Wild Plant-Based Functional Foods, Drugs, and Nutraceuticals

Wild Plants, Mushrooms and Nuts: Functional Food Properties and Applications

Volumn , Issue , 2016, Pages 315-351

  Pinela, José ^a,b   Carocho, Márcio ^a,c   Dias, Maria Inês ^a,b   Caleja, Cristina ^a,b   Barros, Lillian ^a   Ferreira, Isabel C F R ^a  

^a INSTITUTO POLITÉCNICO DE BRAGANÇA   (Portugal)

^b UNIVERSITY OF PORTO   (Portugal)

^c UNIVERSIDAD COMPLUTENSE DE MADRID   (Spain)

Author keywords

Drug development; Functional food; Healthy food; Innovation technology; Medicinal plants; Nutraceutical drug formulations; Phytochemicals; Plant drugs; Plant based nutraceuticals; Wild plants

Indexed keywords

COMMERCE; NUTRITION;

DRUG DEVELOPMENT; HEALTHY FOODS; MEDICINAL PLANTS; NUTRACEUTICALS; PHYTOCHEMICALS; PLANT DRUGS; WILD PLANTS;

FUNCTIONAL FOOD;

EID: 85018892847     PISSN: None     EISSN: None     Source Type: Book    
DOI: 10.1002/9781118944653.ch9     Document Type: Chapter

References (175)

