Dietary sugars stimulate fatty acid synthesis in adults

Journal of Nutrition

Volumn 138, Issue 6, 2008, Pages 1039-1046

  Parks, Elizabeth J ^a   Skokan, Lauren E ^b   Timlin, Maureen T ^c   Dingfelder, Carlus S ^c  

^a UNIVERSITY OF TEXAS SOUTHWESTERN MEDICAL CENTER   (United States)

^b UNIVERSITY OF TEXAS AT ARLINGTON   (United States)

^c UNIVERSITY OF MINNESOTA   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

FATTY ACID; FRUCTOSE; GLUCOSE; INSULIN; LIPOPROTEIN; TRIACYLGLYCEROL;

ADULT; ARTICLE; BODY MASS; CONTROLLED STUDY; ESTERIFICATION; FATTY ACID BLOOD LEVEL; FATTY ACID SYNTHESIS; FEMALE; GLUCOSE BLOOD LEVEL; GLUCOSE TOLERANCE TEST; HUMAN; HUMAN EXPERIMENT; HYPERLIPIDEMIA; INSULIN BLOOD LEVEL; LIPOGENESIS; LIVER; MALE; MASS FRAGMENTOGRAPHY; NORMAL HUMAN; POSTPRANDIAL STATE; SUGAR INTAKE; TRIACYLGLYCEROL BLOOD LEVEL;

EID: 44449096155     PISSN: 00223166     EISSN: 15416100     Source Type: Journal    
DOI: 10.1093/jn/138.6.1039     Document Type: Article

References (38)

