thomas HM, Jess TJ & Bell GI (1991) Expression of human glucose transporters in Xenopus oocytes: Kinetic characterization and substrate specificities of the erythrocyte, liver, and brain isoforms. Biochemistry 30, 5139-5145.
18. Hajduch E, Darakhshan F & Hundal HS (1998) Fructose uptake in rat adipocytes: GLUT5 expression and the effects of streptozotocin-induced diabetes. Diabetologia 41, 821-828.
19. Halperin ML & Cheema-Dhadli S (1982) Comparison of glucose and fructose transport into adipocytes of the rat. Biochemical Journal 202, 717-721.
20. +/glucose co-transporter. Nature 330, 379-381.
21. +/proline cotransporters. Proceedings of the National Academy of Sciences USA 86, 5748-5752.
22. Hediger MA, Kanai Y, You G & Nussberger S (1995) Mammalian ion-coupled solute transporters. Journal of Physiology 482, 7S-17S.
23. Ibberson M, Uldry M & Thorens B (2000) GLUTX1, a novel mammalian glucose transporter expressed in the central nervous system and insulin-sensitive tissues. Journal of Biological Chemistry 275, 4607-4612.
24. James DE, Strube M & Mueckler M (1989) Molecular cloning and characterization of an insulin-regulatable glucose transporter. Nature 338, 83-87.
25. Joost HG, Bell GI, Best JD, Birnbaum MJ, Charron MJ, Chen YT, Doege H, James DE, Lodish HF, Moley KH, Moley JF, Mueckler M, Rogers S, Schurmann A, Seino S & Thorens B (2002) Nomenclature of the GLUT/SLC2A family of sugar/polyol transport facilitators. American Journal of Physiology 282, E974-E976.
26. Joost HG & Thorens B (2001) The extended GLUT-family of sugar/polyol transport facilitators: Nomenclature, sequence characteristics, and potential function of its novel members (review). Molecular Membrane Biology 18, 247-256.
27. +/glucose cotransporter SGLT2. Delineation of the major renal reabsorptive mechanism for D-glucose. Journal of Clinical Investigation 93, 397-404.
28. Katz EB, Burcelin R, Tsao TS, Stenbit AE & Charron MJ (1996) The metabolic consequences of altered glucose transporter expression in transgenic mice. Journal of Molecular Medicine 74, 639-652.
29. Katz EB, Stenbit AE, Hatton K, DePinho R & Charron MJ (1995) Cardiac and adipose tissue abnormalities but not diabetes in mice deficient in GLUT4. Nature 377, 151-155.
30. Kayano T, Burant CF, Fukumoto H, Gould GW, Fan YS, Eddy RL, Byers MG, Shows TB, Seino S & Bell GI (1990) Human facilitative glucose transporters. Isolation, functional characterization, and gene localization of cDNAs encoding an isoform (GLUT5) expressed in small intestine, kidney, muscle, and adipose tissue and an unusual glucose transporter pseudogene-like sequence (GLUT6). Journal of Biological Chemistry 265, 13276-13282.
31. Kayano T, Fukumoto H, Eddy RL, Fan YS, Byers MG, Shows TB & Bell GI (1988) Evidence for a family of human glucose transporter-like proteins. Sequence and gene localization of a protein expressed in fetal skeletal muscle and other tissues. Journal of Biological Chemistry 263, 15245-15248.
32. +/glucose cotransporters. Journal of Biological Chemistry 268, 1509-1512.
33. Lisinski I, Schurmann A, Joost HG, Cushman SW & Al-Hasani H (2001) Targeting of GLUT6 (formerly GLUT9) and GLUT8 in rat adipose cells. Biochemical Journal 358, 517-522.
34. +/glucose cotransporter and not an amino acid transporter. A reinterpretation. Journal of Biological Chemistry 269, 22488-22491.
35. McVie-Wylie AJ, Lamson DR & Chen YT (2001) Molecular cloning of a novel member of the GLUT family of transporters, SLC2a10 (GLUT10), localized on chromosome 20q13.1: A candidate gene for NIDDM susceptibility. Genomics 72, 113-117.
36. Mueckler M (1994) Facilitative glucose transporters. European Journal of Biochemistry 219, 713-725.
37. Mueckler M, Caruso C, Baldwin SA, Panico M, Blench I, Morris HR, Allard WJ, Lienhard GE & Lodish HF (1985) Sequence and structure of a human glucose transporter. Science 229, 941-945.
38. Phay JE, Hussain HB & Moley JF (2000) Strategy for identification of novel glucose transporter family members by using internet-based genomic databases. Surgery 128, 946-951.
39. Rayner DV, Thomas ME & Trayhurn P (1994) Glucose transporters (GLUTs 1-4) and their mRNAs in regions of the rat brain: Insulin-sensitive transporter expression in the cerebellum. Canadian Journal of Physiology and Pharmacology 72, 476-479.
40. Rogers S, Macheda ML, Docherty SE, Carty MD, Henderson MA, Soeller WC, Gibbs EM, James DE & Best JD (2002) Identification of a novel glucose transporter-like protein GLUT-12. American Journal of Physiology 282, E733-E738.
41. Sasaki T, Minoshima S, Shiohama A, Shintani A, Shimizu A, Asakawa S, Kawasaki K & Shimizu N (2001) Molecular cloning of a member of the facilitative glucose transporter gene family GLUT11 (SLC2A11) and identification of transcription variants. Biochemical and Biophysical Research Communications 289, 1218-1224.
42. Shepherd PR, Gibbs EM, Wesslau C, Gould GW & Kahn BB (1992) Human small intestine facilitative fructose/glucose transporter (GLUT5) is also present in insulin-responsive tissues and brain. Investigation of biochemical characteristics and translocation. Diabetes 41, 1360-1365.
43. Shepherd PR & Kahn BB (1999) Glucose transporters and insulin action - Implications for insulin resistance and diabetes mellitus. New England Journal of Medicine 341, 248-257.
44. Stenbit AE, Tsao TS, Li J, Burcelin R, Geenen DL, Factor SM, Houseknecht K, Katz EB & Charron MJ (1997) GLUT4 heterozygous knockout mice develop muscle insulin resistance and diabetes. Nature Medicine 3, 1096-1101.
45. Turk E & Wright EM (1997) Membrane topology motifs in the SGLT cotransporter family. Journal of Membrane Biology 159, 1-20.
46. +/glucose cotransporter. Nature 350, 354-356.
47. +-myo-inositol symporter expressed predominantly in the brain. EMBO Journal 20, 4467-4477.
48. Wells RG, Pajor AM, Kanai Y, Turk E, Wright EM & Hediger MA (1992) Cloning of a human kidney cDNA with similarity to the sodium-glucose cotransporter. American Journal of Physiology 263, F459-F465.
49. +-glucose cotransporters. American Journal of Physiology 280, F10-F18.
50. Wu X, Li W, Sharma V, Godzik A & Freeze HH (2002) Cloning and characterization of glucose transporter 11, a novel sugar transporter that is alternatively spliced in various tissues. Molecular Genetics and Metabolism 76, 37-45.
51. Zisman A, Peroni OD, Abel ED, Michael MD, Mauvais-Jarvis F, Lowell BB, Wojtaszewski JF, Hirshman MF, Virkamaki A, Goodyear LJ, Kahn CR & Kahn BB (2000) Targeted disruption of the glucose transporter 4 selectively in muscle causes insulin resistance and glucose intolerance. Nature Medicine 6, 924-928.