1. Adão, C. R., Silva, B. P. & Parente, J. P. (2011) A new steroidal saponin with antiinflammatory and antiulcerogenic properties from the bulbs of Allium ampeloprasum var. porrum. Fitoterapia 82, 1175-1180.
2. Ahmad, I., Aqil, F., Owais, M., eds. (2006) Modern Phytomedicine: Turning Plants into Drugs. Weinheim: Wiley-Vch.
3. Amagase, H. & Farnsworth, N. R. (2011) A review of botanical characteristics, phytochemistry, clinical relevance in efficacy and safety of Lycium barbarum fruit (Goji). Food Research International 44, 1702-1717.
4. Andlauer, W. & Furst, P. (2002) Nutraceuticals: a piece of history, present status and outlook. Food Research International 35, 171-176.
5. Annunziata, A. & Vecchio, R. (2011) Functional foods development in the European market: a consumer perspective. Journal of Functional Foods 3, 223-228.
6. Ashwell, M. (2003) Concepts of Functional Foods. ILSI Europe Concise Monograph Series. Brussels: ILSI Europe.
7. Avbunudiogba, J. A., Alalor, C. A., Builders, P. F., et al. (2013) Development and evaluation of liquid oral phytoformulation of Phyllanthus amarus. Journal of Pharmacy Research 6, 908-912.
8. Bagchi, D., ed. (2014) Nutraceutical and Functional Food Regulations in the United States and Around the World, 2nd edn. Houston: Academic Press.
9. Balunas, M. J. & Kinghorn, A. D. (2005) Drug discovery from medicinal plants. Life Sciences 78, 431-441.
10. Barolo, M. I., Mostacero, N. R. & López, S. N. (2014) Ficus carica L. (Moraceae): an ancient source of food and health. Food Chemistry 164, 119-127.
11. Barros, L., Carvalho, A. M., Sa Morais, J., et al. (2010) Strawberry-tree, blackthorn and rose fruits: detailed characterisation in nutrients and phytochemicals with antioxidant properties. Food Chemistry 120, 247-254.
12. Barros, L., Cabrita, L., Vilas Boas, M., et al. (2011a) Chemical, biochemical and electrochemical assays to evaluate phytochemicals and antioxidant activity of wild plants. Food Chemistry 127, 1600-1608.
13. Barros, L., Dueñas, M., Ferreira, I. C. F. R., et al. (2011b) Use of HPLC-DAD-ESI/MS to profile phenolic compounds in edible wild greens from Portugal. Food Chemistry 127, 169-173.
14. Bäurle, P., Suter, A. & Wormstall, H. (2009) Safety and effectiveness of a traditional ginkgo fresh plant extract - results from a clinical trial. Forschende Komplementarmedizin 16, 156-161.
15. Bech-Larsen, T. & Scholderer, J. (2007) Functional foods in Europe: consumer research, market experiences and regulatory aspects. Trends in Food Science and Technology 18, 231-234.
16. Bernal, J., Mendiola, J. A., Ibáñez, E., et al. (2011) Advanced analysis of nutraceuticals. Journal of Pharmaceutical and Biomedical Analysis 55, 758-774.
17. Betoret, E., Betoret, N., Vidal, D. et al. (2011) Functional foods development: trends and technologies. Trends in Food Science and Technology 22, 498-508.
18. Bhardwaj, Y. R., Pareek, A., Jain, V., et al. (2014) Chemical delivery systems and soft drugs: retrometabolic approaches to drug design. Saudi Pharmaceutical Journal 22, 290-302.
19. Bhoopat, L., Srichairatanakool, S., Kanjanapothi, D., et al. (2011) Hepatoprotective effects of lychee (Litchi chinensis Sonn.): a combination of antioxidant and anti-apoptotic activities. Journal of Ethnopharmacology 136, 55-66.
20. Bowen-Forbes, C. S., Zhang, Y. & Nair, M. G. (2010) Anthocyanin content, antioxidant, anti-inflammatory and anticancer properties of blackberry and raspberry fruits. Journal of Food Composition and Analysis 23, 554-560.
21. Braithwaite, M. C., Tyagi, C., Tomar, L. K., et al. (2014) Nutraceutical-based therapeutics and formulation strategies augmenting their efficiency to complement modern medicine: an overview. Journal of Functional Foods 6, 82-99.
22. Brinkeborn, R. M., Shah, D. V. & Degenring F. H. (1989) Echinaforce® and other Echinacea fresh plant preparations in the treatment of the common cold. A randomized, placebo controlled, double-blind clinical trial. Phytomedicine 6, 1-5.
23. Butler, M. S. (2005) Natural products to drugs: natural product derived compounds in clinical trials. Natural Products Reports 22, 162-195.
24. Byrne, D. (2003) Health nutrition and labeling. Food Science and Technology 17, 26-28.
25. Caleja, C., Barros, L. Antonio, A. L., et al. (2015) Foeniculum vulgare Mill. as natural conservation enhancer and health promoter by incorporation in cottage cheese. Journal of Functional Foods 12, 428-438.
26. Carocho, M. & Ferreira, I. C. F. R. (2013a) The role of phenolic compounds in the fight against cancer - a review. Anti-Cancer Agents in Medicinal Chemistry 13, 1236-1238.
27. Carocho, M. & Ferreira, I. C. F. R. (2013b) A review on antioxidants, prooxidants and related controversy: natural and synthetic compounds, screening and analysis methodologies and future perspectives. Food and Chemical Toxicology 51, 15-25.
