Reduced Circulating Insulin Enhances Insulin Sensitivity in Old Mice and Extends Lifespan

Cell Reports

Volumn 20, Issue 2, 2017, Pages 451-463

  Templeman, Nicole M ^a   Flibotte, Stephane ^a   Chik, Jenny H L ^b   Sinha, Sunita ^a   Lim, Gareth E ^a   Foster, Leonard J ^b   Nislow, Corey ^a   Johnson, James D ^a  

^a UNIVERSITY OF BRITISH COLUMBIA   (Canada)

^b UNIVERSITY OF BRITISH COLUMBIA   (Canada)

Author keywords

aging; hyperinsulinemia; insulin resistance; longevity; metabolism

Indexed keywords

INSULIN; SOMATOMEDIN C; GLUCOSE; INS2 PROTEIN, MOUSE;

AGED; AGING; ANIMAL EXPERIMENT; ANIMAL TISSUE; ARTICLE; CONTROLLED STUDY; FEMALE; GLUCOSE HOMEOSTASIS; IN VIVO STUDY; INSULIN RESISTANCE; INSULIN SENSITIVITY; LIFESPAN; LIVER TISSUE; LONGEVITY; MOUSE; NONHUMAN; OXIDATIVE STRESS; PRIORITY JOURNAL; PROTEOMICS; SIGNAL TRANSDUCTION; TRANSCRIPTOMICS; TRICEPS SURAE MUSCLE; ANIMAL; BODY COMPOSITION; GENETICS; KNOCKOUT MOUSE; MALE; METABOLISM; PHYSIOLOGY;

ANIMALS; BODY COMPOSITION; FEMALE; GLUCOSE; INSULIN; INSULIN RESISTANCE; MALE; MICE; MICE, KNOCKOUT; PROTEOMICS; SIGNAL TRANSDUCTION;

EID: 85022080943     PISSN: None     EISSN: 22111247     Source Type: Journal    
DOI: 10.1016/j.celrep.2017.06.048     Document Type: Article

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