Dysregulation of fatty acid metabolism in the etiology of type 2 diabetes

Diabetes

Volumn 51, Issue 1, 2002, Pages 7-18

  Denis McGarry, J ^a,b  

^a UNIVERSITY OF TEXAS AT DALLAS   (United States)

^b UNIVERSITY OF TEXAS SOUTHWESTERN MEDICAL CENTER   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

FATTY ACID; GLUCOSE; INSULIN; TRIACYLGLYCEROL;

ANIMAL EXPERIMENT; CONFERENCE PAPER; CONTROLLED STUDY; CORRELATION ANALYSIS; FATTY ACID BLOOD LEVEL; FATTY ACID METABOLISM; FATTY ACID SYNTHESIS; GLUCOSE BLOOD LEVEL; HUMAN; IMPAIRED GLUCOSE TOLERANCE; INCIDENCE; INSULIN RESISTANCE; MOLECULAR INTERACTION; MUSCLE CELL; NON INSULIN DEPENDENT DIABETES MELLITUS; NONHUMAN; OBESITY; PANCREAS ISLET BETA CELL; PATHOPHYSIOLOGY; PRIORITY JOURNAL; RAT; ARTICLE; BIOLOGICAL MODEL; DIABETIC OBESITY; HOMEOSTASIS; METABOLISM; PANCREAS ISLET;

BLOOD GLUCOSE; DIABETES MELLITUS, NON-INSULIN-DEPENDENT; FATTY ACIDS, NONESTERIFIED; GLUCOSE; HOMEOSTASIS; HUMAN; INSULIN; ISLETS OF LANGERHANS; MODELS, BIOLOGICAL; OBESITY IN DIABETES; TRIGLYCERIDES;

EID: 0036092239     PISSN: 00121797     EISSN: None     Source Type: Journal    
DOI: 10.2337/diabetes.51.1.7     Document Type: Conference Paper

References (92)