28. Carocho, M., Barreira, J. C. M., Antonio, A. L., et al. (2015a) The incorporation of plant materials in "Serra da Estrela" cheese improves antioxidant activity without changing the fatty acid profile and visual appearance. European Journal of Lipid Science and Technology 117, 1607-1614.
29. Carocho, M., Barreira, J. C. M., Barros, L., et al. (2015b) Traditional pastry with chestnut flowers as natural ingredients: an approach of the effects on nutritional value and chemical composition. Journal of Food Composition and Analysis 44, 93-101.
30. Cechinel-Filho, V., ed. (2012) Plant Bioactivities and Drug Discovery: Principle, Practice, and Perspectives. New Jersey: John Wiley.
31. Cerqueira, M. A., Pinheiro, A. C., Silva, H. D., et al. (2014) Design of bio-nanosystems for oral delivery of functional compounds. Food Engineering Reviews 6, 1-19.
32. Chen, L., Remondetto, G. E. & Subirade, M. (2006) Food protein-based materials as nutraceutical delivery systems. Trends in Food Science and Technology 17, 272-283.
33. Christoforidis, J. (2014) Quinine. Reference module in biomedical sciences. In: P. Wexler, ed. Encyclopedia of Toxicology, 3rd edn. Philadelphia: Elsevier, pp 19-22.
34. Coppens, P., Silva, M. F. & Pettman, S. (2006) European regulations on nutraceuticals, dietary supplements and functional foods: a framework based on safety. Toxicology 221, 59-74.
35. Costa, A. G. V., Garcia-Diaz, D. F., Jimenez, P. et al. (2013) Bioactive compounds and health benefits of exotic tropical red-black berries. Journal of Functional Foods 5, 539-549.
36. Dapas, B., Dall'Acqua, S., Bullac, R., et al. (2014) Immunomodulation mediated by a herbal syrup containing a standardized Echinacea root extract: a pilot study in healthy human subjects on cytokine gene expression. Phytomedicine 21, 1406-1410.
37. DeFelice, S. L. (1992) The nutraceutical initiative: a recommendation for U.S. economic and regulatory reforms. Genetic Engineering News 12, 13-15.
38. Delva, L. & Goodrich-Schneider, R. (2013) Antioxidant activity and antimicrobial properties of phenolic extracts from acerola (Malpighia emarginata DC) fruit. International Journal of Food Science and Technology 48, 1048-1056.
39. Dias, F. M., Leffa, D. D., Daumann, F., et al. (2014) Acerola (Malpighia emarginata DC.) juice intake protects against alterations to proteins involved in inflammatory and lipolysis pathways in the adipose tissue of obese mice fed a cafeteria diet. Lipids in Health and Disease 13, 1-9.
40. Dias, M. I., Ferreira, I. C. F. R. & Barreiro, M. F. (2015) Microencapsulation of bioactives for food applications. Food and Function 6, 1035-1052.
41. Diplock, A., Aggett, P. J., Ashwell, M., et al. (1999) Scientific concepts of functional foods in Europe: consensus document. British Journal of Nutrition 81, 1-27.
42. Espín, J. C., García-Conesa, M. & Tomás-Barberán, F. (2007) Nutraceuticals: facts and fiction. Phytochemistry 68, 2986-3008.
43. Ezhilarisi, P. N., Karthik, P., Chhanwal, N., et al. (2013) Nanoencapsulation techniques for food bioactive components: a review. Food Bioprocess Technology 6, 628-647.
44. Fabricant, D. S. & Farnsworth, N. R. (2001) The value of plants used in traditional medicine for drug discovery. Environmental Health Perspectives 109, 69-75.
45. FAO (2002) Impact of Cultivation and Gathering of Medicinal Plants on Biodiversity: Global Trends and Issues. Available at: ftp://ftp.fao.org/docrep/fao/005/aa010e/AA010E00.pdf (accessed 27 June 2016).
46. FAO (2005) Trade in Medicinal Plants. Raw Materials, Tropical and Horticultural Products Service Commodities and Trade Division. Available at: ftp://ftp.fao.org/docrep/fao/008/af285e/af285e00.pdf (accessed 27 June 2016).
47. FDA (2014) FDA's Drug Review Process: Continued. Available at: www.fda.gov/Drugs/ResourcesForYou/Consumers/ucm289601.htm (accessed 27 June 2016).
48. Flores, G., Wu, S. B., Negrin, A., et al. (2015) Chemical composition and antioxidant activity of seven cultivars of guava (Psidium guajava) fruits. Food Chemistry 170, 327-335.
49. Fracassetti, D., Costa, C., Moulay, L., et al. (2013) Ellagic acid derivatives, ellagitannins, proanthocyanidins and other phenolics, vitamin C and antioxidant capacity of two powder products from camu-camu fruit (Myrciaria dubia). Food Chemistry 139, 578-588.
50. García-Herrera, P., Morales, P., Fernández-Ruiz, V., et al. (2014) Nutrients, phytochemicals and antioxidant activity in wild populations of Allium ampeloprasum L., a valuable underutilized vegetable. Food Research International 62, 272-279.
51. Garcia-Rios, A., Delgado-Lista, J., Alcala-Diaz, J. F., et al. (2013) Nutraceuticals and coronary heart disease. Current Opinion in Cardiology 28, 475-482.