1. Nikkila EA, Pelkonen R. Enhancement of alimentary hyperglyceridemia by fructose and glycerol in man. Proc Soc Exp Biol Med. 1966;123:91-4.
2. Crapo PA, Reaven GM, Olefsky J. Plasma glucose and insulin responses to orally administered simple and complex carbohydrates. Diabetes. 1976;25:741-7.
3. Hallfrisch J, Reiser S, Prather ES. Blood lipid distribution of hyper-insulinemic men consuming three levels of fructose. Am J Clin Nutr. 1983;37:740-8.
4. Schwarz J-M, Schutz Y, Froidevaux F, Acheson KJ, Jeanpretre N, Schneider H, Felber J-P, Jequier E. Thermogenesis in men and women induced by fructose vs glucose added to a meal. Am J Clin Nutr. 1989;49:667-74.
5. Schwarz JM, Neese RA, Shackelton CHL, Hellerstein MK. De novo lipogenesis (DNL) during fasting and oral fructose in lean and obese hyperinsulinemic subjects. Diabetes. 1993;42 Suppl:39A.
6. Tounian P, Schneiter P, Henry S, Jequier E, Tappy L. Effects of infused fructose on endogenous glucose production, gluconeogenesis, and glycogen metabolism in healthy humans. Am J Physiol. 1994;267:E710-4.
7. Jeppesen J, Chen YDI, Zhou MY, Schaaf P, Coulston A, Reaven GM. Postprandial triglyceride and retinyl ester responses to oral fat: effects of fructose. Am J Clin Nutr. 1995;61:787-91.
8. Lee BM, Wolever TM. Effect of glucose, sucrose and fructose on plasma glucose and insulin responses in normal humans: comparison with white bread. Eur J Clin Nutr. 1998;52:924-8.
9. Bantle JP, Raatz SK, Thomas W, Georgopoulos A. Effects of dietary fructose on plasma lipids in healthy subjects. Am J Clin Nutr. 2000;72:1128-34.
10. 1-4. Am J Clin Nutr. 2006;84:1374-9.
11. Teff K, Elliott S, Tschop M, Kieffer T, Rader D, Heiman M, Townsend R, Keim N, D'Alessio D, Havel P, et al. Dietary fructose reduces circulating insulin and leptin, attenuates postprandial suppression of ghrelin, and increases triglycerides in women. J Clin Endocrinol Metab. 2004;89:2963-72.
12. Hollenbeck C. Dietary fructose effects on lipoprotein metabolism and risk for coronary artery disease. Am J Clin Nutr. 1993;58(Suppl):S800-9.
13. Faeh D, Minehira K, Schwarz J, Periasami R, Seongus P, Tappy L. Effect of fructose overfeeding and fish oil administration on hepatic de novo lipogenesis and insulin sensitivity in healthy males. Diabetes. 2005;54:1907-13.
14. Lammert O, Grunnet N, Faber P, Bjornsbo KS, Dich J, Larsen LO, Neese RA, Hellerstein MK, Quistorff B. Effects of isoenergetic overfeeding of either carbohydrate or fat in young men. Br J Nutr. 2000;84:233-45.
15. McDevitt RM, Bott SJ, Harding M, Coward WA, Bluck LJ, Prentice AM. De novo lipogenesis during controlled overfeeding with sucrose or glucose in lean and obese women. Am J Clin Nutr. 2001;74:737-46.
16. Chong MF, Fielding BA, Frayn KN. Mechanisms for the acute effect of fructose on postprandial lipemia. Am J Clin Nutr. 2007;85:1511-20.
17. Metropolitan Life Insurance Company. Metropolitan height and weight tables. New York: Metropolitan Life Insurance Company; 1983;64(1):3-9.
18. Harris JA, Benedict FG. Biometric study of basal metabolism in man. Washington DC: Carnegie Institute; 1919. Report No.: Publication no. 279.
19. Schwarz JM, Neese RA, Turner S, Dare D, Hellerstein MK. Short-term alterations in carbohydrate energy intake in humans: striking effects on hepatic glucose production, de novo lipogenesis, lipolysis, and whole-body fuel selection. J Clin Invest. 1995;96:2735-43.
20. Barrows BR, Parks EJ. Contributions of different fatty acid sources to VLDL-triacylglycerol in the fasted and fed-states. J Clin Endocrinol Metab. 2006;91:1446-52.
21. Meyer C, Dostou JM, Welle SL, Gerich JE. Role of human liver, kidney, and skeletal muscle in postprandial glucose homeostasis. Am J Physiol. 2002;282:E419-27.
22. Kotite L, Bergeron N, Havel RJ. Quantification of apolipoproteins B-100, B-48, and E in human triglyceride-rich lipoproteins. J Lipid Res. 1995;36:890-900.
23. Havel RJ, Eder HA, Bragdon JH. The distribution and chemical composition of ultracentrifugally separated lipoproteins in human serum. J Clin Invest. 1955;34:1345-53.
24. Parks EJ, Krauss RM, Christiansen MP, Neese RA, Hellerstein MK. Effects of a low-fat, high-carbohydrate diet on VLDL-triglyceride assembly, production and clearance. J Clin Invest. 1999;104:1087-96.
25. Parks EJ, German JB, Davis PA, Frankel EN, Kappagoda CT, Rutledge JC, Hyson DA, Schneeman BO. Reduced susceptibility of LDL from patients participating in an intensive atherosclerosis treatment program. Am J Clin Nutr. 1998;68:778-85.
26. Hellerstein MK, Neese RA. Mass isotopomer distribution analysis at eight years: theoretical, analytic, and experimental considerations. Am J Physiol. 1999;276:E1146-70.
27. Aarsland A, Wolfe RR. Hepatic secretion of VLDL fatty acids during stimulated lipogenesis in men. J Lipid Res. 1998;39:1280-6.
28. Hudgins LC, Hellerstein M, Selfman C, Neese R, Diakun J, Hirsch J. Human fatty acid synthesis is stimulated by a eucaloric low fat, high carbohydrate diet. J Clin Invest. 1996;97:2081-91.
29. Forsythe CE, Phinney SD, Fernandez ML, Quann EE, Wood RJ, Bibus DM, Kraemer WJ, Feinman RD, Volek JS. Comparison of low fat and low carbohydrate diets on circulating fatty acid composition and markers of inflammation. Lipids. 2008;43:65-77.
30. Barrows BR, Timlin MT, Parks EJ. Spillover of dietary fatty acids and use of serum nonesterified fatty acids for the synthesis of VLDL-triacylglycerol under two different feeding regimens. Diabetes. 2005;54:2668-73.
31. Timlin MT, Barrows BR, Parks EJ. Increased dietary substrate delivery alters hepatic fatty acid recycling in healthy men. Diabetes. 2005;54:2694-701.
32. Timlin MT, Parks EJ. The temporal pattern of de novo lipogenesis in the postprandial state. Am J Clin Nutr. 2005;81:35-42.
33. Mayes PA. Intermediary metabolism of fructose. Am J Clin Nutr. 1993;58:S754-65.
34. Vedala A, Wang W, Neese RA, Christiansen MP, Hellerstein MK. Delayed secretory pathway contributions to VLDL-triglycerides from plasma NEFA, diet, and de novo lipogenesis in humans. J Lipid Res. 2006;47:2562-74.
35. Donnelly KL, Smith CI, Schwarzenberg SJ, Jesserun J, Parks EJ. Sources of fatty acids stored in liver and secreted via lipoproteins in patients with nonalcoholic fatty liver disease. J Clin Invest. 2005;115:1343-51.
36. Storlien L, Oakes ND, Kelly DE. Metabolic inflexibility. Proc Nutr Soc. 2004;63:363-8.
37. Ukropcova B, McNeil M, Sereda O, de Jonge L, Xie H, Bray GA, Smith SR. Dynamic changes in fat oxidation in human primary myocytes mirror metabolic characteristics of the donor. J Clin Invest. 2005;115:1934-41.
38. Hudgins LC, Hellerstein MK, Seidman CE, Neese RA, Tremaroli JD, Hirsch J. Relationship between carbohydrate-induced hypertriglyceridemia and fatty acid synthesis in lean and obese subjects. J Lipid Res. 2000;41:595-604.