Elevated circulating lipasin/betatrophin in human type 2 diabetes and obesity

Scientific Reports

Volumn 4, Issue , 2014, Pages

  Fu, Zhiyao ^a   Berhane, Feven ^a   Fite, Alemu ^a   Seyoum, Berhane ^a   Abou Samra, Abdul B ^a,b   Zhang, Ren ^a  

^a WAYNE STATE UNIVERSITY SCHOOL OF MEDICINE   (United States)

^b HAMAD MEDICAL CORPORATION   (Qatar)

Author keywords

[No Author keywords available]

Indexed keywords

BIOLOGICAL MARKER; LIPASIN PROTEIN, HUMAN; PEPTIDE HORMONE;

BLOOD; CASE CONTROL STUDY; COMPARATIVE STUDY; DIABETES MELLITUS, TYPE 2; FEMALE; FOLLOW UP; HUMAN; MALE; MIDDLE AGED; OBESITY; PROGNOSIS;

BIOLOGICAL MARKERS; CASE-CONTROL STUDIES; DIABETES MELLITUS, TYPE 2; FEMALE; FOLLOW-UP STUDIES; HUMANS; MALE; MIDDLE AGED; OBESITY; PEPTIDE HORMONES; PROGNOSIS;

EID: 84901470603     PISSN: None     EISSN: 20452322     Source Type: Journal    
DOI: 10.1038/srep05013     Document Type: Article

References (20)

1. Eckel, R. H., Grundy, S. M. & Zimmet, P. Z. The metabolic syndrome. Lancet 365, 1415-1428 (2005).
2. Zhang, R. Lipasin, a novel nutritionally-regulated liver-enriched factor that regulates serum triglyceride levels. Biochem Biophys Res Commun 424, 786-92 (2012).
3. Fu, Z., Yao, F., Abou-Samra, A. B. & Zhang, R. Lipasin, thermoregulated in brown fat, is a novel but atypical member of the angiopoietin-like protein family. Biochem Biophys Res Commun 430, 1126-31 (2013).
4. Ren, G., Kim, J. Y. & Smas, C. M. Identification of RIFL, a novel adipocyte-enriched insulin target gene with a role in lipid metabolism. Am J Physiol Endocrinol Metab 303, E334-51 (2012).
5. Quagliarini, F. et al. Atypical angiopoietin-like protein that regulates ANGPTL3. Proc Natl Acad Sci USA 109, 19751-6 (2012).
6. Wang, Y. et al. Mice lacking ANGPTL8 (Betatrophin) manifest disrupted triglyceride metabolism without impaired glucose homeostasis. Proc Natl Acad Sci USA (2013).
7. Yi, P., Park, J. S. & Melton, D. A. Betatrophin: a hormone that controls pancreatic beta cell proliferation. Cell 153, 747-58 (2013).
8. Tang, T. et al. A mouse knockout library for secreted and transmembrane proteins. Nat Biotechnol 28, 749-55 (2010).
9. Teslovich, T. M. et al. Biological, clinical and population relevance of 95 loci for blood lipids. Nature 466, 707-13 (2010).
10. Peloso, G. M. et al. Association of low-frequency and rare coding-sequence variants with blood lipids and coronary heart disease in 56, 000 whites and blacks. Am J Hum Genet 94, 223-32 (2014).
11. Espes, D., Lau, J. & Carlsson, P. O. Increased circulating levels of betatrophin in individuals with long-standing type 1 diabetes. Diabetologia 57, 50-3 (2013).
12. Brown, M. S. & Goldstein, J. L. Selective versus total insulin resistance: a pathogenic paradox. Cell Metab 7, 95-6 (2008).
13. Biddinger, S. B. et al. Hepatic insulin resistance is sufficient to produce dyslipidemia and susceptibility to atherosclerosis. Cell Metab 7, 125-34 (2008).
14. Zhang, R. & Abou-Samra, A. B. Emerging roles of Lipasin as a critical lipid regulator. Biochem Biophys Res Commun 432, 401-5 (2013).
15. Uyeda, K. & Repa, J. J. Carbohydrate response element binding protein, ChREBP, a transcription factor coupling hepatic glucose utilization and lipid synthesis. Cell Metab 4, 107-10 (2006).
16. Filhoulaud, G., Guilmeau, S., Dentin, R., Girard, J. & Postic, C. Novel insights into ChREBP regulation and function. Trends Endocrinol Metab 24, 257-68 (2013).
17. Jeong, Y. S. et al. Integrated expression profiling and genome-wide analysis of ChREBP targets reveals the dual role for ChREBP in glucose-regulated gene expression. PLoS One 6, e22544 (2011).
18. Hossain, P., Kawar, B. & El Nahas, M. Obesity and diabetes in the developing world-a growing challenge. N Engl J Med 356, 213-5 (2007).
19. Miller, M. et al. Triglycerides and cardiovascular disease: a scientific statement from the American Heart Association. Circulation 123, 2292-333 (2011).
20. Fenzl, A. et al. Circulating betatrophin correlates with atherogenic lipid profiles but not with glucose and insulin levels in insulin-resistant individuals. Diabetologia, in press (2014).