52. Gaur, S., Wang, Y., Kretzner, L., et al. (2014) Pharmacodynamic and pharmacogenomics study of the nanoparticle conjugate of camptothecin CRLX10 for the treatment of cancer. Nanomedicine: Nanotechnology, Biology, and Medicine 10, 1477-1486.
53. Genta, S., Cabrera, W., Habib, N., et al. (2009) Yacon syrup: beneficial effects on obesity and insulin resistance in humans. Clinical Nutrition 28, 182-187.
54. Giordano, P., Scicchitano, P., Locorotondo, M., et al. (2012) Carotenoids and cardiovascular risk. Current Pharmaceutical Design 18, 5577-5589.
55. Graça, C., Freitas, C. S., Baggio, C.H., et al. (2007) Mikania laevigata syrup does not induce side effects on reproductive system of male Wistar rats. Journal of Ethnopharmacology 111, 29-32.
56. Granato, D., Branco, G. F. & Nazzaro, F. (2010) Functional foods and nondairy probiotic food development: trends, concepts and products. Comprehensive Reviews in Food Science and Food Safety 9, 292-302.
57. Grivetti, L. E. & Ogle, B. M. (2000) Value of traditional foods in meeting macro- and micronutrient needs: the wild plant connection. Nutrition Research Reviews 13, 31-46.
58. Groot, R. S., Wilson, M. A. & Boumans, R. M. J. (2002) A typology for the classification, description and valuation of ecosystem functions, goods and services. Ecological Economics 41, 393-408.
59. Guimarães, R., Barros, L., Dueñas, M., et al. (2013) Characterisation of phenolic compounds in wild fruits from Northeastern Portugal. Food Chemistry 141, 3721-3730.
60. Guimarães, R., Barros, L., Calhelha, R. C., et al. (2014) Bioactivity of different enriched phenolic extracts of wild fruits from Northeastern Portugal: a comparative study. Plant Foods for Human Nutrition 69, 37-42.
61. Gulati, O. P. & Ottaway, P. B. (2006) Legislation relating to nutraceuticals in the European Union with a particular focus on botanical-sourced products. Toxicology 221, 75-87.
62. Gutierrez-Orozco, F. & Failla, M. L. (2013) Biological activities and bioavailability of mangosteen xanthones: a critical review of the current evidence. Nutrients 5, 3163-3183.
63. Hasler, C. M. (2000) The changing face of functional foods. Journal of the American College of Nutrition 19, 499-506.
64. Hasler, C. M. (2002) Functional foods: benefits, concerns and challenges - a position paper from the American Council on Science and Health. Journal of Nutrition 132, 3772-3781.
65. Hawkins, B., ed. (2008) Plants for Life: Medicinal Plant Conservation and Botanic Gardens. London: Botanic Gardens Conservation International.
66. Heinrich, M. & Teoh, H. L. (2004) Galanthamine from snowdrop - the development of a modern drug against Alzheimer's disease from local Caucasian knowledge. Journal of Ethnopharmacology 92, 147-162.
67. Heywood, V. H. (2011) Ethnopharmacology, food production, nutrition and biodiversity conservation: towards a sustainable future for indigenous peoples. Journal of Ethnopharmacology 137, 1-15.
68. Hosseini, S., Jamshidi, L., Mehrzadi, S., et al. (2014) Effects of Juglans regia L. leaf extract on hyperglycemia and lipid profiles in type two diabetic patients: a randomized double-blind, placebo-controlled clinical trial. Journal of Ethnopharmacology 152, 451-456.
69. Howlett, J. (2008) Functional Foods: From Science to Health and Claims. Brussels: ILSI Europe.
70. Huang, G. J., Wang, B. S., Lin, W. C., et al. (2012) Antioxidant and anti-inflammatory properties of longan (Dimocarpus longan Lour.) pericarp. Evidence-Based Complementary and Alternative Medicine 2012, 1-10.
71. Huang, Q., Yu, H. & Ru, Q. (2010b) Bioavailability and delivery of nutraceuticals using nanotechnology. Journal of Food Science 75, 50-57.
72. Huang, W. Y., Cai, Y. Z., Corke, H., et al. (2010a) Survey of antioxidant capacity and nutritional quality of selected edible and medicinal fruit plants in Hong Kong. Journal of Food Composition and Analysis 23, 510-517.
73. Imaga, N. A., Chukwu, C. E., Blankson, A., et al. (2013) Biochemical assessment of Ciklavit®, a nutraceutical used in sickle cell anemia management. Journal of Herbal Medicine 3, 137-148.
74. Ismail, T., Sestili, P. & Akhtar, S. (2012) Pomegranate peel and fruit extracts: a review of potential anti-inflammatory and anti-infective effects. Journal of Ethnopharmacology 143, 397-405.
75. Izzo, R., Simone, G., Giudice, R., et al. (2010) Effects of nutraceuticals on prevalence of metabolic syndrome and on calculated Framingham risk score in individuals with dyslipidaemia. Journal of Hypertension 28, 1482-1487.
76. Janaswamy, S. & Youngren, S. R. (2012) Hydrocolloid-based nutraceutical delivery systems. Food and Function 3, 503-507.
77. Kang, J., Xie, C., Li, Z., et al. (2011) Flavonoids from acai (Euterpe oleracea Mart.) pulp and their antioxidant and anti-inflammatory activities. Food Chemistry 128, 152-157.