1. What if Minkowski had been ageusic? An alternative angle on diabetes
2. The fourth musketeer-from Alexandre Dumas to Claude Bernard
3. Abnormalities in carbohydrate tolerance associated with elevated plasma nonesterified fatty acids
4. Skeletal muscle triglyceride levels are inversely related to insulin action
5. Comparison of localized proton NMR signals of skeletal muscle and fat tissue in vivo: Two lipid compartments in muscle tissue
6. Skeletal muscle triglyceride stores are increased in insulin resistance
7. Relation of triglyceride stores in skeletal muscle cells to central obesity and insulin sensitivity in European and South Asian men
8. 1H NMR spectroscopy study
9. 13C nuclear magnetic resonance spectroscopy assessment in offspring of type 2 diabetic parents
10. Morphometric documentation of abnormal intramyocellular fat storage and reduced glycogen in obese patients with type II diabetes
11. 1H spectroscopy: Validation in vivo
12. Pathogenesis of NIDDM: A balanced overview
13. Intramuscular lipid is increased in subjects with congenital generalized lipodystrophy
14. 1H-MRS study
15. Effects of a 48-h fat infusion on insulin secretion and glucose utilization
16. Mechanism of free fatty acid-induced insulin resistance in humans
17. Mechanisms decreasing glucose oxidation in diabetes and starvation: Role of lipid fuels and hormones
18. Effects of free fatty acids on glucose transport and IRS-1-associated phosphatidylinositol 3-kinase activity
19. Impaired glucose transport as a cause of decreased insulin-stimulated muscle glycogen synthesis in type 2 diabetes
20. The effect of non-insulin-dependent diabetes mellitus and obesity in glucose transport and phosphorylation in skeletal muscle
21. Decreased muscle glucose transport/phosphorylation is an early defect in the pathogenesis of non-insulin-dependent diabetes mellitus
22. Association of increased intramyocellular lipid content with insulin resistance in lean nondiabetic offspring of type 2 diabetic subjects
23. Decrease in triglyceride accumulation in tissues by restricted diet and improvement of diabetes in Otsuka Long-Evans Tokushima fatty rats, a non-insulin-dependent diabetes model
24. Caloric restriction in obese pre-diabetic rats prevents β-cell depletion, loss of β-cell GLUT 2 and glucose incompetence
25. Long-chain acyl-CoA esters as indicators of lipid metabolism and insulin sensitivity in rat and human muscle
26. Peroxisome proliferator-activated receptor (PPAR)-a activation lowers muscle lipids and improves insulin sensitivity in high fat-fed rats
27. Prolonged inhibition of muscle carnitine palmitoyltransferase-1 promotes intramyocellular lipid accumulation and insulin resistance in rats
28. Cellular mechanisms of insulin resistance
29. Muscle lipid accumulation and protein kinase C activation in the insulin-resistant chronically glucose-infused rat
30. Normal insulin-dependent activation of Akt/protein kinase B, with diminished activation of phosphoinositide 3-kinase, in muscle in type 2 diabetes
31. Divergent regulation of Akt 1 and Akt2 isoforms in insulin target tissues of obese Zucker rats
32. Free fatty acid-induced insulin resistance is associated with activation of protein kinase C θ and alterations in the insulin signaling cascade
33. Acute reversal of lipid-induced muscle insulin resistance is associated with rapid alteration in PKC-θ localization
34. Acyl-CoA inhibition of hexokinase in rat and human skeletal muscle is a potential mechanism of lipid-induced insulin resistance
35. Role of the glucosamine pathway in fat-induced insulin resistance
36. Decreased insulin activation of glycogen synthase in skeletal muscles in young nonobese Caucasian first-degree relatives of patients with non-insulin-dependent diabetes mellitus
37. Lilly Lecture 1978: New perspectives in the regulation of ketogenesis
38. Acetyl-CoA carboxylase involvement in the rapid maturation of fatty acid oxidation in the newborn rabbit heart
39. Influence of malonyl-CoA and palmitate concentration on rate of palmitate oxidation in rat muscle
40. Acetyl-CoA carboxylase regulation of fatty acid oxidation in the heart
41. Malonyl-CoA regulation in skeletal muscle: Its link to cell citrate and the glucose-fatty acid cycle
42. Observations on the affinity for carnitine, and malonyl-CoA sensitivity, of carnitine palmitoyltransferase I in animal and human tissues
43. Rat heart expresses two forms of mitochondrial carnitine palmitoyltransferase I
44. Regulation of acetyl-coenzyme A carboxylase I. Purification and properties of two forms of acetyl-coenzyme A carboxylase from rat liver
45. Cloning of human acetyl-CoA carboxylase-β and its unique features
46. The subcellular localization of acetyl-CoA carboxylase 2
47. Malonyl-CoA, fuel sensing, and insulin resistance
48. The AMP-activated/SNF1 protein kinase subfamily: Metabolic sensors of the eukaryotic cell?
49. Inactivation of acetyl-CoA carboxylase and activation of AMP-activated protein kinase in muscle during exercise
50. Activation of malonyl-CoA decarboxylase in rat skeletal muscle by contraction and the AMP-activated protein kinase activator 5-aminoimidazole-4-carboxanude-1-beta-D-ribofuranoside
51. The mitochondrial carnitine palmitoyltransferase system from concept to molecular analysis
52. Insulin inhibition of 5′ adenosine monophosphate-activated protein kinase in the heart results in activation of acetyl coenzyme A carboxylase and inhibition of fatty acid oxidation
53. Continuous fatty acid oxidation and reduced fat storage in mice lacking acetyl-CoA carboxylase 2
54. Failure to increase lipid oxidation in response to increasing dietary fat content in formerly obese women
55. Energy expenditure in obese women before and during weight loss, after refeeding, and in the weight-relapse period
56. Reduced rate of energy expenditure as a risk factor for body-weight gain
57. Skeletal muscle fatty acid metabolism in association with insulin resistance, obesity and weight loss
58. Profiling of Zucker diabetic fatty rats in their progression to the overt diabetic state
59. Metabolic coupling factors in pancreatic β-cell signal transduction
60. Are the β-cell signaling molecules malonyl-CoA and cytosolic long-chain acyl-CoA implicated in multiple tissue defects of obesity and NIDDM?
61. More direct evidence for a malonyl-CoA carnitine palmitoyltransferase I interaction as a key event in pancreatic β-cell signaling
62. Essential role of acetyl-CoA carboxylase in the glucose-induced insulin secretion in a pancreatic β-cell line
63. Molecular or pharmacologic perturbation of the link between glucose and lipid metabolism is without effect on glucose-stimulated insulin secretion
64. Overexpression of a modified human malonyl-CoA decarboxylase blocks the glucose-induced increase in malonyl-CoA level but has no impact on insulin secretion in INS-1-derived (832/13) β-cells
65. Essentiality of circulating fatty acids for glucose-stimulated insulin secretion in the fasted rat
66. Circulating fatty acids are essential for efficient glucose-stimulated insulin secretion after prolonged fasting in humans
67. Effects of fasting on insulin secretion, islet glucose metabolism, and the cyclic adenosine 3′, 5′-monophosphate content of rat pancreatic islets in vitro
68. Hormone-sensitive lipase, the rate-limiting enzyme in triglyceride hydrolysis, is expressed and active in beta-cells
69. The insulinotropic potency of fatty acids is influenced profoundly by their chain length and degree of saturation
70. Fatty acids, lipotoxicity and insulin secretion
71. Dietary fats and insulin action
72. Long term exposure to fatty acids and ketones inhibits β-cell function in human pancreatic islets of Langerhans
73. Chronic exposure to free fatty acid reduces pancreatic β-cell insulin content by increasing basal insulin secretion that is not compensated for by a corresponding increase in proinsulin biosynthesis translation
74. A 48-hour lipid infusion in the rat time-dependently inhibits glucose-induced insulin secretion and β-cell oxidation through a process likely coupled to fatty acid oxidation
75. Chronic perifusion of rat islets with palmitate suppresses glucose-stimulated insulin release
76. β-cell lipotoxicity in the pathogenesis of non-insulin-dependent diabetes mellitus of obese rats: Impairment in adipocyte-β-cell relationships
77. The longitudinal effect of inhibiting fatty acid oxidation in diabetic rats fed a high-fat diet
78. Fatty acid-induced β-cell apoptosis: A link between obesity and diabetes
79. Diseases of liporegulation: New perspective on obesity and related disorders
80. Structure and biology of amylin
81. The relation of diabetes mellitus to lesions of the pancreas: Hyaline degeneration of the islets of Langerhans
82. Measurement of plasma glucose, free fatty acids, lactate, and insulin for 24 h in patients with NIDDM
83. Non-esterified fatty acids and the liver. Why is insulin secreted into the portal vein?
84. Insulin selectively increases SREBP-1c mRNA in the livers of rats with streptozotocin-induced diabetes
85. Induction of hepatic glucose-6-phosphatase gene expression by lipid infusion
86. Decreased IRS-2 and increased SREBP-1c lead to mixed insulin resistance and sensitivity in livers of lipodystrophic and ob/ob mice
87. Diabetes mellitus: A "thrifty" genotype rendered detrimental by "progress"?
88. Positional cloning of the mouse obese gene and its human homologue
89. Obesity and the regulation of energy balance
90. Leptin and the regulation of body weight in mammals
91. New insights into sympathetic regulation of glucose and fat metabolism
92. PPARγ, the ultimate thrifty gene