Lowering of postprandial hyperfructosemia in humans by eucalyptus leaf extract: A randomized, double-blind, placebo-controlled crossover study

Food Science and Technology Research

Volumn 16, Issue 5, 2010, Pages 509-512

  Sugimoto, Keiichiro ^a,b   Kawasaki, Takahiro ^c,d   Tomoda, Mayuko ^e   Nakagawa, Kazuya ^a   Hayashi, Shuichi ^a   Inui, Hiroshi ^b   Kajimoto, Yoshitaka ^e   Yamanouchi, Toshikazu ^c  

^a Nagaoka Perfumery Co Ltd   (Japan)

^b Osaka Prefecture University   (Japan)

^c TEIKYO UNIVERSITY SCHOOL OF MEDICINE   (Japan)

^d Kawakita General Hospital   (Japan)

^e Soiken Inc   (Japan)

Author keywords

Clinical trial; Eucalyptus globulus; Glucose transporter 5; GLUT5; Intestinal fructose absorption; Sucrose tolerance test

Indexed keywords

CLINICAL TRIAL; EUCALYPTUS GLOBULUS; GLUCOSE TRANSPORTER 5; GLUT5; INTESTINAL FRUCTOSE ABSORPTION; SUCROSE TOLERANCE TEST;

ABSORPTION; CONCENTRATION (PROCESS); EXPERIMENTS; GLUCOSE; SUGAR (SUCROSE);

FRUCTOSE;

EUCALYPTUS; EUCALYPTUS GLOBULUS;

EID: 77958597757     PISSN: 13446606     EISSN: None     Source Type: Journal    
DOI: 10.3136/fstr.16.509     Document Type: Article

References (12)

1. Amakura, Y., Yoshimura, M., Sugimoto, N., Yamazaki, T. and Yoshida, T (2009). Marker constituents of the natural antioxidant Eucalyptus leaf extract for the evaluation of food additives. Biosci. Biotechnol. Biochem., 73, 1060-1065.
2. Elliott, S.S., Keim, N.L., Stern, J.S., Teff, K. and Havel, P.J. (2002). Fructose, weight gain, and the insulin resistance syndrome. Am. J. Clin. Nutr, 16, 911-922.
3. Fukuda, H., Iritani, N. and Tanaka, T (1983). Effects of high-fructose diet on lipogenic enzymes and their substrate and effector levels in diabetic rats. J. Nutr. Sci Vitaminol, 29, 691-699.
4. Gould, G.W. and Holman, G.D. (1993). The glucose transporter family: structure, function and tissue-specific expression. Biochem. J., 295, 329-341.
5. Havel, P.J. (2005). Dietary Fructose: Implications for dysregulation of energy homeostasis and lipid/carbohydrate metabolism. Nutr. Rev., 63, 133-157.
6. Johnson, R.J., Segal, M.S., Sautin, Y., Nakagawa, T., Feig, D.I., Kang, D.H., Gersch, MS, Benner, S. and Sánchez-Lozada, L.G. (2007). Potential role of sugar (fructose) in the epidemic of hypertension, obesity and the metabolic syndrome, diabetes, kidney disease, and cardiovascular disease. Am. J. Clin. Nutr., 86, 899906.
7. Kawasaki T. Akanuma H. Yamanouchi T. Increased fructose concentrations in blood and urine in patients with diabetes Diabetes Care 2002 25 2 353-357 DOI 10.2337/diacare.25.2.353 Kawasaki, T., Akanuma, H. and Yamanouchi, T. (2002). Increased fructose concentrations in blood and urine in patients with diabetes. Diabetes Care, 25, 353-357. (Pubitemid 41079635)
8. Kawasaki, T., Ogata, N., Akanuma, H., Sakai, T., Watanabe, H., lchiyanagi, K. and Yamanouchi, T. (2004). Postprandial plasma fructose level is associated with retinopathy in patients with type 2 diabetes. Metabolism, 53, 583-588.
9. Osaki S. Kimura T. Sugimoto T. Hizukuri S. Iritani N. L-arabinose feeding prevents increases due to dietary sucrose in lipogenic enzymes and triacylglycerol levels in rats Journal of Nutrition 2001 131 3 796-799 Osaki, S., Kimura, T., Sugimoto, T., Hizukuri, S. and Iritani, N. (2001). L-arabinose feeding prevents increases due to dietary sucrose in lipogenic enzymes and triacylglycerol levels in rats. J. Nutr., 131, 796-799. (Pubitemid 32199147)
10. Stanhope, K.L., Schwarz, J.M., Keim, N.L., Griffen, S.C., Bremer, A.A., Graham, J.L., Hatcher, B., Cox, C.L., Dyachenko, A., Zhang, W., McGahan, J.P., Seibert, A., Krauss, R.M., Chiu, S., Schaefer, E.J., Ai, M., Otokozawa, S., Nakajima, K., Nakano, T., Beysen, C., Hellerstein, M.K., Berglund, L. and Havel, P.J. (2009). Consuming fructose-sweetened, not glucose-sweetened, beverages increases visceral adiposity and lipids and decreases insulin sensitivity in overweight/obese humans. J. Clin. Invest., 119, 1322-1334.
11. Sugimoto K. Suzuki J. Nakagawa K. Hayashi S. Enomoto T. Fujita T. Yamaji R. Inui H. Nakano Y. Eucalyptus leaf extract inhibits intestinal fructose absorption, and suppresses adiposity due to dietary sucrose in rats British Journal of Nutrition 2005 93 6 957-963 DOI 10.1079/BJN20051436 Sugimoto, K., Suzuki, J., Nakagawa, K., Hayashi, S., Enomoto, T., Fujita, T., Yamaji, R., Inui, H. and Nakano, Y. (2005). Eucalyptus leaf extract inhibits intestinal fructose absorption, and suppresses adiposity due to dietary sucrose in rats. Br. J. Nutr, 93, 957-963. (Pubitemid 43899576)
12. Sugimoto, K., Nakagawa, K., Hayashi, S., Amakura, Y., Yoshimura, M., Yoshida, T., Yamaji, R., Nakano, Y and Inui, H. (2009). Hydrolyzable tannins as antioxidants in the leaf extract of Eucalyptus globulus possessing tyrosinase and hyaluronidase inhibitory activities. Food Sci Technol. Res., 15, 331-336.