78. Katiyar, C., Gupta, A., Kanjilal, S., et al. (2012) Drug discovery from plant sources: an integrated approach. AYU 33, 10-19.
79. Kelly-Pieper, K., Patil, S. P., Busse, P., et al. (2009) Safety and tolerability of an antiasthma herbal formula (ASHMI™) in adult subjects with asthma: a randomized, double-blinded, placebo-controlled, dose-escalation phase I study. Journal of Alternative and Complementary Medicine 15, 735-743.
80. Khoo, C. & Falk, M. (2014) Cranberry polyphenols: effects on cardiovascular risk factors. In: R. R. Watson, V. R. Preedy & S. Zibadi, eds. Polyphenols in Human Health and Disease. San Diego: Academic Press, pp 1049-1065.
81. Kianbakht, S. & Dabaghian, F. H. (2013) Improved glycemic control and lipid profile in hyperlipidemic type 2 diabetic patients consuming Salvia officinalis L. leaf extract: a randomized placebo controlled clinical trial. Complementary Therapies in Medicine 21, 441-446.
82. Kim, J., Lee, K. W. & Lee, H. J. (2011) Cocoa (Theobroma cacao) seeds and phytochemicals in human health. In: V. R. Preedy, R. R. Watson & V. B. Patel, eds. Nuts and Seeds in Health and Disease Prevention. Philadelphia: Elsevier, pp 351-360.
83. Kwak, N. S. & Jukes, D. J. (2001) Functional foods. Part 2: The impact of current regulatory terminology. Food Control 12, 109-117.
84. Lai, T. N. H., Andre, C., Rogez, H., et al. (2015) Nutritional composition and antioxidant properties of the sim fruit (Rhodomyrtus tomentosa). Food Chemistry 168, 410-416.
85. Lange, D. (2004) Medicinal and aromatic plants: trade, production, and management of botanical resources. Acta Horticulturae 629, 177-197.
86. Leite, A. V., Malta, L. G., Riccio, M. F., et al. (2011) Antioxidant potential of rat plasma by administration of freeze-dried jaboticaba peel (Myrciaria jaboticaba Vell Berg). Journal of Agricultural and Food Chemistry 59, 2277-2283.
87. Lenoir, S., Degenring, F. H. & Saller, R. (1999) A double-blind randomised trial to investigate three different concentrations of a standardised fresh plant extract obtained from the shoot tips of Hypericum perforatum L. Phytomedicine 6, 141-146.
88. Lenzi, R. M., Campestrini, L. H., Okumura, L. M., et al. (2013) Effects of aqueous fractions of Uncaria tomentosa (Willd.) D.C.on macrophage modulatory activities. Food Research International 53, 767-779.
89. Li, A. N., Li, S., Li, H. B., et al. (2014a) Total phenolic contents and antioxidant capacities of 51 edible and wild flowers. Journal of Functional Foods 6, 319-330.
90. Li, X., Zhao, J., Yang, M., et al. (2014c) Physalins and withanolides from the fruits of Physalis alkekengi L. var. franchetii (Mast.) Makino and the inhibitory activities against human tumor cells. Phytochemistry Letters 10, 95-100.
91. Li, Y., Ahmad, A., Kong, D., et al. (2014b) Recent progress on nutraceutical research in prostate cancer. Cancer and Metastasis Review 33, 629-640.
92. Liu, Y., Singh, D. & Nair, M. G. (2012) Pods of Khejri (Prosopis cineraria) consumed as a vegetable showed functional food properties. Journal of Functional Foods 4, 116-121.
93. Luis, G., Rubio, C., Gutiérrez, A. J., et al. (2012) Palm tree syrup: nutritional composition of a natural edulcorant. Nutrición Hospitalaria 27, 548-552.
94. Lv, Q., Si, M., Yan, Y., et al. (2014) Effects of phenolic-rich litchi (Litchi chinensis Sonn.) pulp extracts on glucose consumption in human HepG2 cells. Journal of Functional Foods 7, 621-629.
95. Madhavi, D. L., Bomser, J., Smith, M. A. L., et al. (1998) Isolation of bioactive constituents from Vaccinium myrtillus (bilberry) fruits and cell cultures. Plant Science 131, 95-103.
96. Malafaia, C. R. A., Silva, B. P., Tinoco, L. W., et al. (2015) Structural characterization and gastroprotective property of a novel glucofructan from Allium ampeloprasum var. porrum. Carbohydrate Research 402, 44-49.
97. Manchali, S., Murthy, K. N. C. & Patil, B. S. (2012) Crucial facts about health benefits of popular cruciferous vegetables. Journal of Functional Foods 4, 94-106.
98. Mannarino, M. R., Ministrini, S. & Pirro, M. (2014) Nutraceuticals for the treatment of hypercholesterolemia. European Journal of Internal Medicine 25, 592-599.
99. Martins, A., Barros, L., Carvalho, A. M., et al. (2014) Phenolic extracts of Rubus ulmifolius Schott flowers: characterization, microencapsulation and incorporation into yogurts as nutraceutical sources. Food and Function 5, 1091-1100.
100. Martins, D., Barros, L., Carvalho, A. M., et al. (2011) Nutritional and in vitro antioxidant properties of edible wild greens in Iberian Peninsula traditional diet. Food Chemistry 125, 488-494.
101. Matthias, A., Addison, R. S., Agnew, L. L., et al. (2007) Comparison of Echinacea alkylamide pharmacokinetics between liquid and tablet preparations. Phytomedicine 14, 587-590.
102. McAlindon, T.E. (2006) Nutraceuticals: do they work and when should we use them? Clinical Rheumatology 20, 99-115.
103. McCook-Russell, K. P., Nair, M. G., Facey, P. C., et al. (2012) Nutritional and nutraceutical comparison of Jamaican Psidium cattleianum (strawberry guava) and Psidium guajava (common guava) fruits. Food Chemistry 134, 1069-1073.
104. McNamara, S. H. (1997) Dietary supplement legislation enhances opportunities to market nutraceutical-type products. Journal of Nutraceuticals, Functional and Medical Foods 1, 47-59.
105. Mezadri, T., Villaño, D., Fernandez-Pachón, M. S., et al. (2008) Antioxidant compounds and antioxidant activity in acerola (Malpighia emarginata DC.) fruits and derivatives. Journal of Food Composition and Analysis 21, 282-290.
106. Milesi, M., Lacan, D., Brosse, H., et al. (2009) Effect of an oral supplementation with a proprietary melon juice concentrate (Extramel®) on stress and fatigue in healthy people: a pilot, double-blind, placebo-controlled clinical trial. Nutrition Journal 8, 1-7.
107. Milner, J. A. (2000) Functional foods: the US perspective. American Journal of Clinical Nutrition, 71, 1654-1659.
108. MMWR (1999) Achievements in public health, 1900-1999: safer and healthier foods. Morbidity and Mortality Weekly Report, 48, 905-913.
109. Mojani, M. S., Ghasemzadeh, A., Rahmat, A., et al. (2014) Assessment of bioactive compounds, nutritional composition and antioxidant activity of Malaysian young ginger (Zingiber officinale Roscoe). International Food Research Journal 21, 1931-1935.
110. Morales, P., Carvalho, A. M., Sanchez-Mata, M. C., et al. (2012) Tocopherol composition and antioxidant activity of Spanish wild vegetables. Genetic Resources and Crop Evolution 59, 851-863.
111. Najda, A., Dyduch-Siemińska, M., Dyduch, J., et al. (2014) Comparative analysis of secondary metabolites contents in Fragaria vesca L. fruits. Annals of Agricultural and Environmental Medicine 21, 339-343.
112. Newman, D. J., Cragg, G. M. & Snader, K. M. (2000) The influence of natural products upon drug discovery. Natural Product Reports 17, 215-234.
113. Ninfali, P. & Angelino, D. (2013) Nutritional and functional potential of Beta vulgaris cicla and rubra. Fitoterapia 89, 188-199.
114. Nöthlings, U., Murphy, S. P., Wilkens, L. R., et al. (2007) Flavonols and pancreatic cancer risk - the multiethnic cohort study. American Journal of Epidemiology 166, 924-931.
115. Oben, J., Enonchong, E., Kothari, S., et al. (2009) Phellodendron and Citrus extracts benefit joint health in osteoarthritis patients: a pilot, double-blind, placebo-controlled study. Nutrition Journal 8, 1-9.
116. Ohama, H., Ikeda, H. & Moriyama, H. (2006) Health foods and foods with health claims in Japan. Toxicology 221, 95-111.
117. Ortuño, J., Covas, M. I., Farre, M., et al. (2010) Matrix effects on the bioavailability of resveratrol in humans. Food Chemistry 120, 1123-1130.
118. Osbourn, A. E. & Lanzotti, V., eds. (2009) Plant-Derived Natural Products: Synthesis, Function and Application. Berlin: Springer Science + Business Media, LLC.
119. Palma, S., Luján, C., Llabot, J. M., et al. (2002) Design of Peumus boldus tablets by direct compression using a novel dry plant extract. International Journal of Pharmaceutics 233, 191-198.
120. Pardo de Santayana, M., Tardío, J., Blanco, E., et al. (2007) Traditional knowledge of wild edible plants used in the northwest of the Iberian Peninsula (Spain and Portugal): a comparative study. Journal of Ethnobiology and Ethnomedicine 3, 1-11.
121. Paul, S. M., Mytelka, D. S., Dunwiddie, C. T., et al. (2010) How to improve R&D productivity: the pharmaceutical industry's grand challenge. Nature Reviews 9, 203-214.
122. Pedraza-Chaverri, J., Cárdenas-Rodríguez, N., Orozco-Ibarra, M., et al. (2008) Medicinal properties of mangosteen (Garcinia mangostana). Food and Chemical Toxicology 46, 3227-3239.
123. Peng, K., Yang, L., Zhao, S., et al. (2013) Chemical constituents from the fruit of Gardenia jasminoides and their inhibitory effects on nitric oxide production. Bioorganic and Medicinal Chemistry Letters 23, 1127-1131.
124. Pereira, C., Barros, L., Carvalho, A. M., et al. (2011) Nutritional composition and bioactive properties of commonly consumed wild greens: potential sources for new trends in modern diets. Food Research International 44, 2634-2640.
125. Pereira, C., Calhelha, R. C., Barros, L., et al. (2013b) Antioxidant properties, antihepatocellular carcinoma activity and hepatotoxicity of artichoke, milkthistle and borututu. Industrial Crops Production 49, 61-65.
126. Pereira, C., Calhelha, R. C., Barros, L., et al. (2014) Synergisms in antioxidant and antihepatocellular carcinoma activities of artichoke, milk thistle and borututu syrups. Industrial Crops and Products 52, 709-713.
127. Pereira, E., Barros, L. & Ferreira, I. C. F. R. (2013a) Chemical characterization of Ginkgo biloba L. and antioxidant properties of its extracts and dietary supplements. Industrial Crops and Products 51, 244-248.
128. Phillipson, J. D. (2007) Phytochemistry and pharmacognosy. Phytochemistry 68, 2960-2972.
129. Pierro, F. D., Putignano, P., Villanova, N., et al. (2013) Preliminary study about the possible glycemic clinical advantage in using a fixed combination of Berberis aristata and Silybum marianum standardized extracts versus only Berberis aristata in patients with type 2 diabetes. Clinical Pharmacology: Advances and Applications 5, 167-174.
130. Puoci, F., Iemma, F., Spizzirri, U. G., et al. (2011) Antioxidant activity of a Mediterranean food product: "fig syrup". Nutrients 3, 317-329.
131. Quispe, C., Petroll, K., Theoduloz, C., et al. (2014) Antioxidant effect and characterization of South American Prosopis pods syrup. Food Research International 56, 174-181.
132. Ramawat, K. G. & Mérillon, J., eds. (2008) Bioactive Molecules and Medicinal Plants. Berlin: Springer-Verlag.
133. Rathee, S., Rathee, P., Rathee, D., et al. (2010) Phytochemical and pharmacological potential of Kair (Capparis decidua). International Journal of Phytomedicine 2, 10-17.
134. Ribeiro, A. B., Chisté, R. C., Freitas, M., et al. (2014) Psidium cattleianum fruit extracts are efficient in vitro scavengers of physiologically relevant reactive oxygen and nitrogen species. Food Chemistry 165, 140-148.
135. Roberfroid, M. B. (2007) Concepts and strategy of functional food science: the European perspective. American Journal of Clinical Nutrition 71, 1660-1664.
136. Romano, J. (2013) Therapeutic review: colchicine. Journal of Exotic Pet Medicine 22, 405-408.
137. Ross, S. (2000) Functional foods: the Food and Drug Administration perspective. American Journal of Clinical Nutrition 71, 1735-1738.
138. Rufino, M. S. M., Alves, R. E., Brito, E. S., et al. (2010) Bioactive compounds and antioxidant capacities of 18 non-traditional tropical fruits from Brazil. Food Chemistry 121, 996-1002.
139. Sarker S. D. & Nahar, L., eds. (2012) Natural Products Isolation. New York: Humana Press, Springer.
140. Schippmann, U., Leaman, D. J. & Cunningham, A. B. (2002) Impact of Cultivation and Gathering of Medicinal Plants on Biodiversity: Global Trends and Issues. FAO Biodiversity and the Ecosystem Approach in Agriculture, Forestry and Fisheries. Satellite event on the occasion of the Ninth Regular Session of the Commission on Genetic Resources for Food and Agriculture. Inter-Departmental Working Group on Biological Diversity for Food and Agriculture. Rome: FAO.
141. Schulp, C. J. E., Thuiller, W. & Verburg, P. H. (2014) Wild food in Europe: s synthesis of knowledge and data of terrestrial wild food as an ecosystem service. Ecological Economics 105, 292-305.
142. Scicchitano, P., Cameli, M., Maiello, M., et al. (2014) Nutraceuticals and dyslipidaemia: beyond the common therapeutics. Journal of Functional Food 6, 11-32.
143. Sener, B. & Orhan, L. (2005) Discovery of drug candidates from some Turkish plants and conservation of biodiversity. Pure and Applied Chemistry 77, 53-64.
144. Sengupta, G., Hazra, A., Kundu, A., et al. (2011) Comparison of Murraya koenigiiand Tribulus terrestris-based oral formulation versus tamsulosin in the treatment of benign prostatic hyperplasia in men aged >50 years: a double-blind, double-dummy, randomized controlled trial. Clinical Therapeutics 33, 1943-1952.
145. Sengupta, K., Krishnaraju, A. V., Vishal, A. A., et al. (2010) Comparative efficacy and tolerability of 5-Loxin® and Aflapin® against osteoarthritis of the knee: a double blind, randomized, placebo controlled clinical study. International Journal of Medicinal Sciences 7, 366-377.
146. Shad, A. A., Ahmad, S., Ullah, R., et al. (2014) Phytochemical and biological activities of four wild medicinal plants. Scientific World Journal 2014, 1-7.
147. Sharma, B., Salunke, R., Balomajumder, C., et al. (2010) Anti-diabetic potential of alkaloid rich fraction from Capparis decidua on diabetic mice. Journal of Ethnopharmacology, 127, 457-462.
148. Shegokar, R. & Müller, R. H. (2010) Nanocrystals: industrially feasible multifunctional formulation technology for poorly soluble actives. International Journal of Pharmaceutics 399, 129-139.
149. Sidor, A. & Gramza-Michałowska, A. (2014) Advanced research on the antioxidant and health benefit of elderberry (Sambucus nigra) in food - a review. Journal of Functional Foods 18, 941-958.
150. Singh, A. P., Wilson, T., Kalk, A. J., et al. (2009) Isolation of specific cranberry flavonoids for biological activity assessment. Food Chemistry 116, 963-968.
151. Singh, J., & Sinha, S. (2012) Classification, regulatory acts and applications of nutraceuticals for health. International Journal of Pharma and Bio Sciences 2, 177-187.
152. Spernath, A. & Aserin, A. (2006) Microemulsions as carriers for drugs and nutraceuticals. Advances in Colloid and Interface Science 128-130, 47-64.
153. Stauss-Grabo, M., Atiyea, S., Warnke, A., et al. (2011) Observational study on the tolerability and safety of film-coated tablets containing ivy extract (Prospan® Cough Tablets) in the treatment of colds accompanied by coughing. Phytomedicine 18, 433-436.
154. Sticher, O. (2008) Natural product isolation. Natural Products Reports 25, 517-554.
155. Takachi, R., Inoue, M., Ishihara, J., et al. (2008) Fruit and vegetable intake and risk of total cancer and cardiovascular diseasee Japan public health center-based prospective study. American Journal of Epidemiology 167, 59-70.
156. Talbott, S. M., Talbott, J. A. & Pugh, M. (2013) Effect of Magnolia officinalis and Phellodendron amurense (Relora®) on cortisol and psychological mood state in moderately stressed subjects. Journal of the International Society of Sports Nutrition 10, 2-6.
157. Thomson, M., Al-Qattan, K. K., Al-Sawan, S. M., et al. (2002) The use of ginger (Zingiber officinale Rosc.) as a potential anti-inflammatory and antithrombotic agent. Prostaglandins, Leukotrienes and Essential Fatty Acids 67, 475-478.
158. Tijhuis, M. J., Jong, N., Pohjola, M. V., et al. (2012) State of the art in benefit-risk analysis: food and nutrition. Food and Chemical Toxicology 50, 5-25.
159. Trivedi, P. C., ed. (2009) Medicinal Plants: Utilisation and Conservation. Chaura Rasta: Aaviskar Publishers
160. Tu, Y., Sun, W., Wan, Y., et al. (2013) Huangkui capsule, an extract from Abelmoschus manihot (L.) medic, ameliorates adriamycin-induced renal inflammation and glomerular injury via inhibiting p38MAPK signaling pathway activity in rats. Journal of Ethnopharmacology 147, 311-320.
161. Vulić, J. J., Ćebović, T. N., Čanadanović-Brunet, J. M., et al. (2014) In vivo and in vitro antioxidant effects of beetroot pomace extracts. Journal of Functional Foods 6, 168-175.
162. Wagner, H. & Jurcic, K. (2002) Immunological studies of Revitonil®, a phytopharmaceutical containing Echinacea purpurea and Glycyrrhiza glabra root extract. Phytomedicine 9, 390-397.
163. Weathers, P. J. & Towler, M. J. (2014) Changes in key constituents of clonally propagated Artemisia annua L. during preparation of compressed leaf tablets for possible therapeutic use. Industrial Crops and Products 62, 173-178.
164. WHO (2003) Diet, Nutrition and the Prevention of Chronic Diseases. WHO Technical Report Series 916. Geneva: World Health Organization.
165. Wong, C. K., Tse, P. S., Wong, E. L. Y., et al. (2004) Immunomodulatory effects of Yun Zhi and Danshen capsules in health subjects - a randomized, double-blind, placebo-controlled, crossover study. International Immunopharmacology 4, 201-211.
166. Wootton-Beard, P. C. & Ryan, L. (2011) A beetroot juice shot is a significant and convenient source of bioaccessible antioxidants. Journal of Functional Foods 3, 329-334.
167. Wrick, K. L. (2005) The impact of regulation on the business of nutraceuticals in the United States: yesterday, today, and tomorrow. In: C. M. Hasler, ed. Regulation of Functional Foods and Nutraceuticals: A Global Perspective. Ames: Wiley-Blackwell, pp 3-36.
168. Wu, P., Ma, G., Li, N., et al. (2015) Investigation of in vitro and in vivo antioxidant activities of flavonoids rich extract from the berries of Rhodomyrtus tomentosa (Ait.) Hassk. Food Chemistry 173, 194-202.
169. Xu, J., Seo, A. Y., Vorobyeva, D. A., et al. (2010) Beneficial effects of a Q-ter® based nutritional mixture on functional performance, mitochondrial function, and oxidative stress in rats. PLoS One 5, 1-10.
170. Yakoot, M., Salem, A. & Helmy, S. (2013) Effect of Memo®, a natural formula combination, on Mini-Mental State Examination scores in patients with mild cognitive impairment. Clinical Interventions in Aging 8, 975-981.
171. Yang, B., Jiang, Y., Shi, J., et al. (2011) Extraction and pharmacological properties of bioactive compounds from longan (Dimocarpus longan Lour.) fruit - a review. Food Research International 44, 1837-1842.
172. Yu, L., Jiang, B. P., Luo, D., et al. (2012) Bioactive components in the fruits of Ziziphus jujuba Mill. against the inflammatory irritant action of Euphorbia plants. Phytomedicine 19, 239-244.
173. Zeisel, S. H. (1999) Regulation of nutraceuticals. Science 285, 1853-1855.
174. Zhang, C. R., Dissanayake, A. A., Kevseroğlu, K., et al. (2015) Evaluation of coriander spice as a functional food by using in vitro bioassays. Food Chemistry 167, 24-29.
175. Zia-Ul-Haq, M., Ćavar, S., Qayum, M., et al. (2011) Compositional studies: antioxidant and antidiabetic activities of Capparis decidua (Forsk.) Edgew. International Journal of Molecular Sciences 12, 8846-8861.